Amino Acids (AA)

H-Ala-Phe-Ala-OH is a peptidomimetic that has been shown to have hydrogen bonding interactions with caco-2 cells. It also has the ability to form micelles and x-ray diffraction data show that the molecule has a right handed helical conformation. This compound was synthesized by reacting H-Ala-Phe with H-Gly-Gly in an amino acid condensation reaction, followed by hydrolysis of the amide bonds. The bioisosteres for this compound are tripeptides, which are amino acids linked by peptide bonds. The interaction of this compound with caco-2 cells is thought to be due to the hydrogen bonding interactions between this molecule and the hydroxyl groups on the cell surface.

Ac-DL-Phe-pNA is a synthetic derivative of the natural substrate Ac-Lys-pNA. It binds to the active site of serine proteases and blocks the release of their active form, which results in inhibition of collagen synthesis. The reaction is reversible and it can be hydrolyzed by chymotrypsin or elastase. Ac-DL-Phe-pNA has been shown to inhibit protein–protein interactions between epimastigotes and extracellular matrix proteins, leading to cell death. This compound has also been found to have an optimum pH of 6.5, which is neutral.

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Neuropeptide EI is a cyclic peptide that has been shown to have receptor activity in the caudate putamen, as well as locomotor activity and metabolic rate. Neuropeptide EI has also been shown to inhibit lymphatic vessels and amide sequences in fat cells. It has been shown to have various biological functions, such as an anti-inflammatory agent, an analgesic, and a chemotherapeutic agent. It is active against cancer cells and autoimmune diseases, but is inactive against bacteria.

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Fmoc-rink amide resin is a synthetic, radionuclide, and constant polymer. It is used in chemical ligation to produce peptides from amines and growth factors. Fmoc-rink amide resin also has antimicrobial properties due to its ability to inhibit the growth of bacteria and fungi by binding to their cell membranes. This polymer can be conjugated with growth factor or antimicrobial peptides for use as a therapeutic agent or used in the production of antibodies against a particular protein. Fmoc-rink amide resin has been shown to increase epidermal growth factor (EGF) uptake into cells by targeting EGF receptors on the cell surface.