Peptides

<p>Primary SIL peptide for Cetuximab detection and quantification</p>

<p>Nav1.3 activator</p>

<p>Blocker of Nav1.4 channels</p>

<p>Blocker of Nav1.7 channel</p>

<p>Blocker of voltage-gated sodium channels</p>

<p>Ryanodine receptors agonist</p>

<p>Biotin-SARS-CoV-2 Spike RBD 395-430 peptide is the biotinylated version of SARS-CoV-2 Spike RBD 395-430 peptide. SARS-CoV-2 Spike RBD 395-430 peptide is an epitope of interest of the SARS-CoV-2 Spike S glycoprotein Receptor-Binding Domain (RBD). Biotin-SARS-CoV-2 Spike RBD 395-430 peptide is useful for vaccine development and for structure-activity relationship studies<br>SARS-CoV-2 Spike (S) glycoprotein<br>Spike (S) glycoprotein corresponds to one of the leading targets for COVID-19 disease. Present on the surface of Sars-CoV-2 virus, Spike S protein is a class I fusion protein that allows the virus to enter host cells.<br>With a 1 273 aa length, Spike protein has 2 subunits : S1 contains the receptor-binding domain RBD and S2 induces the fusion of the viral envelop with the cellular membrane.<br>SARS-CoV-2 Spike RBD:<br>The receptor-binding domain in SARS-CoV-2 Spike protein allows binding to the Angiotensin-Converting Enzyme receptor 2 (ACE2 receptor) which mediates the viral entry.</p>

<p>Blocker of Kv1.3, Kv1.1 and Kv1.2 channels / Cell Penetrating Peptide</p>

<p>Blocker of A-type potassium channels</p>

<p>Selective blocker of insects calcium channels</p>

<p>MOG (183-191) FVIVPVLGP</p>

<p>NH2-dPEG®4-Glu(OH)-NH-dPEG®4-Glu(OH)-NH-m-dPEG®24 is a peptide containing polyethylene glycol (PEG) as spacer to alter their pharmacokinetic properties and pharmodynamics.</p>

<p>This is a Von Willebrand Factor Heavy Tryptic Peptide Standard for use in protein identification and quantitation. Von Wilebrand Factor is a glycoprotein involved in platelet adhesion and when it is deficient in the body it can result in diseases such as von Willebrand disease.</p>

<p>Cystatin C Heavy Tryptic Peptide Standard for use in protein identification and quantitation studies. Cystatin C is a non-glycosylated, basic protein which can be used as a biomarker to determine kidney function.</p>

<p>Ac-Asp-Asn-Leu-Asp-H (aldehyde) is a peptide that is an agonist of the ion channels. It can be used as a research tool in studies on protein interactions and receptor pharmacology. Ac-Asp-Asn-Leu-Asp-H (aldehyde) binds to the ligand binding site of ion channels, which activates or inhibits their function. This peptide has been shown to inhibit the activity of potassium channels and glutamate receptors, and it can be used as an antibody for cell biology and immunology experiments.</p>

<p>Anti-Substance P Serum is a high purity protein that specifically binds to the receptor for substance P, which is a peptide hormone. This product has an affinity for the high affinity binding site of the receptor and inhibits the activity of substance P. Anti-Substance P Serum is used as a research tool in pharmacology and cell biology, as well as in antibody production.</p>

<p>Bis-dPEG®13-NHS Ester is a PEG polymer categorised as homobifunctional PEG (X-PEG X). Used as a linker, bis-dPEG®13-NHS Ester is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.</p>

<p>Fmoc-N-Amido-dPEG®36-Acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Fmoc-N-Amido-dPEG®36-Acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Amino-dPEG®12-OH is a PEG polymer categorised as monofunctional (OH-PEG-X). Used as a linker, amino-dPEG®12-OH is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.</p>

<p>Azido-dPEG®8-Acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Azido-dPEG®8-Acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Amino-dPEG®4-(m-dPEG®8)3 is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Amino-dPEG®4-(m-dPEG®8)3 is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of PREB antibody, catalog no. 70R-8016</p>

<p>Arg-Arg-Leu-Ile-Glu-Asp-Ala-Glu-Tyr-Ala-Ala-Arg-Gly is a peptide with the molecular formula C14H20N4O2. It is an inhibitor of protein interactions, activator of ligands and receptor, and has a CAS number of 2382-80-1. This product is used in research to study ion channels and antibodies.</p>

<p>Des-Arg9-bradykinin is a peptide that is a potent activator of the B2 receptor. It is a potent inhibitor of ion channels, including Ca2+, K+ and Na+ channels. Des-Arg9-bradykinin has been used as a research tool in cell biology, particularly to investigate the role of bradykinins in signal transduction pathways. This chemical is highly purified and can be obtained from Sigma-Aldrich with CAS No. 15958-92-6.</p>

<p>4,7,8,9-Ac4-Neu5Troc(2→O)-O-C(CF3)=NPh Methyl Ester is a glycosylated peptide that is conjugated with an acetate ester. This compound is a member of the Acetyl Neu5Ac family of glycoconjugates that are found on the surface of cells and are involved in cell-cell interactions and immune responses. 4,7,8,9-Ac4-Neu5Troc(2→O)-O-C(CF3)=NPh Methyl Ester has been shown to inhibit bacterial growth by interfering with the synthesis of bacterial cell walls.</p>

<p>Boc-Leu-Ser-Thr-Arg-AMC is a fluorescent peptide used as a research tool to study protein interactions. It can be used to activate or inhibit ion channels. Boc-Leu-Ser-Thr-Arg-AMC is a high purity, water soluble peptide that has been purified by HPLC and characterized for its purity and integrity by mass spectrometry and amino acid analysis.</p>

<p>Gly-Gly is a natural compound that belongs to the group of esters. It has been shown to have an antioxidative effect in vitro and in vivo. Gly-Gly has been shown to inhibit the growth of carcinoma cells by binding with hydrogen bonding interactions, which leads to cell death. This compound also has a strong antibacterial efficacy against Gram-positive bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA). In addition, gly-gly has been shown to be effective against Mycobacterium tuberculosis and Mycobacterium avium complex. This compound may be useful for treating infectious diseases caused by Gram-positive bacteria such as MRSA or methicillin resistant Staphylococcus aureus (MRSA).</p>

<p>DNP-dPEG®4-Acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. DNP-dPEG®4-Acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>This product contains disulfide bonds between Cys3-Cys14. Somatostatin is a hormone that regulates the release of growth hormones, insulin, and glucagon from the pancreas. It is widely expressed throughout the body for example in the gastrointestinal (GI) tract, hypothalamus, pancreas and the central nervous system. In the central nervous system somatostatin plays a role in neurotransmission modification and it has also demonstrated to be effective against a number of cancers such as squamous carcinoma.</p>

<p>His-Leu is a signal peptide that contains the amino acid sequence His-Leu. It is used in a variety of diagnostic tests and has been shown to bind to the p-hydroxybenzoic acid inhibitor binding site on the enzyme histone H1. This peptide has also been shown to inhibit the activity of histone H1 enzymes, which are involved in the regulation of DNA replication and transcription. In addition, His-Leu has been shown to inhibit specific enzymes that regulate human serum albumin synthesis, such as preparative high performance liquid chromatography (Hplc) and terminal residues. His-Leu can be used for diagnosis or as an inhibitor for infectious diseases.</p>

<p>Motilin is a peptide that is used as a research tool in the fields of cell biology, pharmacology, and biochemistry. It is an activator of the motilin receptor and has been shown to bind to ligand-gated ion channels. Motilin has also been shown to inhibit the activity of high-voltage activated calcium channels.</p>

<p>Platelet Factor-4 (PF4) is an activator of G protein coupled receptors that belongs to the group of peptides. PF4 binds to the CXCR1 receptor and activates it, which causes a change in the ion channels. It has been shown that PF4 can activate other G protein coupled receptors such as CXCR2 and CXCR3. This protein is used in research as a ligand for antibody production or as a research tool for studying the interactions between proteins. Platelet Factor-4 has been shown to inhibit ATPase activity in cell membranes and may be useful in pharmacological studies.</p>

<p>CGRP (Rat) product with the disulfide Bonds: Cys2-Cys7 and available as a 0.5mg vial. CGRP is the calcitonin gene-related peptide (CGRP), a neuropeptide that plays an important role in the regulation of vascular tone and blood flow, as well as pain perception, inflammation, and neurogenic inflammation. It is a potent vasodilator and has been implicated in a wide range of physiological and pathophysiological processes.<br>This product has the potential for use in the study of the physiological and pathological roles of CGRP and to investigate the effects of CGRP on blood vessels, neurons, and other tissues. It has also been used to develop models of migraine headaches and other conditions associated with CGRP dysfunction.</p>

<p>NPY is a peptide that is released by neurons and acts as an activator. It is also found in the central nervous system and regulates appetite, as well as other autonomic, behavioral, and endocrine functions. NPY has been shown to be an inhibitor of ion channels in the central nervous system. NPY has been shown to bind to receptors on the surface of cells, which are ligands for NPY. This binding activates or inhibits the receptor's signaling pathway. The CAS number for NPY is 1139-14-1 and it has a molecular weight of 9.6 kDa.END&gt;</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of NOL6 antibody, catalog no. 70R-4744</p>

<p>Particle size: 130 µmcapacity: 0.2 - 0.3 mmol/g</p>

<p>Fmoc-Amido-dPEG®24-Amido-dPEG®24-Acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Fmoc-Amido-dPEG®24-Amido-dPEG®24-Acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Brazzien (2-54) is a peptide that binds to the extracellular domain of the human receptor for Advanced Glycation Endproducts (RAGE). This receptor plays an important role in many cellular processes, including tissue damage and inflammation. Brazzien (2-54) is a potent inhibitor of RAGE activity and has been shown to inhibit the binding of RAGE ligands to RAGE.</p>

<p>Substance P is a member of the tachykinin neuropeptide family which is produced in the central nervous system (CNS) and acts through its specific receptor neurokinin 1 receptor (NK-1R). NK-1R is present in neurons and on glial cell types. Substance P is involved in: pain perceptions as a neurotransmitter; gut motility; increased inflammation in the lungs, gastrointestinal tract and the skin and neuroinflammation. Interestingly the levels of Substance P are raised in inflammatory bowel diseases and through its involvement in cytokine release, it contributes to asthma pathology. These diverse selection of functions makes substance P a target for therapeutic research.</p>

<p>DOTA-tris(Acid)-Amido-dPEG®3-Bromoacetamide is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. DOTA-tris(Acid)-Amido-dPEG®3-Bromoacetamide is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>MAL-dPEG®4-Glu(TFP Ester)-NH-m-dPEG®24 is a peptide containing polyethylene glycol (PEG) as spacer to alter their pharmacokinetic properties and pharmodynamics.</p>

<p>[D-Ala2,Met5]-Enkephalinamide is a peptide that belongs to the group of opioid peptides. It acts as an agonist and binds to the µ-opioid receptor. This receptor is involved in transmitting signals from outside the cell to inside the cell by regulating ion channels and controlling protein interactions. The binding of [D-Ala2,Met5]-Enkephalinamide to this receptor results in an inhibitory effect on neurotransmitter release, leading to a decrease of pain sensation. It has also been shown that [D-Ala2,Met5]-Enkephalinamide can act as an antagonist at other opioid receptors, such as the κ-opioid receptor.</p>

<p>CH3O-PEG-NH2 is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. CH3O-PEG-NH2 is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Please enquire for more information about DBCO-Acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of PROS1 antibody, catalog no. 70R-6073</p>

<p>NT 3 Mouse is a peptide that belongs to the group of activators. It is used as a research tool for its ability to activate the protein tyrosine kinase receptor, and is also an antibody. NT 3 Mouse has been shown to be an inhibitor of ion channels and protein interactions. This peptide binds to the receptor and blocks the binding of ligands such as ATP, which are necessary for signaling. The CAS number for NT 3 Mouse is 51101-54-6.</p>

<p>Gastrokine 2 is a recombinant human peptide that inhibits the activity of an enzyme called protein kinase C (PKC). PKC is involved in a number of cellular processes, including signal transduction and cell proliferation. Gastrokine 2 has been shown to inhibit PKC activity in vitro and in vivo. It has been used as a research tool for studying PKC-mediated signal transduction pathways.</p>

<p>A TIMP1 Light Tryptic Peptide Standard for protein identification and quantitation studies. TIMP1, also known as TIMP metallopeptidase inhibitor 1 is an inhibitor of matrix metalloproteinases, which are enzymes that break down the extracellular matrix. It has also been associated with cell proliferation promotion and may have a role in apoptosis.</p>

<p>Please enquire for more information about Fmoc-N-Lys-(dPEG®12-Biotin)-OH-(Acid) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Anti-TNF-alpha (rat) serum is a protein that blocks the effects of tumor necrosis factor-alpha. This protein has been shown to regulate the immune system and inhibit inflammation. Anti-TNF-alpha (rat) serum is a high quality, purified protein for use as a research tool in cell biology or other life science applications. The product is supplied at a concentration of 1 mg/ml in phosphate buffered saline with 0.02% sodium azide and is suitable for use in mammalian experiments.</p>

<p>Anti TNF-Alpha (Rat) Serum Host Goat is a research tool that is used to inhibit the production of tumor necrosis factor-α (TNF-α). It is an antibody that binds to TNF-α and prevents it from binding to its receptor. Anti TNF-Alpha (Rat) Serum Host Goat has been shown to inhibit the production of TNF-α in vitro, but not in vivo. This serum can be used as a control for other antibodies that are inhibiting the production of TNF-α.</p>

<p>Gly-Gly-His is a peptide that binds to copper and forms a complex. It has been shown to have antimicrobial properties in a model system using human serum. Gly-Gly-His is a diazonium salt that reacts with histidine, leading to the formation of an amide bond. The histidine residue can be replaced by other amino acids, such as lysine, arginine, or asparagine. This peptide also has calcium binding properties and has been shown to have biological properties in the femoral vein of rats.</p>

<p>A standard for use in proteomics</p>

<p>APOA1 MS Calibrator-2 is a New England Peptide that is a member of the apolipoprotein A family. APOA1 MS Calibrator-2 has been used in proteomics research as a control peptide for quantitative analysis of Apo-AI by MALDI TOF MS. It has also been used as an internal standard in mass spectrometry experiments to quantify Apo-AI and other proteins.</p>

<p>Brain Natriuretic Peptide is a peptide that belongs to the family of atrial natriuretic peptides. It is primarily secreted by the ventricles in response to high blood pressure, and also acts as an endogenous ligand for the G-protein coupled receptor NPR1. Brain Natriuretic Peptide has been shown to be an activator of ion channels and receptors that are implicated in cell biology, such as potassium channels. Brain Natriuretic Peptide also has been shown to inhibit the effects of peptides such as angiotensin II, which may be due to its ability to inhibit the binding of angiotensin II to its receptor.</p>

<p>MAL-dPEG®2-TFP Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. MAL-dPEG®2-TFP Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Angiotensin converting enzyme (ACE) heavy tryptic peptide standard for use in proteomics studies. ACE is involved in the regulation of blood pressure through converting inactive angiotensin I to active angiotensin II and also degrading active Bradykinin.</p>

<p>Interleukin-2 (IL-2) is a cytokine that has been shown to be effective in the treatment of autoimmune diseases, such as ulcerative colitis and Crohn's disease. IL-2 may also play a role in cancer prevention and treatment. IL-2 is a protein sequence of 191 amino acids that stimulates T cells to produce other cytokines, such as Interferon gamma. IL-2 is available in freeze-dried form or desiccated form, depending on how it will be used. To reconstitute the desiccated form, mix 1 mL of sterile water with one vial of IL-2 that needs to be reconstituted. The reconstituted IL-2 should be stored at room temperature for up to 24 hours before use.</p>

<p>Anti Leptin (Rat) Serum is a peptide that is used as a research tool to activate the receptor. Anti Leptin (Rat) Serum has been shown to inhibit protein interactions and may be used in pharmacology to study the effects of leptin on ion channels. This antibody can be used for immunohistochemistry, Western blotting, and ELISA.</p>

<p>Anti PTH (1-15) (Rat) Serum is a research tool that is used to study the activity of the parathyroid hormone. This product can be used as an activator or ligand in cell biology experiments. It has been shown to have a high affinity for the parathyroid hormone receptor and can be used to study protein interactions. Anti PTH (1-15) (Rat) Serum can also be used in pharmacological studies and may inhibit ion channels. This product has been shown to bind with peptides, which are small proteins, as well as antibodies and it may also inhibit protein synthesis.</p>

<p>Neuromedin U Precursor-Related Peptide 33 (Rat, Mouse) is a research tool that can be used to study the effects of neuromedin U on the activation of receptors. This peptide is a ligand for the receptor and has been shown to inhibit ion channels. Neuromedin U Precursor-Related Peptide 33 (Rat, Mouse) may also be used as an antibody or in protein interactions studies. This product is made from high purity materials and can be used in pharmacology and life science experiments.</p>

<p>IL-8 (1-72) is a chemokine that belongs to the IL-8 family. It is a potent neutrophil chemoattractant and activator. IL-8 (1-72) has been shown to stimulate the production of other proinflammatory cytokines, such as IL-6, and to promote leukocyte migration across endothelial cells in vitro.</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of ZNF651 antibody, catalog no. 20R-1109</p>

<p>IL-5 is a mouse monoclonal antibody that is used as a research tool. This antibody binds to the IL-5 receptor and is an activator of the receptor. IL-5 has been shown to activate ion channels and inhibit protein interactions, among other things. IL-5 has been shown to inhibit the binding of Ligand to Receptor, which may be due to its ability to bind to both Ligand and Receptor simultaneously.</p>

<p>m-dPEG®48-NH-CO(CH2)3CO-TFP Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. m-dPEG®48-NH-CO(CH2)3CO-TFP Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>PDGFD is a potent inhibitor of protein interactions. PDGFD has been shown to inhibit the interaction between Kv1.2 and its ligand, as well as inhibit the activation of potassium channels by ATP. PDGFD has also been used in research as a tool to study receptor-ligand interactions and ion channels. This product is a recombinant human protein that has been expressed in E. coli cells with an N-terminal hexahistidine tag for easy purification, and is &gt;95% pure.</p>

<p>Leptin is a hormone that regulates energy metabolism by modulating appetite and body weight. Leptin is produced by fat cells and signals to the hypothalamus of the brain about how much fat tissue there is. It also helps regulate other metabolic processes, such as insulin resistance and glucose tolerance. Leptin has been shown to have an anorectic effect in rodents, which may be due to its ability to reduce food intake or increase energy expenditure. In humans, leptin levels are higher in obese individuals than in those with normal weight, which indicates that this hormone may play a role in obesity.</p>

<p>Please enquire for more information about Val-His-[D7]Leu-Thr-Pro-Glu including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Lipoprotein-associated phospholipase A2 (LP-PLA2) heavy tryptic peptide standard for protein identification and quantitation studies. LP-PLA2 is a phospholipase A2 enzyme known as platelet-activating factor acetylhydrolase and it is largely associated with low density lipoprotein in the blood.</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of FYTTD1 antibody, catalog no. 70R-10077</p>

<p>HMGB1 is a protein that belongs to the family of high-mobility group box proteins. It is involved in regulating the release of inflammatory mediators and cytokines, such as IL-1β, IL-6, TNF-α and MCP-1. HMGB1 also plays a role in activation of neutrophils and macrophages. The recombinant form of HMGB1 has been shown to be an excellent research tool for studying protein interactions and receptor ligand interactions. High purity HMGB1 can be used as a pharmacological inhibitor or activator.</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of EXOSC2 antibody, catalog no. 70R-1344</p>

<p>NRGN is a protein that is encoded by the neurogranin gene. It is expressed in the human brain and has been shown to be involved in synaptic transmission and memory formation. NRGN binds to calmodulin and phosphorylates protein kinase C, which activates MAPK pathways. The molecular mass of NRGN is about 60 kDa for recombinant human proteins.</p>

<p>Ac-Asp-Met-Gln-Asp-H aldehyde is a synthetic peptide that has been shown to inhibit protein interactions with the extracellular domain of the human insulin receptor. It also has been shown to activate the receptor, which leads to increased intracellular calcium levels and increased insulin secretion. Ac-Asp-Met-Gln-Asp-H aldehyde may be used as a research tool for studying protein interactions or as an antibody labeling agent. It is highly pure and can be used in cell biology and life science laboratories.</p>

<p>6-TAMRA-Amyloid beta-Protein (Human, 1-40) is a fluorescent dye that has been used to study the interaction of amyloid beta protein with ion channels. It can be used in research as a tool to investigate the pharmacology of peptides and proteins. 6-TAMRA-Amyloid beta-Protein (Human, 1-40) is a high purity product that has been shown to inhibit amyloid beta protein binding to receptors.</p>

<p>MOCA is a small peptide with anti-inflammatory properties that binds to the receptor IL-1R. It has been shown to inhibit sodium currents in neurons by binding to the Na+ channel and preventing the influx of sodium ions, which leads to an inhibition of action potentials. MOCA has also been shown to bind with high affinity to the IL-1R and blocks its activity. This inhibition of IL-1R leads to decreased production of proinflammatory cytokines.<br>MOCA has not been shown to have any affinity for other receptors or ligands.</p>

<p>A potent vasoconstrictor (Source rat, 110-123) containing disulfide bonds between Cys8-Cys13 and available as a 0.5mg vial.  <br>Urotensin II is a peptide involved in biological systems such as the nervous, endocrine, cardiovascular and renal and in rats it is primarily found in brainstem and spinal cord motor neurons. Like that of urotensin II-related peptide, urotensin II contains the hexapeptide -CYS-TYR-LYS-TRP-PHE-CYS- known as the core and this is crucial to its biological function.<br>Urotensin II can also increase the concentration of intercellular calcium through binding to its G protein coupled receptor: urotensin-II receptor which causes the activation of Protein kinase C followed by the activation of Phospholipase C.<br>UT-II has been shown to have a wide range of physiological effects in rats, including vasoconstriction, modulation of blood pressure, and stimulation of the release of aldosterone and vasopressin.<br>In addition to its physiological effects, UT-II has also been implicated in the pathogenesis of various cardiovascular and metabolic disorders, including hypertension, heart failure, and diabetes. Inhibition of UT-II signaling has been suggested as a potential therapeutic target for these conditions.</p>

<p>Human BRCA2 is a key contributor to DNA damage repair and thus genomic integrity. Along with RAD51, BRCA2 ensures accurate and timely progression of homologous recombination (HR) at sites of double strand breaks to facilitate repair. BRCA2 also has an important additional function at the replication fork. BRCA2 therefore has anti-tumour properties and mutations in human BRCA2 protein cause a predisposition to breast and ovarian cancers and increase susceptibility to other tumorigenic conditions.BRCA2 interacts with RAD51 through a series of eight motifs called BRC repeats and a separate binding site located in the C-terminal region. Among eight BRC repeats involved in RAD51 binding, BRC4 displays the highest affinity for RAD51. The BRC4-RAD51 interaction may inhibit RAD51 oligomerization. Low concentrations of BRC4 enhance RAD51 binding to single stranded DNA and stimulate RAD51-mediated strand exchange, high concentrations of BRC4 disrupt RAD51 filament formation. Contains an N-terminal biotin tag for easy detection and purification.</p>

<p>FRETS-25Lys is a peptide that can be used as an activator, inhibitor, or ligand for various receptors and ion channels. It has been shown to bind with high affinity to the acetylcholine receptor on the surface of muscle cells. FRETS-25Lys also inhibits the interaction between protein kinase C (PKC) and phospholipase Cγ2 (PLCγ2).</p>

<p>IGF1 is a protein hormone that stimulates growth and development. It binds to the IGF-1 receptor and activates it. IGF1 is used in research as an activator, ligand, or receptor for cell biology studies. IGF1 can be used in antibody production, ion channels, and peptide synthesis. It has been shown to inhibit the binding of other proteins to DNA and RNA. IGF1 is also used in pharmacology and life science research for its protein interactions and pharmacological effects.</p>

<p>Antiproliferative factor Sialoglycopeptide is a research tool that has been shown to activate the immune system. It has been used as a vaccine carrier and in immunotherapy. Antiproliferative factor Sialoglycopeptide binds to the C-type lectin receptor on erythrocytes, triggering an antibody response. This protein also interacts with ion channels, such as Ca2+ channels, and inhibits protein synthesis by inhibiting the tyrosine kinase activity of protein kinase A (PKA). Antiproliferative factor Sialoglycopeptide is a peptide that is active against many types of cancer cells and has been shown to inhibit tumor growth in mice. The CAS number for Antiproliferative Factor Sialoglycopeptide is 12074-48-2.</p>

<p>Please enquire for more information about Fmoc Gly TentaGel® S RAM resin (particle size: 90 µm capacity: 0.2 - 0.25 mmol/g) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>C-Peptide II (Mouse)-EIA Kit is a Mouse C-Peptide II (C-PEPTIDE) ELISA Kit. This kit is designed to measure the level of C-peptide in mouse serum by using a sandwich enzyme immunoassay. The assays are carried out in microtiter plates coated with monoclonal antibodies specific for mouse C-peptide. After incubation, unbound material is removed and the wells are washed. The amount of bound mouse C-peptide is then determined by adding an enzyme conjugate that reacts with the mouse C-peptide and measuring the degree of color development with a spectrophotometer.</p>

<p>PDGF AA is a protein that belongs to the group of growth factors. It interacts with its receptor, PDGFR, which is a type I transmembrane tyrosine kinase receptor. The binding of PDGF AA to the receptor leads to activation of the tyrosine kinase activity and subsequent phosphorylation of downstream targets. PDGF AA has been shown to be an activator for ion channels and ligands as well as inhibitory for antibodies.<br>PDGF AA is used in research tools and cell biology studies as a potent inhibitor of tumor growth and angiogenesis.</p>

<p>Anti Bombesin Serum is a research tool that can be used to study the interactions of proteins with receptors and ion channels. Anti Bombesin Serum may also be used to study the inhibition of peptide receptor activity, for example, by bombesin or other ligands. This product is made from high-quality antibodies that have been selected for their ability to bind bombesin.</p>

<p>Suc-Ala-Leu-Pro-Phe-pNA is a synthetic peptide that can bind to the beta 2 adrenergic receptor. It is an activator of the receptor and it can be used as a research tool to study protein interactions. This peptide is a potent inhibitor of the receptor. Suc-Ala-Leu-Pro-Phe-pNA binds to the beta 2 adrenergic receptor by preventing the binding of other ligands and thus reducing its activity. The peptide has been shown to bind with high affinity, but low potency, in vitro.<br>Suc-Ala-Leu-Pro-Phe pNA is not toxic as it does not lead to cell death.</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of CHAD antibody, catalog no. 70R-5470</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of STK11 antibody, catalog no. 70R-9641</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of MED8 antibody, catalog no. 70R-3778</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of ETFA antibody, catalog no. 70R-2504</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of TMEM75 antibody, catalog no. 70R-6592</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of TSPAN6 antibody, catalog no. 70R-5977</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of ACTL6A antibody, catalog no. 70R-3160</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of PRKACA antibody, catalog no. 70R-9553</p>

<p>Omega-Conotoxin GVIA is a peptide toxin that binds to the nicotinic acetylcholine receptor (nAChR) and blocks its function. It has been shown to be an inhibitor of voltage-gated potassium channels, which are responsible for regulating the electrical activity in cells. Omega-conotoxin GVIA is purified with a high degree of purity and has been shown to have no significant cross-reactivity with other nAChR subtypes. This toxin can be used as a research tool to study nAChR physiology or as an antibody to target this receptor in cell biology experiments.</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of KCNJ12 antibody, catalog no. 70R-5160</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of CTDSPL antibody, catalog no. 70R-2916</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of ZNF780B antibody, catalog no. 70R-8873</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of ERCC4 antibody, catalog no. 70R-2117</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of EFHA2 antibody, catalog no. 70R-3476</p>