Metabolismo

<p>Obeversen is a DGAT-2 synthesis reducer [1] .</p>

<p>ER 50891 quarterhydrate is a potent RARα (retinoic acid receptor α) antagonist that markedly diminishes the inhibitory effects of ATRA (all-trans retinoic acid</p>

<p>IOX2-NH2-1 inhibits E. coli EGLN-3 (prolyl hydroxylase) with an IC50 of 0.02–1 μM.</p>

<p>D-threo-PPMP, a powerful glucosylceramide (GlcCer) synthase inhibitor, effectively impedes karyokinesis and decreases cyst formation.</p>

<p>Adenosine deaminase is an enzyme that catalyzes the irreversible deamination of 2'-deoxyadenosine and adenosine to 2'-deoxyinosine and inosine, respectively.</p>

<p>ACAT-IN-5 inhibits ACAT, suppressing NF-κB-mediated transcription.</p>

<p>N-Desmethyl Sildenafil (UK-103,320) (Desmethylsildenafil) is a prominent metabolite of Sildenafil, a potent inhibitor of phosphodiesterase type 5 (PDE5).</p>

<p>DSPE-PEG1000-TH is a PEG compound composed of DSPE and a pH-responsive cell-penetrating peptide (TH). In acidic environments, such as the tumor microenvironment, TH is activated, enabling the selective delivery of small molecules, oligonucleotides, proteins, and other agents into tumor cells.</p>

<p>Sp-cAMPS triethylamine activates PKA I/II and inhibits PDE3A (Ki 47.6µM), binds PDE10 GAF (EC50 40µM).</p>

<p>Lysinoalanine is an unusual amino acid, not a dipeptide, which exists in proteins of cooked foods. It is formed in food that is heated or treated with alkali.</p>

<p>DSPE-PEG1000-LyP-1 is a PEG compound composed of DSPE and a nine-residue peptide (LyP-1). LyP-1 specifically targets tumor-associated lymphatic vessels and macrophages.</p>

<p>ACAT-IN-2, from EP1236468A1 (ex. 187), inhibits ACAT and blocks NF-κB transcription.</p>

<p>DSPE-PEG1000-APRPG is a PEG compound composed of DSPE and the APRPG peptide. It is applicable for drug delivery.</p>

<p>N-Nitrosoglyphosate sodium, a nitrosamine degradation product and synthetic impurity of glyphosate herbicide [1], is a chemical compound resulting from the</p>

<p>Impurity F of Calcipotriol is a impurity of Calcipotriol. Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors.</p>

<p>Carbonic anhydrase inhibitor29 (Compound 5d) is an inhibitor targeting carbonic anhydrase IX and XII, with an inhibition constant (Ki) of 26.6 nM for carbonic anhydrase IX and a Ki of 10.9 nM for carbonic anhydrase XII. Carbonic anhydrase inhibitor29 can be used in cancer research.</p>

<p>1-Palmitoyl-2-hydroxy-sn-glycero-3-PE is a naturally occurring lysophospholipid and endogenous metabolite used in biochemical experiments</p>

<p>Galactose 1-phosphate, an intermediate substance in both galactose metabolism and nucleotide sugar processes, plays a crucial role in the biochemical pathways</p>

<p>O-Methyl Atorvastatin, an Atorvastatin impurity, orally inhibits HMG-CoA reductase to lower blood lipids.</p>

<p>Tauro-β-muricholic Acid sodium is a endogenous metabolite, is a competitive and reversible antagonist of farnesoid X receptor (FXR)(IC50 of 40 μM).</p>

<p>Beauveriolide I, a cyclodepsipeptide from Beauveria, inhibits lipid droplet and cholesterol synthesis in mouse macrophages; IC50=0.78 μM.</p>

<p>Avenacin A 1 is a biochemical.</p>

<p>HIF1-IN-3 (Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-) is an effective inhibitor of HIF-1 (EC50 = 0.9 μM) and can be used in</p>

<p>CB 300919, a quinazoline antitumor, inhibits CH1 ovarian tumor growth (IC50: 2 nM) over 96h.</p>

<p>SAICAR is an intermediate of de novo purine nucleotide biosynthesis, activates pyruvate kinase isoform M2 (PKM2) in an isozyme-selective manner (EC50: 0.3 mM).</p>

<p>Nedosiran sodium, a GalNAc-dsRNA conjugate, is engineered to suppress the synthesis of the hepatic lactate dehydrogenase (LDH) enzyme.</p>

<p>α-Amylase-IN-4 (Compd 10y) exhibits the highest level of amylase inhibition, demonstrating an IC50 value of 17.83 ± 0.14 μg/mL [1].</p>

<p>glutamate transport blocker</p>

<p>A collection of xnum selected human endogenous metabolites for high throughput and high content screening.</p>

<p>DSPE-PEG2000-CTT2 is a PEG compound consisting of DSPE and the gelatinase inhibitor CTT2 (CTTHWGFTLC). It possesses the ability to specifically target tumors. DSPE-PEG2000-CTT2 is suitable for drug delivery applications.</p>

<p>N6-Isopentenyladenosine, an end product of the mevalonate pathway, is an autophagy inhibitor with anti-melanoma activity.</p>

<p>DSPE-PEG5000-CREKA is a PEG compound composed of DSPE and the fibrin-targeting peptide (CREKA). The CREKA peptide is utilized for targeting tumor cells and tumor vasculature, exhibiting anti-tumor activity. DSPE-PEG5000-CREKA is applicable in drug delivery systems.</p>

<p>8′-Hydroxy ABA (8'-OH-ABA), a key metabolite of abscisic acid (ABA), exhibits hormonal activity by promoting enhanced oil synthesis.</p>

<p>HIV-1 Inhibitor-58 (Compound 10c) is a non-nucleoside reverse transcriptase inhibitor with broad-spectrum antiviral properties, effective against both wild-type</p>

<p>IDO1-IN-7 is a potent IDO1 inhibitor with a 6.1 nM IC50 and immunomodulatory effects for cancer research.</p>

<p>PDE1-IN-5 (Compound 10c) is a selective PDE1C inhibitor with an IC50 of 15 nM, exhibiting anti-inflammatory properties through the inhibition of iNOS, TNF-α, IL</p>

<p>(+)-Geodin, a fungal metabolite, boosts fibrinolysis in BAECs (50-150 μM) and glucose uptake in rat adipocytes (1-100 μg/ml).</p>

<p>DOTA-XYIMSR-01 is a molecular probe targeting CAIX, capable of being labeled with 177Lu for the treatment and localization of malignant gliomas. The uptake of [177Lu]Lu-XYIMSR-01 in U87MG tumors is 6.19% injected dose per gram (% ID/g), with a tumor-to-muscle uptake ratio of 20.14. In an orthotopic glioma model, co-administration with temozolomide significantly enhances survival rates and inhibits tumor growth in mice. DOTA-XYIMSR-01 shows potential for research in the field of cancer treatment.</p>

<p>cis-5-Tetradecenoic acid, found in blood, helps study Long Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency.</p>

<p>GLX481369 is a redox-active substance that functions as an NOX4 inhibitor, exhibiting antioxidant effects [1].</p>

<p>Bam 12P acetate is the putative enkephalin precursor in bovine adrenal, pituitary, and hypothalamus.</p>

<p>Lurasidone metabolite 14326 hydrochloride, an active metabolite of the atypical antipsychotic Lurasidone, maintains its significant function in pharmacological</p>

<p>CETP-IN-4 is a cholesteryl ester transfer protein (CETP) inhibitor.</p>

<p>Ercalcidiol is a metabolite of vitamin D2 and can be used in monitoring vitamin D therapy.</p>

<p>Quinaprilat: active form of quinapril; treats heart failure, hypertension.</p>

<p>DSPE-PEG5000-GRGDS is a PEG compound composed of DSPE and the anti-adhesion peptide (GRGDS). GRGDS can inhibit the binding and adhesion between the extracellular matrix and cell surface integrins. DSPE-PEG5000-GRGDS is applicable for drug delivery.</p>

<p>Cholesteryl Linolenate is a human endogenous metabolite.</p>

<p>DSPE-PEG2000-RVG29 is a PEG compound composed of DSPE and rabies virus glycoprotein 29 (RVG29). RVG29 specifically binds to nicotinic acetylcholine receptors (nAChR) at the blood-brain barrier (BBB) and can traverse the BBB.</p>

<p>2,3-Dihydroxybenzaldehyde exhibits activity against NADH dehydrogenase (Km = 35 µM) and can be used in biochemical experiments and drug synthesis.</p>

<p>PF-03049423: potent, selective PDE-5A inhibitor, IC50 ~0.2 nM, for rat/human thrombomodulin; used in ischemic stroke research.</p>

<p>Secalciferol is a Vitamin D metabolite,Secalciferol is a possibly anti-inflammatory steroid which is involved in bone ossification.</p>

<p>RMC-4630 (SHP2-IN-7) is an inhibitor of SHP2.</p>

<p>7-hydroxy Coumarin sulfate, a phase II coumarin metabolite, aids as an internal standard for GC/LC-MS metabolic analyses.</p>

<p>Compound 6T, designated as Carbonic anhydrase inhibitor26, acts as an inhibitor of Carbonic Anhydrase II (Carbonic AnhydraseII), exhibiting an IC50 value of 9.10 ± 0.26 μM.</p>

<p>α-Glucosidase-IN-75 (compound 13) is an inhibitor of α-glucosidase, exhibiting an IC50 value of 3.81 μM. It is employed in the study of cardiovascular diseases induced by high glucose levels.</p>

<p>Monoisobutyl phthalic acid is a metabolite of phthalate that is in human semen and in meconium.</p>

<p>Guanosine triphosphate tritris (GTP tritris) serves as a crucial enhancer in myocyte differentiation, playing an essential role in regulating miRNA-muscle regulatory factors. It promotes the release of exosomes rich in guanine and guanine-derived molecules, and is considered an activation precursor for RNA synthesis. In mitochondrial functionality, GTP is involved in the entry of proteins into the matrix, which is vital for various regulatory pathways. It initiates peptide synthesis by facilitating the binding of formylmethionine-tRNA to the ribosome, and aids in polypeptide chain elongation. Additionally, GTP acts as a carrier for phosphates and pyrophosphates, channeling chemical energy into specific biosynthetic pathways. It activates signal transduction G proteins, regulates cellular processes such as proliferation and differentiation, and its hydrolysis by small GTPases (including Ras and Rho) is indispensable for both proliferation and apoptosis. Furthermore, the small GTPase Rab assists in vesicle docking, fusion, and formation. Beyond signal transduction, GTP is also an energy-rich precursor in the biosynthesis of DNA and RNA enzymes.</p>

<p>Nor-Acetildenafil is a derivative of Acetildenafil, a synthetic phosphodiesterase inhibitor.</p>

<p>5(S)-HETE, an endogenous metabolite found in the blood, is utilized in researching Rheumatoid Arthritis, Rhinitis, and Asthma [1] [2].</p>

<p>PTP1B-IN-14 is a selective inhibitor of Protein Tyrosine Phosphatase 1B (PTP1B) that targets the allosteric site, exhibiting an inhibitory concentration (IC50)</p>

N-Lactylleucine is an endogenous metabolite detectable in patients with intermediate maple syrup urine disease.

<p>5,6-Dihydro-2H-pyran-2-one is a carbonic anhydrase 1/9 inhibitor that inhibits KB cell viability.</p>

<p>ecMetAP-IN-1 可用作 QSAR 模型，以使用多元线性回归研究蛋氨酸氨基肽酶抑制剂作为抗癌剂。</p>

<p>Cy3 IRGD-PEG-DSPE is a PEG phospholipid containing Cy3 dye, applicable for protein/nucleic acid labeling and fluorescence microscopy. It self-assembles in aqueous solutions to form micelles or lipid bilayers, which are useful for creating liposomes or nanoparticles for the delivery of nutrients, such as mRNA or DNA vaccines.</p>

<p>Phosphatidylethanolamine PLPE: a cell membrane component, studied for anandamide biosynthesis, sPLA2-IIA activity substrate.</p>

<p>α-Muricholic acid is the most abundant primary bile acid in rodents.</p>

<p>Vitamin B12a monohydrochloride (Hydroxocobalamin) is an essential water-soluble vitamin.a cyanide detoxifier and nutritional supplement, injection, inhalation.</p>

<p>Crotonyl-CoA: key in butyric acid fermentation, lysine and tryptophan metabolism, crucial for fatty and amino acid processing.</p>

<p>5A2-SC8 TFA is an ionizable amino lipid used in lipid nanoparticles (LNPs), offering high delivery potential and low in vivo toxicity. It effectively delivers small RNAs, such as siRNA and miRNA, to tumor cells. Moreover, 5A2-SC8 TFA LNPs provide unique delivery paths for RNA within the liver, enhancing therapeutic outcomes in cancer models.</p>

<p>Creatine riboside, a urinary metabolite, is a diagnostic and prognostic biomarker of lung cancer.</p>

<p>IDO-IN-15 is an IDO1 inhibitor ( IC 50 &lt; 0.51 nM).</p>

<p>Febuxostat sec-butoxy acid is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K i of 0.6 nM [1] .</p>

<p>Lipoxygenase (LOX) is a dioxygenase that catalyzes the peroxidation of linoleic acid (LA) or arachidonic acid (AA) in the presence of molecular oxygen.</p>

<p>2,4-Dimethylquinoline is a potential CYP1A2 inhibitor , and it also exhibits weak inhibitory activity against CYP2A5, CYP2A6, and CYP2B6.</p>

<p>Citrulline malate is a cpd of anti-fatigue.</p>

<p>2-Methylnicotinamide is an endogenous metabolite of nicotinamide and can be used for related research in the life sciences.</p>

<p>Galactosylhydroxylysine hydrochloride, found in bone collagen, is higher in metabolic bone loss due to resorption.</p>

<p>1alpha, 24, 25-Trihydroxy VD2 is a vitamin D analog.</p>

<p>MK-8245 trifluoroacetate: Potent liver-targeting SCD inhibitor, IC50=1nM (human). Anti-diabetic/anti-dyslipidemic. Selective, with low adverse event exposure.</p>

<p>1-epi-Regadenoson is an α-isomer impurity of Regadenoson, a highly selective adenosine A2A receptor agonist [1].</p>

<p>DSPE-PEG2000-LyP-1 is a PEG compound composed of DSPE and a nine-residue peptide (LyP-1). LyP-1 specifically targets tumor-associated lymphatic vessels and macrophages.</p>

<p>Nε,Nε,Nε-Trimethyllysine chloride (Lys(Me)3-OH Chloride) is a methylated derivative of the amino acid lysine and a component of histone proteins.</p>

<p>9(R)-HODE cholesteryl ester, from atherosclerotic lesions, may form enzymatically or by lipid peroxidation; used as a chiral analysis standard.</p>

<p>7-Methylguanosine 5’-diphosphate (7-Methyl-GDP) sodium, a cap analog, is utilized in the synthesis of mRNA cap analogues[1].</p>

<p>BAY-588 is an inactive control probe of BAY-876 which is an inhibitor of GLUT1.</p>

<p>DSPE-PEG5000-RVG29 is a PEG compound comprised of DSPE and rabies virus glycoprotein 29 (RVG29). RVG29 specifically binds to nicotinic acetylcholine receptors (nAChR) at the blood-brain barrier (BBB) and facilitates passage through the BBB.</p>

<p>L-Lysine, sulfite (2:1) is a drug/ therapeutic agent.</p>

<p>2-Hydroxy atorvastatin lactone, a metabolite of Atorvastatin, is an orally active HMG-CoA reductase inhibitor that efficiently reduces blood lipids [1][2].</p>

<p>Pyrrophenone selectively and reversibly inhibits cPLA2 (IC50=4.2 nM), blocks AA, PGE2, and LTC4 production in cells, and is less effective on other PLA2s.</p>

<p>DSPE-PEG: a phospholipid-polymer for stable, efficient drug delivery with longer circulation.</p>

<p>(1R,2R)-MK-8189 is an isomer of MK-8189, a potent and selective pyrimidine PDE10A inhibitor.</p>

<p>α-Cyclopentyl-4-(2-quinolinylmethoxy)benzeneacetic acid was identified as possible dual inhibitors for hLTA4H and hLTC4S enzymes by the computer-aided</p>

<p>Endogenous metabolite in urine, 1-O-Hexadecyl-2-O-docosahexaenoyl-sn-glycero-3-phosphorylcholine, linked to obesity research.</p>

<p>Cetirizine 3-chloro impurity is an impurity of Cetirizine 3-chloro [1] .</p>

<p>5-(3-Hydroxyphenyl)-5-phenylhydantoin is a bioactive chemical.</p>

<p>MTHFD2-IN-1 (compound 12) is a potent inhibitor of methylenetetrahydrofolate dehydrogenase (MTHFD2) [1].</p>

<p>Neo-Inositol, a stable, polar compound, is a rare natural inositol stereoisomer.</p>

<p>Melittin Acetate, a PLA2 activator, enhances low-weight PLA2 activity but not high-weight PLA2.</p>

<p>13-cis-Retinyl palmitate in corn flakes is 75% as active as all-trans form.</p>

<p>Ingenol disoxate (LEO43204) is a compound for treating actinic keratosis, a natural Euphorbia peplus extract.</p>

<p>Oxytetracycline calcium is a tetracycline antibiotic effective against Gram-negative and Gram-positive bacteria, inhibits protein synthesis, and fights HSV-1.</p>

<p>Carboxylesterase-IN-1, a pesticide inhibits carboxylesterase at 50 μg/mL, akin to triphenyl phosphate.</p>

<p>Ethylidene-4-nitrophenyl-a-D-Maltoheptaoside (pNP-G7) is a substrate for α-amylase, used to measure α-amylase activity.</p>

<p>Speract, a peptide from sea urchin eggs, regulates sperm motility and stimulates sperm mitochondrial metabolism.</p>

<p>Sphingomyelin phosphodiesterase, a hydrolase, converts sphingomyelin into phosphocholine and ceramide, affecting cellular processes and cholesterol metabolism.</p>