Metabolismo
Los inhibidores del metabolismo son compuestos que interfieren con las vías metabólicas, alterando la producción y utilización de energía dentro de las células. Estos inhibidores se utilizan para estudiar la regulación del metabolismo, el papel de las vías metabólicas en enfermedades como el cáncer y la diabetes, y para desarrollar nuevas estrategias terapéuticas. Los inhibidores del metabolismo pueden dirigirse a diversas enzimas y procesos involucrados en la glucólisis, la oxidación de ácidos grasos y otras funciones metabólicas. En CymitQuimica, ofrecemos una amplia gama de inhibidores del metabolismo de alta calidad para apoyar su investigación en bioquímica, trastornos metabólicos y desarrollo de fármacos.
Subcategorías de "Metabolismo"
- AhR(41 productos)
- Aminopeptidasa(67 productos)
- CETP(18 productos)
- Anhídrido carbónico(178 productos)
- Caseína quinasa(130 productos)
- DHFR(33 productos)
- Descarboxilasa(4 productos)
- Deshidrogenasa(270 productos)
- FAAH(64 productos)
- FXR(58 productos)
- Factor Xa(80 productos)
- Ácido graso sintasa(33 productos)
- Ferroptosis(215 productos)
- GR(3 productos)
- GSNOR(3 productos)
- Glucoquinasa(54 productos)
- HIF / HIF Prolilhidroxilasa(142 productos)
- HMG-CoA reductasa(33 productos)
- Hidroxilasa(30 productos)
- IDO(82 productos)
- LDL(8 productos)
- Lipasa(97 productos)
- Lípido(59 productos)
- Lipoxigenasa(125 productos)
- MAO(87 productos)
- MPO(2 productos)
- NAMPT(36 productos)
- P450(6 productos)
- PAI-1(25 productos)
- PDE(166 productos)
- PED(1 productos)
- PKM(15 productos)
- PPAR(164 productos)
- Fosfolipasa(82 productos)
- ROR(42 productos)
- Receptor de retinoides(29 productos)
- SGK(11 productos)
- Tiorredoxina(12 productos)
- Transferasa(30 productos)
- Transportador(42 productos)
- UGT(4 productos)
- Inhibidores de la xantina oxidasa (XO)(9 productos)
Mostrar 34 subcategorías más
Se han encontrado 8625 productos de "Metabolismo"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
SGK1-IN-3 hydrochloride
<p>SGK1-IN-3 hydrochloride (compound 3a) is an efficacious, orally bioavailable SGK1 inhibitor. The serine/threonine kinase SGK1 acts as an activator of the β-catenin pathway and strongly stimulates cartilage degradation, being upregulated under genomic control in diseased osteoarthritic cartilage. SGK1-IN-3 hydrochloride holds potential for osteoarthritis research.</p>Fórmula:C23H21Cl3N6O3SPeso molecular:566.04614α-Glucosidase-IN-76
<p>α-Glucosidase-IN-76 (Compound 4r) is an inhibitor of α-glucosidase, with an IC50 of 5.44 μM. It can clear ABTS+ free radicals, with a TEAC value of 0.49. Additionally, α-Glucosidase-IN-76 inhibits the proliferation of T24 bladder cancer cells, with an IC50 of 1.74 μM.</p>Fórmula:C21H24N4O10Forma y color:SolidPeso molecular:492.44LZ-007
CAS:<p>LZ-007 is an agonist of the Farnesoid X receptor (FXR), with an EC50 of 51 nM as determined by TR-FRET assay, and an EC50 of 76 nM in HepG2 cells. It exhibits favorable pharmacokinetic properties in SD rats and can improve metabolic dysfunction-associated steatohepatitis induced by high-fat diets and CCl4 in mice.</p>Fórmula:C27H29F3N2O5Forma y color:SolidPeso molecular:518.53PTP1B-IN-25
<p>PTP1B-IN-25 (Compound 19) is an inhibitor of PTP1B with notable antiviral, antibacterial, and antidiabetic activities. It exhibits IC50 values of 0.37 μM for PTP1B, 8.6 μM for HIV, 3.7 μM for α-Glucosidase, and 29 μM for methicillin-resistant Staphylococcus aureus (MRSA).</p>Fórmula:C44H66O17Peso molecular:866.43AChE/BChE-IN-17
<p>AChE/BChE-IN-17 (compound 8m) is a potent inhibitor of AChE and BChE, displaying IC50 values of 125.06 nM and 119.68 nM, respectively. Additionally, AChE/BChE-IN-17 inhibits α-glucosidase, with an IC50 of 41050 nM.</p>Fórmula:C28H25N3O4Peso molecular:467.18451APOL1-IN-2
CAS:<p>APOL1-IN-2 (Compound 467) acts as an inhibitor of apolipoprotein L1 (APOL1). It effectively reduces HEK293 cell death induced by APOL1 G2/G1, with EC50 values of 4.74 nM and 14.3 nM, respectively. Additionally, APOL1-IN-2 decreases the mortality of trypanosomes triggered by APOL1 G2/G1/G0, with EC50 values of 2.24, 6.03, and 3.72 nM, respectively.</p>Fórmula:C28H30ClF3N4O5Forma y color:SolidPeso molecular:595.01Irsenontrine maleate
CAS:<p>Irsenontrine (E2027) maleate is a selective and orally active inhibitor of phosphodiesterase 9 (PDE9). It can be utilized in the study of neurological diseases.</p>Fórmula:C26H26N4O7Forma y color:SolidPeso molecular:506.515E0924G
CAS:<p>E0924G is an orally active PPARδ agonist with an EC50 of 2.82 μM. It enhances the upregulation of osteoprotegerin (OPG) expression, with an EC50 of 0.29 μM. E0924G reduces RANKL-induced osteoclast differentiation and inhibits F-actin ring formation in RAW264.7 macrophages. Additionally, E0924G modulates bone density and bone loss in models of ovariectomy (OVX) and age-related osteoporosis.</p>Fórmula:C12H12N2O3Forma y color:SolidPeso molecular:232.245-Aminoisotonitazene
CAS:<p>5-Aminoisotonitazene is a metabolite of the synthetic opioid analgesic agent, Isotonitazene, found in urine.</p>Fórmula:C23H32N4OForma y color:SolidPeso molecular:380.53SW209049
CAS:<p>SW209049 is a stearoyl-CoA 9-desaturase inhibitor. SW209049 exhivits potent activity against H2122 cell with IC50 of 0.13uM.</p>Fórmula:C25H18N2O4SPureza:99.72%Forma y color:SolidPeso molecular:442.49AUPF02
CAS:<p>AUPF02, a 5-aryluracil derivative, is an effective anti-breast cancer compound with an IC50 value of 23.4 µM against MCF-7 cells.</p>Fórmula:C14H9F5N2OForma y color:SolidPeso molecular:316.23SMS2-IN-1
CAS:<p>SMS2-IN-1: potent SMS2 inhibitor; IC50: 6.5 nM, Kd: 37 nM; 150x selectivity over SMS1.</p>Fórmula:C34H37F6N3O5Pureza:98%Forma y color:SolidPeso molecular:681.67Fumiquinazoline D
CAS:<p>Fumiquinazoline D, from A. fumigatus, inhibits Gram-positive/negative bacteria (MIC 8-16 μg/ml) and F. solani, C. albicans (MIC 32, 64 μg/ml).</p>Fórmula:C24H21N5O4Forma y color:SolidPeso molecular:443.463SBI993
CAS:<p>SBI993, a SBI-477 analog, confirms MondoA gene action in vivo and lowers muscle TAG and liver fat.</p>Fórmula:C23H23N3O5SPureza:99.20%Forma y color:SolidPeso molecular:453.515-(3',4'-Dihydroxyphenyl)-γ-valerolactone
CAS:<p>5-(3',4'-Dihydroxyphenyl)-γ-valerolactone is a metabolic byproduct of gut microbiota processing of (-)-Epicatechin. [5-(3',4'-Dihydroxyphenyl)-γ-valerolactone] exhibits antioxidant properties.</p>Fórmula:C11H12O4Forma y color:SolidPeso molecular:208.21isomer-CM 352
CAS:<p>isomer-CM 352 is a metalase inhibitor that can be used to slow brain damage.</p>Fórmula:C24H29N3O6SPureza:99.65%Forma y color:SoildPeso molecular:487.57Ilexoside O
CAS:<p>Ilexoside O, a root-derived triterpene saponin, modestly blocks XOD with an IC50 of 53.05 μM.</p>Fórmula:C53H86O22Forma y color:SolidPeso molecular:1075.24916(S)-HETE
CAS:<p>16(S)-HETE, a CYP450 byproduct of arachidonic acid, inhibits kidney tubule ATPase by 60% at 2 μM upon angiotensin II trigger.</p>Fórmula:C20H32O3Forma y color:SolidPeso molecular:320.473Glycidamide
CAS:<p>Glycidamide is a carcinogen and metabolite of acrylamide that induces DNA adduct formation and mutations.</p>Fórmula:C3H5NO2Forma y color:SolidPeso molecular:87.08Angiotensin 1/2 (1-9)
CAS:<p>Angiotensin 1/2 (1-9) is containing the amino acids 1-9 that are converted from Angiotensin I/II peptide.</p>Fórmula:C56H78N16O13Pureza:98%Forma y color:SolidPeso molecular:1183.32Olanzapine N-Oxide
CAS:<p>Olanzapine N-Oxide is a metabolite of Olanzapine which shows antipsychotic activity.</p>Fórmula:C17H20N4OSPureza:98.21%Forma y color:SolidPeso molecular:328.43Octocog alfa
CAS:<p>Octocog alfa, a second-generation, full-length recombinant antihemophilic factor VIII (AHF), is utilized for the treatment of Hemophilia A [1].</p>Forma y color:SolidN-Trifluoroacetyladriamycin
CAS:<p>N-Trifluoroacetyladriamycin, Valrubicin's metabolite, treats bladder cancer; it's an analog of doxorubicin, infused into the bladder.</p>Fórmula:C29H28F3NO12Forma y color:SolidPeso molecular:639.533IYPTNGYTR acetate
<p>IYPTNGYTR acetate, a deamidation-sensitive peptide derived from Trastuzumab, is a suitable tool for monitoring the metabolism of Trastuzumab in vivo [1].</p>Forma y color:Liquid5,6-Dihydro-2H-pyran-2-one
CAS:<p>5,6-Dihydro-2H-pyran-2-one is a carbonic anhydrase 1/9 inhibitor that inhibits KB cell viability.</p>Fórmula:C5H6O2Forma y color:SolidPeso molecular:98.1ecMetAP-IN-1
CAS:<p>ecMetAP-IN-1 可用作 QSAR 模型，以使用多元线性回归研究蛋氨酸氨基肽酶抑制剂作为抗癌剂。</p>Fórmula:C13H11N3Pureza:99.34%Forma y color:SolidPeso molecular:209.25SB-435495 ditartrate
CAS:<p>SB-435495 ditartrate is a potent, selective, reversible, non-covalent, and orally active inhibitor of Lp-PLA2, demonstrating an IC50 value of 0.06 nM [1] [3].</p>Fórmula:C46H52F4N6O14SForma y color:SolidPeso molecular:1020.99Cy3 IRGD-PEG-DSPE
<p>Cy3 IRGD-PEG-DSPE is a PEG phospholipid containing Cy3 dye, applicable for protein/nucleic acid labeling and fluorescence microscopy. It self-assembles in aqueous solutions to form micelles or lipid bilayers, which are useful for creating liposomes or nanoparticles for the delivery of nutrients, such as mRNA or DNA vaccines.</p>Forma y color:Odour SolidDios-Arg (trifluoroacetate salt)
CAS:<p>Dios-Arg, a steroid cationic lipid, binds DNA for transfection, but is cytotoxic to H1299/HeLa cells at 83.5/74.1 μg/ml IC50s.</p>Fórmula:C43H67F6N5O9Forma y color:SolidPeso molecular:912.01FASN-IN-6
<p>FASN-IN-6 (compound 44), a potent fatty acid biosynthesis (FAB) inhibitor, serves as an antibacterial agent, exhibiting minimum inhibitory concentrations (MICs</p>Fórmula:C24H16BrF4N3O2Forma y color:SolidPeso molecular:534.3Xanthine oxidase-IN-8
CAS:<p>Xanthine oxidase-IN-8 (Icarisids J) (Compound 7) serves as an inhibitor of xanthine oxidase, exhibiting an inhibitory concentration (IC50) value of 29.71 μM [1</p>Fórmula:C44H58O23Forma y color:SolidPeso molecular:954.922-γ-Linolenoyl-1,3-dilinoleoyl-sn-glycerol
CAS:<p>2-γ-Linolenoyl-1,3-dilinoleoyl-sn-glycerol is a triglyceride.</p>Fórmula:C57H96O6Pureza:98%Forma y color:SolidPeso molecular:877.374,5-Dimethylthiazole
CAS:<p>4,5-Dimethylthiazole exhibits inhibitory against mitochondrial respiration in liver cells and can be used in biochemical experiments and drug synthesis.</p>Fórmula:C5H7NSForma y color:SolidPeso molecular:113.18Crotonyl-CoA
CAS:<p>Crotonyl-CoA: key in butyric acid fermentation, lysine and tryptophan metabolism, crucial for fatty and amino acid processing.</p>Fórmula:C25H40N7O17P3SForma y color:SolidPeso molecular:835.615A2-SC8 TFA
<p>5A2-SC8 TFA is an ionizable amino lipid used in lipid nanoparticles (LNPs), offering high delivery potential and low in vivo toxicity. It effectively delivers small RNAs, such as siRNA and miRNA, to tumor cells. Moreover, 5A2-SC8 TFA LNPs provide unique delivery paths for RNA within the liver, enhancing therapeutic outcomes in cancer models.</p>Forma y color:Odour SolidPenicitide A
CAS:<p>Penicitide A: marine metabolite, moderately cytotoxic to A. brassicae, HepG2 cells.</p>Fórmula:C18H34O4Forma y color:SolidPeso molecular:314.46β-Galactose dehydrogenase
CAS:Beta-Galactose dehydrogenase converts galactose to galactonolactone, reducing NAD to fluorescent NADH; useful in galactose measurement.IDO-IN-15
CAS:<p>IDO-IN-15 is an IDO1 inhibitor ( IC 50 < 0.51 nM).</p>Fórmula:C29H39N5O4Forma y color:SolidPeso molecular:521.662H-Gly-Pro-Gly-NH2
CAS:<p>H-Gly-Pro-Gly-NH2, a tripeptide, inhibits HIV-1 and HIV-2 replication (EC50: 35µM, 30µM) by blocking capsid formation.</p>Fórmula:C9H16N4O3Forma y color:SolidPeso molecular:228.25Sarcinapterin
CAS:<p>Sarcinapterin is a coenzyme isolated from Methanosarcina barkeri.</p>Fórmula:C35H48N7O19PForma y color:SolidPeso molecular:901.773DBPR-110
CAS:<p>DBPR-110: NS5A inhibitor, EC50 of 3.9 pM for HCV1b, SI >12.8 million; EC50 of 228.8 pM for HCV2a, SI >173,130.</p>Fórmula:C50H48N6O4S2Pureza:98%Forma y color:SolidPeso molecular:861.09GZ22-4
<p>GZ22-4 is a near-infrared (NIR) fluorescent probe with a high affinity for carbonic anhydrase IX (CAIX), exhibiting a dissociation constant (Kd) of 0.2 nM. It is applicable in studies for visualizing CAIX-positive tumors.</p>Fórmula:C88H126F3N6NaO24S4Peso molecular:1858.7556110-FTHF
CAS:<p>10-FTHF is a donor of formyl groups in anabolism used as a substrate in formyltransferase reactions, which is important in purine biosynthesis.</p>Fórmula:C20H23N7O7Forma y color:SolidPeso molecular:473.44RORγt inverse agonist 31
<p>RORγt inverse agonist 31 (14g) is a potent antagonist of the retinoic acid receptor-related orphan receptor γt (RORγt), exhibiting an inhibitory concentration (</p>Fórmula:C23H15Cl2F3N4O3SPureza:98%Forma y color:SolidPeso molecular:555.36Ascorbate oxidase
CAS:<p>Ascorbate oxidase, a REDOX enzyme, catalyzes ascorbic acid and oxygen to dehydroascorbic acid, regulating the extracellular matrix.</p>Forma y color:SolidCatestatin acetate
<p>Catestatin acetate is a non-competitive antagonist of nAChR and inhibits catecholamine release.</p>Fórmula:C109H177N37O28SPureza:99.28%Forma y color:SolidPeso molecular:2485.876α-hydroxy Paclitaxel
CAS:<p>6α-hydroxy Paclitaxel (6α-OH-PTX) is a major metabolite of the anticancer compound paclitaxel and is partially cytotoxic.</p>Fórmula:C47H51NO15Pureza:99.33%Forma y color:SolidPeso molecular:869.91α-Amylase/α-Glucosidase-IN-14
<p>α-Amylase/α-Glucosidase-IN-14 is an orally bioactive inhibitor of α-amylase and α-glucosidase, with IC50 values of 45.53 μM and 27.73 μM, respectively.</p>Fórmula:C24H19FN4O2SPeso molecular:446.12128ABC34
CAS:<p>ABC34, an inactive JJH260 control, poorly inhibits AIG1 enzyme at IC50 >25 μM; potently blocks off-target hydrolases ABHD6 and PPT1.</p>Fórmula:C31H33N5O6Forma y color:SolidPeso molecular:571.634α-Amylase/α-Glucosidase-IN-9
<p>α-Amylase/α-Glucosidase-IN-9 (compound 5h) is a dual inhibitor of α-amylase (IC50= 16.4 μM) and α-glucosidase (IC50= 31.6 μM).</p>Fórmula:C20H16ClN5O4Peso molecular:425.08908
