Metabolismo
Los inhibidores del metabolismo son compuestos que interfieren con las vías metabólicas, alterando la producción y utilización de energía dentro de las células. Estos inhibidores se utilizan para estudiar la regulación del metabolismo, el papel de las vías metabólicas en enfermedades como el cáncer y la diabetes, y para desarrollar nuevas estrategias terapéuticas. Los inhibidores del metabolismo pueden dirigirse a diversas enzimas y procesos involucrados en la glucólisis, la oxidación de ácidos grasos y otras funciones metabólicas. En CymitQuimica, ofrecemos una amplia gama de inhibidores del metabolismo de alta calidad para apoyar su investigación en bioquímica, trastornos metabólicos y desarrollo de fármacos.
Subcategorías de "Metabolismo"
- AhR(42 productos)
- Aminopeptidasa(76 productos)
- CETP(20 productos)
- Anhídrido carbónico(196 productos)
- Caseína quinasa(138 productos)
- DHFR(32 productos)
- Descarboxilasa(4 productos)
- Deshidrogenasa(302 productos)
- FAAH(64 productos)
- FXR(62 productos)
- Factor Xa(85 productos)
- Ácido graso sintasa(37 productos)
- Ferroptosis(226 productos)
- GR(3 productos)
- GSNOR(3 productos)
- Glucoquinasa(57 productos)
- HIF / HIF Prolilhidroxilasa(146 productos)
- HMG-CoA reductasa(34 productos)
- Hidroxilasa(36 productos)
- IDO(84 productos)
- LDL(7 productos)
- Lipasa(107 productos)
- Lípido(61 productos)
- Lipoxigenasa(134 productos)
- MAO(87 productos)
- MPO(2 productos)
- NAMPT(40 productos)
- P450(6 productos)
- PAI-1(26 productos)
- PDE(169 productos)
- PED(1 productos)
- PKM(17 productos)
- PPAR(170 productos)
- Fosfolipasa(86 productos)
- ROR(47 productos)
- Receptor de retinoides(21 productos)
- SGK(10 productos)
- Tiorredoxina(12 productos)
- Transferasa(29 productos)
- Transportador(44 productos)
- UGT(4 productos)
- Inhibidores de la xantina oxidasa (XO)(9 productos)
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Se han encontrado 9166 productos de "Metabolismo"
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RORγt inverse agonist 29
RORγt inverse agonist 29 is a potent, selective, orally active RORγt inverse agonist with an IC50 value of 21 nM.Fórmula:C25H24N2O5SForma y color:SolidPeso molecular:464.53PDE4-IN-12
PDE4-IN-12 is a potent and safe PDE4 ubiquitous inhibitor that acts on PDE4 (IC50: 3.5 nM, SI: 2.71) and PDE7 (IC50: 15 nM, SI: 4.27).Fórmula:C34H35NO6Forma y color:SolidPeso molecular:553.64PKM2-IN-9
CAS:PKM2-IN-9 (compound C1) is a potent inhibitor of PKM2, demonstrating a 75% inhibition rate at 50 μM. It plays a significant role in cancer research.Fórmula:C24H22N4O2Forma y color:SolidPeso molecular:398.457Darlifarnib
CAS:Darlifarnib (Compound (S)-058) is an inhibitor of farnesyl transferase and geranylgeranyltransferase, with IC50 values of ≤ 10 nM and > 1000 nM, respectively. It exhibits high metabolic stability in human and mouse liver microsomes, with a half-life of over 100 minutes.Fórmula:C29H20N6OForma y color:SolidPeso molecular:468.509Enpp-1-IN-11
Enpp-1-IN-11 inhibits ENPP1 with a 45 nM Ki, is plasma stable, and has low clearance in human/mouse livers, potentially aiding cancer research.Fórmula:C15H15N5O3SForma y color:SolidPeso molecular:345.38TMX-4116
CAS:TMX-4116 is a CK1α degrader targeting multiple cell lines with DC50s below 200 nM, used in multiple myeloma research and protein degradation strategy studies.Fórmula:C17H19N5O4SForma y color:SolidPeso molecular:389.43MAFP
CAS:MAFP (Methyl Arachidonyl Fluorophosphonate) is an effective irreversible inhibitor of anandamide amidase.Fórmula:C21H36FO2PForma y color:SolidPeso molecular:370.4815-epi-PGE1
CAS:15-epi-PGE1 (15R-Prostaglandin E1; 15-Epiprostaglandin E1), a stereoisomer of PGE1, exhibits reduced biological activity [2]. This compound acts as a non-competitive inhibitor of human placental 15-Hydroxyprostaglandin dehydrogenase (15-PGDH), with an inhibitory concentration 50 (IC50) value of 170 μM [1].Fórmula:C20H34O5Forma y color:SolidPeso molecular:354.48TAP311
TAP311 is an inhibitor of cholesteryl ester transfer protein (CETP)(IC50 of 62 nM).Fórmula:C34H40F6N6O4Pureza:98%Forma y color:SolidPeso molecular:710.71DOCP
CAS:DOCP (2-((2,3-Bis(oleoyloxy)propyl)dimethylammonio)ethyl hydrogen phosphate) is a lipid characterized by an opposite charge orientation compared to traditional phosphatidylcholine (PC) lipids, featuring quaternary ammonium near the bilayer interface and phosphate groups projecting into the aqueous environment. This unique structure of iPC lipids presents an excellent opportunity to investigate the biophysical characteristics and biological activities influenced by the reversal of surface charges on bilayers.Fórmula:C43H82NO8PForma y color:SolidPeso molecular:772.091-Stearoyl-sn-glycerol 3-phosphate sodium
CAS:1-Stearoyl-sn-glycerol 3-phosphate sodium, a biologically active phospholipid, plays a crucial role in regulating cell motility, proliferation, invasion, survival, and the production of growth factors through interactions with G protein-coupled receptors (GPCR). Synthesized during the formation of membrane phospholipids, this compound typically has a low plasma concentration (approximately 100nM) and originates from various cell types, including activated platelets, epithelial cells, leukocytes, neuronal cells, and tumor cells. Its distinctive structure features stearic acid at the sn-1 position and a hydroxyl group at the sn-2 position.Fórmula:C21H42NaO7PForma y color:SolidPeso molecular:460.52CYP2C1/CYP2C19-IN-2
CYP2C1/CYP2C19-IN-2 is a potent inhibitor of CYP2C9/CYP2C19 without liver toxicity or genotoxicity and can be used to study Zika virus (ZIKV) infection.Fórmula:C27H28N2O6SForma y color:SolidPeso molecular:508.59NAZ2329
CAS:NAZ2329: Cell-permeable, targets R5 RPTPs, inhibits hPTPRZ1 (IC50=7.5 μM) & hPTPRG (IC50=4.8 μM), hampers glioblastoma growth, affects stem cell traits.Fórmula:C21H18F3NO4S3Forma y color:SoildPeso molecular:501.56ABD957
CAS:ABD957: covalent ABHD17 depalmitoylases inhibitor, IC50 0.21µM for ABHD17B, blocks N-Ras, halts NRAS-mutant AML cell growth.Fórmula:C27H36F3N7O5SForma y color:SolidPeso molecular:627.68Magnesium ionophore III
CAS:Magnesium ionophore III (ETH 4030) is an ion carrier that regulates intracellular magnesium ion concentrations. It enhances cellular functions and metabolic activities by increasing the permeability of cell membranes to magnesium ions. Additionally, Magnesium ionophore III is utilized in research to explore the significance of magnesium ions in biological processes and their impact on cellular physiology.Fórmula:C30H58N4O4Forma y color:SolidPeso molecular:538.81LRAT-IN-1
CAS:LRAT-IN-1 (compound 1) is an inhibitor of lecithin retinol acyltransferase (LRAT) with an IC50 value of 21.1 μM. This compound works by inhibiting the esterification of retinol to form retinyl esters, thereby increasing the availability of retinol in the skin to deliver anti-aging benefits. LRAT-IN-1 is under investigation for its potential use as an anti-aging ingredient in cosmetics.Fórmula:C27H47N5O5S2Forma y color:SolidPeso molecular:585.82HSD17B13-IN-30
CAS:HSD17B13-IN-30 (compound 64) serves as a potent inhibitor of hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), exhibiting an IC 50 value of less than 0.1 μM? with estradiol? as substrates. This compound is significantly implicated in the management of nonalcoholic fatty liver diseases (NAFLDs), including nonalcoholic steatohepatitis (NASH) [1].Fórmula:C24H16Cl2F3N3O4Forma y color:SolidPeso molecular:538.37-Hydroxy-4-phenylcoumarin
CAS:7-Hydroxy-4-phenylcoumarin is a dual inhibitor of ALDH-2 and MAO, with IC50 values of 1.5 µM and 0.5 µM, respectively.Fórmula:C15H10O3Forma y color:SolidPeso molecular:238.238PF-00489791
CAS:PF-00489791 (PF4634817) is a long-acting PDE5 inhibitor with hypotensive activity for the study of diabetic nephropathy.Fórmula:C20H28N8O4SPureza:99.97%Forma y color:SolidPeso molecular:476.552R,4R-Sacubitril
CAS:2R,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is used in combination with valsartan for the treatment of patients with heart failure.Fórmula:C24H29NO5Pureza:98%Forma y color:SolidPeso molecular:411.49
