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Tirosina quinasa / adaptadores

Tirosina quinasa / adaptadores

Los inhibidores de tirosina quinasa y adaptadores son compuestos que se dirigen a las tirosina quinasas y sus proteínas adaptadoras asociadas, las cuales desempeñan roles cruciales en la señalización celular, el crecimiento y la diferenciación. Estos inhibidores son herramientas esenciales en la investigación del cáncer, ya que muchas tirosina quinasas están involucradas en las vías de señalización que impulsan el crecimiento tumoral y la metástasis. Al inhibir las tirosina quinasas, estos compuestos pueden bloquear cascadas de señalización críticas, ofreciendo potenciales estrategias terapéuticas para varios tipos de cáncer y otras enfermedades que implican una señalización celular anormal. En CymitQuimica, ofrecemos una amplia gama de inhibidores de tirosina quinasa y adaptadores de alta calidad para apoyar su investigación en oncología, biología molecular y desarrollo de terapias dirigidas.

Subcategorías de "Tirosina quinasa / adaptadores"

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Se han encontrado 1370 productos de "Tirosina quinasa / adaptadores"

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  • SST0116CL1

    CAS:
    <p>SST0116CL1 is an HSP90 inhibitor (IC50: 0.21 μM) that targets the ATP-binding pocket of Hsp90, disrupting its chaperone function and leading to the degradation of client proteins (EGFR, CDK4, and AKT). It induces the degradation of Her2 in BT-474 cells (IC50: 0.2 μM) and exhibits antiproliferative activity, inhibiting tumor growth.</p>
    Fórmula:C22H31ClN4O6
    Forma y color:Solid
    Peso molecular:482.96
  • Lucitanib dihydrochloride

    CAS:
    <p>Lucitanib dihydrochloride (E-3810 dihydrochloride) is an efficient VEGFR1-3, FGFR1-3, and PDGFRalpha/β inhibitor, used in metastatic breast cancer research.</p>
    Fórmula:C26H27Cl2N3O4
    Forma y color:Solid
    Peso molecular:516.42
  • ROS1-IN-2

    CAS:
    <p>ROS1-IN-2 (Compound 3), a ROS1 inhibitor, is utilized in cancer research.</p>
    Fórmula:C29H37ClN5O2P
    Forma y color:Solid
    Peso molecular:554.06
  • HER2-IN-12


    <p>HER2-IN-12 is an HER2 inhibitor with an IC50 value of 121 nM and can be used to study cancers such as breast cancer.</p>
    Fórmula:C17H18BrN5O2S
    Forma y color:Solid
    Peso molecular:436.33
  • EGFR/HER2-IN-4


    <p>EGFR/HER2-IN-4: oral, irreversible dual EGFR inhibitor (IC50: 0.6 nM), targets L858R/T790M mutations, potent anti-lung cancer effects in vivo.</p>
    Forma y color:Solid
  • 8-Br-cGMP-AM

    CAS:
    <p>8-Br-cGMP-AM, a derivative of 8-Br-cGMP, acts as an activator of PKG (cGMP-dependent protein kinase), inducing various biological effects such as vasodilation and platelet inhibition. This compound is utilized in the research of cardiovascular diseases.</p>
    Fórmula:C13H15BrN5O9P
    Forma y color:Solid
    Peso molecular:496.16
  • EGFR/HER2/DHFR-IN-1


    <p>Potent EGFR/HER2/DHFR inhibitor for MCF-7 breast cancer; IC50: 0.153/0.108/0.291 μM; arrests G1/S phase, triggers apoptosis.</p>
    Fórmula:C14H11BrN4O2S
    Forma y color:Solid
    Peso molecular:379.23
  • TRK-IN-28

    CAS:
    TRK-IN-28 (compound 30f) functions as a TRK inhibitor, displaying potencies with IC 50 values of 0.55 nM for TRK WT, 25.1 nM for TRK G595R, and 5.4 nM for TRK G667C. Another TRK inhibitor, TRK-IN-2, exhibits antiproliferative effects with IC 50 values against multiple cell lines: 9.5 nM for Ba/F3-ETV6-TRKA WT, 3.7 nM for Ba/F3-ETV6-TRKB WT, 205.0 nM for Ba/F3-LMNA-TRK G595R, and 48.3 nM for Ba/F3-LMNA-TRKA G667C [1].
    Fórmula:C27H25F2N7
    Forma y color:Solid
    Peso molecular:485.53
  • TrkA-IN-7

    CAS:
    <p>TrkA-IN-7 (Compound 4) is an inhibitor of tropomyosin receptor kinase A (TrkA), with a Kd value of 40 μM.</p>
    Fórmula:C16H13N3O3
    Forma y color:Solid
    Peso molecular:295.293
  • JBJ-02-112-05

    CAS:
    <p>JBJ-02-112-05 is a potent, mutant-selective, allosteric and orally active inhibitor of EGFR with an IC 50 of 15 nM for EGFR L858R/T790M [1].</p>
    Fórmula:C27H20N4O2S
    Pureza:98%
    Forma y color:Solid
    Peso molecular:464.54
  • KRC-00715

    CAS:
    <p>KRC-00715 is an orally effective inhibitor of c-Met, exhibiting high selectivity with an IC50 of 9.0 nM. This compound specifically inhibits the growth of gastric cancer cell lines with high c-Met expression by inducing G1/S phase block, and reduces the activity of downstream signals, including Akt, Erk, and c-Met itself. In the gastric cancer cell line Hs746T, KRC-00715 demonstrates cytotoxicity with an IC50 of 39 nM and selectively inhibits the proliferation of cell lines that overexpress c-Met. Additionally, KRC-00715 decreases tumor size in Hs746T xenograft mouse models.</p>
    Fórmula:C25H25F3N8O3
    Forma y color:Solid
    Peso molecular:542.51
  • TRK-IN-26

    CAS:
    <p>TRK-IN-26 (compound 12), a TRK inhibitor, holds potential for use in cancer research [1].</p>
    Fórmula:C30H22F2N6O4
    Forma y color:Solid
    Peso molecular:568.53
  • BTK-IN-16

    CAS:
    <p>BTK-IN-16 is a potential inhibitor of wild-type BTK and C481S mutants.BTK-IN-16 can be used to study various autoimmune diseases and cancers caused by BTK.</p>
    Fórmula:C15H14N4O2
    Pureza:99.04%
    Forma y color:Soild
    Peso molecular:282.3
  • AZ8010

    CAS:
    AZ8010 (AZ12908010) serves as an effective inhibitor of FGFR1-3 and exhibits antiproliferative properties, making it useful for cancer research.
    Fórmula:C27H34N4O3
    Forma y color:Solid
    Peso molecular:462.58
  • HER2-IN-8

    CAS:
    <p>HER2-IN-8 is an inhibitor of HER-2 that can be used in the study of cancer and inflammation-related diseases.</p>
    Fórmula:C26H25F2N9O3
    Forma y color:Solid
    Peso molecular:549.53
  • EGFR-IN-159

    CAS:
    <p>EGFR-IN-159 (compound 12) is a dihydropyrimidine and a potent EGFR inhibitor with an IC50 of 29.00 nM. It exhibits dose-dependent inhibition of EGFR and HER2. The compound shows cytotoxicity against MCF-7 breast cancer cells and Vero cells with IC50 values of 16.07 μg/mL and 35.98 μg/mL, respectively. EGFR-IN-159 does not cross the blood-brain barrier (BBB) and demonstrates significant anticancer activity.</p>
    Fórmula:C21H23N3O5
    Forma y color:Solid
    Peso molecular:397.424
  • EGFR-IN-38

    CAS:
    <p>EGFR-IN-38: low-toxic acrylamide-derived EGFR inhibitor, targets NSCLC, patented for research on EGFR mutation-related diseases.</p>
    Fórmula:C25H24ClN7O2
    Forma y color:Solid
    Peso molecular:489.96
  • EGFR-IN-126

    CAS:
    <p>EGFR-IN-126 (compound 9d) is an effective inhibitor of EGFR L858R/T790M/C797S, displaying an IC50 value of 0.005 μM. It exhibits antitumor activity both in vivo and in vitro.</p>
    Fórmula:C28H28BrFN4O3
    Forma y color:Solid
    Peso molecular:567.45
  • BTK-IN-38

    CAS:
    <p>BTK-IN-38 (Example 125) is an efficacious inhibitor of BTK. It effectively suppresses the proliferation of DOHH2 and BT474 cells, with IC50 values of 114 nM and 340 nM, respectively.</p>
    Fórmula:C27H26F2N4O2
    Forma y color:Solid
    Peso molecular:476.52
  • BNN-20

    CAS:
    <p>BNN-20 is a synthetic micro-neurotrophic factor that mimics Brain-Derived Neurotrophic Factor (BDNF) and exhibits region-specific neuroprotective and neurogenesis-promoting effects. It is applicable in research related to Parkinson's disease.</p>
    Fórmula:C20H30O2
    Forma y color:Solid
    Peso molecular:302.45
  • MerTK/Axl-IN-1

    CAS:
    <p>MerTK/Axl-IN-1 (Compound A-910) is a potent and selective dual inhibitor of MerTK/Axl, exhibiting IC50 values of 4.2 nM and 8.8 nM in Ba/F3 cells, and 0.2 nM and 0.9 nM in HTRF cells, respectively. It effectively inhibits pMerTK in vivo and possesses a long half-life and high oral bioavailability.</p>
    Fórmula:C40H47FN6O4
    Forma y color:Solid
    Peso molecular:694.84
  • c-Kit-IN-8

    CAS:
    <p>C-Kit-IN-8 (Compound 53) acts as an inhibitor of c-Kit kinase, hampering uKIT kinase activity with an IC50 greater than 1 μM. Additionally, it inhibits the proliferation of both wild-type and mutant GIST430 and BaF3 cancer cells, exhibiting an IC50 greater than 0.1 μM.</p>
    Fórmula:C24H26FN5O4
    Forma y color:Solid
    Peso molecular:467.49
  • EGFR-IN-135


    <p>EGFR-IN-135 (compound 3d) is an EGFR inhibitor with an IC50 value of 0.086 µM. It inhibits cell growth and arrests the cell cycle in the S phase in breast cancer cell lines.</p>
    Fórmula:C12H14N4OS2
    Forma y color:Solid
    Peso molecular:294.4
  • EGFR/VEGFR2-IN-2


    <p>EGFR/VEGFR2-IN-2 (compound 4b) serves as a dual inhibitor of VEGFR-2 and EGFR.</p>
    Fórmula:C24H15FO3
    Forma y color:Solid
    Peso molecular:370.37
  • CL-A3-7

    CAS:
    <p>CL-A3-7 is a viral-cell fusion inhibitor targeting the RSVF protein. It functions by blocking the interaction between the virus and the host's IGF1R, effectively inhibiting the infection of both wild-type and K394R mutant strains of RSV. This compound is suitable for use in antiviral drug development and resistance studies related to RSV.</p>
    Fórmula:C24H22Br2F2N2O3
    Forma y color:Solid
    Peso molecular:584.25
  • TAS05567

    CAS:
    <p>TAS05567 is a potent, highly selective, and ATP-competitive Syk inhibitor (IC50: 0.37 nM).</p>
    Fórmula:C21H29N9O2
    Pureza:98%
    Forma y color:Solid
    Peso molecular:439.51
  • DYRKs-IN-1

    CAS:
    <p>DYRKs-IN-1 has antitumor activity.</p>
    Fórmula:C30H30ClN7O4
    Pureza:98%
    Forma y color:Solid
    Peso molecular:588.06
  • 2-Methyl-3-phenylquinoxaline

    CAS:
    <p>2-Methyl-3-phenylquinoxaline (compound 38) serves as an effective inhibitor of the Platelet-Derived Growth Factor Receptor Tyrosine Kinase (PDGF-RTK), exhibiting significant inhibitory activity against the full-length PDGFR kinase in intact cells (IC50 greater than 100 μM).</p>
    Fórmula:C15H12N2
    Forma y color:Solid
    Peso molecular:220.27
  • BIIB129

    CAS:
    <p>BIIB129 is a selective and brain-penetrant BTK covalent inhibitor used to study B-cell proliferation-related diseases.</p>
    Fórmula:C19H22N6O2
    Pureza:98.56%
    Forma y color:Solid
    Peso molecular:366.42
  • D-69491 hydrochloride

    CAS:
    <p>D-69491 hydrochloride is an inhibitor of HER-2 tyrosine kinase activity, blocking the phosphorylation of HER-2 and inhibiting the proliferation of SKOV-3 cells. It exhibits antitumor activity.</p>
    Fórmula:C25H26Cl2FN7O3
    Forma y color:Solid
    Peso molecular:562.42
  • Pred17


    <p>Pred17 is an effective EGFR inhibitor with potential applications in lung cancer research.</p>
    Fórmula:C27H22BN3O
    Forma y color:Solid
    Peso molecular:415.29
  • ES-072

    CAS:
    <p>ES-072, a selective inhibitor targeting the EGFR mutant (EGFR-T790M), is administered orally. By hindering EGFR-T790M activity, it activates GSK3α, which subsequently leads to the phosphorylation of PD-L1 at Ser279 and Ser283. This phosphorylation facilitates the recruitment of the E3 ubiquitin ligase ARIH1, resulting in the ubiquitination and proteasomal degradation of PD-L1. Such a process not only curtails the growth of cancer cells but also amplifies the anti-tumor immune response by diminishing PD-L1 levels. ES-072 has shown efficacy in impeding the proliferation of non-small cell lung cancer (NSCLC) cells.</p>
    Fórmula:C25H27F3N8O2
    Forma y color:Solid
    Peso molecular:528.53
  • BPI-15086

    CAS:
    <p>BPI-15086 is an orally active, effective, irreversible inhibitor selective for mutations, targeting both EGFR and the T790M resistance mutation tyrosine kinase. It can be utilized in the study of non-small cell lung cancer.</p>
    Fórmula:C29H33ClN8O4
    Forma y color:Solid
    Peso molecular:593.08
  • NMS-P626

    CAS:
    <p>NMS-P626 functions as an inhibitor targeting TRKA, TRKB, and TRKC, exhibiting IC 50 values of 8 nM, 7 nM, and 3 nM respectively. It effectively suppresses KM12 cell growth by inhibiting the phosphorylation of TPM3-TRKA and the subsequent downstream signaling, demonstrating an IC 50 of 19 nM specifically for KM12 cells. This compound is applicable in the study of colorectal cancer.</p>
    Fórmula:C28H35F2N7O4S
    Forma y color:Solid
    Peso molecular:603.68
  • Neptinib

    CAS:
    <p>Neptinib (NEP010), a derivative of Afatinib, exhibits enhanced antitumor properties and improved pharmacokinetics when administered orally. It demonstrates a notable suppression of tumor expansion in mouse models of non-small cell lung cancer harboring various EGFR mutations. Furthermore, Neptinib effectively inhibits the EGFR kinase family, exhibiting IC 50 values of 0.24 nM for EGFR wt, 7.25 nM for EGFR L858R/T790M, 0.46 nM for EGFR L858R, and 1.79 nM for EGFR T790M.</p>
    Fórmula:C22H23ClFN5O2
    Forma y color:Solid
    Peso molecular:443.90
  • HS-345

    CAS:
    <p>HS-345, a TrkA/Akt inhibitor, exhibits potent anti-pancreatic cancer properties. This compound inhibits the growth and proliferation of pancreatic cancer cells by blocking the TrkA/Akt signaling pathway and induces cell apoptosis (Apoptosis). Additionally, HS-345 inhibits angiogenesis by reducing the expression of HIF-1α and VEGF. It holds promise for use in pancreatic cancer research.</p>
    Fórmula:C19H18N6O2S
    Forma y color:Solid
    Peso molecular:394.45
  • EGFR-IN-24


    <p>EGFR-IN-24 is a potent inhibitor of EGFR and inhibits EGFR (del19/T790M/C797S) and EGFR (L858R/T790M/C797S).</p>
    Fórmula:C30H35FN6O3
    Forma y color:Solid
    Peso molecular:546.64
  • PET-cGMP

    CAS:
    <p>PET-cGMP is an analogue of cyclic guanosine monophosphate and functions as a potent, selective agonist for PKGI. It exhibits an EC50 of 3.8 nM for PKGIβ and 193 nM for PKGII.</p>
    Fórmula:C18H16N5O7P
    Forma y color:Solid
    Peso molecular:445.323
  • HER2-IN-6

    CAS:
    <p>HER2-IN-6, a potent HER2 inhibitor, may target wild/mutant EGFR and HER2-mediated tumors. (Patent WO2021164697A1, compound 11)</p>
    Fórmula:C26H32N8O3
    Forma y color:Solid
    Peso molecular:504.58
  • EGFR-IN-34


    <p>EGFR-IN-34 is a low-toxicity, acrylamide derivative antitumor agent that is a potent inhibitor of EGFR.</p>
    Fórmula:C26H27ClN6O2
    Forma y color:Solid
    Peso molecular:490.98
  • EGFR-IN-17


    <p>EGFR-IN-17: potent, selective EGFR inhibitor, IC50 of 0.2 nM, overcomes C797S drug resistance.</p>
    Fórmula:C27H31ClN7O3P
    Forma y color:Solid
    Peso molecular:568.01
  • Sacibertinib

    CAS:
    <p>Sacibertinib inhibits Trk, targeting EGFR-TK (EC50 110 nM) &amp; HER2 (EC50 244 nM), with anticancer properties.</p>
    Fórmula:C32H31ClN6O4
    Forma y color:Solid
    Peso molecular:599.08
  • EGFR/HER2-IN-8


    <p>EGFR/HER2-IN-8 inhibits EGFR, HER2, DHFR (IC50: 0.45, 0.244, 5.669 μM); useful in cancer research, safe and selective.</p>
    Fórmula:C16H16N4O2S
    Forma y color:Solid
    Peso molecular:328.39
  • EGFR-IN-35

    CAS:
    <p>EGFR-IN-35, an acrylamide-based EGFR inhibitor, shows promise for EGFR mutation-related cancers like NSCLC.</p>
    Fórmula:C25H24ClN7O2
    Forma y color:Solid
    Peso molecular:489.96
  • EGFR-IN-18


    <p>EGFR-IN-18 strongly inhibits L858R/T790M/C797S mutant EGFR (4.9 nM) and also targets wild-type EGFR (47 nM).</p>
    Fórmula:C33H28N6O3S
    Forma y color:Solid
    Peso molecular:588.68
  • EGFR-IN-23

    CAS:
    <p>EGFR-IN-23, identified as compound 8 in WO2021244502A1, is a potent EGFR tyrosine kinase inhibitor (TKI) demonstrating an inhibitory concentration (IC50) of 8.</p>
    Fórmula:C36H44BrN10O3P
    Forma y color:Solid
    Peso molecular:775.68
  • Vecabrutinib

    CAS:
    <p>Vecabrutinib (SNS-062) is a potent and noncovalent BTK and ITK inhibitor (Kd: 0.3 nM and 2.2 nM, respectively). Vecabrutinib displays an IC50 of 24 nM for ITK.</p>
    Fórmula:C22H24ClF4N7O2
    Pureza:99.74%
    Forma y color:Solid
    Peso molecular:529.92
  • Zotizalkib

    CAS:
    <p>TPX-0131: potent, selective, CNS-ready, oral ALK inhibitor (WT IC50: 1.4nM, G1202R/L1196M IC50: 0.3nM) with robust antitumor effects.</p>
    Fórmula:C21H20F3N5O3
    Pureza:98.7%
    Forma y color:Solid
    Peso molecular:447.41
  • AZ12601011

    CAS:
    <p>AZ12601011 is a TGFBR1 kinase inhibitor that inhibits the growth of breast tumors.</p>
    Fórmula:C19H15N5
    Pureza:98.81%
    Forma y color:Solid
    Peso molecular:313.36
  • Enbezotinib

    CAS:
    <p>Enbezotinib is an inhibitor of RET autophosphorylation and can be used in cancer research.</p>
    Fórmula:C21H21FN6O3
    Pureza:99.84%
    Forma y color:Solid
    Peso molecular:424.43
  • AGL-2263

    CAS:
    <p>AGL-2263 is a blocker of insulin receptor (IR)</p>
    Fórmula:C17H10N2O5
    Forma y color:Solid
    Peso molecular:322.27

    Ref: TM-T14142

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  • EGFR-IN-7

    CAS:
    <p>EGFR-IN-7 (TQB3804) is a selective and potent EGFR kinase inhibitor.</p>
    Fórmula:C32H41BrN9O2P
    Pureza:95.32% - 99.64%
    Forma y color:Solid
    Peso molecular:694.6

    Ref: TM-T11161

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  • HMBD-001


    <p>HMBD-001 is a humanized IgG1 monoclonal antibody inhibitor that targets HER3. By inhibiting the dimerization of HER3, HMBD-001 suppresses the growth and proliferation of tumor cells. It holds potential for research in cancer treatments, specifically for pancreatic cancer and non-small cell lung cancer.</p>
    Forma y color:Odour Liquid

    Ref: TM-T9901A-949

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  • Tyrosine kinase inhibitor

    CAS:
    <p>Tyrosine kinase inhibitor is a tyrosine kinase inhibitor used in combination with fragmenting aromatic nitrogen compounds as antiproliferative agents.</p>
    Fórmula:C31H31FN6O5
    Pureza:98%
    Forma y color:Solid
    Peso molecular:586.61

    Ref: TM-T17184

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  • Nimotuzumab (powder)

    CAS:
    <p>Nimotuzumab (powder) is a humanized IgG1 monoclonal antibody that specifically targets the epidermal growth factor receptor (EGFR), possessing a dissociation constant (KD) of 0.21 nM. It blocks the binding to its ligand by targeting the extracellular domain of EGFR. Nimotuzumab exhibits strong antitumor activity by inducing both antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC), exerting cytolytic effects on target tumors.</p>
    Forma y color:Liquid

    Ref: TM-T9901A-1025

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  • TLC9995-0188

    CAS:
    <p>Tyrosine-protein kinase ABL, IC50: 1500 nM</p>
    Fórmula:C16H15N5
    Forma y color:Yellow Solid
    Peso molecular:277.331

    Ref: TM-T116837

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  • Duligotuzumab

    CAS:
    <p>Duligotuzumab (MEHD-7945A) is a bispecific humanised IgG-κ monoclonal antibody targeting HER3 and EGFR, solid tumours, head and neck cancer,colorectal cancer.</p>
    Pureza:95%
    Forma y color:Liquid

    Ref: TM-T80604

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  • EGFR-IN-82

    CAS:
    <p>EGFR-IN-82 (Compound 8a) is a potent, orally active inhibitor of EGFR, exhibiting IC50 values of 0.09 nM for EGFR L858R/T790M/C797S and 0.06 nM for EGFR Del19/</p>
    Fórmula:C32H41BrN9O2P
    Pureza:98%
    Forma y color:Solid
    Peso molecular:694.6

    Ref: TM-T78788

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  • Trk-IN-4

    CAS:
    <p>Trk-IN-4 (PF-6683324) is a potent pan-Trk inhibitor and antinociceptive. It is also a selective type II PTK6 inhibitor antitumor.</p>
    Fórmula:C24H23F4N5O4
    Pureza:98.13%
    Forma y color:Solid
    Peso molecular:521.46

    Ref: TM-T17169

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  • FGFR1 inhibitor-10

    CAS:
    <p>FGFR1 inhibitor-10 (Compound 4i), with an IC50 of 28 nM, effectively inhibits FGFR1 phosphorylation.</p>
    Fórmula:C26H30F3N7O2S
    Pureza:98%
    Forma y color:Solid
    Peso molecular:561.62

    Ref: TM-T79686

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  • APG-2449

    CAS:
    <p>APG-2449 is an orally active inhibitor targeting ALK, ROS1, and FAK, demonstrating antitumor efficacy in mouse models of non-small cell lung cancer (NSCLC) [1].</p>
    Fórmula:C33H42ClN5O4S
    Pureza:98%
    Forma y color:Solid
    Peso molecular:640.24

    Ref: TM-T79363

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  • JDB175

    CAS:
    <p>JDB175, a selective BTK inhibitor with oral bioavailability, demonstrates excellent penetration through the blood-brain barrier.</p>
    Fórmula:C26H21F3N4O2
    Pureza:98%
    Forma y color:Solid
    Peso molecular:478.47

    Ref: TM-T82010

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  • YK-029A

    CAS:
    <p>YK-029A, an orally active EGFR mutant inhibitor, targets both EGFR T790M and EGFRex20ins mutations.</p>
    Fórmula:C27H32N8O2
    Pureza:98%
    Forma y color:Solid
    Peso molecular:500.6

    Ref: TM-T79461

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  • BTK-IN-27

    CAS:
    <p>BTK-IN-27 (example 8), a potent BTK inhibitor with an IC50 of 0.2 nM, demonstrates anti-proliferative effects in TMD8 cells with an IC50 of less than 5 nM.</p>
    Fórmula:C31H35N7O2
    Pureza:98%
    Forma y color:Solid
    Peso molecular:537.66

    Ref: TM-T79812

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  • Syk-IN-8

    CAS:
    <p>Syk-IN-8 (compound 19q) functions as a Syk inhibitor with demonstrated antiproliferative effects on a variety of hematological tumor cells.</p>
    Fórmula:C23H26N10
    Pureza:98%
    Forma y color:Solid
    Peso molecular:442.52

    Ref: TM-T79443

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  • TrkB-IN-1

    CAS:
    <p>TrkB-IN-1 is a potent, orally active agonist of the TrkB receptor, with favorable pharmacokinetic (PK) properties.</p>
    Fórmula:C19H16N2O6
    Pureza:98%
    Forma y color:Solid
    Peso molecular:368.34

    Ref: TM-T79011

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  • Canlitinib

    CAS:
    <p>Canlitinib, a tyrosine kinase inhibitor, holds potential for cancer research.</p>
    Fórmula:C33H31F2N3O7
    Pureza:98%
    Forma y color:Solid
    Peso molecular:619.61

    Ref: TM-T78206

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  • BTK-IN-25

    CAS:
    <p>BTK-IN-25 (compound 71) is a potent BTK inhibitor, demonstrating an IC50 of 0.77 nM against BTK(C481S) and achieving an IC50 of 1 nM in DOHH2 cells [1].</p>
    Fórmula:C28H27F2N3O5
    Pureza:98%
    Forma y color:Solid
    Peso molecular:523.53

    Ref: TM-T79113

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  • EGFR-IN-122

    CAS:
    <p>EGFR-IN-122 (compound Yfq07) serves as a potent inhibitor of EGFR. It effectively inhibits the proliferation of PC-9GR and HCC827GR cells.</p>
    Fórmula:C19H20N4O3
    Forma y color:Solid
    Peso molecular:352.39

    Ref: TM-T200157

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  • EGFR-IN-123

    CAS:
    <p>EGFR-IN-123 (compound D06) is an effective EGFR inhibitor. It exhibits inhibitory activity against several cell lines including PC-9G, A549, A431, and HCT116, with IC50 values of 0.74, 1.36, 1.20, and 2.53 μM respectively.</p>
    Fórmula:C24H27F3N6O
    Forma y color:Solid
    Peso molecular:472.51

    Ref: TM-T200485

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