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Tirosina quinasa / adaptadores

Tirosina quinasa / adaptadores

Los inhibidores de tirosina quinasa y adaptadores son compuestos que se dirigen a las tirosina quinasas y sus proteínas adaptadoras asociadas, las cuales desempeñan roles cruciales en la señalización celular, el crecimiento y la diferenciación. Estos inhibidores son herramientas esenciales en la investigación del cáncer, ya que muchas tirosina quinasas están involucradas en las vías de señalización que impulsan el crecimiento tumoral y la metástasis. Al inhibir las tirosina quinasas, estos compuestos pueden bloquear cascadas de señalización críticas, ofreciendo potenciales estrategias terapéuticas para varios tipos de cáncer y otras enfermedades que implican una señalización celular anormal. En CymitQuimica, ofrecemos una amplia gama de inhibidores de tirosina quinasa y adaptadores de alta calidad para apoyar su investigación en oncología, biología molecular y desarrollo de terapias dirigidas.

Subcategorías de "Tirosina quinasa / adaptadores"

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Se han encontrado 1342 productos de "Tirosina quinasa / adaptadores"

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  • FGFR3-IN-7
    Targetmol
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    FGFR3-IN-7

    CAS:
    <p>FGFR3-IN-7 is a potent, selective inhibitor of FGFR 3, demonstrating an IC50 value of less than 350 nM , and is utilized in cancer research [1].</p>
    Fórmula:C25H24FN9O
    Pureza:98%
    Forma y color:Solid
    Peso molecular:485.52

    Ref: TM-T82404

  • Tyrphostin AG1433
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    Tyrphostin AG1433

    CAS:
    <p>Tyrphostin AG1433 (AG1433) is an inhibitor of tyrosine kinases and also a dual inhibitor of PDGFRβ(IC50s = 5.0 μM) and VEGFR-2 (Flk-1/KDR)(IC50s = 9.3 μM).</p>
    Fórmula:C16H14N2O2
    Pureza:98.47%
    Forma y color:Solid
    Peso molecular:266.29

    Ref: TM-T13238

  • Resigratinib
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    Resigratinib

    CAS:
    <p>Resigratinib (KIN-3248) is an oral, irreversible pan-FGFR family protein inhibitor, covalently binds to and inhibits all four FGFR isoforms(FGFR1/2/3/4).</p>
    Fórmula:C26H27F2N7O3
    Pureza:98.58%
    Forma y color:Solid
    Peso molecular:523.53

    Ref: TM-T79856

  • BGB-102
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    BGB-102

    CAS:
    <p>BGB-102 (JNJ-26483327) is a kinase inhibitor targeting FLT3 and YES1 and an antagonist targeting EGFR and VEGFR3.</p>
    Fórmula:C22H25BrN4O2
    Pureza:99.02%
    Forma y color:Solid
    Peso molecular:457.36

    Ref: TM-T10531

  • AKB-6899
    Targetmol
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    AKB-6899

    CAS:
    <p>AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated</p>
    Fórmula:C14H11FN2O4
    Pureza:97.87%
    Forma y color:Solid
    Peso molecular:290.25

    Ref: TM-T29797

  • ARRY-382
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    ARRY-382

    CAS:
    <p>ARRY-382 is a highly selective oral inhibitor of CSF-1R with an IC50 of 9 nM.</p>
    Fórmula:C32H36N8O2
    Pureza:99.76%
    Forma y color:Solid
    Peso molecular:564.68

    Ref: TM-T35333

  • Lifirafenib
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    Lifirafenib

    CAS:
    <p>Lifirafenib (Beigene-283) is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinant</p>
    Fórmula:C25H17F3N4O3
    Pureza:98% - 98.25%
    Forma y color:Solid
    Peso molecular:478.42

    Ref: TM-T22272

  • EGFR-IN-36
    Targetmol
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    EGFR-IN-36

    CAS:
    <p>EGFR-IN-36 inhibits EGFR, HER2, &amp; mutants with IC50s: 19.09 nM (EGFR WT), 120.01 nM (HER2 WT), 2.35 nM (HER2 mutant).</p>
    Fórmula:C26H25ClN6O2
    Forma y color:Solid
    Peso molecular:488.97

    Ref: TM-T63265

  • VEGFR-2-IN-9
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    VEGFR-2-IN-9

    CAS:
    <p>VEGFR-2-IN-9 (KDR-in-4) is a potent KDR/VEGFR2 inhibitor (IC50: 7 nM). It can be used to study breast cancer.</p>
    Fórmula:C23H25N3O3
    Pureza:97.19%
    Forma y color:Solid
    Peso molecular:391.46

    Ref: TM-T10123

  • JND3229
    Targetmol
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    JND3229

    CAS:
    <p>JND3229 inhibits EGFRC797S; IC50: 5.8-30.5 nM; halts cell growth; effective in non-small cell lung cancer study.</p>
    Fórmula:C33H41ClN8O2
    Pureza:98.75%
    Forma y color:Solid
    Peso molecular:617.18

    Ref: TM-T15615

  • EGFR-IN-1
    Targetmol
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    EGFR-IN-1

    CAS:
    <p>EGFR-IN-1: an oral, irreversible EGFR inhibitor targeting L858R/T790M mutations with high selectivity, showing potent antitumor effects.</p>
    Fórmula:C28H30N6O4
    Pureza:98%
    Forma y color:Solid
    Peso molecular:514.58

    Ref: TM-T11157

  • EGFR mutant-IN-1
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    EGFR mutant-IN-1

    <p>EGFR mutant-in-1, a 5-methylpyrimidopyridone, selectively inhibits EGFRL858R/T790M/C797S mutants with an IC50 of 27.5 nM, lessening EGFRWT impact.</p>
    Fórmula:C34H39ClFN7O2
    Pureza:98%
    Forma y color:Solid
    Peso molecular:632.17

    Ref: TM-T11164

  • EGFR-IN-71
    Targetmol
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    EGFR-IN-71

    CAS:
    <p>EGFR-IN-71 is a potent inhibitor of epidermal growth factor receptor (EGFR) (IC50= 3.7 μM). EGFR-IN-71 has research value in chordoma.</p>
    Fórmula:C16H9ClIN3
    Forma y color:Solid
    Peso molecular:405.62

    Ref: TM-T62009

  • Pirtobrutinib
    Targetmol
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    Pirtobrutinib

    CAS:
    <p>Pirtobrutinib: a selective, non-covalent BTK inhibitor effective against BTK C481 mutations, causing tumor regression in lymphoma models.</p>
    Fórmula:C22H21F4N5O3
    Pureza:99.76% - 99.94%
    Forma y color:Solid
    Peso molecular:479.43

    Ref: TM-T36287

  • VEGFR2-IN-3
    Targetmol
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    VEGFR2-IN-3

    CAS:
    <p>VEGFR2-IN-3 (compound 385) is a potent inhibitor of VEGFR2 [1].</p>
    Fórmula:C26H28ClN5O4
    Pureza:98%
    Forma y color:Solid
    Peso molecular:509.98

    Ref: TM-T79009

  • EGFR-IN-74
    Targetmol
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    EGFR-IN-74

    <p>EGFR-IN-74 is a potent inhibitor targeting EGFR, specifically effective against the L858R/T790M mutations, exhibiting an IC50 value of 138 nM.</p>
    Fórmula:C32H28BrF3N6O4S
    Forma y color:Solid
    Peso molecular:729.57

    Ref: TM-T73170

  • PF-06733804
    Targetmol
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    PF-06733804

    CAS:
    <p>PF-06733804 is a potent inhibitor of pan-Trk in cell-based assays (IC50s: 8.4 nM, 6.2 nM, and 2.2 nM for TrkA, TrkB, and TrkC) with anti-hyperalgesic effect.</p>
    Fórmula:C20H19F5N4O4
    Pureza:98%
    Forma y color:Solid
    Peso molecular:474.38

    Ref: TM-T13207

  • Simotinib
    Targetmol
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    Simotinib

    CAS:
    Simotinib (AL-6802) is an EGFR tyrosine kinase inhibitor (IC50 : 19.9 nM) with antitumour activity for the study of non-small cell lung cancer.
    Fórmula:C25H26ClFN4O4
    Pureza:99.7%
    Forma y color:Solid
    Peso molecular:500.95

    Ref: TM-T35916

  • EGFR-IN-29
    Targetmol
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    EGFR-IN-29

    CAS:
    <p>EGFR-IN-29 is a potent EGFR inhibitor.</p>
    Fórmula:C36H46BrN8O2P
    Forma y color:Solid
    Peso molecular:733.68

    Ref: TM-T73106

  • PAT-505
    Targetmol
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    PAT-505

    CAS:
    <p>PAT-505 is an autologous epidermal growth factor inhibitor.</p>
    Fórmula:C23H18ClF2N3O2S
    Pureza:98.84%
    Forma y color:Solid
    Peso molecular:473.92

    Ref: TM-T12372