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Tirosina quinasa / adaptadores

Tirosina quinasa / adaptadores

Los inhibidores de tirosina quinasa y adaptadores son compuestos que se dirigen a las tirosina quinasas y sus proteínas adaptadoras asociadas, las cuales desempeñan roles cruciales en la señalización celular, el crecimiento y la diferenciación. Estos inhibidores son herramientas esenciales en la investigación del cáncer, ya que muchas tirosina quinasas están involucradas en las vías de señalización que impulsan el crecimiento tumoral y la metástasis. Al inhibir las tirosina quinasas, estos compuestos pueden bloquear cascadas de señalización críticas, ofreciendo potenciales estrategias terapéuticas para varios tipos de cáncer y otras enfermedades que implican una señalización celular anormal. En CymitQuimica, ofrecemos una amplia gama de inhibidores de tirosina quinasa y adaptadores de alta calidad para apoyar su investigación en oncología, biología molecular y desarrollo de terapias dirigidas.

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Se han encontrado 1370 productos de "Tirosina quinasa / adaptadores"

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  • SST0116CL1
    Targetmol
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    SST0116CL1

    CAS:
    <p>SST0116CL1 is an HSP90 inhibitor (IC50: 0.21 μM) that targets the ATP-binding pocket of Hsp90, disrupting its chaperone function and leading to the degradation of client proteins (EGFR, CDK4, and AKT). It induces the degradation of Her2 in BT-474 cells (IC50: 0.2 μM) and exhibits antiproliferative activity, inhibiting tumor growth.</p>
    Fórmula:C22H31ClN4O6
    Forma y color:Solid
    Peso molecular:482.96

    Ref: TM-T200022

  • Lucitanib dihydrochloride
    Targetmol
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    Lucitanib dihydrochloride

    CAS:
    <p>Lucitanib dihydrochloride (E-3810 dihydrochloride) is an efficient VEGFR1-3, FGFR1-3, and PDGFRalpha/β inhibitor, used in metastatic breast cancer research.</p>
    Fórmula:C26H27Cl2N3O4
    Forma y color:Solid
    Peso molecular:516.42

    Ref: TM-T89507

  • ROS1-IN-2
    Targetmol
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    ROS1-IN-2

    CAS:
    <p>ROS1-IN-2 (Compound 3), a ROS1 inhibitor, is utilized in cancer research.</p>
    Fórmula:C29H37ClN5O2P
    Forma y color:Solid
    Peso molecular:554.06

    Ref: TM-T89912

  • Logo de CymitQuimica
    Targetmol
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    HER2-IN-12

    <p>HER2-IN-12 is an HER2 inhibitor with an IC50 value of 121 nM and can be used to study cancers such as breast cancer.</p>
    Fórmula:C17H18BrN5O2S
    Forma y color:Solid
    Peso molecular:436.33

    Ref: TM-T62487

  • Logo de CymitQuimica
    Targetmol
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    EGFR/HER2-IN-4

    <p>EGFR/HER2-IN-4: oral, irreversible dual EGFR inhibitor (IC50: 0.6 nM), targets L858R/T790M mutations, potent anti-lung cancer effects in vivo.</p>
    Forma y color:Solid

    Ref: TM-T64253

  • 8-Br-cGMP-AM
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    8-Br-cGMP-AM

    CAS:
    <p>8-Br-cGMP-AM, a derivative of 8-Br-cGMP, acts as an activator of PKG (cGMP-dependent protein kinase), inducing various biological effects such as vasodilation and platelet inhibition. This compound is utilized in the research of cardiovascular diseases.</p>
    Fórmula:C13H15BrN5O9P
    Forma y color:Solid
    Peso molecular:496.16

    Ref: TM-T88538

  • Logo de CymitQuimica
    Targetmol
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    EGFR/HER2/DHFR-IN-1

    <p>Potent EGFR/HER2/DHFR inhibitor for MCF-7 breast cancer; IC50: 0.153/0.108/0.291 μM; arrests G1/S phase, triggers apoptosis.</p>
    Fórmula:C14H11BrN4O2S
    Forma y color:Solid
    Peso molecular:379.23

    Ref: TM-T61596

  • TRK-IN-28
    Targetmol
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    TRK-IN-28

    CAS:
    TRK-IN-28 (compound 30f) functions as a TRK inhibitor, displaying potencies with IC 50 values of 0.55 nM for TRK WT, 25.1 nM for TRK G595R, and 5.4 nM for TRK G667C. Another TRK inhibitor, TRK-IN-2, exhibits antiproliferative effects with IC 50 values against multiple cell lines: 9.5 nM for Ba/F3-ETV6-TRKA WT, 3.7 nM for Ba/F3-ETV6-TRKB WT, 205.0 nM for Ba/F3-LMNA-TRK G595R, and 48.3 nM for Ba/F3-LMNA-TRKA G667C [1].
    Fórmula:C27H25F2N7
    Forma y color:Solid
    Peso molecular:485.53

    Ref: TM-T87570

  • TrkA-IN-7
    Targetmol
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    TrkA-IN-7

    CAS:
    <p>TrkA-IN-7 (Compound 4) is an inhibitor of tropomyosin receptor kinase A (TrkA), with a Kd value of 40 μM.</p>
    Fórmula:C16H13N3O3
    Forma y color:Solid
    Peso molecular:295.293

    Ref: TM-T204489

  • JBJ-02-112-05
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    JBJ-02-112-05

    CAS:
    <p>JBJ-02-112-05 is a potent, mutant-selective, allosteric and orally active inhibitor of EGFR with an IC 50 of 15 nM for EGFR L858R/T790M [1].</p>
    Fórmula:C27H20N4O2S
    Pureza:98%
    Forma y color:Solid
    Peso molecular:464.54

    Ref: TM-T11713

  • KRC-00715
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    KRC-00715

    CAS:
    <p>KRC-00715 is an orally effective inhibitor of c-Met, exhibiting high selectivity with an IC50 of 9.0 nM. This compound specifically inhibits the growth of gastric cancer cell lines with high c-Met expression by inducing G1/S phase block, and reduces the activity of downstream signals, including Akt, Erk, and c-Met itself. In the gastric cancer cell line Hs746T, KRC-00715 demonstrates cytotoxicity with an IC50 of 39 nM and selectively inhibits the proliferation of cell lines that overexpress c-Met. Additionally, KRC-00715 decreases tumor size in Hs746T xenograft mouse models.</p>
    Fórmula:C25H25F3N8O3
    Forma y color:Solid
    Peso molecular:542.51

    Ref: TM-T200380

  • TRK-IN-26
    Targetmol
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    TRK-IN-26

    CAS:
    <p>TRK-IN-26 (compound 12), a TRK inhibitor, holds potential for use in cancer research [1].</p>
    Fórmula:C30H22F2N6O4
    Forma y color:Solid
    Peso molecular:568.53

    Ref: TM-T87569

  • BTK-IN-16
    Targetmol
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    BTK-IN-16

    CAS:
    <p>BTK-IN-16 is a potential inhibitor of wild-type BTK and C481S mutants.BTK-IN-16 can be used to study various autoimmune diseases and cancers caused by BTK.</p>
    Fórmula:C15H14N4O2
    Pureza:99.04%
    Forma y color:Soild
    Peso molecular:282.3

    Ref: TM-T60542

  • AZ8010
    Targetmol
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    AZ8010

    CAS:
    AZ8010 (AZ12908010) serves as an effective inhibitor of FGFR1-3 and exhibits antiproliferative properties, making it useful for cancer research.
    Fórmula:C27H34N4O3
    Forma y color:Solid
    Peso molecular:462.58

    Ref: TM-T89951

  • HER2-IN-8
    Targetmol
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    HER2-IN-8

    CAS:
    <p>HER2-IN-8 is an inhibitor of HER-2 that can be used in the study of cancer and inflammation-related diseases.</p>
    Fórmula:C26H25F2N9O3
    Forma y color:Solid
    Peso molecular:549.53

    Ref: TM-T63881

  • EGFR-IN-159
    Targetmol
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    EGFR-IN-159

    CAS:
    <p>EGFR-IN-159 (compound 12) is a dihydropyrimidine and a potent EGFR inhibitor with an IC50 of 29.00 nM. It exhibits dose-dependent inhibition of EGFR and HER2. The compound shows cytotoxicity against MCF-7 breast cancer cells and Vero cells with IC50 values of 16.07 μg/mL and 35.98 μg/mL, respectively. EGFR-IN-159 does not cross the blood-brain barrier (BBB) and demonstrates significant anticancer activity.</p>
    Fórmula:C21H23N3O5
    Forma y color:Solid
    Peso molecular:397.424

    Ref: TM-T206989

  • EGFR-IN-38
    Targetmol
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    EGFR-IN-38

    CAS:
    <p>EGFR-IN-38: low-toxic acrylamide-derived EGFR inhibitor, targets NSCLC, patented for research on EGFR mutation-related diseases.</p>
    Fórmula:C25H24ClN7O2
    Forma y color:Solid
    Peso molecular:489.96

    Ref: TM-T63283

  • EGFR-IN-126
    Targetmol
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    EGFR-IN-126

    CAS:
    <p>EGFR-IN-126 (compound 9d) is an effective inhibitor of EGFR L858R/T790M/C797S, displaying an IC50 value of 0.005 μM. It exhibits antitumor activity both in vivo and in vitro.</p>
    Fórmula:C28H28BrFN4O3
    Forma y color:Solid
    Peso molecular:567.45

    Ref: TM-T200496

  • BTK-IN-38
    Targetmol
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    BTK-IN-38

    CAS:
    <p>BTK-IN-38 (Example 125) is an efficacious inhibitor of BTK. It effectively suppresses the proliferation of DOHH2 and BT474 cells, with IC50 values of 114 nM and 340 nM, respectively.</p>
    Fórmula:C27H26F2N4O2
    Forma y color:Solid
    Peso molecular:476.52

    Ref: TM-T201231

  • BNN-20
    Targetmol
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    BNN-20

    CAS:
    <p>BNN-20 is a synthetic micro-neurotrophic factor that mimics Brain-Derived Neurotrophic Factor (BDNF) and exhibits region-specific neuroprotective and neurogenesis-promoting effects. It is applicable in research related to Parkinson's disease.</p>
    Fórmula:C20H30O2
    Forma y color:Solid
    Peso molecular:302.45

    Ref: TM-T201864