Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(6 produits)
- BCL(11 produits)
- Caspase(125 produits)
- FOXO1(3 produits)
- IAP(66 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(125 produits)
- PDK(9 produits)
- PERK(25 produits)
- Sérine/thréonine kinase(15 produits)
- Survivant(13 produits)
- TNF(92 produits)
- c-RET(51 produits)
- p53(62 produits)
Affichez 6 plus de sous-catégories
5592 produits trouvés pour "Apoptose"
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Bcl-2-IN-2
CAS :<p>Bcl-2-IN-2 is a highly potent and selective inhibitor targeting Bcl-2 and Bcl-xL.</p>Formule :C48H57N7O7SCouleur et forme :SolidMasse moléculaire :876.09BRD4 Inhibitor-39
<p>BRD4 Inhibitor-39 (compound 12m) is an orally active inhibitor of BRD4 with an IC50 of 0.02 μM. It can induce apoptosis and demonstrates antitumor activity.</p>Formule :C24H19BrFN9Couleur et forme :SolidMasse moléculaire :532.37Anticancer agent 137
<p>Anticancer agent 137 (8q), a potent PI3k inhibitor, exhibits broad-spectrum anticancer activity by inducing G2/M cell cycle arrest and apoptosis.</p>Formule :C26H27NO6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :449.5AS-99 TFA
<p>AS-99 TFA: potent ASH1L inhibitor, IC50=0.79 μM, combats leukemia, inhibits cell growth, induces apoptosis.</p>Couleur et forme :Solidc-JUN peptide
CAS :<p>Peptide from c-Jun (33-57) blocks JNK binding, inhibits phosphorylation, upregulates p21, and induces HeLa cell apoptosis.</p>Formule :C121H210N36O34SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :2743.55CDK9-Cyclin T1 PPI-IN-1
<p>CDK9-Cyclin T1 PPI-IN-1 (Compound B19) is a selective inhibitor of the CDK9-Cyclin T1 protein-protein interaction (PPI), suppressing cell proliferation in TNBC</p>Degré de pureté :98%Couleur et forme :Odour SolidIndinavir
CAS :<p>Indinavir is an HIV protease inhibitor,HAART. inhibits the activation of MMP-2 in endothelial cells and exhibits affinity for α7-nAchR and SARS-CoV-2 Mpro.</p>Formule :C36H47N5O4Couleur et forme :SolidMasse moléculaire :613.79RWJ-56110 dihydrochloride
CAS :<p>RWJ-56110 dihydrochloride is a potent PAR-1 inhibitor (IC50=0.44μM), blocking platelet aggregation, angiogenesis, and induces apoptosis. No PAR-2/3/4 effect.</p>Formule :C41H44Cl3F2N7O3Couleur et forme :SolidMasse moléculaire :827.2JPS014 TFA
<p>JPS014 TFA, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), effectively degrades class I histone deacetylase (HDAC</p>Formule :C48H60F3N7O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :968.09ZC0109
<p>ZC0109 inhibits IDO1 (50 nM) & TrxR1 (3.0 μM), induces ROS, arrests G1/S phase, causing cancer cell apoptosis.</p>Formule :C22H20BrFN8O4SCouleur et forme :SolidMasse moléculaire :591.41Apoptolidin
CAS :<p>Apoptolidin, from Nocardiopsis, induces apoptosis, targets mitochondrial ATPase (Ki 4-5 μM), kills glial cells, and has antibiotic and antifungal properties.</p>Formule :C58H96O21Couleur et forme :SolidMasse moléculaire :1129.385Apoptosis inducer 37
<p>Apoptosis inducer37 (Derivative 10) is an agent that induces apoptosis and exhibits anticancer properties by causing cell cycle arrest at the S-G2/M phase and promoting cell apoptosis. It significantly inhibits HCT116, SKOV3, and HepG2 cancer cells with IC50 values of 24.98 μM, 26.15 μM, and 23.09 μM, respectively. Apoptosis inducer37 demonstrates antitumor activity and can be utilized in ovarian cancer research.</p>Formule :C27H37BrN2O4SCouleur et forme :SolidMasse moléculaire :564.16574Aspidin BB
CAS :<p>Aspidin BB, a phloroglucinol from Dryopteris, inhibits cancer by causing cell cycle arrest and apoptosis in HO-8910 cells.</p>Formule :C25H32O8Couleur et forme :SolidMasse moléculaire :460.52Albanol B
CAS :<p>Albanol B, from mulberries, combats Alzheimer's, bacteria, and oxidation, hinders cancer growth, and triggers cell arrest and apoptosis.</p>Formule :C34H22O8Couleur et forme :SolidMasse moléculaire :558.53WEHI-3773
<p>WEHI-3773 is an inhibitor of the interaction between VDAC2 and either BAK or BAX. It prevents BAX-mediated apoptosis (Apoptosis) by blocking the recruitment of BAX to the mitochondria through VDAC2. Conversely, WEHI-3773 promotes BAK-mediated apoptosis (Apoptosis) by limiting VDAC2's inhibitory sequestration of BAK. This compound shows promise for research in the field of cancer therapy.</p>Couleur et forme :Odour SolidPI3K-AKT-mTOR Compound Library
<p>A unique collection of 420 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved with</p>Couleur et forme :Odour SolidFPR1 antagonist 2
<p>Compound 25b, an FPR1 antagonist, exhibits potent inhibition of the formyl peptide receptor 1 with an IC50 of 70 nM.</p>Formule :C25H25F3O5Couleur et forme :SolidMasse moléculaire :462.46Enpp/Carbonic anhydrase-IN-2
CAS :<p>Enpp/Carbonic anhydrase-IN-2 is a potent dual inhibitor of Enpp and carbonic anhydrase, inhibiting NPP1, NPP2, NPP3, CA-IX, CA-XII, with IC50 values of 1.13, 1.</p>Formule :C23H24FNO4SDegré de pureté :99.46%Couleur et forme :SoildMasse moléculaire :429.5JNK-1-IN-3
CAS :<p>JNK-1-IN-3 (Compound 9e) downregulates JNK1 and phosphorylated JNK1, reduces c-Jun and c-Fos expression in tumours, and restores p53 activity.</p>Formule :C19H17FN4O3Degré de pureté :97.551%Couleur et forme :SolidMasse moléculaire :368.36EGFR/BRAFV600E-IN-3
<p>EGFR/BRAFV600E-IN-3 is an inhibitor targeting EGFR, BRAFV600E, and EGFRT790M with IC50 values of 57 nM, 68 nM, and 9.70 nM, respectively.</p>Formule :C25H18N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :422.44TNF-α-IN-9
CAS :<p>TNF-α-IN-9 is an NDM-1 inhibitor-3 analog and is a TNF-α inhibitor.TNF-α-IN-9 shows low inhibitory activity.</p>Formule :C17H14O4Degré de pureté :98.28%Couleur et forme :SoildMasse moléculaire :282.29Barasertib
CAS :<p>AZD1152 is a pro-drug of Barasertib (AZD1152)-hQPA. Which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay.</p>Formule :C26H31FN7O6PDegré de pureté :99.63% - 99.92%Couleur et forme :SolidMasse moléculaire :587.54PB28
CAS :<p>PB28: A potent σ2 agonist (Ki 0.68 nM), σ1 antagonist (Ki 0.38 nM), with anti-tumor properties and inhibits SARS-CoV-2 interactions.</p>Formule :C24H38N2OCouleur et forme :SolidMasse moléculaire :370.581PH14
<p>PH14, a dual PI3K/HDAC inhibitor, demonstrates potent inhibition with IC50 values of 20.3 nM for PI3Kα and 24.5 nM for HDAC3.</p>Degré de pureté :98%Couleur et forme :Odour SolidAnticancer agent 154
<p>Anticancer agent 154 (Compound 8h) enhances reactive oxygen species production, causing mitochondrial damage, and promotes cell apoptosis and DNA damage.</p>Formule :C22H23N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :389.45Necroptosis-IN-3
CAS :<p>Necroptosis-IN-3 (Cyclohexanecarboxamide, N-(2-thienylmethyl)-) (Compound 69) is a Necroptosis inhibitor that inhibits TNF-α induced necroptosis.</p>Formule :C12H17NOSDegré de pureté :99.85%Couleur et forme :SoildMasse moléculaire :223.33PPA-904 FA
<p>PPA-904 FA is a cationic photosensitizer with antimicrobial activity that can be used to study chronic leg ulcers and diabetic foot ulcers.</p>Formule :C29H43N3O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :497.74Valproic acid sodium salt
CAS :<p>Sodium valproate is an anti-epileptic, boosting brain GABA levels and possibly affecting potassium channels for membrane stability.</p>Formule :C8H15NaO2Degré de pureté :98.43% - 99.78%Couleur et forme :White PowderMasse moléculaire :166.28-Aminoadenosine
CAS :<p>8-Aminoadenosine reduces ATP, blocks mRNA synthesis, and Akt/mTOR signaling, triggering autophagy and apoptosis independently of p53, with antitumor effects.</p>Formule :C10H14N6O4Couleur et forme :SolidMasse moléculaire :282.26Pralnacasan
CAS :<p>Pralnacasan blocks IL-18, IL-1β, IFN-γ. It’s a potent oral enzyme inhibitor with use in arthritis therapy (Ki: 1.4 nM).</p>Formule :C26H29N5O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :523.54Thalidomide-PEG2-C2-NH2 hydrochloride
CAS :<p>Thalidomide-based cereblon ligand with 2-unit PEG linker for PROTAC, in hydrochloride form.</p>Formule :C19H25ClN4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :440.88NCT-58
CAS :<p>NCT-58 is a potent HSP90 inhibitor that blocks Akt, downregulates HER family, and induces apoptosis in HER2+ breast cancer without triggering HSR.</p>Formule :C27H34N2O5Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :466.57YB-0158 ammonium
<p>YB-0158 ammonium (Wnt pathway inhibitor 2 ammonium) is a reverse-rotation peptidomimetic with translation-enhancing potential and anticancer activity.</p>Formule :C32H40N9O7PDegré de pureté :99.14% - 99.18%Couleur et forme :SolidMasse moléculaire :693.69Ledostomig
CAS :<p>Ledostomig is an immunoglobulin (H-γ1-scFv-L-κ) dimer monoclonal antibody that targets human neurotensin receptor type 5 (NTS5) and programmed death-1 (PD-1). It shows potential for research in various cancer types.</p>Couleur et forme :LiquidConglobatin
CAS :<p>Conglobatin is a natural product for research related to life sciences. The catalog number is T36494 and the CAS number is 72263-05-9.</p>Formule :C28H38N2O6Couleur et forme :SolidMasse moléculaire :498.62Vallesiachotamine
CAS :<p>Vallesiachotamine, a recognized monoterpene indole alkaloid, exhibits anti-tumor activity [1].</p>Formule :C21H22N2O3Couleur et forme :SolidMasse moléculaire :350.41BM-1197
CAS :<p>BM-1197, a highly potent and specific dual inhibitor of Bcl-2 and Bcl-xL, effectively targets these proteins with IC50 values of 3.5 nM and 5.2 nM for Bcl-2 and</p>Formule :C53H59ClF4N6O7S4Couleur et forme :SolidMasse moléculaire :1131.77Apoptosis inducer 13
<p>Apoptosis Inducer 13 (Compound Ru4) promotes apoptosis in cancer cells while also suppressing their migration and invasion.</p>Formule :C59H54ClF6N8O4PRuDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1220.6Thalidomide-O-PEG4-Boc
CAS :<p>Thalidomide-O-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].</p>Formule :C28H38N2O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :578.61Z-VDVA-(DL-Asp)-FMK
CAS :<p>Z-VDVA-(DL-Asp)-FMK is a derivative compound of Z-VDVAD-FMK specifically designed as an inhibitor targeting caspase-2.</p>Formule :C32H46FN5O11Couleur et forme :SolidMasse moléculaire :695.742PTD-p65-P1 Peptide TFA
<p>Ptd-p65-p1 Peptide TFA inhibits NF-kappaB, has a cell-penetrating antennapedia sequence, and selectively blocks NF-kappaB activation.</p>Formule :C170H276F3N57O46SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :3943.52PROTAC EGFR degrader 7
<p>Compound 13b, a potent EGFR degrader, inhibits and induces apoptosis in NSCLC cells with a DC50 of 13.2 nM.</p>Formule :C46H48N10O6Couleur et forme :SolidMasse moléculaire :836.944-oxo-27-TBDMS Withaferin A
CAS :<p>4-oxo-27-TBDMS Withaferin A, a withaferin A derivative, is an anticancer agent cytotoxic to A2780, not A2780/CP70.</p>Formule :C34H50O6SiCouleur et forme :SolidMasse moléculaire :582.853Tubulin inhibitor 34
<p>Tubulin Inhibitor 34 (compound b5), a potent anticancer agent, inhibits tubulin polymerization and induces G2/M arrest and apoptosis.</p>Formule :C21H22N4O3SCouleur et forme :SolidMasse moléculaire :410.49PUMA BH3
<p>PUMA BH3 activates Bak, binds Bcl-2; triggers apoptosis via cytochrome C release; Kd 26 nM.</p>Formule :C128H202N42O43SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :3049.3dTAG-47
CAS :<p>dTAG-47 targets FKBP12 F36V for protein degradation, useful in basal-like breast cancer research.</p>Formule :C59H73N5O14Couleur et forme :SolidMasse moléculaire :1076.24Polyinosinic-polycytidylic acid potassium
CAS :<p>Poly(I:C) potassium is a synthetic RNA analog, activates TLR3/RIG-I, used as a vaccine adjuvant, and induces apoptosis in cancer cells.</p>Formule :(C10H13N4O8P)x·(C9H14N3O8P)x·xKCouleur et forme :SolidBRAFV600E/JNK-IN-1
<p>BRAFV600E/JNK-IN-1 (Compound 14c) is an inhibitor of JNK1, JNK2, JNK3, and BRAFV600E, with IC50 values of 0.51 μM, 0.53 μM, 1.02 μM, and 0.009 μM, respectively. It also inhibits the phosphorylation of MEK1/2 and ERK1/2. Additionally, BRAFV600E/JNK-IN-1 suppresses tumor cell proliferation, NO release, and PGE2 production, exhibiting both antitumor and anti-inflammatory activities.</p>Couleur et forme :Odour SolidPARP-1/2-IN-2
<p>PARP-1/2-IN-2-IN-1 (Compound 12e) effectively inhibits PARP1/2 and CDK12 with IC 50 values of 34 nM, 30 nM, and 285 nM respectively, impairing DNA damage repair</p>Formule :C25H23IN8O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :610.41Bcl-2-IN-5
CAS :<p>Bcl-2-IN-5: BCL-2 inhibitor, IC50: 0.12 nM (wt), 0.14 nM (D103Y), 0.22 nM (G101V); Cell growth IC50: 0.2 nM, 0.44 nM (RS4;11).</p>Formule :C55H63FN8O8SCouleur et forme :SolidMasse moléculaire :1015.2Cathepsin B
CAS :<p>Cathepsin B, a cysteine protease located within the subcellular endosomes and lysosomal compartments, mediates apoptosis and can be used in cancer research.</p>Couleur et forme :SolidNMC-001
<p>NMC-001 is a human IgG1 monoclonal antibody (mAb) that targets MDM2. It is useful for pancreatic cancer research. The recommended isotype control is HumanIgG1kappa, Isotype Control.</p>Couleur et forme :Odour LiquidPROTAC 20S proteasome subunit β5 degrader 1
<p>PROTAC 20S proteasome subunit β5 degrader 1 (compound 12f) serves as a targeted degrader of the 20S proteasome subunit β5, exhibiting a DC50 value of 0.11 μM in FaDu cells. This compound disrupts the cell cycle and promotes apoptosis (apoptosis), while inhibiting cell proliferation and migration in both FaDu and KM3/BTZ cells. It is applicable for research into resistance to Bortezomib in pharyngeal carcinoma and multiple myeloma.</p>Couleur et forme :Odour SolidEGFR/VEGFR2-IN-1
<p>EGFR/VEGFR2-IN-1 (Compound 10e) serves as an inhibitor for VEGFR-2 and EGFR, with respective IC50 values of 0.26 and 0.14 μM. It inhibits microtubule protein polymerization with an IC50 of 40.9 μM and induces cell apoptosis (Apoptosis). EGFR/VEGFR2-IN-1 is applicable in research related to anti-leukemia and anti-lymphoma treatments.</p>Couleur et forme :Odour SolidTRBP-IN-1
<p>TRBP-IN-1 (Compound 13j) is an orally active inhibitor of TAR RNA-binding protein 2 (TRBP) with an IC50 of 12.72 μM. It exhibits significant anti-hepatocellular carcinoma (HCC) activity, effectively suppressing proliferation and metastasis of HCC cells [HCCLM3 cells (IC50: 18.96 μM) and SK-Hep-1 cells (IC50: 16.45 μM)]. TRBP-IN-1 modulates miRNA biosynthesis by targeting TRBP, inhibiting the expression of oncogenic miRNAs. It induces apoptosis and pyroptosis in HCC cells by decreasing miRNA levels. TRBP-IN-1 is suitable for research on targeted HCC therapy.</p>Formule :C25H23F3N2O5SCouleur et forme :SolidMasse moléculaire :520.12798Enniatin complex
CAS :<p>Enniatin complex: fungal cyclohexadepsipeptides inhibit enzymes, induce cancer cell apoptosis, and have ionophoric, antibiotic, and hypolipidemic effects.</p>Degré de pureté :98%Couleur et forme :SolidDJ4
CAS :<p>DJ4 induces a dose-dependent pro-apoptotic effect in the micromolar range.</p>Formule :C19H16N4OSDegré de pureté :≥98%Couleur et forme :SoildMasse moléculaire :348.42ICy-OH
CAS :<p>ICy-OH, an iodinated anticancer photosensitizer, excels in deep tissue imaging (640 nm excitation) and triggers pyroptosis in pancreatic cancer cells.</p>Formule :C26H25I2NO2Couleur et forme :SolidMasse moléculaire :637.29Enterodiol
<p>Enterodiol is a natural product that can be used as a reference standard.</p>Formule :C18H22O4Couleur et forme :SolidMasse moléculaire :302.37Platycoside G3
CAS :<p>Platycoside G3 is a useful organic compound for research related to life sciences. The catalog number is T124100 and the CAS number is 849758-44-7.</p>Formule :C63H102O32Couleur et forme :SolidMasse moléculaire :1371.48CYP51/PD-L1-IN-1
<p>CYP51/PD-L1-IN-1 (compound L11), a quinazoline with antifungal properties, simultaneously inhibits CYP51 (IC50: 0.884 μM) and PD-L1 (IC50: 0.083 μM).</p>Formule :C20H15N5O2Couleur et forme :SolidMasse moléculaire :357.37PQ401
CAS :<p>PQ401 (IGF-1R Inhibitor II) suppresses autophosphorylation of IGF-1R domain(IC50<1 μM).</p>Formule :C18H16ClN3O2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :341.79HJC0416 hydrochloride
CAS :<p>HJC0416 hydrochloride: potent oral STAT3 inhibitor, better anticancer effects than Stattic, promising for breast cancer research.</p>Formule :C18H18Cl2N2O4SCouleur et forme :SolidMasse moléculaire :429.31FLT3/HDAC-IN-1
<p>FLT3/HDAC-IN-1 is a dual inhibitor targeting FLT3 and HDAC, with IC50 values of 30.4 nM for FLT3 and 52.4, 14.7 nM for HDAC1/3, respectively. It induces apoptosis in MV-4-11 cells and exhibits antiproliferative effects against BaF3 cells transformed by FLT3 mutations. FLT3/HDAC-IN-1 is useful for research on refractory solid tumors and hematological malignancies.</p>Couleur et forme :Odour SolidHDAC6 degrader-5
<p>HDAC6degrader-5 (Compound 6) exhibits inhibitory and degradative activity against HDAC6, with an IC50 of 4.95 nM and a DC50 of 0.96 nM. It suppresses the release of TNF-α, IL-1β, and IL-6, and prevents apoptosis in liver cells. Additionally, HDAC6degrader-5 demonstrates anti-inflammatory properties in a mouse model of APAP-induced liver injury.</p>Formule :C21H22N4O3Couleur et forme :SolidMasse moléculaire :378.424Waltonitone
CAS :<p>Waltonitone is a natural ursane-type pentacyclic triterpene isolated from Gentian waltonii Burkill.</p>Formule :C30H48O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :440.7SL-01
CAS :<p>SL-01, an oral gemcitabine derivative, potently induces apoptosis to hinder breast cancer more effectively than gemcitabine.</p>Formule :C18H18ClNO3Degré de pureté :98%Couleur et forme :White PowderMasse moléculaire :331.79VEGFR-2-IN-53
<p>VEGFR-2-IN-53 (Compound 15w) is an inhibitor of VEGFR-2 with an IC50 value of 4.34 μM. It induces cell apoptosis (Apoptosis) and inhibits angiogenesis by blocking VEGFR-2 activity and preventing cell migration. Additionally, it shows an IC50 of 3.87 μM in inhibiting the growth of MCF-7 cells, making it pertinent for research in cancer therapeutics.</p>Couleur et forme :Odour SolidAnti-inflammatory agent 35
CAS :<p>Anti-inflammatory agent 35 is a potent anti-inflammatory agent.</p>Formule :C27H29NO8Degré de pureté :99.98%Couleur et forme :SoildMasse moléculaire :495.52Thalidomide-O-PEG4-amine
CAS :<p>Thalidomide-O-PEG4-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].</p>Formule :C23H31N3O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :493.51CWI1-2
CAS :<p>CWI1-2 is a potent IGF2BP2 inhibitor that inhibits its interaction with M6A-modified target transcripts by binding IGF2BP2.</p>Formule :C22H17Cl3N6O3Degré de pureté :98.27%Couleur et forme :SoildMasse moléculaire :519.77WAY-118959-A
CAS :<p>WAY-118959-A is a potential microtubule acetylation inhibitor.</p>Formule :C16H14N4OS2Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :342.44PROTAC SMARCA2/4 degrader-38
<p>PROTACSMARCA2/4 degrader-38 is a SMARCA2/4 PROTAC degrader with DC50 values of 3.0 nM and 4.0 nM, respectively. It facilitates the ubiquitination and degradation of SMARCA2/4 and can block the G0/G1 phase of the cell cycle, leading to the induction of apoptosis. PROTACSMARCA2/4 degrader-38 is applicable in acute myeloid leukemia (AML) research.</p>Couleur et forme :Odour SolidTCF4/β-catenin-IN-1
<p>TCF4/β-catenin-IN-1 (Compound 8b) is an inhibitor of TCF4/β-catenin that induces apoptosis. This compound enhances the expression of p53, caspase-3, caspase-8, caspase-9, and Bax proteins, while reducing Bcl-2 protein levels. TCF4/β-catenin-IN-1 also inhibits CYP3A4, CYP1A2, and CYP2C19, demonstrating significant cytotoxic activity in cancer cells.</p>Formule :C23H15N7O3Couleur et forme :SolidMasse moléculaire :437.41Bornyl acetate
CAS :<p>Bornyl acetate (Isobornyl acetate) has an anti-inflammatory effect. It is the volatile ingredient in some Chinese traditional herbs and numerous conifer oils.</p>Formule :C12H20O2Degré de pureté :99.19%Couleur et forme :LiquidMasse moléculaire :196.29S-Adenosyl-L-methionine
CAS :<p>S-Adenosyl-L-methionine (Ademetionine) is an intermediate metabolite of methionine,for treatment of primary biliary cirrhosis and major depressive disorder.</p>Formule :C15H22N6O5SDegré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :398.44Lisaftoclax
CAS :<p>Lisaftoclax, an oral Bcl-2/Bcl-xl inhibitor (IC50: 2 nM & 5.9 nM), treats CLL by promoting leukemia cell death.</p>Formule :C45H48ClN7O8SDegré de pureté :97.14% - 99.66%Couleur et forme :SolidMasse moléculaire :882.428-Bromo-cAMP
CAS :<p>8-Bromo-cAMP is a cell-permeable cAMP analogue and activator of CAMP-dependent protein kinase A that induces cell death and reduces proliferation.</p>Formule :C10H11BrN5O6PDegré de pureté :97.30%Couleur et forme :SolidMasse moléculaire :408.1Anti-Mouse TNF α Antibody (TN3-19.12)
<p>Anti-Mouse TNF alpha Antibody is a rat-derived IgG inhibitor targeting mouse TNF alpha.</p>Degré de pureté :95% - ＞10mg/mlCouleur et forme :Odour LiquidThalidomide-O-C8-NH2
CAS :<p>Thalidomide-O-C8-NH2 is a synthetic cereblon ligand & PROTAC linker, serving as an E3 ligase ligand-linker.</p>Formule :C21H27N3O5Couleur et forme :SolidMasse moléculaire :401.463Thalidomide-O-amido-C3-NH2
CAS :<p>Thalidomide-derived cereblon ligand linked to a PROTAC technology linker, Thalidomide-O-amido-C3-NH2, is a synthetic E3 ligase ligand-linker.</p>Formule :C18H20N4O6Couleur et forme :SolidMasse moléculaire :388.37GDCNF-11
CAS :<p>GDCNF-11, an HSP90-based HIM-PROTACGPX4 degrader, facilitates the ubiquitination and degradation of GPX4 through the HSP90 chaperone complex. This reduction in endogenous GPX4 induces ferroptosis in HT-1080 cells, with a DC50 value of 0.08 μM.</p>Formule :C48H53Cl2N13O5SCouleur et forme :SolidMasse moléculaire :994.99DB0614
CAS :<p>DB0614 degrades 26 kinases including AAK1 and CDK6, targeting aberrant activity in disease research.</p>Formule :C41H42N8O7S2Couleur et forme :SolidMasse moléculaire :822.95Ferroptosis inducer-6
CAS :<p>Ferroptosisinducer 6 (6d) is an inducer of ferroptosis (ferroptosis) that exhibits potent potential for Type I/II photodynamic therapy by inducing ROS production, oxidative stress, and mitochondrial damage. Additionally, it demonstrates antitumor activity.</p>Formule :C69H78F12N12P2RuCouleur et forme :SolidMasse moléculaire :1466.44Topoisomerase II inhibitor 14
CAS :<p>Topoisomerase II inhibitor 14: powerful anticancer agent that induces apoptosis, halts S phase, and lowers GSH, MDA, and NO levels.</p>Formule :C15H11Cl2N5Degré de pureté :99.62%Couleur et forme :SoildMasse moléculaire :332.19hCAIX-IN-23
<p>hCAIX-IN-23 (Compound 27) is a human carbonic anhydrase (hCA) inhibitor with Ki values of 10.4 nM for hCA IX and 8.5 nM for hCA XII. It not only inhibits hCA activity but also releases NO, exerting dual anti-tumor effects. By reducing the expression of hCA IX and iron regulatory proteins, hCAIX-IN-23 regulates mitochondrial caspase activity and the ferroptosis pathway, thereby inducing apoptosis. This compound is utilized in research focused on renal cancer.</p>Couleur et forme :Odour SolidCyclo(Arg-Gly-Asp-D-Phe-Val) TFA
CAS :<p>Arg-Gly-Asp-D-Phe-Val (TFA) has anti-tumor activity and is an inhibitor of integrin αvβ3.</p>Formule :C28H39F3N8O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :688.662Thalidomide-4-C3-NH2 hydrochloride
CAS :<p>Thalidomide-4-C3-NH2 HCl is a cereblon ligand for CRBN recruitment, used to make PROTACs with a linker.</p>Formule :C16H18ClN3O4Couleur et forme :SolidMasse moléculaire :351.785CALP1
CAS :<p>Cell-permeable CaM agonist; activates phosphodiesterase, binds to Ca2+ channels, inhibits cytotoxicity (IC50=52μM), protects cells, reduces inflammation.</p>Formule :C40H75N9O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :842.09Euphornin
CAS :<p>Euphornin is a natural product that can be used as a reference standard. The CAS number of Euphornin is 80454-47-3.</p>Formule :C33H44O9Couleur et forme :SolidMasse moléculaire :584.706Aphidicolin
CAS :<p>Aphidicolin blocks DNA synthesis, hinders herpes virus growth, and stimulates apoptosis in leukemia cells; it's a mold-derived DNA polymerase inhibitor.</p>Formule :C20H34O4Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :338.48Tubulin/MMP-IN-3
<p>Tubulin/MMP-IN-3 (Compound 15j) is a dual inhibitor of tubulin polymerization and MMP, effectively inhibiting MMP-2 and MMP-9 with IC50 values of 21.13 μM and 19.24 μM, respectively. It disrupts the NF-κB signaling pathway, leading to mitochondrial dysfunction and mitochondrial-dependent apoptosis. Tubulin/MMP-IN-3 shows antiproliferative activity in various cancer cells by causing cell cycle arrest at the G2/M phase and demonstrates antitumor effects in mouse models.</p>Formule :C38H41N2O12PCouleur et forme :SolidMasse moléculaire :748.712Thalidomide-NH-C6-NH2 TFA
CAS :<p>Thalidomide-based cereblon ligand linked to PROTAC technology as E3 ligase ligand-linker.</p>Formule :C21H25F3N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :486.44MNK8
CAS :<p>MNK8 is a potent STAT3 inhibitor, impairs DNA binding, and inhibits liver cancer cell growth.</p>Formule :C15H12N2O2Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :252.27MDM2-IN-21
CAS :<p>MDM2-IN-21 is a potent MDM2 inhibitor. MDM2-IN-21 can be used for the research of cancer.</p>Formule :C34H40Cl2N4O2Couleur et forme :SolidMasse moléculaire :607.62PROTAC Mcl1 degrader-1
CAS :<p>PROTAC Mcl1 degrader-1 is a Cereblon ligand-based targeted chimeric protein degrader (PROTAC) and an Mcl-1 inhibitor, useful in cancer research.</p>Formule :C45H45BrN6O8SDegré de pureté :98.74%Couleur et forme :SolidMasse moléculaire :909.84EGFR-IN-151
<p>EGFR-IN-151 (Compound 10) inhibits EGFR and its downstream signaling pathways ERK/STAT3. It effectively suppresses the proliferation of various lung cancer cells, with IC50 values of 11.7, 5.19, 7.32, and 1.53 μM for NCI-H1781, HCC827, NCI-H3255, and NCI-H1975, respectively. Additionally, EGFR-IN-151 hinders colony formation and cell migration in H1975, induces G1 phase cell cycle arrest, and triggers apoptosis in H1975 cells.</p>Couleur et forme :Odour SolidUSP7-IN-9
<p>USP7-IN-9 is a potent USP7 inhibitor (IC50 = 40.8 nM), induces apoptosis, arrests RS4;11 cells, and modulates key oncoproteins.</p>Formule :C32H33ClF6N6O8Couleur et forme :SolidMasse moléculaire :779.08Rosamultic acid
<p>Rosamultic acid is a useful organic compound for research related to life sciences and the catalog number is T125342.</p>Formule :C30H46O5Couleur et forme :SolidMasse moléculaire :486.693Galloflavin Potassium
CAS :<p>Galloflavin Potassium is an inhibitor of lactate dehydrogenase.</p>Formule :C12H5KO8Couleur et forme :SolidMasse moléculaire :316.26
