Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(4 produits)
- Caspase(153 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(94 produits)
- PDK(9 produits)
- PERK(26 produits)
- Sérine/thréonine kinase(18 produits)
- Survivant(14 produits)
- TNF(51 produits)
- c-RET(60 produits)
- p53(63 produits)
Affichez 6 plus de sous-catégories
6028 produits trouvés pour "Apoptose"
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Bursehernin
CAS :Bursehernin is a useful organic compound for research related to life sciences and the catalog number is T124894.Formule :C21H22O6Couleur et forme :SolidMasse moléculaire :370.401Biguanidinium-porphyrin free TFA
Biguanidinium-porphyrin free TFA is a mitochondrial-targeting photosensitiser exhibiting low dark toxicity towards human hepatocellular carcinoma HEp2 cells.Formule :C48H36F3N9O2Degré de pureté :98.69%Couleur et forme :SolidMasse moléculaire :827.85MDM2 ligand 4
MDM2ligand 4 is a ligand of MDM2 and can be used in the synthesis of the PROTAC degrader [KT-253].
Formule :C31H33Cl2FN2O4Couleur et forme :SolidMasse moléculaire :587.509EGFR-IN-143
EGFR-IN-143 (Compound 5f) is a potent EGFR inhibitor with an IC50 value of 0.15 μM. It induces apoptosis by arresting the cell cycle at the G2/M phase and exhibits antitumor activity.Formule :C20H21ClN6O3Couleur et forme :SolidMasse moléculaire :428.872Antiproliferative agent-23
Antiproliferative agent-23: destabilizes microtubules, induces apoptosis in cancer cells via mitochondrial path, and triggers ER stress.Formule :C23H28Cl3N3O6PtCouleur et forme :SolidMasse moléculaire :743.93KT-253
CAS :KT-253 is a p53 stabilizer and a PROTAC degrader of MDM2 (DC50=0.4 nM). It inhibits the proliferation of cancer cells RS4;11 with an IC50 of 0.3 nM, induces cell cycle arrest in the G2/M phase, and triggers apoptosis. In mouse models, KT-253 demonstrates antitumor activity. (Pink: ligand for target protein MDM2 ligand 4; Black: linker; Blue: ligand for E3 ligase cereblon)
Formule :C48H52Cl2FN7O6Couleur et forme :SolidMasse moléculaire :912.874HPCR
CAS :HPCR exhibits antiproliferative activity against various cancer cells and is involved in apoptosis (apoptosis).Formule :C52H40O12Couleur et forme :SolidMasse moléculaire :856.867CSN5-IN-1
CSN5-IN-1 (compound Ac-11) serves as an inhibitor of CSN5, exhibiting IC50 values of 12.56 μM in FP assay and 19 μM in fluorescence assay. Additionally, it influences cellular protein expression by downregulating PD-L1 and upregulating NEDD8-Cul1.Formule :C17H22N2O2SCouleur et forme :SolidMasse moléculaire :318.43Resistomycin
CAS :Resistomycin (Geliomycin), a pentacyclic polyketide antibiotic, exhibits potent anticancer properties by triggering apoptosis.
Formule :C22H16O6Degré de pureté :99.34%Couleur et forme :SolidMasse moléculaire :376.36Ref: TM-T21820
1mg107,00€2mg153,00€5mg239,00€10mg353,00€25mg563,00€50mg758,00€100mg1.008,00€200mg1.359,00€TS-IN-5
TS-IN-5 (Compound 15) is an inhibitor of thymidylate synthase (TS). It induces apoptosis by modulating the proteins Bax, BCL-2, PI3K, and STAT1. TS-IN-5 exhibits antitumor activity against liver cancer, breast cancer, and colon cancer.Formule :C16H17N5OSCouleur et forme :SolidMasse moléculaire :327.404Ganoderic acid T1
Ganoderic acid T1, a derivative of Ganoderic acid T, triggers cancer cell apoptosis by boosting ROS and activating caspases.Formule :C34H50O7Couleur et forme :SolidMasse moléculaire :570.76Tubulin-IN-53
Tubulin-IN-53 is a potent inhibitor of microtubulin (Tubulin) with an IC50 of 6.06 μM. By targeting the colchicine binding site on tubulin, Tubulin-IN-53 hinders tubulin polymerization, disrupting the microtubule network. It induces cell cycle arrest at the G2/M phase and apoptosis (apoptosis) in MCF-7 cells, while inhibiting cell migration. This compound also leads to a reduction in mitochondrial membrane potential and an increase in reactive oxygen species (ROS) accumulation. Additionally, Tubulin-IN-53 disrupts angiogenesis in human umbilical vein endothelial cells and is applicable in research on cancers such as breast and lung cancer.Couleur et forme :Odour SolidHDAC-IN-84
HDAC-IN-84 (compound 4a) is a potent HDAC inhibitor with IC50 values of 0.0045, 0.015, 0.013, 0.038, 5.8, and 26 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC11, respectively. It effectively inhibits the proliferation of leukemia cells without causing toxicity.Formule :C17H21N3O5SCouleur et forme :SolidMasse moléculaire :379.431Mcl-1 inhibitor 3
CAS :Mcl-1 inhibitor 3 shows good pharmacokinetic properties and excellent in vivo efficacy without toxicity.Mcl-1 inhibitor 3 is a highly potent and orally activateFormule :C40H52ClF2N5O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :820.39Antibiotic DC 81
CAS :DC 81: Streptomyces-derived antitumor antibiotic, potent nucleic acid synthesis inhibitor, binds DNA sequences, forms covalent adducts.Formule :C13H14N2O3Couleur et forme :SolidMasse moléculaire :246.262,4-D sodium salt
CAS :Sodium 2,4-dichlorophenoxyacetate: selective herbicide, controls broadleaf weeds by disrupting growth and protein/DNA synthesis.Formule :C8H5Cl2NaO3Couleur et forme :SolidMasse moléculaire :243.02CH091138
CH091138 is a potent and selective KRASG12D PROTAC degrader, exhibiting a DC50 value of 148.3 nM in HeLa cells and 469.8 nM in AsPC-1 cells. It selectively targets both exogenous and endogenous KRASG12D through the VHL-mediated ubiquitin-proteasome system, without affecting KRASWT or other KRAS mutants (G12C/G12S/G12V). CH091138 demonstrates significant antitumor activity by inducing apoptosis (apoptosis) in tumor cells and is applicable for research in pancreatic and colon cancers.Couleur et forme :Odour SolidHalleridone
CAS :Halleridone, a natural product, is identified in Teuanchum decipiens and Abeliophyllum distichum.Formule :C8H10O3Couleur et forme :SolidMasse moléculaire :154.165FKBP12 ligand-2
FKBP12 ligand-2 (compound d) is a high-affinity ligand that targets FKBP12. This compound is utilized to selectively enhance the binding of heterobifunctional molecules to BRD4, facilitating the intracellular accumulation of drugs through the "CellTrap" effect. It forms a ternary complex of FKBP12-ligand-BRD4, which inhibits BRD4, suppresses the expression of BRD4 target genes such as MYC, and induces tumor cell death. FKBP12 ligand-2 is applicable in selective cancer research based on the differential levels of presenter proteins within cells.Couleur et forme :Odour Solid
