Méthyltransférase de l’ADN
Les méthyltransférases de l'ADN (DNMT) sont des enzymes qui catalysent l'ajout de groupes méthyles aux résidus de cytosine dans l'ADN, conduisant à la silenciation des gènes. Une méthylation aberrante de l'ADN est associée à diverses maladies, y compris le cancer. Les inhibiteurs de DNMT bloquent l'activité de ces enzymes, réactivant ainsi les gènes silencieux et induisant l'apoptose dans les cellules cancéreuses. Les inhibiteurs de DNMT sont largement utilisés dans la recherche épigénétique et la thérapie contre le cancer. Chez CymitQuimica, nous offrons une gamme d'inhibiteurs de DNMT de haute qualité pour soutenir vos recherches en épigénétique, méthylation de l'ADN et biologie du cancer.
422 produits trouvés pour "Méthyltransférase de l’ADN"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
Genistein
CAS :Formule :C15H10O5Degré de pureté :>98.0%(HPLC)Couleur et forme :White to Light yellow to Light orange powder to crystalMasse moléculaire :270.24N-Phthalyl-L-tryptophan
CAS :Formule :C19H14N2O4Degré de pureté :>98.0%(T)(HPLC)Couleur et forme :Light yellow to Amber to Dark green powder to crystalineMasse moléculaire :334.33Zebularine
CAS :Formule :C9H12N2O5Degré de pureté :>98.0%(T)(HPLC)Couleur et forme :White to Light yellow powder to crystalMasse moléculaire :228.20Chlorogenic Acid
CAS :Formule :C16H18O9Degré de pureté :>98.0%(T)(HPLC)Couleur et forme :White to Light yellow powder to crystalMasse moléculaire :354.31Procaine Hydrochloride
CAS :Formule :C13H20N2O2·HClDegré de pureté :>98.0%(T)(HPLC)Couleur et forme :White to Almost white powder to crystalMasse moléculaire :272.771-Hydrazinophthalazine Hydrochloride
CAS :Formule :C8H8N4·HClDegré de pureté :>99.0%(T)(HPLC)Couleur et forme :White to Almost white powder to crystalMasse moléculaire :196.645-Azacytidine
CAS :Formule :C8H12N4O5Degré de pureté :>98.0%(T)Couleur et forme :White to Almost white powder to crystalMasse moléculaire :244.21(-)-Epigallocatechin Gallate Hydrate
CAS :Formule :C22H18O11·xH2ODegré de pureté :>98.0%(HPLC)Couleur et forme :White to Light yellow to Light orange powder to crystalMasse moléculaire :458.38 (as Anhydrous)Caffeic Acid
CAS :Formule :C9H8O4Degré de pureté :>98.0%(T)(HPLC)Couleur et forme :White to Orange to Green powder to crystalMasse moléculaire :180.16(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3-yl 3,4,5-trihydroxybenzoate
CAS :Formule :C22H18O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :458.3717Ref: IN-DA00IK6L
1g22,00€5g24,00€10g31,00€1kg527,00€25g55,00€50g80,00€5kgÀ demander100g114,00€250g177,00€500g302,00€Tulmimetostat
CAS :<p>Tulmimetostat (CPI-0209) is an orally active EZH1/EZH2 inhibitor.Tulmimetostat has antitumor activity and is used in the study of ovarian cancer and advanced</p>Formule :C28H36ClN3O5SDegré de pureté :98.04% - 99.872%Couleur et forme :SolidMasse moléculaire :562.12(1S,3R,4R,5R)-3-{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}-1,4,5-trihydroxycyclohexane-1-carboxylic acid
CAS :Formule :C16H18O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :354.3087Ref: IN-DA00I681
1g30,00€5g52,00€10g75,00€1kgÀ demander25g153,00€100g489,00€250gÀ demander500gÀ demander50kg41.345,00€250mg26,00€EBI-2511
CAS :<p>EBI-2511 is a highly potent and orally active inhibitor of EZH2 (IC50: 6 nM in Pfeffiera cell lines).</p>Formule :C34H48N4O4Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :576.772(1H)-Pyrimidinone, 1-β-D-ribofuranosyl-
CAS :Formule :C9H12N2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :228.2020Dihydro-5-azacytidine FA
<p>Dihydro-5-azacytidine FA (DHAC) is a pyrimidine analog that has antitumor activity, inhibits cell growth, inhibits DNA methylation, and may be used in the study of malignant mesothelioma.</p>Formule :C9H16N4O7Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :292.25Levetiracetam
CAS :<p>Levetiracetam (SIB-S1) is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onset</p>Formule :C8H14N2O2Degré de pureté :99.67% - 99.86%Couleur et forme :White Crystalline PowderMasse moléculaire :170.21DC-05
CAS :<p>DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 μM and 1.09 μM, respectively).</p>Formule :C25H25N3ODegré de pureté :98.95%Couleur et forme :SolidMasse moléculaire :383.49(E)-3,4-dihydroxycinnamic acid
CAS :Formule :C9H8O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :180.1574N-Phthalyl-L-tryptophan
CAS :Formule :C19H14N2O4Degré de pureté :95%Couleur et forme :SolidMasse moléculaire :334.32554-amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydro-1,3,5-triazin-2-one
CAS :Formule :C8H12N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :228.2053Ref: IN-DA002NLT
1g99,00€5g255,00€10g563,00€25gÀ demander50gÀ demander5mg30,00€100gÀ demander100mg31,00€250mg53,00€A-395
CAS :<p>A-395 blocks PRC2 (EZH2-EED-SUZ12) interactions, strongly inhibiting the complex with an IC50 of 18 nM.</p>Formule :C26H35FN4O2SDegré de pureté :98.43%Couleur et forme :SolidMasse moléculaire :486.65MAK683
CAS :<p>MAK683 is an inhibitor of embryonic ectoderm development (EED) (IC50s: 59, 89, 26 nM in EED Alphascreen binding, LC-MS and ELISA assay).</p>Formule :C20H17FN6ODegré de pureté :98.25% - 99.92%Couleur et forme :SolidMasse moléculaire :376.39Procaine Hydrochloride
CAS :Formule :C13H21ClN2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :272.7710Diperodon hydrochloride
CAS :<p>Diperodon hydrochloride (Diperocaine) is a local anesthetic that can be broken down by serolytic enzymes to produce local anesthetic effects.</p>Formule :C22H28ClN3O4Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :433.935-Azacytidine
CAS :<p>5-Azacytidine (Ladakamycin) is a cytidine nucleoside analog, a DNA methylation inhibitor with specificity.</p>Formule :C8H12N4O5Degré de pureté :99.31% - 99.79%Couleur et forme :Crystals From Methanol Physical Description White Crystalline Powder (Ntp 1992)Masse moléculaire :244.2(-)-Epicatechingallate
CAS :Formule :C22H18O10Degré de pureté :%Couleur et forme :SolidMasse moléculaire :442.3723BVT948
CAS :<p>BVT948 is a protein tyrosine phosphatase (PTP) inhibitor.It can also inhibit lysine methyltransferase SETD8 (KMT5A) and several cytochrome P450 (P450) isoforms.</p>Formule :C14H11NO3Degré de pureté :98.87%Couleur et forme :SolidMasse moléculaire :241.24iso-Azalansta
CAS :<p>(2R,4S)-Azalanstat (Iso-Azalansta) is a selective heme oxygenase (HO) inhibitor that is used in the study of cardiovascular disease.</p>Formule :C22H24ClN3O2SDegré de pureté :99.53% - 99.89%Couleur et forme :SoildMasse moléculaire :429.96Amodiaquine dihydrochloride dihydrate
CAS :<p>Amodiaquine dihydrochloride dihydrate (Amodiaquin hydrochloride) is an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory effects</p>Formule :C20H28Cl3N3O3Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :464.824-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydro-1,3,5-triazin-2-one
CAS :Formule :C8H12N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :244.2047Valemetostat
CAS :<p>Valemetostat (DS-3201) is a first-in-class EZH1/2 dual inhibitor, which can be used to study T-cell lymphoma.Cost-effective and quality-assured.</p>Formule :C26H34ClN3O4Degré de pureté :98.38% - 99.08%Couleur et forme :SolidMasse moléculaire :488.02Phthalazine, 1-hydrazinyl-, hydrochloride (1:1)
CAS :Formule :C8H9ClN4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :196.6369Decitabine
CAS :<p>Decitabine (Deoxycytidine) is a deoxycytidine analog, a DNA methyltransferase inhibitor with oral activity.</p>Formule :C8H12N4O4Degré de pureté :98.06% - 99.87%Couleur et forme :Physical Description Fine White Crystalline Powder Used As A DrugMasse moléculaire :228.214H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-
CAS :Formule :C15H10O5Degré de pureté :97%Couleur et forme :SolidMasse moléculaire :270.2369Ref: IN-DA00I8G3
1g26,00€5g24,00€10g31,00€1kg686,00€25g52,00€50g77,00€5kgÀ demander100g114,00€10kgÀ demander250g181,00€500g320,00€100mg26,00€MRK-990
MRK-990 is an inhibitor of PRMT that targets both PRMT5 and PRMT9, with IC50 values of 30 nM and 10 nM, respectively.Couleur et forme :Odour SolidUNC 0631
CAS :<p>UNC 0631 is a effectvie histone methyltransferase G9a inhibitor (IC50=4 nM).</p>Formule :C37H61N7O2Degré de pureté :98.76%Couleur et forme :SolidMasse moléculaire :635.93OTS186935 FA
<p>OTS186935 FA is a protein methyltransferase SUV39H2 inhibitor.OTS186935 FA inhibits tumor growth in MDA-MB-231 breast cancer cells.</p>Formule :C26H28ClN5O4Degré de pureté :99.52%Couleur et forme :SoildMasse moléculaire :509.98MAK683-CH2CH2COOH hydrochloride
<p>MAK683-CH2CH2COOH, an EED binder, was key in crafting PROTAC EED degrader-1 and -2 targeting VHL-E3 ligase.</p>Formule :C23H22ClFN6O3Couleur et forme :SolidMasse moléculaire :484.91Chaetocin
CAS :<p>Chaetocin: a natural histone methyltransferase inhibitor; IC50 of 0.8, 2.5, and 3 μM for dSU(VAR)3-9, G9a, DIM5.</p>Formule :C30H28N6O6S4Degré de pureté :98.36% - 98.82%Couleur et forme :SolidMasse moléculaire :696.84Aclantate
CAS :<p>Aclantate is a nonsteroidal anti-inflammatory drug.</p>Formule :C15H14ClNO4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :339.79Dihydro-5-azacytidine
CAS :<p>Dihydro-5-azacytidine (DHAC) is a nucleoside analog that interrupts DNA methylation by integrating into DNA. It also exhibits notable antitumor properties.</p>Formule :C8H14N4O5Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :246.22PARP/EZH2-IN-1
CAS :<p>PARP/EZH2-IN-1: Dual PARP (IC50 6.87 nM) & EZH2 (IC50 36.51 nM) inhibitor, potential for BRCA-wild-type triple-negative breast cancer.</p>Formule :C43H41FN8O5Couleur et forme :SolidMasse moléculaire :768.85UNC6852
CAS :<p>UNC6852 contains an EED ligand (IC50 = 247 nM) and a von Hippel-Lindau ligand and is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC.</p>Formule :C43H48N10O6SDegré de pureté :96.64%Couleur et forme :SolidMasse moléculaire :832.97HDACs/EZH2-IN-1
<p>HDACs/EZH2-IN-1 (Compound 22a) is a dual inhibitor of HDACs and EZH2, exhibiting potent inhibitory activity, with EZH2 Y641N being suppressed by 98% at 50 nM. It selectively targets HDAC1 and HDAC6, with IC50 values of 0.23 μM and 0.07 μM, respectively. HDACs/EZH2-IN-1 effectively inhibits the proliferation of diffuse large B-cell lymphoma cells harboring EZH2 mutations and various acute myeloid leukemia cells. Additionally, this compound has the capability to induce cellular differentiation and apoptosis (Apoptosis).</p>Formule :C29H36BrN7O4Couleur et forme :SolidMasse moléculaire :626.54UNC10013
<p>UNC10013 is an allosteric modulator of SETDB1, exhibiting negative allosteric regulation through covalent bond formation with Cys385 on the 3TD domain. It has a kinact/KI value of 1.0 × 10^6 M^-1*s^-1. UNC10013 effectively disrupts SETDB1-mediated Akt methylation, holding potential for application in cancer and neurodegenerative disease research.</p>Couleur et forme :Odour SolidML234
<p>ML234 is a dual inhibitor targeting EZH2/LSD1, with IC50 values of 0.09 and 0.12 μM, respectively. It demonstrates strong antiproliferative effects on prostate cancer cell lines LNCAP, PC3, and 22RV1. Additionally, ML234 inhibits tumor growth in a 22RV1 xenograft mouse model, showing potential as a research agent in prostate cancer therapeutics.</p>Couleur et forme :Odour SolidLSD1-IN-32
<p>LSD1-IN-32 (compound 11e) is a potent inhibitor of LSD1, with an IC50 value of 0.99 µM. It effectively impedes RANKL-induced osteoclastogenesis, bone resorption, and F-actin ring formation, indicating its potential use in osteoporosis research.</p>Formule :C36H56N2O3Si2Masse moléculaire :620.38295Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH
CAS :<p>Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH (Compound 21b), an EZH2 degrader, is employed in lymphoma research [1].</p>Formule :C34H43N3O7Couleur et forme :SolidMasse moléculaire :605.72GpC Methyltransferase
<p>GpC Methyltransferase (GpC) is an enzyme that methylates DNA, specifically targeting cytosine residues within GpC dinucleotides of non-nucleosomal DNA in vitro.</p>BBDDL2204
<p>BBDDL2204 (compound 13) is a potent and selective covalent inhibitor of EZH2, demonstrating an IC50 of 2.5 nM against EZH2Y641F.</p>Formule :C37H47N5O5SCouleur et forme :SolidMasse moléculaire :673.32979TB22
<p>TB22 is a non-nucleoside inhibitor of DOT1LR231Q with anticancer activity. It inhibits the malignant phenotype of lung cancer cells harboring the R231Q mutation via the MAPK/ERK signaling pathway, making it useful for lung cancer research.</p>Couleur et forme :Odour SolidSW2_110A acetate
<p>SW2_110A acetate is a selective, cell-permeable chromobox inhibitor of homologue CBX8 (Kd = 800 nM) bound to CBX8 N-terminal color gamut (ChD).</p>Formule :C44H64N6O9Degré de pureté :98%Couleur et forme :SoildMasse moléculaire :821.01MRTX9768 hydrochloride
<p>MRTX9768 hydrochloride is a potent, orally active PRMT5 inhibitor.</p>Couleur et forme :SolidLarsucosterol Ammonium salt
CAS :<p>Larsucosterol ammonium salt is a derivative of 25HC3S. It is a DNMT inhibitor, a LXR antagonist, an endogenous epigenetic modulator of lipid metabolism.</p>Formule :C27H49NO5SDegré de pureté :>99.99% - >99.99%Couleur et forme :SoildMasse moléculaire :499.75E67-2
CAS :<p>E67-2: Low-toxic, KIAA1718 inhibitor with IC50 of 3.4μM, targets H3K9/H3K4 demethylases.</p>Formule :C21H36N6O2Couleur et forme :SolidMasse moléculaire :404.559PRMT5-IN-9
CAS :<p>PRMT5-IN-9 is a novel PRMT5 inhibitor for treating cancer, with an IC 50 of 0.01 μM.</p>Formule :C25H23F3N6OCouleur et forme :SolidMasse moléculaire :480.495CS-VIP 8 TFA
<p>CS-VIP 8 TFA is a selective allosteric inhibitor of the WDR5 protein (Ki= 0.008 μM). It induces a conformational change in the MLL1 complex, leading to the dissociation of MLL1 from the complex, thereby inhibiting the MLL1 histone methyltransferase activity and modulating HOX gene expression. CS-VIP 8 TFA shows potential for research in hematological disorders such as leukemia.</p>Formule :C45H53F7N12O9Couleur et forme :SolidMasse moléculaire :1038.39467EZH2-IN-15
CAS :<p>A compound inhibits EZH2, overexpressed in cancers, affecting Treg activity and innate immunity.</p>Formule :C32H44N4O4Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :548.72BAY-6035
CAS :<p>BAY-6035 is an inhibitor of SET and MYND domain-containing protein 3 (SMYD3). BAY-6035 has more than 100-fold selectivity over other histone methyltransferases.</p>Formule :C22H28N4O3Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :396.48XF067-68
CAS :<p>XF067-68 is a PROTAC for targeted degradation of WD40 repeat domain protein 5 ( WDR5 )[1] .</p>Formule :C52H59F4N9O7SCouleur et forme :SolidMasse moléculaire :1030.14XF056-132
CAS :<p>XF056-132 is a potent WDR5 (WD40 repeat domain protein 5) PROTAC degrader [1] .</p>Formule :C51H57F4N9O7SCouleur et forme :SolidMasse moléculaire :1016.11Nanaomycin A
CAS :<p>Nanaomycin A, a quinone antibiotic, reactivates cancer suppressor genes and inhibits DNMT3B (IC50=500nM).</p>Formule :C16H14O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :302.28EZH2-IN-22
CAS :<p>EZH2-IN-22 (example 92) is a potent EZH2 inhibitor, exhibiting IC50 values of <0.00051 µM for EZH2(Y641N) and EZH2(Y641F), and 0.00052 µM for EZH2 (wt). Additionally, EZH2-IN-22 demonstrates antiproliferative activity.</p>Formule :C36H50N4O8Couleur et forme :SolidMasse moléculaire :666.8C 21
CAS :<p>PRMT1 inhibitor, IC50=1.8μM; 5x more selective than PRMT6; >250x over PRMT3, CARM1.</p>Formule :C90H161ClN36O24Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2166.94MS8511 HCl
<p>MS8511 HCl is a G9a/GLP inhibitor with anticancer activity that can be used in the study of a variety of cancers including brain cancer.</p>Formule :C28H42ClN5O3Degré de pureté :98.9% - 98.96%Couleur et forme :SolidMasse moléculaire :532.12SETD7-IN-1
<p>SETD7-IN-1 (compound 7), a PFI-2 analogue, acts as both a substrate and inhibitor of histone lysine methyltransferase SETD7, exhibiting an inhibitory</p>Degré de pureté :98%Couleur et forme :Odour SolidPRMT5-IN-14
CAS :<p>PRMT5-IN-14 is a PRMT5 inhibitor to treat cancer, sickle cell, and hereditary persistence of foetal hemoglobin (HPFH) mutations.</p>Formule :C18H18Cl2N4O4Couleur et forme :SolidMasse moléculaire :425.27MS1943
CAS :<p>MS1943 is a orally bioavailable EZH2 selective degrader(IC50 of 120 nM).</p>Formule :C42H54N8O3Degré de pureté :95.41% - 95.82%Couleur et forme :SolidMasse moléculaire :718.93PRMT5-IN-13
CAS :<p>PRMT5-IN-13 is a selective inhibitor of protein arginine methyltransferase 5 (prmt5) .</p>Formule :C18H17ClN4O4Couleur et forme :SolidMasse moléculaire :388.81WDR5-MYC-IN-1
<p>WDR5-MYC-IN-1 (compound 4o) is an effective inhibitor of the WDR5-MYC interaction, demonstrating a Ki value of 1.0 µM and exhibiting antiproliferative activity.</p>Couleur et forme :Odour SolidPRMT5-IN-11
CAS :<p>PRMT5-IN-11 demonstrates potent structure-dependent inhibition against the protein methyltransferase PRMT5:MEP50 complex at submicromolar concentrations.</p>Formule :C13H17N5O4Couleur et forme :SolidMasse moléculaire :307.31PRMT5-IN-15
CAS :<p>PRMT5-IN-15 is a PRMT5 inhibitor with an IC 50 value of 0.84 nM.</p>Formule :C24H23F3N6O2Couleur et forme :SolidMasse moléculaire :484.483DDO-2093
CAS :<p>DDO-2093 inhibits MLL1-WDR5 interaction (IC50: 8.6 nM, Kd: 11.6 nM), with strong antitumor properties and selectivity.</p>Formule :C29H37ClFN9O3Couleur et forme :SolidMasse moléculaire :614.12PRMT3-IN-4
<p>PRMT3-IN-4 (intermediate 15) is an inhibitor of Protein arginine methyltransferase 3 (PRMT3) and serves as the active control for SGC707. It can be utilized in the synthesis of PROTACs targeting PRMT3 and is applicable in research related to leukemia.</p>Couleur et forme :Odour SolidMethylation Compound Library
<p>xnum methylation-related compounds that can be used for high-throughput and high-content screening.</p>Couleur et forme :Odour SolidCS-VIP 8
<p>CS-VIP 8 is a selective allosteric inhibitor of the WDR5 protein (Ki= 0.008 μM). It induces conformational changes in the MLL1 complex, causing the dissociation of MLL1 from the complex and inhibiting MLL1 histone methyltransferase activity, thereby regulating HOX gene expression. CS-VIP 8 shows potential for research in hematological diseases such as leukemia.</p>Formule :C43H52F4N12O7Couleur et forme :SolidMasse moléculaire :924.4018DC-S239
CAS :<p>Ethyl 2-amino-4-methyl-5-thiophene carboxylate is a SETD7 inhibitor (IC50=4.59μM) with anticancer properties.</p>Formule :C15H15N3O5SDegré de pureté :99.37%Couleur et forme :SolidMasse moléculaire :349.36LLY-284
CAS :<p>LLY-284, a less active PRMT5 inhibitor diastereomer of LLY-283, serves as its negative control.</p>Formule :C17H18N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :342.35PRMT5-MTA-IN-2
<p>PRMT5-MTA-IN-2 (compound 1) is a synergistic inhibitor of PRMT5 with an IC50 of less than 1.5 nM.</p>Formule :C30H25F2N7O2Couleur et forme :SolidMasse moléculaire :553.56EZH2-IN-5
CAS :<p>EZH2-IN-5, potent EZH2 inhibitor; IC50: 1.52 nM (wild-type), 4.07 nM (Tyr641 mutant).</p>Formule :C26H37BrN4O2Couleur et forme :SolidMasse moléculaire :517.512G9a-IN-3
<p>G9a-IN-3 (compound 16g) is a potent G9a inhibitor with an IC50 of 0.002 μM. It is applicable for research in sickle cell disease.</p>Formule :C26H29N5O3Couleur et forme :SolidMasse moléculaire :459.22704DNMT1/HDAC-IN-1
<p>DNMT1/HDAC-IN-1 (compound (R)-23a), a potent dual inhibitor targeting both DNMT1 and HDAC, exhibits impressive inhibitory effects specifically on HDAC1 (HDAC1:IC50=0.05 μM), a major HDAC isoform that interacts with DNMT1 across multiple protein complexes involved in the transcriptional silencing of TSGs. This compound has been shown to remodel the tumor immune microenvironment and induce tumor regression, effectively reversing cancer-specific epigenetic abnormalities.</p>Couleur et forme :Odour SolidEEDi-5273
CAS :<p>EEDi-5273: Potent oral EED inhibitor, IC50 ~0.2 nM; induces complete, lasting tumor regression.</p>Formule :C26H22F4N6O2Couleur et forme :SolidMasse moléculaire :526.496EPZ020411 2HCl (1700663-41-7(free base))
<p>EPZ020411 is an effective and specific small molecule PRMT6 inhibitor (IC50=10 nM).</p>Formule :C25H40Cl2N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :515.51MS2133
<p>MS2133 is a DOT1L PROTAC degrader. It facilitates the ubiquitination and degradation of DOT1L in THP-1 and MV4-11 cells, with DC50 values of 56 nM and 25 nM, respectively, and reduces H3K79 methylation. MS2133 also inhibits the growth of MLL-r leukemia cells, demonstrating anticancer activity.</p>Formule :C58H66ClF3N14O11S2Couleur et forme :SolidMasse moléculaire :1290.41175SW2_110A
CAS :<p>SW2_110A: Cell-permeable, CBX8 ChD inhibitor, Kd 800 nM; 5x selective over other CBXs in vitro.</p>Formule :C42H60N6O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :760.96PRMT5 ligand 1
CAS :<p>PRMT5ligand 1 is a ligand of PRMT5, used as a target protein ligand in the synthesis of the PROTAC degrader MS4322.</p>Formule :C20H26N6O2Couleur et forme :SolidMasse moléculaire :382.459CARM1/IKZF3 ligand 1
<p>CARM1/IKZF3 ligand 1 functions as an inhibitor of CARM1 and serves as a target protein ligand for the synthesis of PROTAC CARM1/IKZF3 degrader-1.</p>Formule :C27H35ClN6O3Couleur et forme :SolidMasse moléculaire :527.06CPI-1328
CAS :<p>CPI-1328 is an EZH2 inhibitor with a K i value of 63 fM.</p>Formule :C28H36ClN3O4SCouleur et forme :SolidMasse moléculaire :546.12CARM1 degrader-1
<p>PROTAC CARM1 degrader-1 (compound 3b) serves as a highly potent degrader (DC50=8.1 nM) of the co-activator associated arginine methyltransferase (CARM1).</p>Formule :C71H98N12O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1279.68Anticancer agent 126
<p>Anticancer agent 126 (compound 12), a WDR5 inhibitor, exhibits anticancer properties by disrupting the WDR5-MYC interaction in cells, subsequently reducing MYC</p>Formule :C25H11BBr2F2N2O3S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :724.23CARM1 degrader-2
<p>PROTAC CARM1 degrader-2 (compound 3e), with a DC50 value of 8.8 nM, is a VHL- and proteasome-dependent degrader of co-activator associated</p>Formule :C72H100N12O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1277.71IHMT-EZH2-426
<p>IHMT-EZH2-426 (compound 38) is a potent, covalent degrader of EZH2, demonstrating IC50 values of 1.3 nM for EZH2 wild-type, 1.2 nM for EZH2-A687V, and 1.7-3.5</p>Formule :C31H35FN4O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :578.7PRMT5-IN-34
<p>PRMT5-IN-34 (Compound C) is an inhibitor of MTA-cooperative protein arginine methyltransferase 5 (PRMT5/MAT).</p>Formule :C23H19F2N5O2Masse moléculaire :435.15068MS049 2HCl (1502816-23-0(free base))
<p>MS049 inhibits PRMT4 (IC50=34nM) & PRMT6 (IC50=43nM), less so for PRMT1, PRMT3, PRMT8, not others.</p>Formule :C15H26Cl2N2ODegré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :321.28PRMT5-IN-4
CAS :<p>PRMT5-IN-4 (compound AAA-1) is a PRMT5 inhibitor.</p>Formule :C11H13N3O4SCouleur et forme :SolidMasse moléculaire :283.3SW2_152F
<p>SW2_152F: Potent CBX2 ChD inhibitor, Kd 80 nM, 24-1000x selective over other CBXs in vitro.</p>Formule :C45H62Cl3N7O8Couleur et forme :SolidMasse moléculaire :935.37Dot1L-IN-9
<p>Dot1L-IN-9 (Compound 12) is a DOT1L inhibitor with an IC50 of 125 nM. It effectively reduces H3K79 dimethylation and is utilized in leukemia research.</p>Couleur et forme :Odour SolidFTX-6058
CAS :<p>FTX-6058 is an oral inhibitor of EED that induces HbF and may treat hemoglobinopathies like sickle cell and β-thalassemia.</p>Formule :C22H18FN5O2Couleur et forme :SolidMasse moléculaire :403.417PROTAC EED degrader-1
<p>PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17.</p>Formule :C55H60FN11O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1054.2GSK3735967
CAS :<p>GSK3735967: DNMT1 inhibitor, IC50 40 nM, dicyanopyridine core, binds hemimethylated CpG, interacts with H4K20me3.</p>Formule :C25H31N7OSCouleur et forme :SolidMasse moléculaire :477.62A-893
CAS :<p>A-893 is a cell-active inhibitor of Methyltransferase SMYD2 (IC 50 = 2.8 nM) .</p>Formule :C29H38Cl2N4O4Couleur et forme :SolidMasse moléculaire :577.54UNC4976
<p>UNC4976 is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids.</p>Formule :C47H70N6O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :847.09PROTAC EED degrader-2
<p>PROTAC EED degrader-2 is a PROTAC targeting EED (pKD of 9.27),is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.11.</p>Formule :C50H58FN11O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :960.13PRMT5-IN-41
CAS :PRMT5-IN-41 (compound 130) is an effective orally active inhibitor of PRMT5. It inhibits the hERG ion channel with an IC50 of 1.36 µM.Formule :C22H16F5N5O2Masse moléculaire :477.39PARP/EZH2-IN-2
<p>PARP/EZH2-IN-2 (compound 12e) functions as a dual inhibitor targeting both PARP1 and EZH2, with IC50 values of 6.89 and 27.34 nM, respectively. This compound exhibits anticancer activity without toxicity to normal cells, achieving synthetic lethality indirectly by increasing PARP1 sensitivity through EZH2 inhibition, and inducing cell death by modulating excessive autophagy.</p>Formule :C33H31N7O3Masse moléculaire :573.24884Histone H3K9me3 (1-15) TFA
<p>Histone H3K9me3 (1-15) (H3(1-15)K9me3) TFA is used as a substrate. This post-translational modification (PTM) of histone H3K9me3 is indicative of heterochromatin surrounding the centromere.</p>Formule :C66H124N25O21·xC2HF3O2PRMT5-IN-12
CAS :<p>PRMT5-IN-12 shows remarkable inhibitory activity on PRMT5 .</p>Formule :C32H40N4O4Couleur et forme :SolidMasse moléculaire :544.696PRMT4-IN-3
<p>PRMT4-IN-3 (compound 56) serves as a potent class I protein arginine methyltransferase (PRMT) inhibitor, specifically targeting PRMT4 with an IC50 value of 37</p>Formule :C23H29N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :419.52EML734
CAS :<p>EML734 is a potent, selective inhibitor of PRMT7 and PRMT9, demonstrating inhibitory concentration 50 (IC50) values of 315 nM for PRMT7 and 0.89 μM for PRMT9.</p>Formule :C27H32N10O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :608.61EPZ-719
CAS :<p>EPZ-719: Potent SETD2 inhibitor, IC50=0.005μM, high selectivity, potential for targeted epigenetic therapy.</p>Formule :C22H31FN4O3SCouleur et forme :SolidMasse moléculaire :450.57MC3343
CAS :<p>MC3343, a DNMT1/3A inhibitor, affects tumor proliferation by blocking osteosarcoma cells in the G1 or G2/M phase and induces osteogenic differentiation.</p>Formule :C27H23N7ODegré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :461.52ORIC-944 TFA
<p>ORIC-944 TFA is an orally bioavailable selective polycomb repressive complex 2 (PRC2) inhibitor with antitumor activity.</p>Formule :C28H26F4N6O3Couleur et forme :SoildMasse moléculaire :570.54UNC7096
<p>UNC7096 is a potent, selective degrader of NSD2-PWWP1, exhibiting a dissociation constant (Kd) of 46 nM, and shows promise for treating NSD2-related diseases [1</p>Formule :C61H87N7O18SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1238.44UNC2399
CAS :<p>UNC2399, a biotinylated version of UNC1999, functions as a selective degrader of EZH2 and exhibits strong in vitro efficacy against EZH2, demonstrated by its IC</p>Formule :C67H104N10O17SCouleur et forme :SolidMasse moléculaire :1353.68MS9024
<p>MS9024 is a degrader of DNA methyltransferase 1 (DNMT1), facilitating its degradation in HCT116 cells via the ubiquitin-proteasome pathway, with a DC50 of 35 nM (DC50 values are 254 nM in MDA-MB-468 and 101 nM in H1299). Additionally, MS9024 inhibits DNMT1 with an IC50 of 0.43 μM.</p>Couleur et forme :Odour SolidMS9715
<p>MS9715 is a potent and selective NSD3-targeting PROTAC, designed by leveraging BI-9321, which targets the PWWP1 domain of NSD3, in conjunction with an E3 ligase</p>Formule :C58H74FN9O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1028.33EPZ-025654
CAS :<p>EPZ-025654 is an effective and selective inhibitor of arginine methyltransferase CARM1.</p>Formule :C29H33ClN8O3Couleur et forme :SolidMasse moléculaire :577.08FTX-6058 hydrochloride
CAS :<p>FTX-6058 hydrochloride is a potent EED inhibitor, induces HbF, and aids sickle cell and β-thalassemia research.</p>Formule :C22H19ClFN5O2Couleur et forme :SolidMasse moléculaire :439.87MS33
CAS :<p>MS33 degrades WDR5 protein, Kd 870 nM (VCB), 120 nM (WDR5); uses VHL ligase, aids acute myeloid leukemia study.</p>Formule :C64H84F3N11O7SCouleur et forme :SolidMasse moléculaire :1208.5EEDi-5285
CAS :<p>EEDi-5285: potent EED inhibitor, orally active, IC50=0.2nM, targets EED protein, anti-cancer properties.</p>Formule :C24H22FN5O3SDegré de pureté :100%Couleur et forme :SolidMasse moléculaire :479.53WDR5-47
CAS :<p>WDR5-47 is a potent small molecule to disturb the interaction of MLL1-WDR5 with IC50 value of 0.3μM.</p>Formule :C19H20ClFN4O3Degré de pureté :98.15%Couleur et forme :SoildMasse moléculaire :406.84EZH2-IN-4
CAS :<p>EZH2-IN-4, an oral EZH2 inhibitor, targets WT and mutant forms with IC50s of 0.923 nM and 2.65 nM, showing strong anti-cancer effects.</p>Formule :C29H41N3O3SCouleur et forme :SolidMasse moléculaire :511.73ND-L11B free base
<p>ND-L11B is an effective degrader of the nuclear receptor binding SET domain protein 2 (NSD2) and RE-IIBP, with DC50 values of 1.48 μM and 0.8 μM, respectively, and a Dmax close to 80%.</p>Formule :C37H51F3N10O2Couleur et forme :SolidMasse moléculaire :724.862PRMT1-IN-1
CAS :<p>PRMT1-IN-1 is a PRMT1 inhibitor.</p>Formule :C20H7Br6NO5Couleur et forme :SolidMasse moléculaire :820.702CM112
<p>CM112 is a selective degrader of protein arginine methyltransferase 1 (PRMT1), which connects a hydrophobic adamantane tag to MS023 via a 5-PEG linker. It induces the degradation of PRMT1 in various solid tumor cell lines. CM112 also targets the non-enzymatic functions of PRMT1 by reducing the stability of the orphan receptor TR3. This compound shows potential for cancer research.</p>Formule :C39H61N5O7Couleur et forme :SolidMasse moléculaire :711.4571MAK-683 hydrochloride
CAS :MAK683 hydrochloride is an inhibitor of embryonic ectoderm development (EED), with IC50 values of 59, 26nM measured in EED Alphascreen, ELISA.Cost-effective and quality-assured.Formule :C20H18ClFN6ODegré de pureté :97.02% - >99.99%Couleur et forme :SolidMasse moléculaire :412.85SGC3027
<p>SGC3027 is an inhibitor of histone methyltransferase,also is a first potent, selective and cell active chemical probe for PRMT7.</p>Formule :C41H47ClN6O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :787.37Dot1L-IN-8
<p>Dot1L-IN-8 (Compound 15) is an effective Dot1L inhibitor. It suppresses the viability of HL-60, K562, MV4-11, HH, and KG-1 cells, with IC50 values of 0.45, 1.03, 0.68, 1.66, and 1.12 μM, respectively.</p>Formule :C41H53N7O3SCouleur et forme :SolidMasse moléculaire :723.97NSD2-IN-4
<p>NSD2-IN-4 is a potent, selective inhibitor of the NSD2-SET domain, showing promise for the treatment of diseases related to NSD2 [1].</p>Formule :C18H14ClN3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :355.78NSC 370284
CAS :<p>NSC 370284 inhibits STAT3/5, reducing AML cell viability with TET1 overexpression in vitro/in vivo.</p>Formule :C21H25NO6Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :387.43AS-254s
<p>AS-254s is an inhibitor of absent, small, or homeotic-like 1 protein (ASH1L), with an IC50 of 94 nM (FP assay). It exhibits antiproliferative activity against leukemia cells with MLL1 rearrangement, with a GI50 of less than 1 μM. Additionally, AS-254s can induce differentiation in MLL1-r leukemia cells.</p>Formule :C36H41ClN6O3S2Couleur et forme :SolidMasse moléculaire :705.332GSK 591 dihydrochloride
CAS :<p>Strong PRMT5 inhibitor with 4 nM IC50, surpassing other PRMTs; halts MCL growth in lab tests.</p>Formule :C22H30Cl2N4O2Couleur et forme :SolidMasse moléculaire :453.41Dot1L-IN-1 TFA
<p>Dot1L-IN-1 TFA: potent inhibitor, K i =2 pM, IC 50 <0.1 nM; reduces H3K79 dimethylation (IC 50 =3 nM) & HoxA9 promoter activity (IC 50 =17 nM).</p>Formule :C34H37ClF3N9O4SCouleur et forme :SolidMasse moléculaire :760.23SAH-EZH2
CAS :<p>EZH2/EPP inhibitor, Kd 320 nM. Reduces EZH2, H3K27me3; halts MLL-AF9 leukemia growth; drives monocyte-macrophage differentiation.</p>Formule :C155H256N48O40Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3432.05Gintemetostat
CAS :<p>Gintemetostat (KTX-1001) is a potent NSD2 inhibitor (IC50=0.001-0.01μM) for treating NSD2-dysregulated cancers.</p>Formule :C25H26F4N8O2Couleur et forme :SolidMasse moléculaire :546.52AMI-1 free acid
CAS :<p>AMI-1: Potent reversible PRMT inhibitor; IC50: 8.8 μM (hPRMT1), 3.0 μM (yeast-Hmt1p); blocks substrate binding.</p>Formule :C21H16N2O9S2Degré de pureté :97.8%Couleur et forme :SolidMasse moléculaire :504.49PROTAC EZH2 Degrader-1
CAS :<p>PROTAC EZH2 Degrader-1 suppresses EZH2 methyltransferase activity with IC50 2.7 nM, serving as a potent tool in cancer research and EZH2 inhibition studies.</p>Formule :C54H67N7O8Couleur et forme :SolidMasse moléculaire :942.15MS8511 hydrochloride
CAS :<p>MS8511 hydrochloride is a selective G9a/GLP inhibitor with IC50 values of 100 nM and 140 nM respectively, exhibiting covalent and irreversible characteristics.</p>Formule :C28H42ClN5O3Couleur et forme :SolidMasse moléculaire :532.122'-Deoxy-2'-fluoro-β-D-arabinocytidine hydrochloride
CAS :<p>2'-Deoxy-2'-fluoro-beta-D-arabinocytidine HCl inhibits DNA methyltransferase with potential anti-tumor properties.</p>Formule :C9H13ClFN3O4Degré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :281.67(R)-GSK-3685032
CAS :<p>(R)-GSK-3685032 is a selective, reversible DNMT1 inhibitor, non-covalent, IC50: 0.036 μM; reduces DNA methylation, inhibits cancer growth.</p>Formule :C22H24N6OSCouleur et forme :SolidMasse moléculaire :420.545-Aza-2'-deoxycytidine
CAS :Formule :C8H12N4O4Degré de pureté :>98.0%(HPLC)Couleur et forme :White to Almost white powder to crystalMasse moléculaire :228.21DA-3003-1
CAS :<p>DA-3003-1 (NSC 663284) is a Cdc25 dual specificity phosphatase inhibitor with antitumor activity and inhibits Cdc25B2, Cdc25A, Cdc25B2, and Cdc25C.</p>Formule :C15H16ClN3O3Degré de pureté :99.27% - 99.79%Couleur et forme :SolidMasse moléculaire :321.76EHMT2-IN-1
CAS :<p>EHMT2-IN-1: potent EHMT inhibitor, for blood disorders/cancer research; IC50s <100 nM for EHMT1/2 peptides and cellular EHMT2.</p>Formule :C18H23N7OCouleur et forme :SolidMasse moléculaire :353.42O6-Benzylguanine
CAS :Formule :C12H11N5ODegré de pureté :>98.0%(T)(HPLC)Couleur et forme :White to Light yellow powder to crystalMasse moléculaire :241.25O6BTG-octylglucoside
CAS :O6BTG-octylglucoside is a potent O6-methylguanine-DNAmethyl-transferase (MGMT) inhibitor (IC50s: 10 nM and 32 nM in HeLa S3 cells and in vitro (cell extracts)).Formule :C24H34BrN5O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :616.53EZM0414 TFA
CAS :<p>EZM0414 TFA (SETD2-IN-1 TFA) is a SETD2 inhibitor with anticancer and antiproliferative effects for the study of leukemia and immune dysfunction.</p>Formule :C24H30F4N4O4Degré de pureté :98.88%Couleur et forme :SolidMasse moléculaire :514.51(R)-HH2853
CAS :<p>(R)-HH2853, a mutant EZH2 inhibitor, IC50 <100 nM for EZH2-Y641F, targets cancer/autoimmune diseases.</p>Formule :C31H36F3N7O3Degré de pureté :97.53% - 98.85%Couleur et forme :SolidMasse moléculaire :611.665'-Azido-5'-deoxyadenosine
CAS :<p>5'-Azido-5'-deoxyadenosine is a purine nucleoside analogue, inhibit Trichomonas vaginalis and PRMT5 , click chemistry alkyne, DBCO, or BCN groups.</p>Formule :C10H12N8O3Degré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :292.25PR5-LL-CM01
CAS :<p>PR5-LL-CM01 is a novel protein arginine methyltransferase 5 (PRMT5) inhibitor in colorectal and pancreatic cancers.</p>Formule :C23H27N7Couleur et forme :SolidMasse moléculaire :401.51AZ505 ditrifluoroacetate
CAS :<p>AZ505 ditrifluoroacetate is an effective and selective SMYD2 inhibitor (IC50: 0.12 μM).</p>Formule :C33H40Cl2F6N4O8Couleur et forme :SolidMasse moléculaire :805.59AS-85
CAS :<p>AS-85 is an ASH1L inhibitor with anti-leukemic activity that inhibits leukemic cell growth and increases cLogP.</p>Formule :C26H28F3N5O3S2Degré de pureté :98.96%Couleur et forme :SolidMasse moléculaire :579.66EPZ020411
CAS :<p>EPZ020411 is a specific and effective inhibitor of PRMT6 (IC50=10 nM).</p>Formule :C25H38N4O3Couleur et forme :SolidMasse moléculaire :442.66-Thioguanine
CAS :<p>6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.</p>Formule :C5H5N5SDegré de pureté :98.34% - >99.99%Couleur et forme :Odorless Or Almost Odorless Pale Yellow Crystalline PowderMasse moléculaire :167.195-Methyl-2'-deoxycytidine
CAS :<p>5-Methyl-2'-deoxycytidine (5MedCyd) is a pyrimidine nucleoside that when incorporated into single-stranded DNA can act in cis to signal de novo.</p>Formule :C10H15N3O4Degré de pureté :99.18% - 99.69%Couleur et forme :SolidMasse moléculaire :241.24GSK503
CAS :<p>GSK-503, a potent EZH2 inhibitor, has potential antitumor activity.</p>Formule :C31H38N6O2Degré de pureté :98% - 99.89%Couleur et forme :SolidMasse moléculaire :526.675-Fluoro-2'-deoxycytidine
CAS :<p>5-Fluoro-2'-deoxycytidine (2'-DEOXY-5-FLUOROCYTIDINE) is an inhibitor of DNA methyltransferase (DNMT) .</p>Formule :C9H12FN3O4Degré de pureté :97.91%Couleur et forme :Fine White PowderMasse moléculaire :245.21MR837
CAS :<p>MR837 (NSD2-PWWP1 antagonist 3f) is a NSD2-PWWP1 antagonist.</p>Formule :C16H14N2OSDegré de pureté :99.77% - 99.85%Couleur et forme :SolidMasse moléculaire :282.36SGC2085
CAS :<p>SGC2085 is an effective and selective coactivator-associated arginine methyltransferase 1 (CARM1) inhibitor (IC50: 50 nM).</p>Formule :C19H24N2O2Degré de pureté :99.61% - 99.71%Couleur et forme :SolidMasse moléculaire :312.41Zebularine
CAS :<p>Zebularine (4-Deoxyuridine) is a DNA methylation inhibitor.</p>Formule :C9H12N2O5Degré de pureté :99.04% - >99.99%Couleur et forme :SolidMasse moléculaire :228.2BRD4770
CAS :<p>BRD4770 is a histone methyltransferase G9a inhibitor and induces cell senescence.</p>Formule :C25H23N3O3Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :413.47UNC3866 TFA(1872382-47-2 free base)
CAS :<p>UNC3866 TFA is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen.</p>Formule :C45H67F3N6O10Degré de pureté :98.43%Couleur et forme :SolidMasse moléculaire :909.04GSK343
CAS :<p>GSK343, a specific and effective EZH2 inhibitor (IC50=4 nM), exhibits 60 fold specificity activity against EZH1, and >1000 fold specificity activity against</p>Formule :C31H39N7O2Degré de pureté :98% - 99.9%Couleur et forme :SolidMasse moléculaire :541.69EED226
CAS :<p>EED226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor with an IC50 of 22 nM.</p>Formule :C17H15N5O3SDegré de pureté :98.14% - 99.33%Couleur et forme :SolidMasse moléculaire :369.4Succinic acid sodium
CAS :<p>Succinic acid sodium is an orally active anxiolytic.</p>Formule :C4H6O4·xNaCouleur et forme :Solidγ-Oryzanol
CAS :<p>γ-Oryzanol (Gamma-Oryzanol) is a natural nutrient extract isolated from rice bran oil that contains a mixture of sterols and ferulic acids, which may aid in the</p>Formule :C40H58O4Degré de pureté :mixture - mixtureCouleur et forme :White Or White Crystalline Powder OdourlessMasse moléculaire :602.93-deazaneplanocin A HCl
CAS :<p>3-deazaneplanocin A HCl is both an S-adenosyl-l-homocysteine hydrolase inhibitor and an enhancer of zeste homolog 2(EZH2) inhibitor.</p>Formule :C12H15ClN4O3Degré de pureté :93.24% - 98.9%Couleur et forme :SolidMasse moléculaire :298.73MS023
CAS :<p>MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8,</p>Formule :C17H25N3ODegré de pureté :98.31% - 99.87%Couleur et forme :SolidMasse moléculaire :287.4UNC3866
CAS :<p>UNC3866 is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen.</p>Formule :C43H66N6O8Degré de pureté :88.06% - 99.62%Couleur et forme :SolidMasse moléculaire :795.02JNJ-64619178
CAS :<p>JNJ-64619178: selective, oral, pseudo-irreversible PRMT5 inhibitor (IC50: 0.14 nM), effective in lung cancer.</p>Formule :C22H23BrN6O2Degré de pureté :98.44% - 99.63%Couleur et forme :SolidMasse moléculaire :483.36OTS186935 hydrochloride
<p>OTS186935 HCl inhibits SUV39H2 (IC50 6.49 nM), curbs tumor growth in mice, and modulates γ-H2AX in cancer cells.</p>Formule :C25H27Cl2N5O2Couleur et forme :SolidMasse moléculaire :522.31MRTX9768
CAS :<p>MRTX-9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors.</p>Formule :C24H17FN6ODegré de pureté :97.02%Couleur et forme :SolidMasse moléculaire :424.43OICR-9429
CAS :<p>OICR-9429 blocks WDR5 binding to MLL/Histone 3, hindering acute myeloid leukemia cell growth in vitro.</p>Formule :C29H32F3N5O3Degré de pureté :97.07% - 99.93%Couleur et forme :SolidMasse moléculaire :555.59Pinometostat
CAS :<p>Pinometostat (EPZ-5676) is a potent DOT1L histone methyltransferase inhibitor. Pinometostat has antitumor activity. Cost effective and quality assured.</p>Formule :C30H42N8O3Degré de pureté :99.19% - 99.86%Couleur et forme :SolidMasse moléculaire :562.71TP-064
CAS :<p>TP-064: Potent, selective PRMT4 inhibitor, IC50 < 10nM for H3 methylation, 100x selectivity, blocks MED12 methylation at 43nM.</p>Formule :C28H34N4O2Degré de pureté :97.85%Couleur et forme :SolidMasse moléculaire :458.6SETDB1-TTD-IN-1
CAS :<p>SETDB1-TTD-IN-1 is a potent and selective inhibitor of SET domain bifurcated protein 1 tandem tudor domain (SETDB1-TTD, Kd = 88 nM).Cost-effective and quality-assured.</p>Formule :C28H31N5O2Degré de pureté :98.26% - 99.96%Couleur et forme :SolidMasse moléculaire :469.58CM-579 trihydrochloride
<p>CM-579 trihydrochloride: reversible G9a/DNMT inhibitor with IC50s 16 nM (G9a) & 32 nM (DNMT); potent against various cancer cells.</p>Formule :C29H43Cl3N4O3Couleur et forme :SolidMasse moléculaire :602.04HLCL-61 hydrochloride
CAS :<p>HLCL-61 hydrochloride (HLCL-61 HCL) is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia.</p>Formule :C23H24N2O·ClHDegré de pureté :99.88% - 99.95%Couleur et forme :SolidMasse moléculaire :380.91SGC707
CAS :<p>SGC707 is a potent, selective, and cell-active allosteric inhibitor of PRMT3.</p>Formule :C16H18N4O2Degré de pureté :98.45% - 99.79%Couleur et forme :SolidMasse moléculaire :298.34BRD9539
CAS :<p>BRD9539 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, with an IC50 value of 6.3 μM</p>Formule :C24H21N3O3Degré de pureté :98% - 99.57%Couleur et forme :SolidMasse moléculaire :399.44EPZ004777
CAS :<p>EPZ004777 is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM.</p>Formule :C28H41N7O4Degré de pureté :98.99% - 99.32%Couleur et forme :SolidMasse moléculaire :539.67PF-06726304
CAS :<p>PF-06726304: potent EZH2 inhibitor, effective against tumors, Kis at 0.7 nM (wild-type) and 3.0 nM (Y641N mutant).</p>Formule :C22H21Cl2N3O3Degré de pureté :98.19% - 99.51%Couleur et forme :SolidMasse moléculaire :446.33MS049
CAS :<p>MS 049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC 50 of 34 nM and 43 nM, respectively.</p>Formule :C15H24N2ODegré de pureté :98.91%Couleur et forme :SolidMasse moléculaire :248.36Tazemetostat
CAS :<p>Tazemetostat (EPZ6438): Oral EZH2 inhibitor, blocks histone H3K27 methylation, potential cancer therapy.</p>Formule :C34H44N4O4Degré de pureté :98.24% - ≥95%Couleur et forme :SolidMasse moléculaire :572.74LLY-507
CAS :<p>LLY-507 is an effective, cell-active, and specific inhibitor of protein-lysine Methyltransferase SMYD2.</p>Formule :C36H42N6ODegré de pureté :99.58% - 99.93%Couleur et forme :SolidMasse moléculaire :574.76AMI-1
CAS :<p>AMI-1 is an effective and selective Histone Methyltransferase (HMT) inhibitor (IC50: 3.0/8.8 μM, for yeast Hmt1p, and human PRMT1).</p>Formule :C21H14N2Na2O9S2Degré de pureté :97.53% - 99.9%Couleur et forme :DrypowderMasse moléculaire :548.452',3',5'-triacetyl-5-Azacytidine
CAS :<p>2',3',5'-triacetyl-5-Azacytidine (Nsc291930) is a prodrug form of 5-azacytidine that may be rapidly absorbed orally.</p>Formule :C14H18N4O8Degré de pureté :98.34%Couleur et forme :SolidMasse moléculaire :370.31UNC1999
CAS :<p>UNC1999 is a orally bioavailable, effective and specific inhibitor of EZH2 (IC50=2 nM) and EZH1 (IC50=45).</p>Formule :C33H43N7O2Degré de pureté :99.19% - >99.99%Couleur et forme :SolidMasse moléculaire :569.74TC-E 5003
CAS :<p>TC-E 5003 (NSC-30176) is a selective inhibitor of PRMT1 with IC50 of 1.5 μM.</p>Formule :C16H14Cl2N2O4SDegré de pureté :97.01%Couleur et forme :SolidMasse moléculaire :401.26Gambogenic acid
CAS :Gambogenic acid is a natural product,is an effective inhibitor of EZH2,with anticancer activity.Formule :C38H46O8Degré de pureté :97.47% - 99.6%Couleur et forme :SolidMasse moléculaire :630.77BIX-01294
CAS :<p>BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM).</p>Formule :C28H38N6O2Degré de pureté :98.58% - 99.64%Couleur et forme :SolidMasse moléculaire :490.64MT-DADMe-ImmA
CAS :<p>MT-DADMe-ImmA (MTDIA) is an inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP, Ki: 90 pM).</p>Formule :C13H19N5OSDegré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :293.39AZ505
CAS :<p>AZ505 is an effective and specific SMYD2 inhibitor (IC50: 0.12 μM).</p>Formule :C29H38Cl2N4O4Degré de pureté :98.18%Couleur et forme :SolidMasse moléculaire :577.54Tazemetostat hydrobromide
CAS :<p>Tazemetostat hydrobromide: potent, selective EZH2 inhibitor; blocks PRC2/wild-type EZH2 (Ki: 2.5 nM) & EZH1 (IC50: 392 nM).</p>Formule :C34H45BrN4O4Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :653.65EPZ015666
CAS :<p>EPZ015666 (GSK3235025) is an orally available inhibitor of PRMT5 enzymatic activity.</p>Formule :C20H25N5O3Degré de pureté :98% - 99.64%Couleur et forme :SolidMasse moléculaire :383.44UNC0646
CAS :<p>UNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP with low cellular toxicity.</p>Formule :C36H59N7O2Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :621.9SGC0946
CAS :<p>SGC0946 is a highly effective and specific DOT1L methyltransferase inhibitor (IC50: 0.3 nM); selectively kill mixed lineage leukemia cells.</p>Formule :C28H40BrN7O4Degré de pureté :98% - 99.82%Couleur et forme :SolidMasse moléculaire :618.57UNC1215
CAS :<p>UNC1215, a potent MBT antagonist, targets L3MBTL3 with high selectivity (IC50: 40 nM, Kd: 120 nM, 50x versus MBT family).</p>Formule :C32H43N5O2Degré de pureté :98% - 99.04%Couleur et forme :SolidMasse moléculaire :529.72
![(1S,3R,4R,5R)-3-{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}-1,4,5-trihydroxycyclohexane-1-carb…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb-webp%2FDA00I681.webp&w=3840&q=75)
![4-amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydro-1,3,5-triazin-2-one](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb-webp%2FDA002NLT.webp&w=3840&q=75)
![4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydro-1,3,5-triazin-2-o…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb-webp%2FDA003824.webp&w=3840&q=75)
