Immunologie et Inflammation
Les inhibiteurs en immunologie et inflammation sont des composés qui modulent la réponse immunitaire et les processus inflammatoires. Ces inhibiteurs sont cruciaux pour étudier les mécanismes de la régulation immunitaire, l'auto-immunité et l'inflammation chronique, ainsi que pour développer des traitements pour les maladies inflammatoires, les allergies et les troubles immunitaires. En ciblant des voies clés du système immunitaire, ces inhibiteurs peuvent aider à réduire les réponses immunitaires excessives ou inappropriées. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de haute qualité en immunologie et inflammation pour soutenir vos recherches en immunologie, inflammation et développement thérapeutique.
Sous-catégories appartenant à la catégorie "Immunologie et Inflammation"
- RCC(136 produits)
- CXCR(147 produits)
- Paroi cellulaire(5 produits)
- Récepteur IL(113 produits)
- IκB/IKK(61 produits)
- LTR(3 produits)
- MALT(23 produits)
- MRP(6 produits)
- NADPH-oxydase(1 produits)
- NF-κB(445 produits)
- NOD(17 produits)
- NOS(63 produits)
- Nrf2(78 produits)
- PGE Synthase(31 produits)
- ROS(69 produits)
- TGF-beta/Smad(58 produits)
- TLR(66 produits)
- Thioredoxine(12 produits)
- gp120/CD4(4 produits)
Affichez 11 plus de sous-catégories
3035 produits trouvés pour "Immunologie et Inflammation"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
Isuventatug
CAS :<p>Isuventatug is a monoclonal antibody that targets human MICA (MHC I chain-related molecule A) and MICB (MHC I chain-related molecule B). By binding to MICA and MICB, Isuventatug modulates the interaction between immune cells and tumor cells, exhibiting anti-tumor activity. This compound holds potential for research in cancer immunotherapy.</p>Couleur et forme :LiquidMyD88-IN-1
CAS :<p>MyD88-IN-1: Potent MyD88 inhibitor with anti-inflammatory effects, blocking NF-κB and TLR/IL-1 pathways; potential for cancer and inflammation treatment.</p>Formule :C23H24N6O7SDegré de pureté :>99.99%Couleur et forme :SoildMasse moléculaire :528.54BR102910
CAS :<p>BR102910: Selective FAP inhibitor, features 4-thiazolecarboxamide with cyano-difluoro-pyrrolidine and dichlorophenyl elements.</p>Formule :C18H14Cl2F2N4O2SDegré de pureté :97%Couleur et forme :SolidMasse moléculaire :459.3ENUM006
<p>ENUM006 is a human monoclonal antibody (mAb) that targets CD223/LAG3.</p>Couleur et forme :Odour LiquidSTING agonist-31
CAS :<p>STING agonist-31, a potent STING agonist, exhibits EC50 values of 0.24 μM and 39.51 μM for human STING (h-STING) and murine STING (m-STING), respectively,</p>Formule :C43H51N15O6Couleur et forme :SolidMasse moléculaire :873.96JAK-STAT Compound Library
<p>A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;</p>Couleur et forme :Odour SolidAspulvinone O
CAS :<p>Aspulvinone O, from P. variotti, is an antioxidant with anticancer properties, inhibits GOT1, and reduces SW1990 pancreatic tumor growth in mice.</p>Formule :C27H28O6Couleur et forme :SolidMasse moléculaire :448.515(±)-Phrymarolin II
CAS :<p>(±)-Phrymarolin II is a promising class of inhibitors that targets the tobacco mosaic virus, representing a novel approach in plant virus suppression.</p>Formule :C23H22O10Couleur et forme :SolidMasse moléculaire :458.419Histamine & Melatonin Receptor-Targeted Compound Library
<p>A unique collection of xnum compounds targeting histaminergic receptor and melatonin receptor for high throughput screening (HTS) and high content screening (HCS</p>Couleur et forme :Odour SolidKD014
<p>KD014 (DX-2400) is a human monoclonal antibody (mAb) that targets MMP14, with a Ki of 0.9 nM. It inhibits TGFβ and SMAD2/3 signaling, increases macrophage count and iNOS expression, and shifts macrophage phenotype towards an antitumor M1-like type. KD014 exhibits antitumor activity in three tumor models (MDA-MB-231, MDA-MB-435, and PC3) and is applicable in breast cancer research.</p>Couleur et forme :Odour Liquid(-)-10,11-Dihydroxyfarnesol
CAS :<p>(-)-10,11-Dihydroxyfarnesol, from Cryptomarasmius aucubae, inhibits NO production.</p>Formule :C15H28O3Couleur et forme :SolidMasse moléculaire :256.38Miptenalimab
CAS :<p>Miptenalimab (BI-754111) is an anti-human LAG-3 antibody with a dissociation constant (K D) of 88.6 nM for h LAG-3, effectively blocking the interaction between</p>Couleur et forme :LiquidFM-303
<p>FM-303 is a monoclonal antibody inhibitor that targets interleukin-23 (IL-23). It shows promise for research in immune system and digestive system diseases.</p>Couleur et forme :Odour LiquidZiltivekimab
CAS :<p>Ziltivekimab (MEDI 5117) is a CHO-expressed humanized monoclonal antibody targeting IL-6/IFNb2 for use in immune system diseases.</p>Degré de pureté :95% - 97.9% (SDS-PAGE); 97.3% (SEC-HPLC)Couleur et forme :SoildHPK1-IN-57
<p>HPK1-IN-57 (Compound 10c) is an inhibitor of hematopoietic progenitor kinase 1 (HPK1) with an IC50 of 0.09 nM. It suppresses the activity of HPK1 kinase, inhibits the phosphorylation of downstream adaptor protein SLP76 (IC50 of 33.74 nM), and effectively induces the secretion of the T cell activation marker IL-2 (EC50 of 84.24 nM). HPK1-IN-57 holds promise for research in tumor immunotherapy.</p>Formule :C30H36F2N8O3Couleur et forme :SolidMasse moléculaire :594.655Inhibitor Library
<p>A unique collection of 8328 inhibitors for research in cell signaling, high throughput screening (HTS) and high content screening (HCS) for new drugs;</p>Couleur et forme :Odour SolidJAB-BX102
<p>JAB-BX102 is a human monoclonal antibody (mAb) that targets NT5E/CD73. It is applicable in research studies involving breast cancer, pancreatic cancer, prostate cancer, and other cancers.</p>Couleur et forme :Odour LiquidAR20.5
<p>AR20.5 is a human monoclonal antibody targeting MUC1. It enhances the number of activated CD8 T cells, CD3+CD4−CD8− (DN) T cells, and mature dendritic cells in mice with pancreatic tumors. AR20.5 is applicable for research into anti-pancreatic cancer immunity.</p>Couleur et forme :Odour LiquidPost-Translational Modification Compound Library
<p>Contains xnum active small molecules for research related to post-translational modifications (PTMs);</p>Couleur et forme :Odour SolidNonsteroidal Anti-Inflammatory Compound Library
<p>xnum non-steroidal anti-inflammatory compounds for high-throughput and high-content screening.</p>Couleur et forme :Odour SolidR1-ICR-5
CAS :<p>R1-ICR-5 is a selective PROTAC degrader targeting serine/threonine-protein kinase 1 (RIPK1). Mediated by VHL, R1-ICR-5 promotes the degradation of RIPK1, disrupting the TNFR1 and TLR3/4 signaling hubs, enhancing NF-κB, MAPK, and IFN signal output, and facilitating RIPK3 activation and necroptosis induction. R1-ICR-5 holds potential for research in cancer and inflammatory diseases.</p>Formule :C54H70N8O7S2Couleur et forme :SolidMasse moléculaire :1007.31Transcription Factor-Targeted Compound Library
<p>Well-chosen xnum compounds with unique structures targeting transcription factor;</p>Couleur et forme :Odour SolidPyroptosis Compound Library
<p>xnum types of active small molecules associated with pyroptosis for high-throughput and high-content screening.</p>Couleur et forme :LiquidBifarcept
CAS :<p>Bifarcept, a recombinant antibody targeting the interferon receptor type I (IFN-RI), enhances the serum half-life of IFN-β by facilitating its binding.</p>Couleur et forme :LiquidTMX-201
CAS :<p>TMX-201: TLR7 ligand-phospholipid with potent immune-boosting effect; for breast cancer & melanoma study.</p>Formule :C57H93N6O12PCouleur et forme :SolidMasse moléculaire :1085.36STING ligand-4
<p>STING ligand-4 (Compound 2) is a nitro-free covalent STING inhibitor with an IC50 of less than 0.2 μM. It can be utilized in the synthesis of PROTACSTINGdegrader-4.</p>Formule :C18H18Cl2N6OCouleur et forme :SolidMasse moléculaire :404.09191Rabelomycin
CAS :<p>Rabelomycin is an angucycline group antibiotic.</p>Formule :C19H14O6Couleur et forme :SolidMasse moléculaire :338.31Chemokine Inhibitor Library
<p>A unique collection of xnum chemokines or chemokine receptors targeted compounds for high throughput and high content screening;</p>Couleur et forme :Odour SolidCAY10614
CAS :<p>CAY10614 is a TLR4 antagonist.</p>Formule :C42H78INO2Couleur et forme :SolidMasse moléculaire :755.995Immunology/Inflammation Compound Library
<p>A unique collection of xnum anti-inflammation compounds effective for high throughput screening and high content screening.</p>Couleur et forme :Odour SolidAnti-PSMA Antibody
<p>Anti-PSMA Antibody is a humanized IgG1 monoclonal antibody targeting PSMA. It serves as the antibody component of the ADC molecule ARX517.</p>Couleur et forme :Odour LiquidFletikumab
CAS :<p>Fletikumab (NNC0109-0012) is a monoclonal antibody against IL-20 that is often used as an IL-20 inhibitor.Fletikumab is used in the study of rheumatoid</p>Degré de pureté :100% (SEC-HPLC) - > 95%Couleur et forme :LiquidMasse moléculaire :146.48 kDaAMG-424
<p>AMG-424 (XmAb968) is a human bispecific antibody (bsAb) targeting CD38 and CD3E. It effectively kills cancer cells that express CD38, stimulates T cell proliferation, and reduces cytokine release. AMG-424 exhibits antitumor activity in mouse cancer models with bone marrow invasion and induces peripheral B cell depletion in cynomolgus monkeys. It is used in studies of multiple myeloma. Recommended isotype control: half-IG G1-kappa/(scFv-heavy-lambda)-h-CH2-CH3.</p>Couleur et forme :Odour LiquidGPCR Compound Library
<p>A unique collection of xnum GPCR-active agents for high throughput screening and high content screening for GPCR drug discovery, and new GPCR target</p>Couleur et forme :Odour SolidDeacetylgedunin
CAS :<p>Deacetylgedunin is a limonoid that is the 7-deacetyl derivative of gedunin. It has been isolated from Azadirachta indica.</p>Formule :C26H32O6Couleur et forme :SolidMasse moléculaire :440.53KL-A289
<p>KL-A289 is a human monoclonal antibody (mAb) that targets CD223/LAG3. It can be utilized in research related to metastatic gastric cancer.</p>Couleur et forme :Odour LiquidSTING modulator-5
CAS :<p>STING modulator-5: pIC50 9.5, antagonizes PBMC (pIC50 8.1), THP-1 cell antagonist, for immunology research.</p>Formule :C43H45F4N11O5Couleur et forme :SolidMasse moléculaire :871.88SARS-CoV-2 Mpro-IN-41
<p>SARS-CoV-2 Mpro-IN-41 (Compound 7e) is an orally active inhibitor targeting COX-2 and SARS-CoV-2 Mpro, with respective IC50 values of 9.66 μM and 13.24 μM. It also demonstrates inhibitory activity against COX-1 (IC50: 46.11 μM). This compound significantly suppresses the expression of inflammation-related cytokines such as TNF-α, IL-6, and IL-1β, exhibiting anti-inflammatory properties. By selectively inhibiting COX-2 and SARS-CoV-2 Mpro, SARS-CoV-2 Mpro-IN-41 exerts both anti-inflammatory and antiviral effects, making it a potential candidate for research in inflammation and COVID-19 treatment.</p>Formule :C27H23ClN4O3SCouleur et forme :SolidMasse moléculaire :518.11794HPPD-IN-1
<p>HPPD-IN-1 (compound II-3), a potent HPPD inhibitor, exhibits inhibitory activity against Arabidopsis thaliana HPPD (AtHPPD) with an IC50 of 0.248 μM, surpassing</p>Formule :C12H6F3NO4Couleur et forme :SolidMasse moléculaire :285.18IMP-761
<p>IMP-761 is a human IgG4 monoclonal antibody (mAb) that targets CD223/LAG3. It binds to the D1 domain of human LAG32. The recommended isotype control is Human IgG4 kappa, Isotype Control.</p>Couleur et forme :Odour LiquidNLRP3-IN-76
<p>NLRP3-IN-76 is an orally active NLRP3 inhibitor that suppresses the production of NO and reduces the mRNA levels of pro-inflammatory cytokines (iNOS, IL-6, IL-1β, and TNFα). It exerts anti-inflammatory effects by inhibiting the activation of the NLRP3 inflammasome and the NF-κB signaling pathway. Furthermore, NLRP3-IN-76 can ameliorate DSS-induced colitis and is applicable for studying inflammatory bowel disease (IBD).</p>Couleur et forme :Odour SolidS217879
<p>S217879 is a potent and selective activator of NRF2 that disrupts the KEAP1-NRF2 interaction, resulting in significant activation of the NRF2 pathway.</p>Formule :C29H30N4O7SCouleur et forme :SolidMasse moléculaire :578.64Keap1-IN-1
<p>Keap1-IN-1 (Compound 27) is an inhibitor of Keap1, functioning by covalently modifying the Cys151 residue on the BTB domain of KEAP1, thereby disrupting the interaction between Keap and Nrf. It enhances the mRNA expression of the antioxidant response element (ARE) dependent gene NQO1, with an EC50 of 160 nM, and exhibits cytotoxicity in U2OS cells, with an EC50 of 527 nM.</p>Formule :C17H21Cl2N2O5PS3Couleur et forme :SolidMasse moléculaire :531.434DNV-3
<p>DNV-3 is a human monoclonal antibody (mAb) that targets CD223/LAG3.</p>Couleur et forme :Odour Liquid2-(Phosphonooxy)benzoic acid
CAS :<p>2-(Phosphonooxy)benzoic acid (Fosfosal), used as the anti-inflammatory agent, has the anti-bacterial effect.</p>Formule :C7H7O6PDegré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :218.1Galectin-3-IN-5
<p>Galectin-3-IN-5 (Compound 20) is an orally active inhibitor of galectin-3 (Gal-3), exhibiting an IC50 value of 9.2 nM against hGal-3.</p>Formule :C24H19BrClF5N6O4SCouleur et forme :SoildMasse moléculaire :697.86Keap1-Nrf2-IN-3
CAS :<p>Keap1-Nrf2-IN-3 is a KEAP1:NRF2 protein protein interaction inhibitor, and with a K d value of 2.5 nM for KEAP1 protein.</p>Formule :C31H34N6O3Couleur et forme :SolidMasse moléculaire :538.6521-Hydroxy-ibuprofen
CAS :<p>1-Hydroxy Ibuprofen, a metabolite in P. australis, targets COX-1/COX-2 with IC50s: 13 μM/370 μM.</p>Formule :C13H18O3Couleur et forme :SolidMasse moléculaire :222.2802Antifungal agent 123
<p>Antifungalagent 123 (Compound 4b) demonstrates strong affinity for the oxidoreductase of Staphylococcus aureus or membrane proteins of Candida albicans, exhibiting both antibacterial and antifungal properties. Additionally, it is capable of scavenging free radicals, showcasing antioxidant effects. Antifungalagent 123 also inhibits the TLR signaling pathway and possesses anti-inflammatory activity.</p>Formule :C21H20N4O3Couleur et forme :SolidMasse moléculaire :376.409Guselkumab
CAS :<p>Guselkumab (CNTO 1959) is a recombinant human IgG1 monoclonal antibody targeting the IL-23p19 subunit.</p>Degré de pureté :SDS-PAGE:95% SEC-HPLC:98.97%Couleur et forme :LiquidMasse moléculaire :144.8 kDaVEN-02XX
<p>VEN-02XX is an orally active NLRP3 inhibitor capable of penetrating the brain. It effectively suppresses the release of IL-1β and IL-18, with IC50 values of 0.3 and 0.28 μM, respectively. In the 5XFAD/Rubicon KO mouse model, VEN-02XX aids in restoring memory and cognition, inhibits microgliosis, and alleviates neuroinflammation and tau protein pathology. This compound is valuable for Alzheimer's disease (AD) research.</p>Formule :C18H16ClF3N4OCouleur et forme :SolidMasse moléculaire :396.79AChE-IN-85
<p>AChE-IN-85 (Compound 7k) is an acetylcholinesterase inhibitor with an IC50 of 0.083 μM. It reduces nitric oxide (NO) release, the production of TNF-α and IL-1β, as well as levels of LDH and ROS, and inhibits Aβ42 aggregation. AChE-IN-85 exhibits anti-inflammatory and neuroprotective effects and is applicable for research on diseases such as Alzheimer's.</p>Couleur et forme :Odour SolidCOX-2-IN-52
<p>COX-2-IN-52 (Compound 5l) is an orally active and selective COX-2 inhibitor with an IC50 of 54 nM. It can suppress the release of NO in cells, exhibiting anti-inflammatory properties. COX-2-IN-52 offers high gastrointestinal safety and is suitable for research on oral anti-inflammatory drugs.</p>Formule :C16H13IN4O4S2Couleur et forme :SolidMasse moléculaire :516.333Ara-F-NAD+ sodium
<p>Ara-F-NAD+ sodium, an arabino analogue of NAD+, serves as a potent, reversible, and slow-binding inhibitor of the CD38 NADase [1] [2].</p>Formule :C21H25FN7NaO13P2Couleur et forme :SolidMasse moléculaire :687.4Pam3CSK4-Biotin
CAS :<p>Pam3CSK4-Biotin is a biotinylated derivative of Pam3CSK4, functioning as a Toll-like receptor 1/2 (TLR1/2) agonist.</p>Formule :C103H192N14O17S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1962.85Nrf2/HO-1 activator 3
<p>Nrf2/HO-1 Activator 3 (Compound C3a) is an activator of the Nrf2 signaling pathway that facilitates the translocation of Nrf2 into the nucleus and enhances the expression of heme oxygenase-1 (HO-1). In H9c2 cardiomyocytes subjected to H2O2 or high glucose stimulation, Nrf2/HO-1 Activator 3 inhibits the excessive expression of ROS and MDA, suppressing cell viability and colony formation, thereby exhibiting antioxidant activity.</p>Formule :C27H26N2O6Couleur et forme :SolidMasse moléculaire :474.51Pascolizumab
CAS :<p>Pascolizumab (SB-240683) is a humanized monoclonal antibody against IL-4. Pascolizumab has asthmatic effects and can be used to study allergic rhinitis.</p>Degré de pureté :> 95%Couleur et forme :LiquidMasse moléculaire :147.18 kDaNVP-DKY709
CAS :<p>NVP-DKY709 is a potent IKZF2 inhibitor for the treatment of cancers.</p>Formule :C25H27N3O3Degré de pureté :99%Couleur et forme :SolidMasse moléculaire :417.5ROS inducer 8
<p>ROS inducer 8 (Compound 11g) acts as an inhibitor of glutathione (GSH) and promotes the accumulation of reactive oxygen species (ROS) in Enterococcus faecalis, exhibiting antibacterial properties. It is capable of disrupting biofilms and inhibiting S. aureus and E. faecalis with minimum inhibitory concentrations (MICs) of 8 μg/mL and 2 μg/mL, respectively, demonstrating a post-antibiotic effect. Additionally, ROS inducer 8 shows low hemolytic toxicity on sheep red blood cells with an HC50 greater than 1280 μg/mL.</p>Formule :C26H31FN6O6Couleur et forme :SolidMasse moléculaire :542.56STING agonist-3 trihydrochloride
<p>STING agonist-3 is a selective, non-nucleotide small-molecule with anti-tumor properties and potential in cancer therapy.</p>Formule :C37H45Cl3N12O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :860.19QX006N
<p>QX006N is a humanized monoclonal antibody inhibitor targeting the human interferon α/β receptor 1 (IFNAR1). It is promising for research in systemic lupus erythematosus (SLE) and other IFNAR1-related autoimmune diseases.</p>Couleur et forme :Odour LiquidBasiliximab
CAS :<p>Basiliximab: chimeric IgG1 antibody inhibiting interleukin-2 receptor, used for kidney transplant immunosuppression.</p>Degré de pureté :SDS-PAGE:94.1%;SEC-HPLC:95.3%Couleur et forme :LiquidMasse moléculaire :144.01 kDa(6Z,9Z,12Z,15Z,18Z,21Z)-Tetracosahexaenoyl-CoA
CAS :<p>(6Z,9Z,12Z,15Z,18Z,21Z)-Tetracosahexaenoyl-CoA ((6Z,9Z,12Z,15Z,18Z,21Z)-Tetracosahexaenoyl-coenzyme A) acts as an NLRX1 modulator. This compound shows potential for research into immune and metabolism-related diseases.</p>Formule :C45H70N7O17P3SCouleur et forme :SolidMasse moléculaire :1106.062,4,6-Trichlorol-3-methyl-5-methoxy-phenol 1-O-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranoside
CAS :<p>2,4,6-Trichlorol-3-methyl-5-methoxy-phenol 1-O-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranoside is a chlorophenyl glycoside that is commonly found in the bulbs of</p>Formule :C20H27Cl3O12Couleur et forme :SolidMasse moléculaire :565.78KTX-955
CAS :<p>KTX-955, a potent IRAK4 degrader, exhibits DC50 values of 5 nM for IRAK4 and 130 nM for Ikaros. It is primarily utilized in anticancer research [1] [2].</p>Formule :C46H51F3N8O7Couleur et forme :SolidMasse moléculaire :884.94ROS-ERS inducer 1
<p>Type II ICD agent, ROS-ERS inducer 1, is a Pt(II)-NHC from 4,5-diarylimidazole, boosting ER stress, ROS, and DAMPs in HCC, outperforming Cisplatin.</p>Formule :C24H23F2I2N3PtCouleur et forme :SolidMasse moléculaire :840.35TAB-004
<p>TAB-004 is a human monoclonal antibody targeting MUC1. It specifically identifies the tMUC1 present in all major subtypes of breast cancer without affecting normal breast epithelial cells. Additionally, TAB-004 is applicable for research on triple-negative breast cancer (TNBC).</p>Couleur et forme :Odour LiquidMethyl 3,4-Dihydroxyphenylacetate
CAS :<p>Methyl 3,4-Dihydroxyphenylacetate is an effective enterovirus 71 (EV71) inhibitor, suppressing EV71 replication in rhabdomyosarcoma (RD) cells, antiviral.</p>Formule :C9H10O4Degré de pureté :97.03%Couleur et forme :SolidMasse moléculaire :182.17SIN 14
<p>SIN 14 is an HO-1 activator that targets and activates HO-1 through an allosteric mechanism. Additionally, SIN 14 can induce the polarization of macrophages from the M1 phenotype to the M2 phenotype.</p>Formule :C20H22ClNO4Couleur et forme :SolidMasse moléculaire :375.12374Cyclo(L-Pro-L-Val)
CAS :<p>Cyclo(L-Pro-L-Val), from Mycobacterium spp., has anti-inflammatory effects, hinders phytopathogens, and suppresses IKKα, NF-κB, iNOS, and COX-2 activation.</p>Formule :C10H16N2O2Degré de pureté :98.18%Couleur et forme :SolidMasse moléculaire :196.25SN50 TFA
<p>SN50 TFA is an inhibitor of NF-κB and attenuates alveolar hypercoagulation and fibrinolysis inhibition. SN50 TFA can be used in studies about ARDS.</p>Formule :C129H230N36O29S·XCF3COOHCouleur et forme :SolidMasse moléculaire :2781.5 (free base)Keap1-Nrf2-IN-25
<p>Keap1-Nrf2-IN-25 (Compound 19) is a potent Keap1-Nrf2 inhibitor with an IC50 of 0.55 μM and exhibits a Keap1 binding affinity (Kd of 0.50 μM). This compound activates Nrf2, reducing reactive oxygen species (ROS) and pro-inflammatory cytokines (IL-1β, IL-6). Additionally, Keap1-Nrf2-IN-25 provides protective effects against DSS-induced colitis.</p>Formule :C25H28N2O6SCouleur et forme :SolidMasse moléculaire :484.565FLY26
<p>FLY26 is a selective partial antagonist of GluN2B, with an IC50 value of 0.64 μM. FLY26 inhibits the GluN2B subunit of NMDA receptors, reducing calcium ion influx and reactive oxygen species (ROS) production. It also activates the BDNF/TrkB/CREB neuroprotective signaling pathway, mitigating excitotoxicity and mitochondrial dysfunction. FLY26 holds potential for treating neurological deficits caused by cerebral ischemia-reperfusion injury.</p>Formule :C22H23N5O3Couleur et forme :SolidMasse moléculaire :405.18009AChE-IN-82
<p>AChE-IN-82 (compound 49) is an acetylcholinesterase (AChE) inhibitor. It inhibits eeAChE, eqBChE, hMAO-A, hMAO-B, and BACE-1 with IC50 values of 0.072, 9.81, 14.52, 0.024, and 2.42 μM, respectively. Additionally, AChE-IN-82 inhibits COX-1, COX-2, and 5-LOX with IC50 values of 60.41, 0.187, and 0.18 μM, respectively. The compound also demonstrates strong neuroprotective effects by significantly reducing H2O2-induced oxidative stress.</p>Formule :C21H18N4O5S2Couleur et forme :SolidMasse moléculaire :470.52BRCA2-IN-1
<p>BRCA2-IN-1 (Compound 3j) is a potential BRCA2 inhibitor with antiproliferative activity against the breast cancer MCF-7 cell line. This compound also demonstrates DPPH radical scavenging ability, with an IC50 value of 12.36 µM.</p>Couleur et forme :Odour SolidNT-0249
CAS :<p>NT-0249 is an inflammatory vesicle NLRP3 inhibitor with anti-inflammatory activity that reverses high-fat diet-induced obesity.</p>Formule :C22H28N5NaO4SDegré de pureté :98.11%Couleur et forme :SoildMasse moléculaire :481.54JPE-1375
CAS :<p>JPE-1375: a C5aR1 antagonist, blocks leukocyte mobilization (EC50=6.9 µM), lowers TNF in mice (EC50=4.5 µM), useful for autoimmune/inflammation research.</p>Formule :C49H63FN10O9Couleur et forme :SolidMasse moléculaire :955.08C12-rrw-NH2
<p>C12-rrw-NH2 (Compound Lip7) is an antimicrobial agent effective against Gram-positive bacteria, particularly demonstrating significant activity against Methicillin-resistant Staphylococcus aureus (MRSA). It induces bacterial cell death by depolarizing the bacterial cell membrane, disrupting membrane integrity, causing nucleic acid and protein leakage, and promoting the generation of Reactive Oxygen Species (ROS). C12-rrw-NH2 is applicable in research focused on developing highly stable antimicrobial peptides.</p>Formule :C35H58N10O5Couleur et forme :SolidMasse moléculaire :698.9Nemolizumab
CAS :<p>Nemolizumab (CIM331) is an anti-IL-31 receptor A monoclonal antibody for atopic dermatitis and pruritus study.</p>Degré de pureté :100% (SEC-HPLC) - > 95%Couleur et forme :LiquidMasse moléculaire :144.92 kDaHistone Modification Compound Library
<p>A unique collection of xnum histone modification related compounds for high throughput screening (HTS) and high content screening (HCS);</p>Couleur et forme :Odour SolidRucosopasem manganese
CAS :<p>Rucosopasem manganese (GC4711), a selective SOD mimetic, converts superoxide to peroxide for cancer research.</p>Formule :C27H45MnN5O4Couleur et forme :SolidMasse moléculaire :558.626Tri(TLR4-IN-C34-C2-amide-PEG1)-amide-C3-COOH
<p>Tri(TLR4-IN-C34-C2-amide-PEG1)-amide-C3-COOH, a linker with TLR4-IN-C34, reduces inflammation in mice.</p>Formule :C78H125N7O36Couleur et forme :SolidMasse moléculaire :1736.85BuChE-IN-20
<p>BuChE-IN-20 is a selective hBuChE inhibitor (IC50= 0.13 μM) with the ability to cross the blood-brain barrier (BBB). This compound, a derivative of L-Tryptophan, exhibits neuroprotective effects by inhibiting nitric oxide (NO) production and reducing reactive oxygen species (ROS) levels. It effectively suppresses the self-aggregation of amyloid-beta (Aβ) peptides and is applicable in Alzheimer's disease research.</p>Couleur et forme :Odour SolidIPH5301
<p>IPH5301 is a human IgG1 monoclonal antibody (mAb) that targets NT5E/CD73. It features a functionally silenced Fc domain and specifically inhibits the enzymatic activity of both soluble and membrane-bound CD73, thereby restoring the proliferation of immune T cells. IPH5301 is applicable for research in anti-tumor immunotherapy. Recommended isotype control: HumanIgG1kappa, Isotype Control.</p>Couleur et forme :Odour LiquidAntiviral agent 38
CAS :<p>(6R)-6-Tert-butyl-10-(3-methoxypropoxy)-dihydro-2-oxo-indazole carboxylic acid has antiviral and antibacterial properties, useful for Hepatitis B research.</p>Formule :C23H27N3O5Degré de pureté :99.66%Couleur et forme :SoildMasse moléculaire :425.48CRX 527
CAS :<p>CRX 527 is a TLR4 ligand and serves as an adjuvant for peptide cancer vaccines, enhancing anti-tumor immune responses. CRX 527 also induces hematopoietic stem cell (HSC) differentiation, increasing the proportion and number of LSK cells, and promotes their differentiation into macrophages. This activation bolsters immune defense and protects intestinal epithelium from radiation damage.</p>Formule :C81H151N2O19PCouleur et forme :SolidMasse moléculaire :1488.04PS 1145 dihydrochloride
CAS :<p>IκB kinase (IKK) inhibitor</p>Formule :C17H13Cl3N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :395.67β-Aminoarteether
CAS :<p>β-Aminoarteether (SM934 free base), an orally active derivative of Artemisinin, serves a pivotal role in the research of inflammation and autoimmune disorders,</p>Formule :C17H29NO5Degré de pureté :96.09% - 97.02%Couleur et forme :SolidMasse moléculaire :327.42Itolizumab
CAS :<p>Itolizumab (Anti-Human CD6 Recombinant Antibody) is a recombinant anti-CD6 monoclonal antibody that humanizes the extracellular SRCR distal domain 1 of CD6.</p>Degré de pureté :> 95%Couleur et forme :LiquidMasse moléculaire :144.82 kDaClaseprubart
CAS :<p>Claseprubart is a monoclonal antibody that targets human complement C1s. It specifically binds to complement C1s, inhibiting the activation of the complement system and exerting immunosuppressive effects. Claseprubart shows potential for research in autoimmune diseases and inflammation-related conditions.</p>Couleur et forme :LiquidFITC-labeled ODN 1826 sodium
<p>FITC-labeled ODN 1826 (sodium), a class B CpG ODN (oligodeoxynucleotide) and TLR9 agonist, facilitates the assessment of CpG ODN cellular uptake and</p>Couleur et forme :Odour SolidMesalamine impurity P
CAS :<p>Mesalamine impurity P, a 5-Aminosalicylic acid derivative, is a PPARγ agonist, inhibiting PAK1 and NF-κB.</p>Formule :C13H11NO6SCouleur et forme :SolidMasse moléculaire :309.30Pterisolic acid B
<p>Pterisolic acid B is a useful organic compound for research related to life sciences and the catalog number is T125924.</p>Formule :C20H26O4Couleur et forme :SolidMasse moléculaire :330.424Xanthine oxidase-IN-12
<p>Xanthine oxidase-IN-12 (Compound 11), an inhibitor of xanthine oxidase (XO), possesses an IC50 value of 91 nM and exhibits antioxidant properties, additionally</p>Degré de pureté :98%Couleur et forme :Odour SolidDaclizumab
CAS :<p>Daclizumab (Zenapax), a humanized antibody, blocks IL-2 by targeting CD25, used in multiple sclerosis.</p>Degré de pureté :SDS-PAGE:95% SEC-HPLC:99.99%Couleur et forme :LiquidMasse moléculaire :144.12 kDaMAPK Inhibitor Library
<p>A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;</p>Couleur et forme :Odour SolidGuretolimod hydrochloride
<p>Guretolimod hydrochloride acts as an agonist for Toll-like receptor 7 (TLR7) [1].</p>Formule :C24H35ClF3N5O4Couleur et forme :SolidMasse moléculaire :550.01Carotuximab
CAS :<p>Carotuximab (DE-122), an antibody, inhibits CD105 to reduce angiogenesis, inflammation, and tumor growth.</p>Degré de pureté :> 95%Couleur et forme :LiquidMasse moléculaire :144.8 kDaIromycin A
CAS :<p>Iromycin A: a bacterial metabolite inhibiting NOS III over NOS I, blocks NADH oxidation, IC50 = 0.461 µM.</p>Formule :C19H29NO2Couleur et forme :SolidMasse moléculaire :303.44Inflexuside A
CAS :<p>Inflexuside A, an abietane diterpenoid from Isodon inflexus, and Inflexuside B inhibit NO in LPS-stimulated RAW264.7 cells.</p>Formule :C26H42O9Couleur et forme :SolidMasse moléculaire :498.61
