Immunologie et Inflammation
Les inhibiteurs en immunologie et inflammation sont des composés qui modulent la réponse immunitaire et les processus inflammatoires. Ces inhibiteurs sont cruciaux pour étudier les mécanismes de la régulation immunitaire, l'auto-immunité et l'inflammation chronique, ainsi que pour développer des traitements pour les maladies inflammatoires, les allergies et les troubles immunitaires. En ciblant des voies clés du système immunitaire, ces inhibiteurs peuvent aider à réduire les réponses immunitaires excessives ou inappropriées. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de haute qualité en immunologie et inflammation pour soutenir vos recherches en immunologie, inflammation et développement thérapeutique.
Sous-catégories appartenant à la catégorie "Immunologie et Inflammation"
- RCC(136 produits)
- CXCR(147 produits)
- Paroi cellulaire(5 produits)
- Récepteur IL(113 produits)
- IκB/IKK(61 produits)
- LTR(3 produits)
- MALT(23 produits)
- MRP(6 produits)
- NADPH-oxydase(1 produits)
- NF-κB(445 produits)
- NOD(17 produits)
- NOS(63 produits)
- Nrf2(78 produits)
- PGE Synthase(31 produits)
- ROS(69 produits)
- TGF-beta/Smad(58 produits)
- TLR(66 produits)
- Thioredoxine(12 produits)
- gp120/CD4(4 produits)
Affichez 11 plus de sous-catégories
3035 produits trouvés pour "Immunologie et Inflammation"
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PF-06426779
CAS :<p>PF-06426779 is a potent and selective inhibitor of interleukin 1 receptor associated kinase 4 (IRAK4) , with an IC 50 of 0.3 nM.</p>Formule :C17H18FN3O4Couleur et forme :SolidMasse moléculaire :347.346TLR8 agonist 7
CAS :<p>TLR8 agonist7 is an agonist of Toll-like receptor 8 (TLR8) with an EC50 of less than 250 nM. It remains stable in human and mouse plasma and induces the secretion of the cytokine TNFα with an EC50 of less than 1 μM. In the MC38-HER2 xenograft mouse model, TLR8 agonist7 demonstrates antitumor activity, achieving a tumor growth inhibition (TGI) rate of 98%.</p>Formule :C54H63N9O16Couleur et forme :SolidMasse moléculaire :1094.13S7
CAS :<p>S7, an IL-6 receptor antagonist, prevents the interaction between IL-6 and IL-6R, thereby inhibiting angiogenesis and tumor growth [1].</p>Formule :C37H70N10O10Couleur et forme :SolidMasse moléculaire :815.01KTX-951
CAS :<p>KTX-951, a PROTAC, degrades IRAK4 (DC50=18 nM), 22% oral bioavailability in rats, shows promise as anticancer agent.</p>Formule :C46H52F2N8O6Couleur et forme :SolidMasse moléculaire :850.95HPK1-IN-58
<p>HPK1-IN-58 is an inhibitor of HPK1 (IC50: 2.6 nM) and SLP76 (IC50: 20 nM). It enhances IL-2 secretion, thereby reversing PGE2-induced immunosuppression. HPK1-IN-58 is applicable for research in antitumor immunity.</p>Formule :C26H30N8OCouleur et forme :SolidMasse moléculaire :470.25426FM101
<p>FM101 is a humanized monoclonal anti-IL6 antibody, suitable for use in asthma-related research.</p>Couleur et forme :Odour LiquidPhotosensitizer-4
<p>Compound PS-I (Photosensitizer-4) is an effective photosensitizer that can efficiently kill cancer cells and inhibit tumor growth under light exposure.</p>Couleur et forme :Odour SolidCNTO4088
<p>CNTO4088 is a monoclonal antibody inhibitor that targets interleukin-23 (IL-23). It holds potential for research in autoimmune diseases such as psoriasis and rheumatoid arthritis.</p>Couleur et forme :Odour LiquidFGT-4
<p>FGT-4 is a chimeric molecule targeting folate receptor β (FR-β) and functions as a TLR7 agonist. It enhances the secretion of iNOS and the pro-inflammatory cytokine IL-6 associated with M1 macrophages and promotes the proliferation of cytotoxic CD8+ T cells. FGT-4 demonstrates antitumor activity in the 4T1 breast cancer mouse model and is applicable for cancer immunotherapy research.</p>Formule :C50H57N11O9S2Couleur et forme :SolidMasse moléculaire :1019.37821STING agonist-24
CAS :<p>CF504: non-nucleotide STING agonist, boosts STING, TBK1, IRF3 phosphorylation; raises IFN-β, IL-6, CXCL-10, TNF-α; active against SARS-CoV strains.</p>Formule :C34H37N13O5Couleur et forme :SolidMasse moléculaire :707.74PSB-24000
<p>PSB-24000 (Compound 27) is a selective ecto-5'-nucleotidase (CD73) inhibitor with a Ki value of 563 nM for inhibiting human CD73, and a Ki of 481 nM in membrane-bound CD73 in triple-negative breast cancer cells. It disrupts CD73’s recognition and action on substrate AMP, preventing AMP-induced immunosuppressive and pro-cancer adenosine production. PSB-24000 is promising for cancer research.</p>Couleur et forme :Odour SolidHispaglabridin A
CAS :<p>Hispaglabridin A, an effective antioxidant, inhibits lipid peroxidation [1].</p>Formule :C25H28O4Couleur et forme :SolidMasse moléculaire :392.49Dovanvetmab
CAS :<p>Dovanvetmab (ZTS-00521505) is an IgG1-κ monoclonal antibody that targets feline interleukin 31 (Felcat IL31), primarily produced in Chinese Hamster Ovary (CHO)</p>Couleur et forme :LiquidHuangjiangsu A
CAS :<p>Huangjiangsu A, from D. villosa, may protect the liver from H2O2 damage and reduce ROS, showing therapeutic promise.</p>Formule :C51H82O22Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1047.18Lintuzumab
CAS :<p>Lintuzumab (HuM-195) is an uncoupled humanized mouse monoclonal antibody against CD33 with anti-leukemic activity.</p>Degré de pureté :98% (SDS-PAGE); 98.6% (SEC-HPLC) - 98.1% (SDS-PAGE); 98.2% (SEC-HPLC)Couleur et forme :LiquidNOX4-IN-1
<p>NOX4-IN-1 (Compound 14m) is an inhibitor of NADPH oxidase 4 (NOX4) that reduces the production of reactive oxygen species (ROS). It also inhibits the TGF-β1/Smad signaling pathway, leading to decreased expression of fibrosis-related proteins. Additionally, NOX4-IN-1 impedes the migration of NRK-49F cells.</p>Formule :C26H16ClN3O3Couleur et forme :SolidMasse moléculaire :453.877CD73-IN-17
<p>CD73-IN-17 (compound 19) is an inhibitor of CD73 with an IC50 of 0.1 μM against hCD73. It is applicable in cancer research.</p>Couleur et forme :Odour Solid2-Aminoquinoline
CAS :<p>Compound Fr16621, with CAS No. 580-22-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound Fr16621 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>Formule :C9H8N2Couleur et forme :Light Yellow CrystalsMasse moléculaire :144.18EG01377 2HCl
CAS :<p>EG01377 2HCl is a potent, bioavailable and selective inhibitor of neuropilin-1 (NRP1) with a Kd value of 1.32 μM and an IC50 value of 609 nM for both EG01377</p>Formule :C26H32Cl2N6O6S2Degré de pureté :98.91%Couleur et forme :SoildMasse moléculaire :659.6Eritoran Tetrasodium
CAS :<p>Eritoran Tetrasodium, a TLR4 receptor antagonist, is used potentially for the treatment of type 2 diabetes.</p>Formule :C66H122N2Na4O19P2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1401.58Carboxy-PTIO
CAS :<p>Carboxy-PTIO rapidly scavenges NO, forming NO2, key in preventing hypotension and shock in rats.</p>Formule :C14H17N2O4Couleur et forme :SolidMasse moléculaire :277.3Mik-β-1
<p>Mik-Beta-1 is a human IgG1-kappa monoclonal antibody targeting IL2RB. For isotype control, refer to Human IgG1 kappa, Isotype Control. Mik-Beta-1 is applicable in research related to the prevention of allograft rejection.</p>Couleur et forme :Odour LiquidNogapendekin alfa inbakicept
CAS :<p>Nogapendekin alfa inbakicept is an IL-15 superagonist that enhances anti-tumor immune responses by activating NK cells and T cells. It is being studied for use in non-muscle invasive bladder cancer (NMIBC).</p>Couleur et forme :SolidKTX-612
CAS :<p>KTX-612 is a compound that serves as an orally active IRAK4 degrader, exhibiting a DC50 value of 7 nM. It is primarily utilized in oncology research [1].</p>Formule :C46H51F3N8O6Couleur et forme :SolidMasse moléculaire :868.94STING-IN-12
<p>STING-IN-12 (compound Y2) acts as an inhibitor of STING. It suppresses IFNβ gene expression induced by SR717 with an IC50 of 0.75 μM. Additionally, STING-IN-12 inhibits STING pathway activation induced by the STING agonist SR717 in THP1 cells and by MSA-2 in mice.</p>Couleur et forme :Odour SolidMelredableukin alfa
CAS :<p>Melredableukin alfa, a human IgG1-κ fused with IL2 mutein, is studied for autoimmune hepatitis and ulcerative colitis.</p>Couleur et forme :LiquidTimosaponin E2
CAS :<p>Timosaponin E2 is an anti-inflammatory agent that inhibits active oxygen production [1].</p>Formule :C46H78O20Couleur et forme :SolidMasse moléculaire :951.1STING agonist-29
CAS :<p>CF511: non-nucleotide, small-molecule STING activator; fights SARS-CoV variants.</p>Formule :C38H44N14O6Couleur et forme :SolidMasse moléculaire :792.85TLR7/8 agonist 12
<p>TLR7/8 agonist 12 (compound 9) is a human TLR7/8 agonist with EC50 values of 11 nM for hTLR7 and 150 nM for hTLR8, indicating its potential for immune modulation.</p>Formule :C29H38N6O3Couleur et forme :SolidMasse moléculaire :518.65Goflikicept
CAS :<p>Goflikicept (RPH 104) binds/inactivates IL-1ß/α; may research STEMI.</p>Couleur et forme :LiquidHNGF6A
CAS :<p>increases glucose stimulated insulin secretion and glucose metabolism</p>Formule :C112H198N34O31S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2581.11Murrayafoline A
CAS :<p>Murrayafoline A is a useful organic compound for research related to life sciences. The catalog number is T124835 and the CAS number is 4532-33-6.</p>Formule :C14H13NOCouleur et forme :SolidMasse moléculaire :211.264Olendalizumab
CAS :<p>Olendalizumab (ALXN1007) is a humanized antibody targeting C5a for research on COVID-19-related inflammation.</p>Couleur et forme :LiquidQX-005N
<p>QX 005N is a humanized monoclonal anti-CD124/IL4R/IL-4Rα antibody. It is applicable in research related to asthma.</p>Couleur et forme :Odour LiquidAnti-inflammatory agent 58
<p>Anti-inflammatory agent 58 exhibits IL-1β inhibition with an IC50 value of 1.08 μM and suppresses pro-inflammatory gene expression, protein secretion, and NF-κB</p>Couleur et forme :Odour SolidAnti-inflammatory agent 38
<p>Compound 23d, an Nrf2/HO-1 inhibitor, with IC50 of 0.38 μM for NO, reduces cellular ROS for anti-inflammatory research.</p>Formule :C36H46N2O13SCouleur et forme :SolidMasse moléculaire :746.82Diplacol
CAS :<p>Diplacol, a geranylated flavanone isolated from Paulownia trees (Paulownia coreana UYEKI), exhibits anti-inflammatory properties by inhibiting NO production in LPS-stimulated Raw264.7 cells with an IC50 value of 4.53 μM [1].</p>Formule :C25H28O7Couleur et forme :SolidMasse moléculaire :440.49MJ210
<p>MJ210 is an orally active and blood-brain barrier-permeable modulator of the NF-κB and MAPK pathways, exhibiting neuroprotective properties. In vitro, 5 μM MJ210 can increase the survival rate of rotenone-treated SH-SY5Y cells to 81.9% and reduce levels of ROS. In vivo, 5 mg/kg MJ210 improves motor dysfunction in rat models of Parkinson's disease. MJ210 is useful for research in neurological disorders, including Parkinson's disease.</p>Couleur et forme :Odour SolidNHEJ inhibitor-1
<p>NHEJ inhibitor-1 (C2) is a Pt(II) complex that targets DSB repair to combat Cisplatin-resistant NSCLC by hindering Ku70/Rad51 and inducing ROS.</p>Formule :C30H35N7O8PtSCouleur et forme :SolidMasse moléculaire :848.79E7766 disodium
CAS :<p>E7766 disodium, a macrocycle-bridged STING agonist, exhibits a binding affinity (Kd) of 40 nM, demonstrating potent pan-genotypic and antitumor effects.</p>Formule :C24H26F2N10Na2O8P2S2Couleur et forme :SolidMasse moléculaire :792.58NLRP3-IN-49
<p>NLRP3-IN-49 (compound Z48) is a potent and specific inhibitor of NLRP3, displaying IC50 values of 0.26 μM in THP-1 cells and 0.21 μM in mouse bone marrow-derived macrophages. It directly binds to the NLRP3 protein with a dissociation constant (Kd) of 1.05 μM, effectively preventing the assembly and activation of the NLRP3 inflammasome, thereby exhibiting anti-inflammatory properties. NLRP3-IN-49 is utilized in the research of inflammatory bowel disease.</p>Couleur et forme :Odour SolidNOD1/2-IN-1
<p>NOD1/2-IN-1 (Compound 18) is a potent RIPK2 inhibitor, demonstrating an IC50 value of 1.4 nM in the ADP-Glo assay. It blocks the production of pro-inflammatory cytokines by inhibiting the NOD1/NOD2 pathway (IC50 values are 18 nM and 170 nM for NOD1 and NOD2, respectively), thereby reducing inflammatory responses. This compound is utilized in research related to colitis.</p>Couleur et forme :Odour SolidIsoxaben
CAS :<p>Isoxaben (EL 107) is a specific inhibitor of cell wall biosynthesis, often used as a herbicide, that inhibits the incorporation of radiolabeled glucose into</p>Formule :C18H24N2O4Degré de pureté :98.84%Couleur et forme :SolidMasse moléculaire :332.39diABZI-4
CAS :<p>DiABZI-4 is an orally active STING agonist that exhibits broad-spectrum antiviral activity. It functions by activating STING to induce the production of pro-inflammatory cytokines and activation of lymphocytes. This action inhibits the replication of Influenza A virus (IAV), SARS-CoV-2, and Human Rhinovirus (HRV), with an EC50 range of 11.8-199 nM.</p>Formule :C40H51Cl2N13O6Couleur et forme :SolidMasse moléculaire :880.82Phthalazine
CAS :<p>Compound PDK0135, with CAS No. 253-52-1, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0135 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>Formule :C8H6N2Couleur et forme :Yellow SolidMasse moléculaire :130.14PMX-53
CAS :<p>PMX-53: MrgX2 agonist; C5aR antagonist; lessens atherosclerotic lesions & metastasis in mice; blocks rat hypernociception.</p>Formule :C47H65N11O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :896.09TLR8 agonist 8
CAS :<p>TLR8 agonist8 (Compound II-72) is an agonist of Toll-like receptor 8 (TLR8) with an EC50 of 0.25-1 μM. It demonstrates stability in both human and mouse plasma and induces the secretion of the cytokine TNFα with an EC50 of less than 1 μM. In the MC38-HER2 xenograft mouse model, TLR8 agonist8 exhibits antitumor activity, achieving a tumor growth inhibition (TGI) rate of 89%.</p>Formule :C53H63N11O10Couleur et forme :SolidMasse moléculaire :1014.14LL-37 GKE acetate
<p>LL-37 GKE acetate, a peptide and active structural domain of LL-37, inhibits lps-induced vascular nitric oxide production,less toxic,antimicrobial，sepsis.</p>Formule :C121H206N38O30Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :2673.17TSR-033
CAS :<p>TSR-033 is a human IgG4 antibody with high affinity for LAG-3 (lymphocyte activation gene-3), a co-receptor linked to diminished T cell activity, frequently co-</p>Couleur et forme :LiquidN-Acetyldopamine dimer-2
CAS :<p>Compound 2, an N-acetyldopamine dimer from Periostracum Cicadae, exhibits antioxidant and anti-inflammatory properties.</p>Formule :C20H20N2O6Couleur et forme :SolidMasse moléculaire :384.38Pegcetacoplan acetate
<p>Pegcetacoplan acetate is a pegylated complement C3 inhibitory peptide that functions by binding to complement component 3 (C3) and its activation fragment C3b. This compound is utilized in the study of complement-mediated diseases, including age-related macular degeneration, C3 glomerulopathy, geographic atrophy (GA), and autoimmune hemolytic anemia.</p>Couleur et forme :Odour SolidSirtuin modulator 2
CAS :<p>Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.</p>Formule :C19H15N3O2SDegré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :349.41NLRP3-IN-75
<p>NLRP3-IN-75 is an orally effective inhibitor of NLRP3, capable of suppressing IL-1β secretion with an IC50 of 23 nM. It selectively inhibits NLRP3 activation by disrupting inflammasome assembly without affecting the assembly of NLRC4 or AIM2 inflammasomes. NLRP3-IN-75 demonstrates excellent anti-inflammatory effects in models of acute peritonitis, diabetic nephropathy, and inflammatory bowel disease (IBD).</p>Couleur et forme :Odour SolidDihydromyristicin
CAS :<p>Dihydromyristicin, a plant flavonoid, curbs inflammation by inhibiting ROS and PI3K/Akt/NF-κB pathways.</p>Formule :C11H14O3Couleur et forme :SolidMasse moléculaire :194.235-LOX/sEH-IN-1
<p>Compound 8o (5-LOX/sEH-IN-1) is a dual inhibitor with cardioprotective properties, targeting both 5-LOX and sEH with IC50 values of 3.05 μM and 2.20 nM respectively. It also inhibits the activity of COX-2 (IC50=10.50 μM). Possessing analgesic and anti-inflammatory properties, 5-LOX/sEH-IN-1 reduces ulcerogenicity, making it a potential candidate for developing anti-inflammatory agents with fewer gastrointestinal and cardiovascular side effects.</p>Couleur et forme :Odour SolidADP-β-S trisodium
<p>ADP-β-S (trisodium) is an analog of ADP and acts as a partial agonist. It can induce human platelet aggregation and inhibit PGE1-stimulated adenylate cyclase.</p>Formule :C10H12N5Na3O9P2SCouleur et forme :SolidMasse moléculaire :508.95241Butan-1-amine hydrochloride
CAS :<p>1-Butylamine hydrochloride,butylamine, a potential agonist of Nrf2/ARE (Nuclear Factor Erythroid 2 Associated Factor 2/Antioxidant Response Element).</p>Formule :C4H12ClNCouleur et forme :SolidMasse moléculaire :109.6FITC-labeled ODN 1018 sodium
<p>FITC-labeled ODN 1018 (sodium), a TLR-9 agonist oligodeoxynucleotide, facilitates the assessment of CpG ODN cellular uptake and localization through confocal</p>Couleur et forme :SolidMasse moléculaire :8171Anti-inflammatory agent 64
<p>Anti-inflammatory agent 64 (compound 4b) exhibits antioxidant and anti-inflammatory activities, effectively inhibiting the secretion of IL-6 and TNF-α while</p>Degré de pureté :98%Couleur et forme :Odour SolidDiprovocim-X
<p>Diprovocim-X, a potent TLR1/2 agonist, has EC50s of 0.14nM (hTLR) and 0.75nM (mTLR), enhances mice's adaptive immunity.</p>Formule :C66H83N7O10Couleur et forme :SolidMasse moléculaire :1134.41P2X7-IN-2 TFA
<p>P2X7-IN-2 TFA inhibits IL-Iβ release (IC50=0.01nM), used in autoimmunity, inflammation & cardiovascular research.</p>Formule :C24H22F7N3O4Couleur et forme :SolidMasse moléculaire :549.44Balekafusp alfa
CAS :<p>Balekafusp alfa is a human IgG1κ antibody targeting IL-2, known for its antitumor properties.</p>Couleur et forme :LiquidGSK2831781
<p>GSK2831781 is a human IgG1 monoclonal antibody (mAb) designed to target CD223/LAG3. This compound is applicable in research studies focused on ulcerative colitis. For experimental controls, the recommended isotype control is Human IgG1 kappa.</p>Couleur et forme :Odour LiquidBMS-986179
<p>BMS-986179 is a human monoclonal antibody targeting NT5E/CD73. It inhibits CD73 enzymatic activity both in tumor vasculature and tumor cells. BMS-986179 is applicable for research in advanced solid tumors.</p>Couleur et forme :Odour LiquidNLRP3-IN-48
<p>NLRP3-IN-48 is an inhibitor of NLRP3. It suppresses the activation of the NLRP3 inflammasome by targeting the NLRP3 protein, thereby interfering with the assembly of the NLRP3 inflammasome. Additionally, NLRP3-IN-48 exhibits anti-inflammatory activity in a DSS-induced acute colitis model in mice.</p>Couleur et forme :Odour SolidRIPK1-IN-25
<p>RIPK1-IN-25 (WL8) is a RIPK1 inhibitor with blood-brain barrier permeability, displaying an EC50 of 19.9 nM and a Kd of 25 nM. It is utilized in the research of neurodegenerative diseases.</p>Couleur et forme :Odour SolidModakafusp alfa
CAS :<p>Modakafusp alfa (TAK-573): Humanized anti-CD38 monoclonal antibody with IFNα2b for multiple myeloma research.</p>Couleur et forme :LiquidBI1543673
<p>BI1543673 is an inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4). It can diminish inflammatory responses in human lung tissue stimulated by TLR4 and TLR7/8. Additionally, BI1543673 reduces inflammatory signaling in a mouse lung inflammation model induced by LPS.</p>Couleur et forme :Odour SolidNLRP3-IN-51
<p>NLRP3-IN-51 (Compound 3q) is an effective activator of the cholinergic anti-inflammatory pathway (CAP). This compound demonstrates potential for treating gouty arthritis as it inhibits the production of IL-1β in THP-1 cells induced by monosodium urate (MSU). Furthermore, NLRP3-IN-51 suppresses the phosphorylation of NF-κBp65 triggered by MSU without impacting the self-cleavage and activation of NLRP3, pro-caspase 1, or the second messenger caspase-1. Therefore, the initial stage of NLRP3 inhibition by NLRP3-IN-51 occurs through the activation of CAP.</p>Couleur et forme :Odour SolidEftilagimod alfa
CAS :<p>Eftilagimod alfa (IMP321), a recombinant LAG-3Ig fusion protein, binds to MHC class II and mediates the activation of antigen-presenting cells (APCs), which in</p>Couleur et forme :LiquidAnticancer agent 15
CAS :<p>Anticancer agent 15 raises ROS, causing necroptosis in melanoma cells.</p>Formule :C35H40Cl2N2O5Couleur et forme :SolidMasse moléculaire :639.61Anti-IL11RA Antibody (X209)
<p>Anti-IL11RA Antibody (X209) is a human-derived IgG4, κ type antibody inhibitor targeting human IL-11RA.</p>Couleur et forme :Odour LiquidZL-1102
<p>ZL-1102 is a humanized monoclonal antibody inhibitor targeting interleukin-17A (IL-17A). SCH-900117 is being investigated for its potential use in the treatment of autoimmune diseases such as psoriasis and rheumatoid arthritis.</p>Couleur et forme :Odour LiquidPNT2001
CAS :<p>PNT2001 (LY4181530) is an effective prostate-specific membrane antigen (PSMA) ligand with an IC50 of 3.1 nM. It enhances cellular internalization and, when labeled with 177Lu and 225Ac, is applicable for prostate cancer research.</p>Formule :C85H107N15O32Couleur et forme :SolidMasse moléculaire :1850.84Sacituzumab MMAE
<p>Sacituzumab-MMAE (CHB295) Anti-TROP2 Reference Antibody is produced in CHO cells and consists of a huIgG1 heavy chain and a hukappa light chain. This compound has a predicted molecular weight (MW) of 146.06 kDa.</p>Couleur et forme :LiquidMasse moléculaire :150 kDaJH-FK-08
<p>JH-FK-08 is an inhibitor of the serine/threonine-specific phosphatase enzyme calcineurin (calcium-dependent phosphatase). It demonstrates antifungal activity, effectively inhibiting C. neoformans with a MIC80 of 0.8 µg/mL. Additionally, JH-FK-08 exhibits immunosuppressive properties by inhibiting IL-2 expression with an IC50 of 42.6 nM, and shows anti-infective activity in mouse models.</p>Formule :C45H73N3O13Couleur et forme :SolidMasse moléculaire :864.073Taplitumomab paptox
CAS :<p>Taplitumomab paptox is an anti-CD19 monoclonal antibody utilized in cancer research.</p>Couleur et forme :LiquidMUC5AC motif peptide
<p>MUC5AC motif peptide is a 16-amino acid fragment of mucin 5.</p>Formule :C63H104N16O26Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1501.62IKZF-IN-1
<p>IKZF-IN-1 (Compound I) is a molecular glue that degrades the karos zinc finger family proteins (IKZF) IKZF 1/2/3/4 and is used as an immune modulator in cancer and viral infection research.</p>Formule :C26H28FN5O4Couleur et forme :SolidMasse moléculaire :493.53Varokibart
CAS :<p>Varokibart (TEV-53275) is a human IgG4λ antibody that targets interleukin-5 (IL-5) [1].</p>Couleur et forme :LiquidBRD5075
<p>BRD5075 is an effective activator of GPR65, stimulating the production of cAMP in a GPR65-dependent manner. Additionally, it reduces the gene expression of IL-1, IL-2, TNF, and chemokines. BRD5075 holds potential for researching multiple sclerosis and inflammatory bowel disease (IBD).</p>Couleur et forme :Odour SolidUbletamig
CAS :<p>Ubletamig is a humanized IgG4κ monoclonal antibody that targets MUC16.</p>Couleur et forme :LiquidBTH1704
<p>BTH1704 is a human monoclonal antibody targeting MUC1. It facilitates the killing of iC3b-opsonized tumor cells by leukocytes triggered by PGG. BTH1704 is applicable in studies on pancreatic cancer and breast cancer.</p>Couleur et forme :Odour LiquidZuberitamab
CAS :<p>Zuberitamab (HS006) is a monoclonal antibody targeting CD20, utilized in cancer research, notably in diffuse large B-cell lymphoma [1].</p>Couleur et forme :LiquidNLRP3-IN-46
<p>NLRP3-IN-46 (Compound 3k) activates the cholinergic anti-inflammatory pathway involved in neuro-immune modulation, thereby inhibiting the activation of the NLRP3 inflammasome. Furthermore, NLRP3-IN-46 suppresses the production of IL-1β in THP-1 cells induced by Uric acid sodium, making it relevant for research in gouty arthritis.</p>Couleur et forme :Odour SolidCD73-IN-16
<p>CD73-IN-16 (compound 18) acts as an inhibitor of hCD73, exhibiting an IC50 value of 0.28 μM.</p>Couleur et forme :Odour SolidSU1261
<p>SU1261, an IKK inhibitor, exhibits Ki values of 10 nM for IKKα and 680 nM for IKKβ. It effectively inhibits non-canonical NF-κB signaling in U2OS osteosarcoma cells.</p>Couleur et forme :Odour SolidTLQP-21
CAS :<p>TLQP 21, a VGF-derived peptide, guards CGCs against apoptosis and combats early diet-induced diabetes by boosting energy spend.</p>Formule :C107H170N40O26Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2432.75Romurtide
CAS :<p>Romurtide is a synthetic muramyl dipeptide analog and can be used for the prophylaxis of leukocytopenia during radiation therapy.</p>Formule :C43H78N6O13Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :887.126TLR7 agonist 17
CAS :<p>TLR7 agonist 17 (compound 20) functions as a highly effective TLR7 agonist, exhibiting EC 50 values of 12 nM for hTLR7 and 17 nM for mTLR7. Additionally, this compound has demonstrated anticancer activity [1].</p>Formule :C25H37N7O3Couleur et forme :SolidMasse moléculaire :483.61COX-2-IN-48
<p>COX-2-IN-48 (5-25) serves as an inhibitor of COX-2, exhibiting an IC50 of 51.7 nM against human COX-2. It displays anti-inflammatory and analgesic effects in various rodent models through inhibition of the NF-κB pathway. COX-2-IN-48 (5-25) inhibits the degradation of IκB, phosphorylation and nuclear translocation of NF-κB p65, and the expression of COX-2 and iNOS.</p>Couleur et forme :Odour SolidD-NAME (hydrochloride)
CAS :<p>D-NAME, a less active NO synthase inhibitor enantiomer, has mild cardiovascular effects in rats; inactive in mouse nociception.</p>Formule :C7H16ClN5O4Couleur et forme :SolidMasse moléculaire :269.69Efineptakin alfa
CAS :<p>Efineptakin alfa (NT-17), a recombinant IL-7, boosts CD4+ and CD8+ cell growth and is used in glioblastoma studies.</p>Couleur et forme :LiquidAnti-inflammatory agent 7
<p>Anti-inflammatory Agent 7 suppresses proinflammatory cytokines by hindering the NF-κB/MAPK signaling pathway in both LPS-treated RAW 264.7 cells and mice.</p>Formule :C36H40N4O9Couleur et forme :SolidMasse moléculaire :672.72Nurulimab
CAS :<p>Nurulimab (BCD-145) is an anti-CTLA-4 antibody with anti-cancer activity for the study of skin and musculoskeletal diseases.</p>Degré de pureté :95.5% (SDS-PAGE); 97.3% (SEC-HPLC) - 95.5% (SDS-PAGE); 97.3% (SEC-HPLC)Couleur et forme :LiquidSuc-Tyr-Val-Ala-Asp-pNA
CAS :<p>Suc-YVAD-pNA, a chromogenic caspase-1 substrate.</p>Formule :C31H38N6O12Couleur et forme :SolidMasse moléculaire :686.675Siegesbeckialide I
<p>Siegesbeckialide I effectively suppresses LPS-induced NO production in RAW264.7 murine macrophages by directly interacting with IKKα/β.</p>Formule :C20H28O6Couleur et forme :SolidMasse moléculaire :364.43Exosome Compound Library
<p>76 exosome-related compounds that can be used for high-throughput and high-content screening.</p>Couleur et forme :Odour SolidLYT-200
<p>Lyt-200 is a humanized monoclonal antibody targeting galectin-9 (Galectin-9). It effectively inhibits leukemia cells and can also be studied in combination with methotrexate.</p>Couleur et forme :Odour LiquidCD22 ligand-1
CAS :<p>CD22 ligand-1 is a potent, selective hCD22 binder (K D 0.335 µM) with potential for B-cell disease research.</p>Formule :C33H34N5NaO10Couleur et forme :SolidMasse moléculaire :683.64Isuventatug
CAS :<p>Isuventatug is a monoclonal antibody that targets human MICA (MHC I chain-related molecule A) and MICB (MHC I chain-related molecule B). By binding to MICA and MICB, Isuventatug modulates the interaction between immune cells and tumor cells, exhibiting anti-tumor activity. This compound holds potential for research in cancer immunotherapy.</p>Couleur et forme :LiquidMyD88-IN-1
CAS :<p>MyD88-IN-1: Potent MyD88 inhibitor with anti-inflammatory effects, blocking NF-κB and TLR/IL-1 pathways; potential for cancer and inflammation treatment.</p>Formule :C23H24N6O7SDegré de pureté :>99.99%Couleur et forme :SoildMasse moléculaire :528.54BR102910
CAS :<p>BR102910: Selective FAP inhibitor, features 4-thiazolecarboxamide with cyano-difluoro-pyrrolidine and dichlorophenyl elements.</p>Formule :C18H14Cl2F2N4O2SDegré de pureté :97%Couleur et forme :SolidMasse moléculaire :459.3ENUM006
<p>ENUM006 is a human monoclonal antibody (mAb) that targets CD223/LAG3.</p>Couleur et forme :Odour LiquidSTING agonist-31
CAS :<p>STING agonist-31, a potent STING agonist, exhibits EC50 values of 0.24 μM and 39.51 μM for human STING (h-STING) and murine STING (m-STING), respectively,</p>Formule :C43H51N15O6Couleur et forme :SolidMasse moléculaire :873.96JAK-STAT Compound Library
<p>A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;</p>Couleur et forme :Odour SolidAspulvinone O
CAS :<p>Aspulvinone O, from P. variotti, is an antioxidant with anticancer properties, inhibits GOT1, and reduces SW1990 pancreatic tumor growth in mice.</p>Formule :C27H28O6Couleur et forme :SolidMasse moléculaire :448.515(±)-Phrymarolin II
CAS :<p>(±)-Phrymarolin II is a promising class of inhibitors that targets the tobacco mosaic virus, representing a novel approach in plant virus suppression.</p>Formule :C23H22O10Couleur et forme :SolidMasse moléculaire :458.419Histamine & Melatonin Receptor-Targeted Compound Library
<p>A unique collection of xnum compounds targeting histaminergic receptor and melatonin receptor for high throughput screening (HTS) and high content screening (HCS</p>Couleur et forme :Odour SolidKD014
<p>KD014 (DX-2400) is a human monoclonal antibody (mAb) that targets MMP14, with a Ki of 0.9 nM. It inhibits TGFβ and SMAD2/3 signaling, increases macrophage count and iNOS expression, and shifts macrophage phenotype towards an antitumor M1-like type. KD014 exhibits antitumor activity in three tumor models (MDA-MB-231, MDA-MB-435, and PC3) and is applicable in breast cancer research.</p>Couleur et forme :Odour Liquid(-)-10,11-Dihydroxyfarnesol
CAS :<p>(-)-10,11-Dihydroxyfarnesol, from Cryptomarasmius aucubae, inhibits NO production.</p>Formule :C15H28O3Couleur et forme :SolidMasse moléculaire :256.38Miptenalimab
CAS :<p>Miptenalimab (BI-754111) is an anti-human LAG-3 antibody with a dissociation constant (K D) of 88.6 nM for h LAG-3, effectively blocking the interaction between</p>Couleur et forme :LiquidFM-303
<p>FM-303 is a monoclonal antibody inhibitor that targets interleukin-23 (IL-23). It shows promise for research in immune system and digestive system diseases.</p>Couleur et forme :Odour LiquidZiltivekimab
CAS :<p>Ziltivekimab (MEDI 5117) is a CHO-expressed humanized monoclonal antibody targeting IL-6/IFNb2 for use in immune system diseases.</p>Degré de pureté :95% - 97.9% (SDS-PAGE); 97.3% (SEC-HPLC)Couleur et forme :SoildHPK1-IN-57
<p>HPK1-IN-57 (Compound 10c) is an inhibitor of hematopoietic progenitor kinase 1 (HPK1) with an IC50 of 0.09 nM. It suppresses the activity of HPK1 kinase, inhibits the phosphorylation of downstream adaptor protein SLP76 (IC50 of 33.74 nM), and effectively induces the secretion of the T cell activation marker IL-2 (EC50 of 84.24 nM). HPK1-IN-57 holds promise for research in tumor immunotherapy.</p>Formule :C30H36F2N8O3Couleur et forme :SolidMasse moléculaire :594.655Inhibitor Library
<p>A unique collection of 8328 inhibitors for research in cell signaling, high throughput screening (HTS) and high content screening (HCS) for new drugs;</p>Couleur et forme :Odour SolidJAB-BX102
<p>JAB-BX102 is a human monoclonal antibody (mAb) that targets NT5E/CD73. It is applicable in research studies involving breast cancer, pancreatic cancer, prostate cancer, and other cancers.</p>Couleur et forme :Odour LiquidAR20.5
<p>AR20.5 is a human monoclonal antibody targeting MUC1. It enhances the number of activated CD8 T cells, CD3+CD4−CD8− (DN) T cells, and mature dendritic cells in mice with pancreatic tumors. AR20.5 is applicable for research into anti-pancreatic cancer immunity.</p>Couleur et forme :Odour LiquidPost-Translational Modification Compound Library
<p>Contains xnum active small molecules for research related to post-translational modifications (PTMs);</p>Couleur et forme :Odour SolidNonsteroidal Anti-Inflammatory Compound Library
<p>xnum non-steroidal anti-inflammatory compounds for high-throughput and high-content screening.</p>Couleur et forme :Odour SolidR1-ICR-5
CAS :<p>R1-ICR-5 is a selective PROTAC degrader targeting serine/threonine-protein kinase 1 (RIPK1). Mediated by VHL, R1-ICR-5 promotes the degradation of RIPK1, disrupting the TNFR1 and TLR3/4 signaling hubs, enhancing NF-κB, MAPK, and IFN signal output, and facilitating RIPK3 activation and necroptosis induction. R1-ICR-5 holds potential for research in cancer and inflammatory diseases.</p>Formule :C54H70N8O7S2Couleur et forme :SolidMasse moléculaire :1007.31Transcription Factor-Targeted Compound Library
<p>Well-chosen xnum compounds with unique structures targeting transcription factor;</p>Couleur et forme :Odour SolidPyroptosis Compound Library
<p>xnum types of active small molecules associated with pyroptosis for high-throughput and high-content screening.</p>Couleur et forme :LiquidBifarcept
CAS :<p>Bifarcept, a recombinant antibody targeting the interferon receptor type I (IFN-RI), enhances the serum half-life of IFN-β by facilitating its binding.</p>Couleur et forme :LiquidTMX-201
CAS :<p>TMX-201: TLR7 ligand-phospholipid with potent immune-boosting effect; for breast cancer & melanoma study.</p>Formule :C57H93N6O12PCouleur et forme :SolidMasse moléculaire :1085.36STING ligand-4
<p>STING ligand-4 (Compound 2) is a nitro-free covalent STING inhibitor with an IC50 of less than 0.2 μM. It can be utilized in the synthesis of PROTACSTINGdegrader-4.</p>Formule :C18H18Cl2N6OCouleur et forme :SolidMasse moléculaire :404.09191Rabelomycin
CAS :<p>Rabelomycin is an angucycline group antibiotic.</p>Formule :C19H14O6Couleur et forme :SolidMasse moléculaire :338.31Chemokine Inhibitor Library
<p>A unique collection of xnum chemokines or chemokine receptors targeted compounds for high throughput and high content screening;</p>Couleur et forme :Odour SolidCAY10614
CAS :<p>CAY10614 is a TLR4 antagonist.</p>Formule :C42H78INO2Couleur et forme :SolidMasse moléculaire :755.995Immunology/Inflammation Compound Library
<p>A unique collection of xnum anti-inflammation compounds effective for high throughput screening and high content screening.</p>Couleur et forme :Odour SolidAnti-PSMA Antibody
<p>Anti-PSMA Antibody is a humanized IgG1 monoclonal antibody targeting PSMA. It serves as the antibody component of the ADC molecule ARX517.</p>Couleur et forme :Odour LiquidFletikumab
CAS :<p>Fletikumab (NNC0109-0012) is a monoclonal antibody against IL-20 that is often used as an IL-20 inhibitor.Fletikumab is used in the study of rheumatoid</p>Degré de pureté :100% (SEC-HPLC) - > 95%Couleur et forme :LiquidMasse moléculaire :146.48 kDaAMG-424
<p>AMG-424 (XmAb968) is a human bispecific antibody (bsAb) targeting CD38 and CD3E. It effectively kills cancer cells that express CD38, stimulates T cell proliferation, and reduces cytokine release. AMG-424 exhibits antitumor activity in mouse cancer models with bone marrow invasion and induces peripheral B cell depletion in cynomolgus monkeys. It is used in studies of multiple myeloma. Recommended isotype control: half-IG G1-kappa/(scFv-heavy-lambda)-h-CH2-CH3.</p>Couleur et forme :Odour LiquidGPCR Compound Library
<p>A unique collection of xnum GPCR-active agents for high throughput screening and high content screening for GPCR drug discovery, and new GPCR target</p>Couleur et forme :Odour SolidDeacetylgedunin
CAS :<p>Deacetylgedunin is a limonoid that is the 7-deacetyl derivative of gedunin. It has been isolated from Azadirachta indica.</p>Formule :C26H32O6Couleur et forme :SolidMasse moléculaire :440.53KL-A289
<p>KL-A289 is a human monoclonal antibody (mAb) that targets CD223/LAG3. It can be utilized in research related to metastatic gastric cancer.</p>Couleur et forme :Odour LiquidSTING modulator-5
CAS :<p>STING modulator-5: pIC50 9.5, antagonizes PBMC (pIC50 8.1), THP-1 cell antagonist, for immunology research.</p>Formule :C43H45F4N11O5Couleur et forme :SolidMasse moléculaire :871.88SARS-CoV-2 Mpro-IN-41
<p>SARS-CoV-2 Mpro-IN-41 (Compound 7e) is an orally active inhibitor targeting COX-2 and SARS-CoV-2 Mpro, with respective IC50 values of 9.66 μM and 13.24 μM. It also demonstrates inhibitory activity against COX-1 (IC50: 46.11 μM). This compound significantly suppresses the expression of inflammation-related cytokines such as TNF-α, IL-6, and IL-1β, exhibiting anti-inflammatory properties. By selectively inhibiting COX-2 and SARS-CoV-2 Mpro, SARS-CoV-2 Mpro-IN-41 exerts both anti-inflammatory and antiviral effects, making it a potential candidate for research in inflammation and COVID-19 treatment.</p>Formule :C27H23ClN4O3SCouleur et forme :SolidMasse moléculaire :518.11794HPPD-IN-1
<p>HPPD-IN-1 (compound II-3), a potent HPPD inhibitor, exhibits inhibitory activity against Arabidopsis thaliana HPPD (AtHPPD) with an IC50 of 0.248 μM, surpassing</p>Formule :C12H6F3NO4Couleur et forme :SolidMasse moléculaire :285.18IMP-761
<p>IMP-761 is a human IgG4 monoclonal antibody (mAb) that targets CD223/LAG3. It binds to the D1 domain of human LAG32. The recommended isotype control is Human IgG4 kappa, Isotype Control.</p>Couleur et forme :Odour LiquidNLRP3-IN-76
<p>NLRP3-IN-76 is an orally active NLRP3 inhibitor that suppresses the production of NO and reduces the mRNA levels of pro-inflammatory cytokines (iNOS, IL-6, IL-1β, and TNFα). It exerts anti-inflammatory effects by inhibiting the activation of the NLRP3 inflammasome and the NF-κB signaling pathway. Furthermore, NLRP3-IN-76 can ameliorate DSS-induced colitis and is applicable for studying inflammatory bowel disease (IBD).</p>Couleur et forme :Odour SolidS217879
<p>S217879 is a potent and selective activator of NRF2 that disrupts the KEAP1-NRF2 interaction, resulting in significant activation of the NRF2 pathway.</p>Formule :C29H30N4O7SCouleur et forme :SolidMasse moléculaire :578.64Keap1-IN-1
<p>Keap1-IN-1 (Compound 27) is an inhibitor of Keap1, functioning by covalently modifying the Cys151 residue on the BTB domain of KEAP1, thereby disrupting the interaction between Keap and Nrf. It enhances the mRNA expression of the antioxidant response element (ARE) dependent gene NQO1, with an EC50 of 160 nM, and exhibits cytotoxicity in U2OS cells, with an EC50 of 527 nM.</p>Formule :C17H21Cl2N2O5PS3Couleur et forme :SolidMasse moléculaire :531.434DNV-3
<p>DNV-3 is a human monoclonal antibody (mAb) that targets CD223/LAG3.</p>Couleur et forme :Odour Liquid2-(Phosphonooxy)benzoic acid
CAS :<p>2-(Phosphonooxy)benzoic acid (Fosfosal), used as the anti-inflammatory agent, has the anti-bacterial effect.</p>Formule :C7H7O6PDegré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :218.1Galectin-3-IN-5
<p>Galectin-3-IN-5 (Compound 20) is an orally active inhibitor of galectin-3 (Gal-3), exhibiting an IC50 value of 9.2 nM against hGal-3.</p>Formule :C24H19BrClF5N6O4SCouleur et forme :SoildMasse moléculaire :697.86Keap1-Nrf2-IN-3
CAS :<p>Keap1-Nrf2-IN-3 is a KEAP1:NRF2 protein protein interaction inhibitor, and with a K d value of 2.5 nM for KEAP1 protein.</p>Formule :C31H34N6O3Couleur et forme :SolidMasse moléculaire :538.6521-Hydroxy-ibuprofen
CAS :<p>1-Hydroxy Ibuprofen, a metabolite in P. australis, targets COX-1/COX-2 with IC50s: 13 μM/370 μM.</p>Formule :C13H18O3Couleur et forme :SolidMasse moléculaire :222.2802Antifungal agent 123
<p>Antifungalagent 123 (Compound 4b) demonstrates strong affinity for the oxidoreductase of Staphylococcus aureus or membrane proteins of Candida albicans, exhibiting both antibacterial and antifungal properties. Additionally, it is capable of scavenging free radicals, showcasing antioxidant effects. Antifungalagent 123 also inhibits the TLR signaling pathway and possesses anti-inflammatory activity.</p>Formule :C21H20N4O3Couleur et forme :SolidMasse moléculaire :376.409Guselkumab
CAS :<p>Guselkumab (CNTO 1959) is a recombinant human IgG1 monoclonal antibody targeting the IL-23p19 subunit.</p>Degré de pureté :SDS-PAGE:95% SEC-HPLC:98.97%Couleur et forme :LiquidMasse moléculaire :144.8 kDaVEN-02XX
<p>VEN-02XX is an orally active NLRP3 inhibitor capable of penetrating the brain. It effectively suppresses the release of IL-1β and IL-18, with IC50 values of 0.3 and 0.28 μM, respectively. In the 5XFAD/Rubicon KO mouse model, VEN-02XX aids in restoring memory and cognition, inhibits microgliosis, and alleviates neuroinflammation and tau protein pathology. This compound is valuable for Alzheimer's disease (AD) research.</p>Formule :C18H16ClF3N4OCouleur et forme :SolidMasse moléculaire :396.79AChE-IN-85
<p>AChE-IN-85 (Compound 7k) is an acetylcholinesterase inhibitor with an IC50 of 0.083 μM. It reduces nitric oxide (NO) release, the production of TNF-α and IL-1β, as well as levels of LDH and ROS, and inhibits Aβ42 aggregation. AChE-IN-85 exhibits anti-inflammatory and neuroprotective effects and is applicable for research on diseases such as Alzheimer's.</p>Couleur et forme :Odour SolidCOX-2-IN-52
<p>COX-2-IN-52 (Compound 5l) is an orally active and selective COX-2 inhibitor with an IC50 of 54 nM. It can suppress the release of NO in cells, exhibiting anti-inflammatory properties. COX-2-IN-52 offers high gastrointestinal safety and is suitable for research on oral anti-inflammatory drugs.</p>Formule :C16H13IN4O4S2Couleur et forme :SolidMasse moléculaire :516.333Ara-F-NAD+ sodium
<p>Ara-F-NAD+ sodium, an arabino analogue of NAD+, serves as a potent, reversible, and slow-binding inhibitor of the CD38 NADase [1] [2].</p>Formule :C21H25FN7NaO13P2Couleur et forme :SolidMasse moléculaire :687.4Pam3CSK4-Biotin
CAS :<p>Pam3CSK4-Biotin is a biotinylated derivative of Pam3CSK4, functioning as a Toll-like receptor 1/2 (TLR1/2) agonist.</p>Formule :C103H192N14O17S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1962.85Nrf2/HO-1 activator 3
<p>Nrf2/HO-1 Activator 3 (Compound C3a) is an activator of the Nrf2 signaling pathway that facilitates the translocation of Nrf2 into the nucleus and enhances the expression of heme oxygenase-1 (HO-1). In H9c2 cardiomyocytes subjected to H2O2 or high glucose stimulation, Nrf2/HO-1 Activator 3 inhibits the excessive expression of ROS and MDA, suppressing cell viability and colony formation, thereby exhibiting antioxidant activity.</p>Formule :C27H26N2O6Couleur et forme :SolidMasse moléculaire :474.51Pascolizumab
CAS :<p>Pascolizumab (SB-240683) is a humanized monoclonal antibody against IL-4. Pascolizumab has asthmatic effects and can be used to study allergic rhinitis.</p>Degré de pureté :> 95%Couleur et forme :LiquidMasse moléculaire :147.18 kDaNVP-DKY709
CAS :<p>NVP-DKY709 is a potent IKZF2 inhibitor for the treatment of cancers.</p>Formule :C25H27N3O3Degré de pureté :99%Couleur et forme :SolidMasse moléculaire :417.5ROS inducer 8
<p>ROS inducer 8 (Compound 11g) acts as an inhibitor of glutathione (GSH) and promotes the accumulation of reactive oxygen species (ROS) in Enterococcus faecalis, exhibiting antibacterial properties. It is capable of disrupting biofilms and inhibiting S. aureus and E. faecalis with minimum inhibitory concentrations (MICs) of 8 μg/mL and 2 μg/mL, respectively, demonstrating a post-antibiotic effect. Additionally, ROS inducer 8 shows low hemolytic toxicity on sheep red blood cells with an HC50 greater than 1280 μg/mL.</p>Formule :C26H31FN6O6Couleur et forme :SolidMasse moléculaire :542.56STING agonist-3 trihydrochloride
<p>STING agonist-3 is a selective, non-nucleotide small-molecule with anti-tumor properties and potential in cancer therapy.</p>Formule :C37H45Cl3N12O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :860.19QX006N
<p>QX006N is a humanized monoclonal antibody inhibitor targeting the human interferon α/β receptor 1 (IFNAR1). It is promising for research in systemic lupus erythematosus (SLE) and other IFNAR1-related autoimmune diseases.</p>Couleur et forme :Odour LiquidBasiliximab
CAS :<p>Basiliximab: chimeric IgG1 antibody inhibiting interleukin-2 receptor, used for kidney transplant immunosuppression.</p>Degré de pureté :SDS-PAGE:94.1%;SEC-HPLC:95.3%Couleur et forme :LiquidMasse moléculaire :144.01 kDa(6Z,9Z,12Z,15Z,18Z,21Z)-Tetracosahexaenoyl-CoA
CAS :<p>(6Z,9Z,12Z,15Z,18Z,21Z)-Tetracosahexaenoyl-CoA ((6Z,9Z,12Z,15Z,18Z,21Z)-Tetracosahexaenoyl-coenzyme A) acts as an NLRX1 modulator. This compound shows potential for research into immune and metabolism-related diseases.</p>Formule :C45H70N7O17P3SCouleur et forme :SolidMasse moléculaire :1106.062,4,6-Trichlorol-3-methyl-5-methoxy-phenol 1-O-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranoside
CAS :<p>2,4,6-Trichlorol-3-methyl-5-methoxy-phenol 1-O-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranoside is a chlorophenyl glycoside that is commonly found in the bulbs of</p>Formule :C20H27Cl3O12Couleur et forme :SolidMasse moléculaire :565.78KTX-955
CAS :<p>KTX-955, a potent IRAK4 degrader, exhibits DC50 values of 5 nM for IRAK4 and 130 nM for Ikaros. It is primarily utilized in anticancer research [1] [2].</p>Formule :C46H51F3N8O7Couleur et forme :SolidMasse moléculaire :884.94ROS-ERS inducer 1
<p>Type II ICD agent, ROS-ERS inducer 1, is a Pt(II)-NHC from 4,5-diarylimidazole, boosting ER stress, ROS, and DAMPs in HCC, outperforming Cisplatin.</p>Formule :C24H23F2I2N3PtCouleur et forme :SolidMasse moléculaire :840.35TAB-004
<p>TAB-004 is a human monoclonal antibody targeting MUC1. It specifically identifies the tMUC1 present in all major subtypes of breast cancer without affecting normal breast epithelial cells. Additionally, TAB-004 is applicable for research on triple-negative breast cancer (TNBC).</p>Couleur et forme :Odour LiquidMethyl 3,4-Dihydroxyphenylacetate
CAS :<p>Methyl 3,4-Dihydroxyphenylacetate is an effective enterovirus 71 (EV71) inhibitor, suppressing EV71 replication in rhabdomyosarcoma (RD) cells, antiviral.</p>Formule :C9H10O4Degré de pureté :97.03%Couleur et forme :SolidMasse moléculaire :182.17SIN 14
<p>SIN 14 is an HO-1 activator that targets and activates HO-1 through an allosteric mechanism. Additionally, SIN 14 can induce the polarization of macrophages from the M1 phenotype to the M2 phenotype.</p>Formule :C20H22ClNO4Couleur et forme :SolidMasse moléculaire :375.12374Cyclo(L-Pro-L-Val)
CAS :<p>Cyclo(L-Pro-L-Val), from Mycobacterium spp., has anti-inflammatory effects, hinders phytopathogens, and suppresses IKKα, NF-κB, iNOS, and COX-2 activation.</p>Formule :C10H16N2O2Degré de pureté :98.18%Couleur et forme :SolidMasse moléculaire :196.25SN50 TFA
<p>SN50 TFA is an inhibitor of NF-κB and attenuates alveolar hypercoagulation and fibrinolysis inhibition. SN50 TFA can be used in studies about ARDS.</p>Formule :C129H230N36O29S·XCF3COOHCouleur et forme :SolidMasse moléculaire :2781.5 (free base)Keap1-Nrf2-IN-25
<p>Keap1-Nrf2-IN-25 (Compound 19) is a potent Keap1-Nrf2 inhibitor with an IC50 of 0.55 μM and exhibits a Keap1 binding affinity (Kd of 0.50 μM). This compound activates Nrf2, reducing reactive oxygen species (ROS) and pro-inflammatory cytokines (IL-1β, IL-6). Additionally, Keap1-Nrf2-IN-25 provides protective effects against DSS-induced colitis.</p>Formule :C25H28N2O6SCouleur et forme :SolidMasse moléculaire :484.565FLY26
<p>FLY26 is a selective partial antagonist of GluN2B, with an IC50 value of 0.64 μM. FLY26 inhibits the GluN2B subunit of NMDA receptors, reducing calcium ion influx and reactive oxygen species (ROS) production. It also activates the BDNF/TrkB/CREB neuroprotective signaling pathway, mitigating excitotoxicity and mitochondrial dysfunction. FLY26 holds potential for treating neurological deficits caused by cerebral ischemia-reperfusion injury.</p>Formule :C22H23N5O3Couleur et forme :SolidMasse moléculaire :405.18009AChE-IN-82
<p>AChE-IN-82 (compound 49) is an acetylcholinesterase (AChE) inhibitor. It inhibits eeAChE, eqBChE, hMAO-A, hMAO-B, and BACE-1 with IC50 values of 0.072, 9.81, 14.52, 0.024, and 2.42 μM, respectively. Additionally, AChE-IN-82 inhibits COX-1, COX-2, and 5-LOX with IC50 values of 60.41, 0.187, and 0.18 μM, respectively. The compound also demonstrates strong neuroprotective effects by significantly reducing H2O2-induced oxidative stress.</p>Formule :C21H18N4O5S2Couleur et forme :SolidMasse moléculaire :470.52BRCA2-IN-1
<p>BRCA2-IN-1 (Compound 3j) is a potential BRCA2 inhibitor with antiproliferative activity against the breast cancer MCF-7 cell line. This compound also demonstrates DPPH radical scavenging ability, with an IC50 value of 12.36 µM.</p>Couleur et forme :Odour SolidNT-0249
CAS :<p>NT-0249 is an inflammatory vesicle NLRP3 inhibitor with anti-inflammatory activity that reverses high-fat diet-induced obesity.</p>Formule :C22H28N5NaO4SDegré de pureté :98.11%Couleur et forme :SoildMasse moléculaire :481.54JPE-1375
CAS :<p>JPE-1375: a C5aR1 antagonist, blocks leukocyte mobilization (EC50=6.9 µM), lowers TNF in mice (EC50=4.5 µM), useful for autoimmune/inflammation research.</p>Formule :C49H63FN10O9Couleur et forme :SolidMasse moléculaire :955.08C12-rrw-NH2
<p>C12-rrw-NH2 (Compound Lip7) is an antimicrobial agent effective against Gram-positive bacteria, particularly demonstrating significant activity against Methicillin-resistant Staphylococcus aureus (MRSA). It induces bacterial cell death by depolarizing the bacterial cell membrane, disrupting membrane integrity, causing nucleic acid and protein leakage, and promoting the generation of Reactive Oxygen Species (ROS). C12-rrw-NH2 is applicable in research focused on developing highly stable antimicrobial peptides.</p>Formule :C35H58N10O5Couleur et forme :SolidMasse moléculaire :698.9Nemolizumab
CAS :<p>Nemolizumab (CIM331) is an anti-IL-31 receptor A monoclonal antibody for atopic dermatitis and pruritus study.</p>Degré de pureté :100% (SEC-HPLC) - > 95%Couleur et forme :LiquidMasse moléculaire :144.92 kDaHistone Modification Compound Library
<p>A unique collection of xnum histone modification related compounds for high throughput screening (HTS) and high content screening (HCS);</p>Couleur et forme :Odour SolidRucosopasem manganese
CAS :<p>Rucosopasem manganese (GC4711), a selective SOD mimetic, converts superoxide to peroxide for cancer research.</p>Formule :C27H45MnN5O4Couleur et forme :SolidMasse moléculaire :558.626Tri(TLR4-IN-C34-C2-amide-PEG1)-amide-C3-COOH
<p>Tri(TLR4-IN-C34-C2-amide-PEG1)-amide-C3-COOH, a linker with TLR4-IN-C34, reduces inflammation in mice.</p>Formule :C78H125N7O36Couleur et forme :SolidMasse moléculaire :1736.85BuChE-IN-20
<p>BuChE-IN-20 is a selective hBuChE inhibitor (IC50= 0.13 μM) with the ability to cross the blood-brain barrier (BBB). This compound, a derivative of L-Tryptophan, exhibits neuroprotective effects by inhibiting nitric oxide (NO) production and reducing reactive oxygen species (ROS) levels. It effectively suppresses the self-aggregation of amyloid-beta (Aβ) peptides and is applicable in Alzheimer's disease research.</p>Couleur et forme :Odour SolidIPH5301
<p>IPH5301 is a human IgG1 monoclonal antibody (mAb) that targets NT5E/CD73. It features a functionally silenced Fc domain and specifically inhibits the enzymatic activity of both soluble and membrane-bound CD73, thereby restoring the proliferation of immune T cells. IPH5301 is applicable for research in anti-tumor immunotherapy. Recommended isotype control: HumanIgG1kappa, Isotype Control.</p>Couleur et forme :Odour LiquidAntiviral agent 38
CAS :<p>(6R)-6-Tert-butyl-10-(3-methoxypropoxy)-dihydro-2-oxo-indazole carboxylic acid has antiviral and antibacterial properties, useful for Hepatitis B research.</p>Formule :C23H27N3O5Degré de pureté :99.66%Couleur et forme :SoildMasse moléculaire :425.48CRX 527
CAS :<p>CRX 527 is a TLR4 ligand and serves as an adjuvant for peptide cancer vaccines, enhancing anti-tumor immune responses. CRX 527 also induces hematopoietic stem cell (HSC) differentiation, increasing the proportion and number of LSK cells, and promotes their differentiation into macrophages. This activation bolsters immune defense and protects intestinal epithelium from radiation damage.</p>Formule :C81H151N2O19PCouleur et forme :SolidMasse moléculaire :1488.04PS 1145 dihydrochloride
CAS :<p>IκB kinase (IKK) inhibitor</p>Formule :C17H13Cl3N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :395.67β-Aminoarteether
CAS :<p>β-Aminoarteether (SM934 free base), an orally active derivative of Artemisinin, serves a pivotal role in the research of inflammation and autoimmune disorders,</p>Formule :C17H29NO5Degré de pureté :96.09% - 97.02%Couleur et forme :SolidMasse moléculaire :327.42Itolizumab
CAS :<p>Itolizumab (Anti-Human CD6 Recombinant Antibody) is a recombinant anti-CD6 monoclonal antibody that humanizes the extracellular SRCR distal domain 1 of CD6.</p>Degré de pureté :> 95%Couleur et forme :LiquidMasse moléculaire :144.82 kDaClaseprubart
CAS :<p>Claseprubart is a monoclonal antibody that targets human complement C1s. It specifically binds to complement C1s, inhibiting the activation of the complement system and exerting immunosuppressive effects. Claseprubart shows potential for research in autoimmune diseases and inflammation-related conditions.</p>Couleur et forme :LiquidFITC-labeled ODN 1826 sodium
<p>FITC-labeled ODN 1826 (sodium), a class B CpG ODN (oligodeoxynucleotide) and TLR9 agonist, facilitates the assessment of CpG ODN cellular uptake and</p>Couleur et forme :Odour SolidMesalamine impurity P
CAS :<p>Mesalamine impurity P, a 5-Aminosalicylic acid derivative, is a PPARγ agonist, inhibiting PAK1 and NF-κB.</p>Formule :C13H11NO6SCouleur et forme :SolidMasse moléculaire :309.30Pterisolic acid B
<p>Pterisolic acid B is a useful organic compound for research related to life sciences and the catalog number is T125924.</p>Formule :C20H26O4Couleur et forme :SolidMasse moléculaire :330.424Xanthine oxidase-IN-12
<p>Xanthine oxidase-IN-12 (Compound 11), an inhibitor of xanthine oxidase (XO), possesses an IC50 value of 91 nM and exhibits antioxidant properties, additionally</p>Degré de pureté :98%Couleur et forme :Odour SolidDaclizumab
CAS :<p>Daclizumab (Zenapax), a humanized antibody, blocks IL-2 by targeting CD25, used in multiple sclerosis.</p>Degré de pureté :SDS-PAGE:95% SEC-HPLC:99.99%Couleur et forme :LiquidMasse moléculaire :144.12 kDaMAPK Inhibitor Library
<p>A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;</p>Couleur et forme :Odour SolidGuretolimod hydrochloride
<p>Guretolimod hydrochloride acts as an agonist for Toll-like receptor 7 (TLR7) [1].</p>Formule :C24H35ClF3N5O4Couleur et forme :SolidMasse moléculaire :550.01Carotuximab
CAS :<p>Carotuximab (DE-122), an antibody, inhibits CD105 to reduce angiogenesis, inflammation, and tumor growth.</p>Degré de pureté :> 95%Couleur et forme :LiquidMasse moléculaire :144.8 kDaIromycin A
CAS :<p>Iromycin A: a bacterial metabolite inhibiting NOS III over NOS I, blocks NADH oxidation, IC50 = 0.461 µM.</p>Formule :C19H29NO2Couleur et forme :SolidMasse moléculaire :303.44Inflexuside A
CAS :<p>Inflexuside A, an abietane diterpenoid from Isodon inflexus, and Inflexuside B inhibit NO in LPS-stimulated RAW264.7 cells.</p>Formule :C26H42O9Couleur et forme :SolidMasse moléculaire :498.61
