Métabolisme
Les inhibiteurs du métabolisme sont des composés qui interfèrent avec les voies métaboliques, modifiant ainsi la production et l'utilisation de l'énergie au sein des cellules. Ces inhibiteurs sont utilisés pour étudier la régulation du métabolisme, le rôle des voies métaboliques dans des maladies telles que le cancer et le diabète, et pour développer de nouvelles stratégies thérapeutiques. Les inhibiteurs du métabolisme peuvent cibler diverses enzymes et processus impliqués dans la glycolyse, l'oxydation des acides gras et d'autres fonctions métaboliques. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de métabolisme de haute qualité pour soutenir vos recherches en biochimie, troubles métaboliques et développement de médicaments.
Sous-catégories appartenant à la catégorie "Métabolisme"
- AhR(41 produits)
- Aminopeptidase(67 produits)
- CETP(18 produits)
- Anhydrase carbonique(178 produits)
- Caséine Kinase(130 produits)
- DHFR(33 produits)
- Décarboxylase(4 produits)
- Déshydrogénase(271 produits)
- FAAH(64 produits)
- FXR(58 produits)
- Facteur Xa(80 produits)
- Synthase des acides gras(33 produits)
- Ferroptose(215 produits)
- GR(3 produits)
- GSNOR(3 produits)
- Glucokinase(54 produits)
- Prolyl-Hydroxylase de HIF/HIF(142 produits)
- HMG-CoA Réductase(33 produits)
- Hydroxylase(30 produits)
- IDO(82 produits)
- LDL(8 produits)
- Lipase(98 produits)
- Lipides(58 produits)
- Lipoxygénase(124 produits)
- MAO(87 produits)
- MPO(2 produits)
- NAMPT(36 produits)
- P450(6 produits)
- PAI-1(25 produits)
- PDE(166 produits)
- PED(1 produits)
- PKM(15 produits)
- PPAR(165 produits)
- Phospholipase(82 produits)
- ROR(42 produits)
- Récepteur de rétinoïdes(29 produits)
- SGK(11 produits)
- Thioredoxine(12 produits)
- Transférase(30 produits)
- Tansporteur(42 produits)
- UGT(4 produits)
- Inhibiteurs de la xanthine oxydase (XO)(9 produits)
Affichez 34 plus de sous-catégories
8628 produits trouvés pour "Métabolisme"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
DS44470011
CAS :<p>DS44470011 is an inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) with oral bioavailability. It enhances the release of erythropoietin (EPO) from cells and is utilized in research related to renal anemia.</p>Formule :C21H19N3O4Couleur et forme :SolidMasse moléculaire :377.39PF-00489791
CAS :<p>PF-00489791 (PF4634817) is a long-acting PDE5 inhibitor with hypotensive activity for the study of diabetic nephropathy.</p>Formule :C20H28N8O4SDegré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :476.55Desmonomethylpromazine
CAS :<p>Desmonomethylpromazine is a demethylated metabolite of Promazine that can penetrate the brain. It enters red blood cells and tissues via passive diffusion and is distributed in organs such as the lungs, liver, and kidneys in rats.</p>Formule :C16H18N2SCouleur et forme :SolidMasse moléculaire :270.39AChE/PDE4-IN-1
<p>AChE/PDE4-IN-1, compound 12c, dual inhibitor; IC50: 0.28μM for AChE, 1.88μM for PDE4D, may reduce Alzheimer's neuroinflammation.</p>Formule :C23H28N2O3Couleur et forme :SolidMasse moléculaire :380.48FTI-2153 TFA
<p>FTI-2153 TFA inhibits farnesyltransferase with high selectivity (IC50: 1.4 nM), over 3000x more than Rap1A processing.</p>Formule :C27H31F3N4O5SCouleur et forme :SolidMasse moléculaire :580.62PDHK-IN-5
<p>PDHK-IN-5, potent PDHK2 (0.006 μM IC50) & PDHK4 (0.0329 μM IC50) inhibitor, may be explored for cancer and diabetes treatment.</p>Formule :C30H31N5O2Couleur et forme :SolidMasse moléculaire :493.6α-Glucosidase-IN-43
CAS :<p>α-Glucosidase-IN-43 (compound AS14) is an α-glucosidase inhibitor with an IC50 of 4.32 μM, demonstrating acute blood-glucose-lowering properties. It is safe and effective in vivo, showing no toxicity to normal fibroblasts in mice and can ameliorate diabetes induced by streptozotocin in rats. α-Glucosidase-IN-43 is applicable for research on postprandial hyperglycemia in diabetic patients.</p>Formule :C27H31N3O4Masse moléculaire :461.55FAAH/MAGL-IN-2
CAS :<p>FAAH/MAGL-IN-2: potent, reversible, oral FAAH & MAGL inhibitor, IC50: 11/36 nM, may research neuropathic pain, no locomotion issue.</p>Formule :C15H13Cl2N3O3SCouleur et forme :SolidMasse moléculaire :386.25L-Sepiapterin
CAS :<p>L-Sepiapterin aids in making BH4, a coenzyme essential for eNOS, enhancing artery function and angiogenesis, while suppressing ovarian cancer cell growth.</p>Formule :C9H11N5O3Couleur et forme :SolidMasse moléculaire :237.22FABP1-IN-1
CAS :FABP1-IN-1 (44) is a selective FABP1 inhibitor with an IC50 value of 4.46 μM. It is applicable in research related to alcoholic fatty liver disease.Formule :C30H25NO5Masse moléculaire :479.52Enpp-1-IN-11
<p>Enpp-1-IN-11 inhibits ENPP1 with a 45 nM Ki, is plasma stable, and has low clearance in human/mouse livers, potentially aiding cancer research.</p>Formule :C15H15N5O3SCouleur et forme :SolidMasse moléculaire :345.38TMX-4116
CAS :<p>TMX-4116 is a CK1α degrader targeting multiple cell lines with DC50s below 200 nM, used in multiple myeloma research and protein degradation strategy studies.</p>Formule :C17H19N5O4SCouleur et forme :SolidMasse moléculaire :389.43ABD957
CAS :<p>ABD957: covalent ABHD17 depalmitoylases inhibitor, IC50 0.21µM for ABHD17B, blocks N-Ras, halts NRAS-mutant AML cell growth.</p>Formule :C27H36F3N7O5SCouleur et forme :SolidMasse moléculaire :627.68RORγt/DHODH-IN-1
CAS :RORγt/DHODH-IN-1 (compound (R)-14d) is a potent, orally active dual inhibitor of RORγt (IC50: 0.083 μM) and DHODH (IC50: 0.172 μM), which exhibits significantFormule :C24H26ClF6N3O3SCouleur et forme :SolidMasse moléculaire :585.99PF-07202954
CAS :<p>PF-07202954, a weakly basic diacylglycerol O-acyltransferase 2 (DGAT2) inhibitor, exhibits an inhibition concentration half-maximum (IC50) of 10 nM against</p>Formule :C22H23FN6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :438.45Etamicastat
CAS :<p>Etamicastat can be used in the research of cardiovascular diseases.</p>Formule :C14H15F2N3OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :311.35BMS-214662 mesylate
CAS :<p>BMS-214662 mesylate is a potent and selective farnesyl transferase inhibitor with an IC50 of 1.35 nM. It exhibits antitumor activity and is applicable in cancer research.</p>Formule :C26H27N5O5S3Couleur et forme :SolidMasse moléculaire :585.718EB-0156
<p>EB-0156: potent ER α-glucosidase inhibitor, IC50 of 0.0479/ <0.001 μM, N-substituted valerian, broad-spectrum antiviral potential.</p>Formule :C21H32N6O7Couleur et forme :SolidMasse moléculaire :480.51LXRβ agonist-3
CAS :<p>LXRβ agonist-3 is a potent and selective LXRβ (liver X receptor β) agonist (EC50: 0.095 μM).</p>Formule :C30H33N3O6SCouleur et forme :SolidMasse moléculaire :563.66Calcipotriol Impurity C
CAS :<p>Calcipotriol Impurity C is the impurity of Calcipotriol. Calcipotriol is a VDR-like receptors ligand.</p>Formule :C27H40O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :412.614Omesdafexor
CAS :<p>Omesdafexor is an FXR agonist that can be used to study diseases caused by liver disease or metabolic inflammation.</p>Formule :C34H43N3O3Couleur et forme :SolidMasse moléculaire :541.72Nampt-IN-13
CAS :Nampt-IN-13 (example 58m) is an NAMPT inhibitor used in the synthesis of antibody-drug conjugates (ADCs).Formule :C24H30N6O2Couleur et forme :SolidMasse moléculaire :434.53MAFP
CAS :MAFP (Methyl Arachidonyl Fluorophosphonate) is an effective irreversible inhibitor of anandamide amidase.Formule :C21H36FO2PCouleur et forme :SolidMasse moléculaire :370.48sEH inhibitor-2
<p>SEH inhibitor-2 is an orally active sEH blocker (IC50=0.9 nM) with predicted 71.2-88.4% absorption, potentially aiding cardiovascular health.</p>Formule :C23H18N4O3Couleur et forme :SolidMasse moléculaire :398.41L-Afegostat
CAS :<p>L-Afegostat (5-epi-Isofagomine), an iminosugar, inhibits glycosidase and β-Glucosidase (K i 30 μM), aids in carbohydrate synthesis.</p>Formule :C6H13NO3Couleur et forme :SolidMasse moléculaire :147.17Utibaprilat
CAS :<p>Utibaprilat is the primary degradation product of Utibapril and functions as an ACE inhibitor.</p>Formule :C20H27N3O5SCouleur et forme :SolidMasse moléculaire :421.51ROR1-IN-1
CAS :<p>ROR1-IN-1 (Compound 19h) is an inhibitor of receptor tyrosine kinase-like orphan receptor 1 (ROR1) with a Ki of 0.10 μM. It inhibits the proliferation of cancer cell lines H1975, A549, and MDA-MB-231, with IC50 values of 0.36 μM, 1.37 μM, and 0.47 μM, respectively. In mice, ROR1-IN-1 demonstrates antitumor efficacy and exhibits favorable pharmacokinetic properties in a rat model.</p>Formule :C33H27N5O3Masse moléculaire :541.607PPD-Q
CAS :<p>7PPD-Q is a substituted p-phenylenediamine antioxidant derivative. It exhibits toxicity towards the bacterium V. fischeri (EC50= 14.9 mg/L).</p>Formule :C19H24N2O2Couleur et forme :SolidMasse moléculaire :312.41BMS-341400 mesylate
CAS :<p>BMS-341400 mesylate (Compound 6) is an orally active selective phosphodiesterase 5 (PDE5) inhibitor with an IC50 value of 0.3 nM and is useful in the study of erectile dysfunction.</p>Formule :C24H26ClN9O5SCouleur et forme :SolidMasse moléculaire :588.039BLT-4
CAS :<p>BLT-4 is a specific and reversible inhibitor of scavenger receptor class B type I (SR-BI). It effectively blocks the SR-BI-mediated transfer of lipids between high-density lipoprotein (HDL) and cells.</p>Formule :C18H16N2O2Couleur et forme :SolidMasse moléculaire :292.332α-Amylase-IN-7
CAS :<p>α-Amylase-IN-7 (Compound 6e) is an inhibitor of α-Amylase, with an IC50 of 40 μM, indicating its potency. This compound shows potential as an anti-diabetic medication.</p>Formule :C18H15ClN6O2SMasse moléculaire :414.871-Phenylethanamine
CAS :<p>1-Phenylethanamine, a potential central nervous system stimulant related to β-phenylethylamine (β-phenylethylamine), exhibits diminished glycogenolysis activity in the brain due to its benzene ring being replaced by an indole group. This reduction in activity makes it useful for investigating how the chemical structure of phenylethylamine derivatives influences their effects on the central nervous system. Additionally, 1-Phenylethanamine is also utilized in the synthesis of the tyrosine kinase (tyrosine kinase) inhibitor CLM3.</p>Formule :C8H11NCouleur et forme :SolidMasse moléculaire :121.18Fluopimomide
CAS :<p>Fluopimomide (LH2010A), a powerful insecticide, is extensively utilized in the control of agricultural pests. It adversely affects the growth, locomotor behavior, reproduction, and lifespan of nematodes. Concurrently, it leads to increased production of reactive oxygen species (ROS), accumulation of lipids and lipofuscins, as well as a rise in malondialdehyde content. Additionally, Fluopimomide inhibits the antioxidant system of nematodes.</p>Formule :C15H8ClF7N2O2Couleur et forme :SolidMasse moléculaire :416.68FAAH/MAGL-IN-1
<p>FAAH/MAGL-IN-1 (SIH 3) inhibits FAAH & MAGL with IC50 of 31 & 29 nM, useful in neuropathic pain research.</p>Formule :C15H9Cl2N3O3Couleur et forme :SolidMasse moléculaire :350.16PLAP-IN-1
CAS :<p>PLAP-IN-1: Potent, selective inhibitor of PLAP, IC50 of 32 nM; doesn't notably inhibit TNAP.</p>Formule :C25H21Cl2N3O5Couleur et forme :SoildMasse moléculaire :514.36Rosiptor acetate
CAS :<p>Rosiptor (AQX-1125) activates SHIP1, inhibits Akt, and reduces inflammation and allergy in rodents.</p>Formule :C22H39NO4Degré de pureté :98%Couleur et forme :Solid PowderMasse moléculaire :381.55Lp-PLA2-IN-5
CAS :<p>Lp-PLA2-IN-5 inhibits Lp-PLA2 and PAF-AH, potentially useful in Alzheimer's and atherosclerosis studies.</p>Formule :C23H18F5N3O4Couleur et forme :SolidMasse moléculaire :495.4ZSH-2208
CAS :ZSH-2208 is a retinoic acid A analogue that inhibits tumour cell proliferation and survival through RARγ-TNFAIP3 and retinoid receptors.Formule :C20H18O3SDegré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :338.42IDO1-IN-14
<p>IDO1-IN-14 is an IDO1 enzyme inhibitor with an IC50 of 396.9 nM and suppresses HeLa cell activity with an EC50 of 3393 nM.</p>Formule :C18H12Cl2FN3O2Couleur et forme :SolidMasse moléculaire :392.21(E)-10-Hydroxynortriptyline maleate
CAS :<p>(E)-10-Hydroxy Nortriptyline maleate, a derivative of antidepressant Nortriptyline, eases depression symptoms.</p>Formule :C23H25NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :395.455RXR antagonist 2
<p>RXR antagonist 2 is a potent antagonist of RXR (Ki: 0.391 μM, Kd: 0.281 μM). RXR antagonist 2 has shown research potential for RXR-related diseases.</p>Formule :C29H35F3N2O3Couleur et forme :SolidMasse moléculaire :516.6Complex III-IN-2
<p>Complex III-IN-2 inhibits complex III, with antifungal EC50: 29.31 mg/L vs R. solani, 29.98 mg/L vs S. sclerotiorum.</p>Formule :C15H21ClN2O2SCouleur et forme :SolidMasse moléculaire :328.86CK1δ-IN-3
CAS :<p>CK1δ-IN-3 (compound 376) is a CK1δ (casein kinase 1δ) inhibitor that can be used to study neurodegenerative diseases such as Alzheimer's disease.</p>Formule :C24H19N3O2SDegré de pureté :99.27%Couleur et forme :SolidMasse moléculaire :413.49NTPDase-IN-1
<p>NTPDase-IN-1 selectively inhibits NTPDases 1, 2, 8 with IC50 of 0.05, 0.23, 0.54 μM. Non-competitive, K m 21 μM, used in cancer, immune, infection research.</p>Formule :C18H25N3OS2Couleur et forme :SolidMasse moléculaire :363.54CP 524515
CAS :<p>CP 524515 is a potent inhibitor of cholesterol ester transfer protein (CETP), which results in increased levels of high-density lipoprotein cholesterol.</p>Formule :C27H27F9N2O4Couleur et forme :SolidMasse moléculaire :614.5Complex III-IN-1
<p>Complex III-IN-1 inhibits complex III, has antifungal properties, and an EC50 of 18.53 mg/L against S. sclerotiorum.</p>Formule :C14H20ClNO2S2Couleur et forme :SolidMasse moléculaire :333.9PNPLA3 modifier 1
CAS :<p>PNPLA3 Modifier 1 (Compound 10), a modifier of patatin-like phospholipase domain-containing protein 3 (pnpla3), exhibits a geometric mean EC50 of 4.9 nM.</p>Formule :C16H19ClF2N2O4SCouleur et forme :SolidMasse moléculaire :408.85PDE5-IN-8
CAS :<p>PDE5-IN-8 (compound 2) is an inhibitor of PDEs.</p>Formule :C22H20ClN3O2Couleur et forme :SolidMasse moléculaire :393.87Zaragozic acid C
CAS :<p>Zaragozic acid C is an effective inhibitor of squalene synthase.</p>Formule :C40H50O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :754.82Nomelidine
CAS :Nomelidine, the active N-demethylated metabolite of zimelidine, has been used as an antidepressant and analgesic.Formule :C15H15BrN2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :303.2020-HEDE
CAS :20-HEDE (WIT 002) is a 20-hydroxyeicosatetraenoic acid (20-HETE) antagonist.Formule :C20H36O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :324.50L 668411
CAS :L 668411, the 2,3-ditritiated methyl ester of L 659699, inhibits HMG-CoA synthase.Formule :C19H30O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :338.44GGACK
CAS :GGACK (H-Glu-Gly-Arg-CMK) is an irreversible substrate-like inhibitor of the serine protease urokinase-type plasminogen activator (uPA).Formule :C14H25ClN6O5Masse moléculaire :392.84Mucidin
CAS :<p>Mucidin is an antifungal antibiotic that inhibits electron transfer reactions within the mitochondrial respiratory chain's cytochrome bc1 complex.</p>Formule :C16H18O3Masse moléculaire :258.31PKR Inhibitor, negative control
CAS :<p>The PKR Inhibitor, negative control, is an inactive structural analog of RNA-dependent protein kinase (PKR) inhibitors, serving as a negative control. Additionally, it can inhibit LK-induced neuronal death, demonstrating significant neuroprotective properties.</p>Formule :C15H8Cl3NO2Masse moléculaire :340.59SDX-7539
CAS :<p>SDX-7539 is a selective MetAP2 inhibitor that inhibits the proliferation of HUVEC, with an IC50 of 120 μM. It has demonstrated antitumor activity in xenografted NSCLC in athymic nude mice.</p>Formule :C23H38N2O5Masse moléculaire :422.56Phospho-L-arginine
CAS :<p>Phospho-L-arginine is a derivative of arginine.</p>Formule :C6H15N4O5PMasse moléculaire :254.18Carbonic anhydrase inhibitor 17
CAS :<p>Carbonic anhydrase inhibitor 17 (compound 7c) is a pyrazine-based sulfonamide that acts as a carbonic anhydrase II inhibitor, with an IC50 value of 0.63 nM.</p>Formule :C18H15ClN4O3S2Masse moléculaire :434.92CIT-ALD
CAS :<p>CIT-ALD is an aldehyde intermediate formed during the metabolism of Citalopram. It has potential applications in the research of neurological disorders.</p>Formule :C18H14FNO2Masse moléculaire :295.31Z21090
CAS :<p>Z21090 (ZL40) is a highly effective inhibitor of PDE 4, exhibiting an IC 50 value of 37.4 nM, and possesses oral bioavailability. It is significant in the study of alcohol-related diseases [1].</p>Formule :C12H14ClN3O3Couleur et forme :SolidMasse moléculaire :283.71NAMPT activator-6
CAS :<p>NAMPT activator-6, a regulatory molecule for the optical control system of NAMPT and NAD+, can be used to design efficient photoswitchable proteolysis-targeting chimeras (PS-PROTACs) for light-dependent, reversible regulation of NAMPT and NAD+, thereby reducing toxicity associated with inhibitor-based PS-PROTACs. This enables antitumor activity and in vivo modulation of NAMPT and NAD+ through optical manipulation [1].</p>Formule :C17H21N5O3SCouleur et forme :SolidMasse moléculaire :375.45Antidiabetic agent 5
CAS :<p>Compound S1 (antidiabetic agent 5) is an antidiabetic agent that effectively inhibits the enzymes α-glucosidase and α-amylase, demonstrating IC50 values of 3.91 µM and 8.89 µM, respectively. It reduces sugar levels and holds potential for type-II diabetes research [1].</p>Formule :C17H15N3O4SCouleur et forme :SolidMasse moléculaire :357.38ICMT-IN-55
CAS :ICMT-IN-55 (compound 31) acts as an ICMT inhibitor, exhibiting an IC50 value of 90 nM [1].Formule :C22H26F3NO2Couleur et forme :SolidMasse moléculaire :393.44α-Amylase/α-Glucosidase-IN-7
CAS :<p>α-Amylase/α-Glucosidase-IN-7 (Compound 3f) serves as a competitive inhibitor for the enzymes α-glucosidase and α-amylase, exhibiting IC50 values of 18.52 µM and 20.25 µM, respectively. Additionally, it effectively inhibits AChE and BChE, with IC50 values of 9.25 µM and 10.06 µM, respectively. This compound is useful in research related to diabetes and Alzheimer's [1].</p>Formule :C15H9Cl2FN2OSCouleur et forme :SolidMasse moléculaire :355.21LXRα agonist 1
CAS :<p>LXRα agonist 1 (Compound 40) is a selective activator of LXRα, with an EC50 of 42 nM, and also demonstrates some activation effects on LXRβ, with an EC50 of 266 nM. It promotes target gene transcription by stabilizing the ligand-binding domain (LBD) of LXRα. When combined with the Raf inhibitor Sorafenib, LXRα agonist 1 shows significant antitumor activity in liver cancer cells. This compound is applicable in research focused on lipotoxicity-related cancers.</p>Formule :C28H27N3O2Couleur et forme :SolidMasse moléculaire :437.533Anticancer agent 143
CAS :<p>Anticancer Agent 143 (Compound 369), a potent dual inhibitor targeting PTPN2 and PTP1B, exhibits IC50 values below 2.5 nM.</p>Formule :C19H15BrF2N3O6PS2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :594.3411-Mercaptoundecanoate-NHS
CAS :<p>11-Mercaptoundecanoate-NHS is a lipid utilized in the synthesis of Linkers.</p>Formule :C15H25NO4SCouleur et forme :SolidMasse moléculaire :315.428Casein kinase 1δ-IN-26
CAS :<p>Casein kinase1δ-IN-26 (compound 505) is a potent inhibitor of casein kinase 1δ. This compound is applicable in research related to neurodegenerative disorders such as Alzheimer’s disease.</p>Formule :C16H13N3O4SCouleur et forme :SolidMasse moléculaire :343.357HSD17B13-IN-40
CAS :HSD17B13-IN-40 (compound 6) serves as a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), exhibiting an IC50 value of less than 0.1 μM using estradiol as substrates. This compound is significant in the treatment of nonalcoholic fatty liver diseases (NAFLDs), including nonalcoholic steatohepatitis (NASH) [1].Formule :C23H14Cl2F3N3O3Masse moléculaire :508.28HSD17B13-IN-32
CAS :HSD17B13-IN-32 (Compound 67) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤0.1 μM for estradiol. It can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) [1].Formule :C23H15Cl2N5O3Masse moléculaire :480.33-Oxochenodeoxycholic acid
CAS :3-Oxochenodeoxycholic acid is an endogenous metabolite detectable in feces and may serve as a diagnostic marker for various diseases, including COVID-19.Formule :C24H38O4Masse moléculaire :390.556RO5101576
CAS :<p>RO5101576 is a potent antagonist of LTB4 receptor.</p>Formule :C36H38O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :630.751,2-Dipentadecanoyl-rac-glycerol
CAS :1,2-Dipentadecanoyl-rac-glycerol (DG(15:0/15:0/0:0)) is a compound referenced in studies examining the effect of insulin on the content of 1,2-diacylglycerol in rat hearts. Insulin is observed to increase the amount of 1,2-diacylglycerol containing specific fatty acid compositions in the heart, which may be linked to cardiac contractility.Formule :C33H64O5Couleur et forme :SolidMasse moléculaire :540.863-Benzylidenecamphor
CAS :<p>3-Benzylidenecamphor, a UV absorber, is noted for its excellent photostability and antioxidant activity. It is extensively utilized in sunscreen products to shield the skin from UV damage. Additionally, 3-Benzylidenecamphor is used in cosmetics to enhance product shelf life and safety.</p>Formule :C17H20OCouleur et forme :SolidMasse moléculaire :240.34BPU17
CAS :<p>BPU17 interacts with PHB1 and disrupts the PHB1-PHB2 interaction, causing slight mitochondrial dysfunction. This damage hinders transcription dependent on SRF/CArG-box, thereby inhibiting epithelial-mesenchymal transition (EMT) in retinal pigment epithelial cells (RPEs). BPU17 has demonstrated anti-fibrotic activity in vivo. It holds potential as a research agent for anti-angiogenic age-related macular degeneration (nAMD).</p>Formule :C12H13ClN2O2Couleur et forme :SolidMasse moléculaire :252.70SAR114137
CAS :<p>SAR114137 is a highly effective pharmaceutical compound characterized by potent bioactivity. It exhibits variations in its amorphous content during the physical processing of crystalline active pharmaceutical ingredients (APIs). The amorphous API content of SAR114137 significantly decreases when subjected to various jet milling techniques. Additionally, SAR114137 demonstrates good chemical stability in drug formulations.</p>Formule :C17H24F2N4O2Couleur et forme :SolidMasse moléculaire :354.39EpoY
CAS :EpoY (SD-142) is an irreversible inhibitor of the primary brain microtubule-associated tyrosine carboxypeptidase (TCP), a complex formed by vasohibin-1 (VASH1) and small vasohibin-binding protein (SVBP). By inhibiting TCP with an IC50 value of approximately 500 nM, EpoY effectively reduces the levels of detyrosinated α-tubulin, which is crucial for microtubule dynamics and neuronal differentiation. This inhibition results in significant differentiation defects and is linked to potential issues related to cancer and cardiomyopathy.Formule :C15H17NO7Couleur et forme :SolidMasse moléculaire :323.30MRS4458
CAS :<p>MRS4458 is an effective inhibitor of the P2Y14 Receptor.</p>Formule :C24H20F3N5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :515.51Diethylumbelliferyl phosphate
CAS :<p>Diethylumbelliferyl phosphate (DEUP) is a potent and selective inhibitor of cholesterol esterase that does not inhibit protein kinase A activity in vitro. It disrupts steroidogenesis by blocking cholesterol transport to mitochondria in steroidogenic cells, with an IC50 of 11.6 μM. This compound may also limit the absorption of dietary cholesterol.</p>Formule :C14H17O6PCouleur et forme :SolidMasse moléculaire :312.25DLCI-1
CAS :<p>DLCI-1 is a potent and selective oral inhibitor of cytochrome P450 2A6 (CYP2A6), significantly reducing self-administered nicotine doses in both male and female mice.</p>Formule :C12H14N2SCouleur et forme :SolidMasse moléculaire :218.323-Ferrocenylpropionic anhydride
CAS :3-Ferrocenylpropionic anhydride is extensively used in compound synthesis, serving as an intermediary for producing various bioactive compounds. Additionally, by modulating specific enzyme activities, 3-Ferrocenylpropionic anhydride has demonstrated potential anti-tumor properties.Formule :C26H26Fe2O3Couleur et forme :SolidMasse moléculaire :498.177α,24(S)-Dihydroxycholesterol
CAS :<p>7α,24(S)-Dihydroxycholesterol ((3β,7α,24S)-Cholest-5-ene-3,7,24-triol) acts as a ligand for liver X receptors (LXR), specifically binding to the ligand-binding domains of LXRα and LXRβ. This compound is synthesized through the E-α,β-unsaturated ketone process, starting with arsindole and J-secondary-butyl dimethylsiloxy-bis-positive-5-cholestenal as the initial materials. It undergoes a series of transformations to produce 7α,24(S)-dihydroxycholesterol.</p>Formule :C27H46O3Couleur et forme :SolidMasse moléculaire :418.65Dioctanoylphosphatidic acid sodium
CAS :Dioctanoylphosphatidic acid sodium serves as a modulator of phagocyte respiratory bursts, a precursor to diacylglycerol and lyso-phosphatidic acid, and influences the phosphorylation of the mammalian target of rapamycin (mTOR). Additionally, it enhances the viability of gallbladder cancer cells inhibited by histone deacetylase inhibitors (HDACI). This compound is derived from glycerophospholipids through the action of phospholipase D.Formule :C19H36NaO8PCouleur et forme :SolidMasse moléculaire :446.45LRAT-IN-1
CAS :<p>LRAT-IN-1 (compound 1) is an inhibitor of lecithin retinol acyltransferase (LRAT) with an IC50 value of 21.1 μM. This compound works by inhibiting the esterification of retinol to form retinyl esters, thereby increasing the availability of retinol in the skin to deliver anti-aging benefits. LRAT-IN-1 is under investigation for its potential use as an anti-aging ingredient in cosmetics.</p>Formule :C27H47N5O5S2Couleur et forme :SolidMasse moléculaire :585.82Magnesium ionophore III
CAS :<p>Magnesium ionophore III (ETH 4030) is an ion carrier that regulates intracellular magnesium ion concentrations. It enhances cellular functions and metabolic activities by increasing the permeability of cell membranes to magnesium ions. Additionally, Magnesium ionophore III is utilized in research to explore the significance of magnesium ions in biological processes and their impact on cellular physiology.</p>Formule :C30H58N4O4Couleur et forme :SolidMasse moléculaire :538.811-Stearoyl-sn-glycerol 3-phosphate sodium
CAS :1-Stearoyl-sn-glycerol 3-phosphate sodium, a biologically active phospholipid, plays a crucial role in regulating cell motility, proliferation, invasion, survival, and the production of growth factors through interactions with G protein-coupled receptors (GPCR). Synthesized during the formation of membrane phospholipids, this compound typically has a low plasma concentration (approximately 100nM) and originates from various cell types, including activated platelets, epithelial cells, leukocytes, neuronal cells, and tumor cells. Its distinctive structure features stearic acid at the sn-1 position and a hydroxyl group at the sn-2 position.Formule :C21H42NaO7PCouleur et forme :SolidMasse moléculaire :460.52DOCP
CAS :DOCP (2-((2,3-Bis(oleoyloxy)propyl)dimethylammonio)ethyl hydrogen phosphate) is a lipid characterized by an opposite charge orientation compared to traditional phosphatidylcholine (PC) lipids, featuring quaternary ammonium near the bilayer interface and phosphate groups projecting into the aqueous environment. This unique structure of iPC lipids presents an excellent opportunity to investigate the biophysical characteristics and biological activities influenced by the reversal of surface charges on bilayers.Formule :C43H82NO8PCouleur et forme :SolidMasse moléculaire :772.09Sphingomyelin (d18:1/12:0)
CAS :Sphingomyelin (d18:1/12:0) is a polar lipid known for its role in modulating cell signal transduction. It plays a critical role in cell membranes, influencing their fluidity and stability. Additionally, sphingomyelin (d18:1/12:0) is involved in lipid metabolism and has potential in promoting neuronal cell growth. This compound is essential for the functioning and development of the nervous system.Formule :C35H71N2O6PCouleur et forme :SolidMasse moléculaire :646.92TAK-915
CAS :<p>TAK-915: potent, brain-ready PDE2A inhibitor, 0.61 nM IC50, 4100x selectivity over PDE1A.</p>Formule :C19H18F4N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :458.36(+)-Potassium Ds-threo-isocitrate monobasic
CAS :(+)-Potassium Ds-threo-isocitrate monobasic is a bioactive compound known for its role in enhancing cellular metabolism and regulating energy production. This substance is also utilized in researching metabolic pathways and the regulation of enzyme activities. Widely applied in biochemical research, (+)-Potassium Ds-threo-isocitrate monobasic is studied for its potential functions in cellular processes and disease mechanisms.Formule :C6H7KO7Couleur et forme :SolidMasse moléculaire :230.21Deamino-NAD sodium
CAS :<p>Deamino-NAD sodium, a structural analog of NAD+, serves as a substrate for rabbit muscle glyceraldehyde 3-phosphate dehydrogenase (GPDH) in glycolysis. It exhibits a Km of 2300 pm and a Kd of 112 pm.</p>Formule :C21H25N6NaO15P2Couleur et forme :SolidMasse moléculaire :686.39Ketomethylenebestatin
CAS :<p>Ketomethylenebestatin, a weaker carba-analog of aminopeptidase inhibitor bestatin, is 10x less potent.</p>Formule :C17H25NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :307.38Oxoprolintane
CAS :<p>Oxoprolintane is a metabolite of the psychoactive compound Prolintane. It exhibits activity in modulating the central nervous system and may serve as a potential neuroprotective agent. Oxoprolintane shows promise for research in the field of neurological disorders.</p>Formule :C15H21NOCouleur et forme :SolidMasse moléculaire :231.333Lunacalcipol
CAS :<p>Lunacalcipol is used for the treatment of Secondary Hyperparathyroidism.</p>Formule :C28H42O4SCouleur et forme :SolidMasse moléculaire :474.7SMase-IN-1
CAS :<p>SMase-IN-1 (Compound 4) is a bacterial sphingomyelinase (SMase) inhibitor with an IC50 value of 6.43 µM against Bacillus cereus SMase. It also inhibits eqBuChE with an inhibition rate of 59.50% at a concentration of 50 µM. SMase-IN-1 forms a complex with Cu2+ through bio-metal interactions and can inhibit hemolysis of sheep red blood cells induced by Bacillus cereus.</p>Formule :C8H5ClN2OSCouleur et forme :SolidMasse moléculaire :212.656RXR antagonist 1
<p>RXR antagonist 1 is a Retinoid X Receptor (RXR) modulator that exhibits high RXR antagonism (pA2: 8.06). RXR antagonist 1 can be used to study type 2 diabetes.</p>Formule :C28H33F3N2O3Couleur et forme :SolidMasse moléculaire :502.57Casein kinase 1δ-IN-18
CAS :<p>Casein kinase1δ-IN-18 (compound 660) is an inhibitor of casein kinase 1δ (CK1δ), which can be utilized for research in neurodegenerative diseases.</p>Formule :C16H12ClN3O2S2Couleur et forme :SolidMasse moléculaire :377.868PD-224378
CAS :<p>PD-224378 is the lactam form of glycamine (β-isomer), produced through a Maillard reaction between pregabalin and lactose.</p>Formule :C20H35NO11Couleur et forme :SolidMasse moléculaire :465.492PTP1B-IN-16
<p>PTP1B-IN-16: selective benzimidazole inhibitor of PTP1B, Ki: 12.6 μM, potential for type 2 diabetes research.</p>Formule :C26H18ClN3O4SCouleur et forme :SolidMasse moléculaire :503.96BAY 3389934
CAS :<p>BAY 3389934 is a dual inhibitor of factor IIa (factor IIa) and factor Xa (factor Xa), providing anticoagulant and organ-protective effects. It alleviates coagulopathy and organ dysfunction in baboon models of Staphylococcus aureus sepsis.</p>Formule :C26H30ClN5O7S2Couleur et forme :SolidMasse moléculaire :624.129
