Métabolisme
Les inhibiteurs du métabolisme sont des composés qui interfèrent avec les voies métaboliques, modifiant ainsi la production et l'utilisation de l'énergie au sein des cellules. Ces inhibiteurs sont utilisés pour étudier la régulation du métabolisme, le rôle des voies métaboliques dans des maladies telles que le cancer et le diabète, et pour développer de nouvelles stratégies thérapeutiques. Les inhibiteurs du métabolisme peuvent cibler diverses enzymes et processus impliqués dans la glycolyse, l'oxydation des acides gras et d'autres fonctions métaboliques. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de métabolisme de haute qualité pour soutenir vos recherches en biochimie, troubles métaboliques et développement de médicaments.
Sous-catégories appartenant à la catégorie "Métabolisme"
- AhR(41 produits)
- Aminopeptidase(67 produits)
- CETP(18 produits)
- Anhydrase carbonique(178 produits)
- Caséine Kinase(130 produits)
- DHFR(33 produits)
- Décarboxylase(4 produits)
- Déshydrogénase(271 produits)
- FAAH(64 produits)
- FXR(58 produits)
- Facteur Xa(80 produits)
- Synthase des acides gras(33 produits)
- Ferroptose(215 produits)
- GR(3 produits)
- GSNOR(3 produits)
- Glucokinase(54 produits)
- Prolyl-Hydroxylase de HIF/HIF(142 produits)
- HMG-CoA Réductase(33 produits)
- Hydroxylase(30 produits)
- IDO(82 produits)
- LDL(8 produits)
- Lipase(98 produits)
- Lipides(58 produits)
- Lipoxygénase(124 produits)
- MAO(87 produits)
- MPO(2 produits)
- NAMPT(36 produits)
- P450(6 produits)
- PAI-1(25 produits)
- PDE(166 produits)
- PED(1 produits)
- PKM(15 produits)
- PPAR(165 produits)
- Phospholipase(82 produits)
- ROR(42 produits)
- Récepteur de rétinoïdes(29 produits)
- SGK(11 produits)
- Thioredoxine(12 produits)
- Transférase(30 produits)
- Tansporteur(42 produits)
- UGT(4 produits)
- Inhibiteurs de la xanthine oxydase (XO)(9 produits)
Affichez 34 plus de sous-catégories
8628 produits trouvés pour "Métabolisme"
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AXKO-0046
<p>AXKO-0046 is an indole derivative and small-molecule LDHB selective inhibitor.</p>Formule :C25H33N3Couleur et forme :SolidMasse moléculaire :375.55Nonsteroidal aromatase inhibitor 1
<p>Compound 13h, a nonsteroidal aromatase inhibitor, has a potent IC50 of 0.09 nM against CYP19A1, showing promise for breast cancer research.</p>Formule :C22H16N4O2Couleur et forme :SolidMasse moléculaire :368.39Lp(a)-IN-5
CAS :<p>Lp(a)-IN-5 (Compound A) is an orally active inhibitor of lipoprotein (a) [Lp(a)]. It effectively inhibits the assembly of Apo(a) and ApoB proteins, with an IC50 value of 0.41 nM. Lp(a)-IN-5 shows potential for research into diseases associated with elevated plasma Lp(a) levels, such as cardiovascular diseases.</p>Formule :C43H56N4O7Couleur et forme :SolidMasse moléculaire :740.927Omesdafexor
CAS :<p>Omesdafexor is an FXR agonist that can be used to study diseases caused by liver disease or metabolic inflammation.</p>Formule :C34H43N3O3Couleur et forme :SolidMasse moléculaire :541.72sEH inhibitor-4
<p>Compound B15: potent sEH inhibitor (0.03 nm), reduces inflammation & pain.</p>Formule :C27H28Cl2N4O3Couleur et forme :SolidMasse moléculaire :527.443-Ferrocenylpropionic anhydride
CAS :3-Ferrocenylpropionic anhydride is extensively used in compound synthesis, serving as an intermediary for producing various bioactive compounds. Additionally, by modulating specific enzyme activities, 3-Ferrocenylpropionic anhydride has demonstrated potential anti-tumor properties.Formule :C26H26Fe2O3Couleur et forme :SolidMasse moléculaire :498.17PHGDH-IN-2
<p>PHGDH-IN-2: potent PHGDH inhibitor, IC50=5.2μM; hinders PHGDH cancer cell growth & serine synthesis in MDA-MB-468.</p>Formule :C22H20N4O3SCouleur et forme :SolidMasse moléculaire :420.48Ketomethylenebestatin
CAS :<p>Ketomethylenebestatin, a weaker carba-analog of aminopeptidase inhibitor bestatin, is 10x less potent.</p>Formule :C17H25NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :307.3811-trans Leukotriene E4
CAS :Slow isomerization of the C-11 double bond of LTE4 leads to the formation of 11-trans LTE4. 11-trans LTE4 is equipotent to LTE4 in contracting guinea pig ileum.Formule :C23H37NO5SCouleur et forme :SolidMasse moléculaire :439.61DLCI-1
CAS :<p>DLCI-1 is a potent and selective oral inhibitor of cytochrome P450 2A6 (CYP2A6), significantly reducing self-administered nicotine doses in both male and female mice.</p>Formule :C12H14N2SCouleur et forme :SolidMasse moléculaire :218.32HIF-2α-IN-7
CAS :<p>HIF-2α-IN-7 is a hypoxia inducible factor 2α (HIF-2α) inhibitor.</p>Formule :C18H9F6NO2Couleur et forme :SolidMasse moléculaire :385.26Casein kinase 1δ-IN-19
CAS :<p>Casein kinase1δ-IN-19 (compound 492) is a potent inhibitor of casein kinase 1δ. It is utilized in research related to neurodegenerative disorders, such as Alzheimer's disease.</p>Formule :C21H19N5O3Couleur et forme :SolidMasse moléculaire :389.407Retezorogant
CAS :<p>Retezorogant is a retinoic acid receptor-related orphan receptor gamma (RORγ) antagonist.</p>Formule :C23H33ClN2O3Couleur et forme :SolidMasse moléculaire :420.97(-)-Mesembrine
CAS :<p>Mesembrine is a serotonin reuptake inhibitor and is also a weak inhibitor of the enzyme phosphodiesterase 4 (PDE4).</p>Formule :C17H23NO3Couleur et forme :SolidMasse moléculaire :289.37PENAO
CAS :<p>PENAO is a potent mitochondrial toxin for tumor cells. It deactivates the mitochondria of tumor cells by targeting the adenine nucleotide translocase in the cell membrane.</p>Formule :C13H19AsN2O5SCouleur et forme :SolidMasse moléculaire :390.29GJG057
CAS :<p>GJG057 is a highly efficient and selective Leukotriene C4 synthase (LTC4S) inhibitor with an IC50 of 44 nM in human whole blood LTC4 release assays and oral activity. It demonstrates anti-inflammatory efficacy in a mouse asthma exacerbation model and can be used for the treatment of allergic inflammation.</p>Formule :C21H21F5N4O2Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :456.41CAII-IN-1
<p>CAII-IN-1 (3n) is a selective bovine CA-II inhibitor with 10.3 μM IC50, used in carbonic anhydrase disorder studies.</p>Formule :C19H21FN4SCouleur et forme :SolidMasse moléculaire :356.467-Hydroxy-4-phenylcoumarin
CAS :<p>7-Hydroxy-4-phenylcoumarin is a dual inhibitor of ALDH-2 and MAO, with IC50 values of 1.5 µM and 0.5 µM, respectively.</p>Formule :C15H10O3Couleur et forme :SolidMasse moléculaire :238.238TMX-4113
<p>TMX-4113 has potential to be used in cancer that is a phosphodiesterase 6D(PDE6D) and casein kinase 1α(CK1α) degrader [1].</p>Formule :C12H12N4O2S2Couleur et forme :SolidMasse moléculaire :308.38Squalestatin 3
CAS :Squalestatin 3 is an inhibitor of squalene synthase.Formule :C25H30O13Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :538.5Quinapril
CAS :<p>Quinapril is an orally active, non-peptide, and non-thiol angiotensin-converting enzyme (ACE) inhibitor. It primarily blocks the conversion of angiotensin I to angiotensin II in both plasma and tissues. Upon enzymatic hydrolysis, Quinapril is converted into the pharmacologically active Quinaprilat and is effective in hypertension models.</p>Formule :C25H30N2O5Couleur et forme :SolidMasse moléculaire :438.516OMDM169
CAS :<p>OMDM169: potent/selective MAGL inhibitor, raises 2-AG, analgesic via cannabinoid receptors, IC50: 0.13-0.41μM in rat/COS-7, inactive at CB1/CB2.</p>Formule :C25H45NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :439.63Lp-PLA2-IN-10
<p>Lp-PLA2-IN-10, a potent Lp-PLA2 inhibitor, may research neurodegenerative and cardiovascular diseases.</p>Formule :C21H15F5N4O4Couleur et forme :SolidMasse moléculaire :482.36BMS-214662 mesylate
CAS :<p>BMS-214662 mesylate is a potent and selective farnesyl transferase inhibitor with an IC50 of 1.35 nM. It exhibits antitumor activity and is applicable in cancer research.</p>Formule :C26H27N5O5S3Couleur et forme :SolidMasse moléculaire :585.718ZK168281
CAS :<p>ZK168281 is a 1α,25(OH)2D3 analog, VDR antagonist with 0.1 nM Kd, and blocks receptor CoA interaction.</p>Formule :C32H46O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :510.70Carbonic anhydrase inhibitor 5
<p>Potent hCA inhibitor: targets hCA II, IX & XII with IC50s of 42.9, 47.6, & 6.7 nM respectively.</p>Formule :C24H20ClN3O3SCouleur et forme :SolidMasse moléculaire :465.95NAZ2329
CAS :<p>NAZ2329: Cell-permeable, targets R5 RPTPs, inhibits hPTPRZ1 (IC50=7.5 μM) & hPTPRG (IC50=4.8 μM), hampers glioblastoma growth, affects stem cell traits.</p>Formule :C21H18F3NO4S3Couleur et forme :SoildMasse moléculaire :501.56SAR114137
CAS :<p>SAR114137 is a highly effective pharmaceutical compound characterized by potent bioactivity. It exhibits variations in its amorphous content during the physical processing of crystalline active pharmaceutical ingredients (APIs). The amorphous API content of SAR114137 significantly decreases when subjected to various jet milling techniques. Additionally, SAR114137 demonstrates good chemical stability in drug formulations.</p>Formule :C17H24F2N4O2Couleur et forme :SolidMasse moléculaire :354.39CYP2C1/CYP2C19-IN-2
<p>CYP2C1/CYP2C19-IN-2 is a potent inhibitor of CYP2C9/CYP2C19 without liver toxicity or genotoxicity and can be used to study Zika virus (ZIKV) infection.</p>Formule :C27H28N2O6SCouleur et forme :SolidMasse moléculaire :508.59Enpp-1-IN-12
<p>ENPP1-IN-12 is a potent, oral ENPP1 inhibitor with a Ki of 41 nM and anti-tumor properties.</p>Formule :C17H19N5O3SCouleur et forme :SolidMasse moléculaire :373.43Darlifarnib
CAS :<p>Darlifarnib (Compound (S)-058) is an inhibitor of farnesyl transferase and geranylgeranyltransferase, with IC50 values of ≤ 10 nM and > 1000 nM, respectively. It exhibits high metabolic stability in human and mouse liver microsomes, with a half-life of over 100 minutes.</p>Formule :C29H20N6OCouleur et forme :SolidMasse moléculaire :468.509PDE4-IN-12
<p>PDE4-IN-12 is a potent and safe PDE4 ubiquitous inhibitor that acts on PDE4 (IC50: 3.5 nM, SI: 2.71) and PDE7 (IC50: 15 nM, SI: 4.27).</p>Formule :C34H35NO6Couleur et forme :SolidMasse moléculaire :553.64Lipoxin A5
CAS :<p>LXA5 is made from EPA by leukocytes, contracts guinea pig lungs like LXA4/LXB4, but doesn't dilate aorta.</p>Formule :C20H30O5Couleur et forme :SolidMasse moléculaire :350.45PDE4-IN-14
CAS :<p>PDE4-IN-14 (Compound 1) serves as an inhibitor of phosphodiesterase 4 (PDE4), applicable in research concerning diseases associated with PDE4, including</p>Formule :C19H20F2N4O3SCouleur et forme :SolidMasse moléculaire :422.45Lipid HTO12
CAS :<p>Lipid HTO12 is an ionizable lipid used for forming lipid nanoparticles (LNP). It facilitates the delivery of siRNA and mRNA.</p>Formule :C41H83NO4Couleur et forme :SolidMasse moléculaire :654.1023,3'-[Dithiobis[2,1-ethanediyl(methylimino)]]bis[1-propanol]
CAS :<p>The compound 3,3'-[Dithiobis[2,1-ethanediyl(methylimino)]]bis[1-propanol] is an SS-cleavable, proton-activated lipid-like substance (SSPalm) that facilitates the delivery of plasmid DNA.</p>Formule :C12H28N2O2S2Couleur et forme :SolidMasse moléculaire :296.493GGACK
CAS :GGACK (H-Glu-Gly-Arg-CMK) is an irreversible substrate-like inhibitor of the serine protease urokinase-type plasminogen activator (uPA).Formule :C14H25ClN6O5Masse moléculaire :392.84Carbonic anhydrase inhibitor 19
CAS :<p>Carbonic anhydrase inhibitor19 (compound 26a) targets glaucoma-associated isozymes hCA II and hCA XII, with inhibition constants (Kis) of 9.4 nM and 6.7 nM, respectively. This compound is effective in reducing intraocular pressure.</p>Formule :C23H25N3O6S2Masse moléculaire :503.59α-Glucosidase-IN-43
CAS :<p>α-Glucosidase-IN-43 (compound AS14) is an α-glucosidase inhibitor with an IC50 of 4.32 μM, demonstrating acute blood-glucose-lowering properties. It is safe and effective in vivo, showing no toxicity to normal fibroblasts in mice and can ameliorate diabetes induced by streptozotocin in rats. α-Glucosidase-IN-43 is applicable for research on postprandial hyperglycemia in diabetic patients.</p>Formule :C27H31N3O4Masse moléculaire :461.55TAK-828F
CAS :<p>TAK-828F: potent, selective RORγt inverse agonist. Oral. IC50=1.9 nM; reporter gene IC50=6.1 nM.</p>Formule :C28H32FN3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :509.57SDX-7539
CAS :<p>SDX-7539 is a selective MetAP2 inhibitor that inhibits the proliferation of HUVEC, with an IC50 of 120 μM. It has demonstrated antitumor activity in xenografted NSCLC in athymic nude mice.</p>Formule :C23H38N2O5Masse moléculaire :422.56Phospho-L-arginine
CAS :<p>Phospho-L-arginine is a derivative of arginine.</p>Formule :C6H15N4O5PMasse moléculaire :254.18(R,R)-BMS-986397
CAS :<p>(R,R)-BMS-986397 is a CK1α degrader with a DC50 ranging from 0.1 to 0.5 pM. This compound is applicable in leukemia research.</p>Formule :C21H16ClF3N4O4Couleur et forme :SolidMasse moléculaire :480.82DDO-3733
CAS :<p>DDO-3733 is a conformational activator of Protein Phosphatase 5 (PP5) that functions independently of TRP, facilitating the dephosphorylation of downstream substrates.</p>Formule :C10H6F2N2OSCouleur et forme :SolidMasse moléculaire :240.23D-Citrulline
CAS :D-Citrulline (H-D-Cit-OH), a stereoisomer of L-citrulline, effectively reduces cardiac contractile dysfunction caused by polymorphonuclear leukocyte (PMN) in isolated perfused rat hearts undergoing ischemia/reperfusion. This protective effect is mediated through a non-NO-mediated mechanism.Formule :C6H13N3O3Couleur et forme :SolidMasse moléculaire :175.195-LOX/MAOs-IN-1
CAS :<p>Compound 3, known as 5-LOX/MAOs-IN-1, acts as an inhibitor of 5-LOX/MAOs and is an effective free radical scavenger, displaying antioxidant characteristics. It has demonstrated neuroprotective effects in cell models damaged by oxidative stress and is capable of activating the neurogenesis microenvironment in adult mouse neural stem cells. This compound is utilized in research focused on neurodegenerative diseases.</p>Formule :C18H18N2O2Couleur et forme :SolidMasse moléculaire :294.356′SLN
CAS :<p>6′SLN is a characteristic glycan found on the surface of cancer-related extracellular vesicles (EVs) and serves as the primary form of protein glycosylation within EVs. Additionally, 6′SLN, a derivative of sialic acid, interacts with hemagglutinins (HAs) from both human and avian influenza strains, making it relevant in the study of anti-influenza drugs.</p>Formule :C25H42N2O19Couleur et forme :SolidMasse moléculaire :674.6IDO1-IN-25
CAS :<p>IDO1-IN-25, a dual inhibitor of IDO1/TDO2, showcases IC50 values of 0.17 μM for IDO1 and 3.2 μM for TDO2. It effectively suppresses NO production in RAW264.7 cells following stimulation with lipopolysaccharide (LPS). Additionally, IDO1-IN-25 demonstrates anti-inflammatory properties in a mouse ear edema model of acute inflammation induced by croton oil.</p>Formule :C14H8Cl3NO2SCouleur et forme :SolidMasse moléculaire :360.64Clopidogrel-β-D-glucuronide
CAS :<p>Clopidogrel-β-D-glucuronide is a metabolite of Clopidogrel. It directly interacts with the CYP2C8 enzyme and strongly inhibits the hepatic enzyme CYP2C8.</p>Formule :C21H22ClNO8SCouleur et forme :SolidMasse moléculaire :483.919Desmonomethylpromazine
CAS :<p>Desmonomethylpromazine is a demethylated metabolite of Promazine that can penetrate the brain. It enters red blood cells and tissues via passive diffusion and is distributed in organs such as the lungs, liver, and kidneys in rats.</p>Formule :C16H18N2SCouleur et forme :SolidMasse moléculaire :270.39Urobilin hydrochloride
CAS :<p>Urobilin hydrochloride, a metabolic byproduct of Hemoglobin, is excreted through urine and feces in various mammals. It also serves as an indicator of human waste contamination.</p>Formule :C33H43ClN4O6Couleur et forme :SolidMasse moléculaire :627.17SelB-1
CAS :<p>SelB-1 acts as a dual inhibitor of Topoisomerase I/II (TopoisomeraseI/II), exhibiting anticancer activity suitable for research on prostate and colon cancers. Additionally, SelB-1 can induce the expression of autophagy (autophagy) genes and lipid peroxidation while reducing GSH levels.</p>Formule :C32H24O5Couleur et forme :SolidMasse moléculaire :488.53Vimirogant
CAS :<p>Vimirogant is a RORγ inhibitor (Ki: <100 nM).</p>Formule :C27H35F3N4O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :552.65h15-LOX-2 inhibitor 3
CAS :<p>Compound 13, identified as h15-LOX-2 inhibitor 3, exhibits inhibitory activity against h15-LOX, with IC50 and Ki values of 25 μM and 15.1 μM, respectively.</p>Formule :C22H13N5O3Couleur et forme :SolidMasse moléculaire :395.37FTI 276 TFA
CAS :FTI 276 TFA targets plasmodium falciparum & humans, inhibits PFT with IC50s: 0.9 nM (parasite) & 0.5 nM (human).Formule :C23H28F3N3O5S2Couleur et forme :SolidMasse moléculaire :547.61Diacylglycerol acyltransferase inhibitor-2
CAS :<p>Diacylglycerolacyltransferaseinhibitor-2 (Example 8) acts as an inhibitor for diacylglycerol acyltransferase 2 (DGAT2), exhibiting an IC50 value of 3.7 nM.</p>Formule :C21H20FN5O4Couleur et forme :SolidMasse moléculaire :425.41Cgs 25155
CAS :<p>Cgs 25155 is an orally active inhibitor of NEP 24.11.</p>Formule :C25H34N2O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :490.6120-HEDE
CAS :20-HEDE (WIT 002) is a 20-hydroxyeicosatetraenoic acid (20-HETE) antagonist.Formule :C20H36O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :324.50CIT-ALD
CAS :<p>CIT-ALD is an aldehyde intermediate formed during the metabolism of Citalopram. It has potential applications in the research of neurological disorders.</p>Formule :C18H14FNO2Masse moléculaire :295.31Mibefradil
CAS :<p>Mibefradil is a calcium channel blocker with moderate selectivity for T-type Ca2+ channels (IC50s: 2.7 μM and 18.6 μM for T-type and L-type currents).</p>Formule :C29H38FN3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :495.633'-Hydroxy Repaglinide
CAS :<p>'3'-Hydroxy Repaglinide, a CYP2C8 metabolite of Repaglinide, treats type II diabetes.</p>Formule :C27H36N2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.59Xanthosine-5'-monophosphate
CAS :<p>Xanthosine 5'-monophosphate is produced from inosine monophosphate (IMP) through the catalytic action of inosine monophosphate dehydrogenase (IMPDH).</p>Formule :C10H13N4O9PCouleur et forme :SolidMasse moléculaire :364.21Etamicastat
CAS :<p>Etamicastat can be used in the research of cardiovascular diseases.</p>Formule :C14H15F2N3OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :311.35P5SA-2
CAS :<p>P5SA-2 is a selective allosteric activator of PPP5C, functioning by modulating the structure of the PPP5C phosphatase domain. At a concentration of 100 μM, it can enhance PPP5C activity by 3.2-fold, with an apparent affinity constant of 7.8 μM. P5SA-2 is applicable in research related to cancer and Alzheimer's disease.</p>Formule :C17H15ClN2O3Couleur et forme :SolidMasse moléculaire :330.766Bestatin methyl ester
CAS :<p>Bestatin methyl ester (600, 900 µM; 24 h) inhibits spore cell differentiation in Dictyostelium discoideum.</p>Formule :C17H26N2O4Couleur et forme :SolidMasse moléculaire :322.4CGS 24592
CAS :<p>CGS-24592 is an orally active, selective, and potent inhibitor of neutral endopeptidase 24.11 (NEP), with an IC50 value of 1.6 nmol/L. It reduces the degradation of atrial natriuretic peptide (ANP), thereby increasing plasma ANP concentration and lowering blood pressure. CGS-24592 shows potential for research in cardiovascular diseases such as hypertension and congestive heart failure.</p>Formule :C19H23N2O6PCouleur et forme :SolidMasse moléculaire :406.37LTA4H-IN-2
CAS :<p>LTA4H-IN-2 (compound (S)-2) acts as an orally active inhibitor targeting Leukotriene A4 Hydrolase, exhibiting potent activity with an IC 50 of less than 3 nM [1].</p>Formule :C20H19FN6O2Couleur et forme :SolidMasse moléculaire :394.4UGT1A1-IN-1
CAS :<p>UGT1A1-IN-1 (compound 2) acts as a non-competitive inhibitor of UGT1A1, effectively inhibiting the 1-O-glucuronidation process mediated by UGT1A1 with a Ki value of 5.02 μM. This compound binds to the same ligand-binding site on UGT1A1 as bilirubin and additionally functions as a 'turn-on' fluorescent probe substrate for UGT1A1 [1].</p>Formule :C22H19NO3Couleur et forme :SolidMasse moléculaire :345.39MAGL-IN-15
CAS :<p>MAGL-IN-15 (Compound 6), a MAGL inhibitor, holds potential for research into diseases and disorders associated with the regulation of endocannabinoid system signaling activities [1].</p>Formule :C16H16F6N4O3Couleur et forme :SolidMasse moléculaire :426.31Glucokinase activator 8
CAS :<p>Glucokinase activator8 is an activator of glucose kinase (glucokinase).</p>Formule :C14H13N3O2SCouleur et forme :SolidMasse moléculaire :287.337ABHD antagonist 1
CAS :ABHD antagonist 1 is an inhibitor of ABHD6 (α/β-Hydrolase domain containing 6), involved in modulating biochemical pathways affected by ABHD6, thereby influencing cell function and inflammatory responses. This compound is applicable for research in fields such as pain, neurological disorders, inflammatory diseases, autoimmune diseases, metabolic disorders, and cancer.Formule :C19H20BrN3O3SCouleur et forme :SolidMasse moléculaire :450.35BRD7539
CAS :<p>BRD7539B: PfDHODH inhibitor, IC50 0.033μM; selective vs HsDHODH, IC50 >50μM.</p>Formule :C23H22FN3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :391.44DC371739
CAS :<p>DC371739 is an effective oral PCSK9 inhibitor that decreases both PCSK9 and ANGPTL3 mRNA expression. It also reduces PCSK9 protein expression while enhancing that of LDLR. Given its properties, DC371739 has potential applications in the study of hyperlipidemia.</p>Formule :C29H30N2O4Couleur et forme :SolidMasse moléculaire :470.56α-Amylase-IN-12
CAS :<p>α-Amylase-IN-12 (Compound 5e) is an α-amylase inhibitor with an IC50 of 0.15 mM, functioning through a mixed inhibition mode. It exhibits an IC50 of 9.40 mM against α-glucosidase. This compound enhances glucose uptake in yeast cells and demonstrates significant anti-glycation activity at high concentrations. α-Amylase-IN-12 is applicable for diabetes research.</p>Formule :C16H11NO4Couleur et forme :SolidMasse moléculaire :281.263Deamino-NAD sodium
CAS :<p>Deamino-NAD sodium, a structural analog of NAD+, serves as a substrate for rabbit muscle glyceraldehyde 3-phosphate dehydrogenase (GPDH) in glycolysis. It exhibits a Km of 2300 pm and a Kd of 112 pm.</p>Formule :C21H25N6NaO15P2Couleur et forme :SolidMasse moléculaire :686.39Glycerophosphoglycerol
CAS :<p>Glycerophosphoglycerol is a precursor in phospholipid synthesis. By enhancing phospholipid formation, it aids in the reconstruction and proliferation of membrane structures in tumor cells. Glycerophosphoglycerol holds promise for research in breast cancer cells.</p>Formule :C6H15O8PCouleur et forme :SolidMasse moléculaire :246.15Fmoc-NH-PEG6-alcohol
CAS :<p>Fmoc-NH-PEG6-alcohol, a cleavable ADC linker, is employed in the synthesis of antibody-drug conjugates (ADCs) [1].</p>Formule :C27H37NO8Couleur et forme :SolidMasse moléculaire :503.58α-Glucosidase-IN-63
CAS :<p>α-Glucosidase-IN-63 (Compound 4d) serves as an α-Glucosidase inhibitor with an IC 50 value of 0.44 μM. Additionally, it exhibits inhibitory activity against hCA II, demonstrating a K i of 7.0 nM. The compound is also effective when administered orally. [1]</p>Formule :C16H12FN3O3S2Couleur et forme :SolidMasse moléculaire :377.41ABCB1-IN-4
CAS :<p>ABCB1-IN-4 (Compound C6z) is an orally active inhibitor of α-amylase and α-glucosidase, with IC50 values of 1.63 μM and 0.14 μM, respectively. It holds potential for diabetes research.</p>Formule :C16H14N4SCouleur et forme :SolidMasse moléculaire :294.374E234G HYPE-IN-1
CAS :<p>Compound I2.10 (E234G HYPE-IN-1) functions as an AMPylase inhibitor and exhibits low cytotoxicity toward human cell lines [1].</p>Formule :C14H9N5O2Couleur et forme :SolidMasse moléculaire :279.25MGAT2-IN-1
CAS :MGAT2-IN-1 is an orally active monoacylglycerol acyltransferase (MGAT2)inhibitor (human and mouse MGAT2 with IC50 of 7.8 and 2.4 nM , respectively).Formule :C27H21ClF5N7O3SCouleur et forme :SolidMasse moléculaire :654.01Carbonic anhydrase inhibitor 8
<p>R-13, a carbonic anhydrase inhibitor, has Ki of 60.7 nM (hCA I), 320.7 nM (hCA II), and 2298 nM (hCA IV).</p>Formule :C20H25N3O4SCouleur et forme :SolidMasse moléculaire :403.5GKA50 quarterhydrate
<p>GKA50 quarterhydrate: glucokinase activator, EC50 of 33 nM, boosts insulin, cuts glucose in rats.</p>Formule :C26H30N2O7Couleur et forme :SolidMasse moléculaire :469.01WAY-606344
CAS :<p>WAY-606344 (Compound 97) is an inhibitor of Casein kinase 1δ and shows potential for Alzheimer's disease research.</p>Formule :C14H8ClN3O2Couleur et forme :SolidMasse moléculaire :285.685PDE4B-IN-3
<p>PDE4B-IN-3 is a potent inhibitor of PDE4B (IC50: 0.94 μM) and exhibits anti-inflammatory effects.</p>Formule :C30H35N3O4S2Couleur et forme :SolidMasse moléculaire :565.75RORγt inverse agonist 32
CAS :RORγt inverse agonist 32 (compound b14) exhibits oral activity and can be utilized in inflammatory research studies.Formule :C24H28F3NO5SCouleur et forme :SolidMasse moléculaire :499.54CK1δ-IN-10
CAS :<p>CK1δ-IN-10 (Compound 85) is an inhibitor of casein kinase 1 (CK1), specifically targeting CK1δ (CSNKID), with an IC50 value of 0.255 μM.</p>Formule :C17H11F4N5Couleur et forme :SolidMasse moléculaire :361.296BAY R3401
CAS :<p>BAY R3401 is an orally active inhibitor of glycogen phosphorylase, leading to irreversible and non-selective inhibition of liver glycogenolysis. It suppresses glycogen breakdown in hepatocytes with IC50 values of 27.06 μM in HL-7702 cells and 52.83 μM in HepG2 cells. BAY R3401 is applicable for research in type 2 diabetes.</p>Formule :C20H22ClNO4Couleur et forme :SolidMasse moléculaire :375.846Lumirubin
CAS :<p>Lumirubin is a water-soluble photoproduct of bilirubin formed in vivo during phototherapy.</p>Formule :C33H36N4O6Couleur et forme :SolidMasse moléculaire :584.66Tovinontrine
CAS :<p>Tovinontrine (IMR-687) (IMR-687) is a potent and selective inhibitor of phosphodiesterase-9 (PDE9), designed to target sickle cell disease treatment.</p>Formule :C21H26N6O2Degré de pureté :98.14%Couleur et forme :SolidMasse moléculaire :394.47NTPDase-IN-2
CAS :<p>NTPDase-IN-2 inhibits h-NTPDase-2/-8 (IC50: 0.04, 2.27 µM), non-competitive for h-NTPDase-1/-2 (Km: 74 µM); useful in cancer, immune, bacterial research.</p>Formule :C24H20FN3OS2Couleur et forme :SolidMasse moléculaire :449.56Glucosylceramide synthase-IN-3
<p>Glucosylceramide synthase-IN-3 (BZ1) is a potent, brain-accessible, oral GCS inhibitor with a 16 nM IC50, relevant for Gaucher's disease study.</p>Formule :C21H20FN3O3Couleur et forme :SolidMasse moléculaire :381.4GSK864
CAS :<p>GSK864 is an inhibitor of isocitrate dehydrogenase 1 (IDH1) mutant. GSK864 inhibits IDH1 mutants R132C, R132H, and R132G (IC50: 8.8, 15.2, and 16.6 nM).</p>Formule :C30H31FN6O4Degré de pureté :97.07%Couleur et forme :SolidMasse moléculaire :558.6RORγt inverse agonist 34
CAS :<p>RORγt inverse agonist 34 (compound 5a) is an inverse agonist for RORγt, exhibiting an IC50 of 0.094 μM for the inhibition of RORγt-LBD. This compound is utilized in psoriasis research.</p>Formule :C31H37N3O3SCouleur et forme :SolidMasse moléculaire :531.709NAMPT activator-6
CAS :<p>NAMPT activator-6, a regulatory molecule for the optical control system of NAMPT and NAD+, can be used to design efficient photoswitchable proteolysis-targeting chimeras (PS-PROTACs) for light-dependent, reversible regulation of NAMPT and NAD+, thereby reducing toxicity associated with inhibitor-based PS-PROTACs. This enables antitumor activity and in vivo modulation of NAMPT and NAD+ through optical manipulation [1].</p>Formule :C17H21N5O3SCouleur et forme :SolidMasse moléculaire :375.45AChE/PDE4-IN-1
<p>AChE/PDE4-IN-1, compound 12c, dual inhibitor; IC50: 0.28μM for AChE, 1.88μM for PDE4D, may reduce Alzheimer's neuroinflammation.</p>Formule :C23H28N2O3Couleur et forme :SolidMasse moléculaire :380.48Raloxifene N-Oxide
CAS :<p>Raloxifene N-Oxide is a Raloxifene oxidative degradation product.</p>Formule :C28H27NO5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :489.58Miaosporone A
<p>Miaosporone A: angucyclic quinone, cytotoxic to MCF-7, NCI-H187, Vero cells; anti-TB and anti-malaria with IC50 of 2.4 μM, 2.5 μM.</p>Formule :C19H18O5Couleur et forme :SolidMasse moléculaire :326.34FAAH/MAGL-IN-1
<p>FAAH/MAGL-IN-1 (SIH 3) inhibits FAAH & MAGL with IC50 of 31 & 29 nM, useful in neuropathic pain research.</p>Formule :C15H9Cl2N3O3Couleur et forme :SolidMasse moléculaire :350.16DC360
CAS :<p>DC360 is a synthetic analog of all-trans retinoic acid (ATRA) that can induce the expression of RARβ. It is useful for studies characterizing the retinoic acid signaling pathway.</p>Formule :C23H23NO2Couleur et forme :SolidMasse moléculaire :345.434
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