Métabolisme
Les inhibiteurs du métabolisme sont des composés qui interfèrent avec les voies métaboliques, modifiant ainsi la production et l'utilisation de l'énergie au sein des cellules. Ces inhibiteurs sont utilisés pour étudier la régulation du métabolisme, le rôle des voies métaboliques dans des maladies telles que le cancer et le diabète, et pour développer de nouvelles stratégies thérapeutiques. Les inhibiteurs du métabolisme peuvent cibler diverses enzymes et processus impliqués dans la glycolyse, l'oxydation des acides gras et d'autres fonctions métaboliques. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de métabolisme de haute qualité pour soutenir vos recherches en biochimie, troubles métaboliques et développement de médicaments.
Sous-catégories appartenant à la catégorie "Métabolisme"
- AhR(41 produits)
- Aminopeptidase(67 produits)
- CETP(18 produits)
- Anhydrase carbonique(178 produits)
- Caséine Kinase(130 produits)
- DHFR(33 produits)
- Décarboxylase(4 produits)
- Déshydrogénase(271 produits)
- FAAH(64 produits)
- FXR(58 produits)
- Facteur Xa(80 produits)
- Synthase des acides gras(33 produits)
- Ferroptose(215 produits)
- GR(3 produits)
- GSNOR(3 produits)
- Glucokinase(54 produits)
- Prolyl-Hydroxylase de HIF/HIF(142 produits)
- HMG-CoA Réductase(33 produits)
- Hydroxylase(30 produits)
- IDO(82 produits)
- LDL(8 produits)
- Lipase(98 produits)
- Lipides(58 produits)
- Lipoxygénase(124 produits)
- MAO(87 produits)
- MPO(2 produits)
- NAMPT(36 produits)
- P450(6 produits)
- PAI-1(25 produits)
- PDE(166 produits)
- PED(1 produits)
- PKM(15 produits)
- PPAR(164 produits)
- Phospholipase(82 produits)
- ROR(42 produits)
- Récepteur de rétinoïdes(29 produits)
- SGK(11 produits)
- Thioredoxine(12 produits)
- Transférase(30 produits)
- Tansporteur(42 produits)
- UGT(4 produits)
- Inhibiteurs de la xanthine oxydase (XO)(9 produits)
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8626 produits trouvés pour "Métabolisme"
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FR 901537
CAS :<p>FR 901537 is a new aromatase inhibitor with antitumor effects.</p>Formule :C23H29N3O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :507.62PLAP-IN-1
CAS :<p>PLAP-IN-1: Potent, selective inhibitor of PLAP, IC50 of 32 nM; doesn't notably inhibit TNAP.</p>Formule :C25H21Cl2N3O5Couleur et forme :SoildMasse moléculaire :514.36Lp(a)-IN-7
CAS :<p>Lp(a)-IN-7 (example 1) is an inhibitor of lipoprotein (a) [Lp(a)] formation, exhibiting an IC50 of 2.51 nM in media containing apolipoprotein B (apoB) and apolipoprotein (a). This compound is applicable in cardiovascular disease research.</p>Formule :C20H30Cl2N2O4Couleur et forme :SolidMasse moléculaire :433.369PKR Inhibitor, negative control
CAS :<p>The PKR Inhibitor, negative control, is an inactive structural analog of RNA-dependent protein kinase (PKR) inhibitors, serving as a negative control. Additionally, it can inhibit LK-induced neuronal death, demonstrating significant neuroprotective properties.</p>Formule :C15H8Cl3NO2Masse moléculaire :340.59SHP2 IN-1
CAS :<p>SHP2 IN-1 is an allergic SHP2 (PTPN11) inhibitor(IC50 : 3 nM).</p>Formule :C18H22Cl2N6OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :441.38D-2-Phosphoglyceric acid
CAS :D-2-Phosphoglyceric acid is a crucial metabolic intermediate known for its role in enhancing cellular energy metabolism and regulating biosynthesis. It plays a key role in both glycolysis and photosynthesis, which are essential for cellular energy supply. Additionally, D-2-Phosphoglyceric acid serves as a biomarker for monitoring metabolic states in various organisms.Formule :C3H7O7PCouleur et forme :SolidMasse moléculaire :186.06Lp-PLA2-IN-10
<p>Lp-PLA2-IN-10, a potent Lp-PLA2 inhibitor, may research neurodegenerative and cardiovascular diseases.</p>Formule :C21H15F5N4O4Couleur et forme :SolidMasse moléculaire :482.36Mucidin
CAS :<p>Mucidin is an antifungal antibiotic that inhibits electron transfer reactions within the mitochondrial respiratory chain's cytochrome bc1 complex.</p>Formule :C16H18O3Masse moléculaire :258.314-(4-Bromophenyl)-4-hydroxypiperidine
CAS :<p>4-(4-Bromophenyl)-4-hydroxypiperidine (BPHP) is a metabolite of Bromperidol (BRO), produced through the N-dealkylation of BRO.</p>Formule :C11H14BrNOCouleur et forme :SolidMasse moléculaire :256.139FXIa-IN-9
CAS :<p>FXIa-IN-9, a potent FXIa inhibitor (K i : human 0.17 nM, rabbit 0.5 nM), forms hydrogen bonds and has anticoagulant properties.</p>Formule :C23H18Cl2F3N9O2Couleur et forme :SolidMasse moléculaire :580.35BAY R3401
CAS :<p>BAY R3401 is an orally active inhibitor of glycogen phosphorylase, leading to irreversible and non-selective inhibition of liver glycogenolysis. It suppresses glycogen breakdown in hepatocytes with IC50 values of 27.06 μM in HL-7702 cells and 52.83 μM in HepG2 cells. BAY R3401 is applicable for research in type 2 diabetes.</p>Formule :C20H22ClNO4Couleur et forme :SolidMasse moléculaire :375.8467-Hydroxyrisperidone
CAS :<p>7-Hydroxyrisperidone (7-RispOH) is a metabolite of Risperidone. Risperidone acts as a 5-HT2 receptor blocker, an inhibitor of P-glycoprotein (P-Glycoprotein), and an antagonist of the dopamine D2 receptor.</p>Formule :C23H27FN4O3Couleur et forme :SolidMasse moléculaire :426.484CB30865
CAS :CB30865 (ZM 242421) is a selective and highly effective nicotinamide phosphoribosyltransferase (Nampt) inhibitor with potential antitumor activity.Formule :C26H22BrN5O2Degré de pureté :99.04%Couleur et forme :SolidMasse moléculaire :516.39BMS-214662 mesylate
CAS :<p>BMS-214662 mesylate is a potent and selective farnesyl transferase inhibitor with an IC50 of 1.35 nM. It exhibits antitumor activity and is applicable in cancer research.</p>Formule :C26H27N5O5S3Couleur et forme :SolidMasse moléculaire :585.718MAFP
CAS :MAFP (Methyl Arachidonyl Fluorophosphonate) is an effective irreversible inhibitor of anandamide amidase.Formule :C21H36FO2PCouleur et forme :SolidMasse moléculaire :370.48α-Glucosidase-IN-43
CAS :<p>α-Glucosidase-IN-43 (compound AS14) is an α-glucosidase inhibitor with an IC50 of 4.32 μM, demonstrating acute blood-glucose-lowering properties. It is safe and effective in vivo, showing no toxicity to normal fibroblasts in mice and can ameliorate diabetes induced by streptozotocin in rats. α-Glucosidase-IN-43 is applicable for research on postprandial hyperglycemia in diabetic patients.</p>Formule :C27H31N3O4Masse moléculaire :461.55Carbonic anhydrase inhibitor 19
CAS :<p>Carbonic anhydrase inhibitor19 (compound 26a) targets glaucoma-associated isozymes hCA II and hCA XII, with inhibition constants (Kis) of 9.4 nM and 6.7 nM, respectively. This compound is effective in reducing intraocular pressure.</p>Formule :C23H25N3O6S2Masse moléculaire :503.59ALOX15-IN-1
<p>ALOX15-IN-1 (8b) inhibits rabbit/human ALOX15; IC50: 0.04 μM for LA, 2.06 μM for AA.</p>Formule :C24H31N3O5SCouleur et forme :SolidMasse moléculaire :473.59GJG057
CAS :<p>GJG057 is a highly efficient and selective Leukotriene C4 synthase (LTC4S) inhibitor with an IC50 of 44 nM in human whole blood LTC4 release assays and oral activity. It demonstrates anti-inflammatory efficacy in a mouse asthma exacerbation model and can be used for the treatment of allergic inflammation.</p>Formule :C21H21F5N4O2Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :456.41RORγt modulator 5
CAS :<p>RORγt modulator 5, a potent RORγt modulator, exhibits a dissociation constant (K_i) of <100 nM.</p>Formule :C27H22F5N3O6SCouleur et forme :SolidMasse moléculaire :611.54Perfluorohexane sulfonamide
CAS :<p>Perfluorohexane sulfonamide (FHxSA) serves as an inhibitor of carbonic anhydrase (CA), effectively inhibiting bovine CA and human CAII with IC50 values of 0.122 and 1.38 μM, respectively. Additionally, it acts as a delayed-action insecticide for controlling red imported fire ants (Solenopsis invicta). Furthermore, Perfluorohexane sulfonamide is considered a potential environmental pollutant.</p>Formule :C6H2F13NO2SCouleur et forme :SolidMasse moléculaire :399.13hCAI/II/XII-IN-1
CAS :<p>hCAI/II/XII-IN-1 (compound 7) is an inhibitor of human carbonic anhydrases hCAI, hCAII, and hCAXII, with Ki values of 78.5 nM, 9.1 nM, 605 nM, 7.7 nM, and 3.7 nM.</p>Formule :C12H12N2O2SCouleur et forme :SolidMasse moléculaire :248.301FAAH/MAGL-IN-1
<p>FAAH/MAGL-IN-1 (SIH 3) inhibits FAAH & MAGL with IC50 of 31 & 29 nM, useful in neuropathic pain research.</p>Formule :C15H9Cl2N3O3Couleur et forme :SolidMasse moléculaire :350.16SGK1-IN-6
CAS :<p>SGK1-IN-6 (compound 12f) is an SGK1 inhibitor with an IC50 value of 0.39 μM. In PC3 xenograft models using BALB/c nude mice, SGK1-IN-6 effectively hinders tumor growth without causing any observable toxicity.</p>Formule :C30H30F3N5O4Couleur et forme :SolidMasse moléculaire :581.586GGACK
CAS :GGACK (H-Glu-Gly-Arg-CMK) is an irreversible substrate-like inhibitor of the serine protease urokinase-type plasminogen activator (uPA).Formule :C14H25ClN6O5Masse moléculaire :392.8411-Mercaptoundecanoate-NHS
CAS :<p>11-Mercaptoundecanoate-NHS is a lipid utilized in the synthesis of Linkers.</p>Formule :C15H25NO4SCouleur et forme :SolidMasse moléculaire :315.428FABP1-IN-1
CAS :FABP1-IN-1 (44) is a selective FABP1 inhibitor with an IC50 value of 4.46 μM. It is applicable in research related to alcoholic fatty liver disease.Formule :C30H25NO5Masse moléculaire :479.52FXIa-IN-8
<p>FXIa-IN-8: potent FXIa blocker (IC50: 14.2 nM), anti-thrombotic, low bleeding/toxicity risk.</p>Couleur et forme :SolidSqualestatin 3
CAS :Squalestatin 3 is an inhibitor of squalene synthase.Formule :C25H30O13Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :538.5ROR1-IN-1
CAS :<p>ROR1-IN-1 (Compound 19h) is an inhibitor of receptor tyrosine kinase-like orphan receptor 1 (ROR1) with a Ki of 0.10 μM. It inhibits the proliferation of cancer cell lines H1975, A549, and MDA-MB-231, with IC50 values of 0.36 μM, 1.37 μM, and 0.47 μM, respectively. In mice, ROR1-IN-1 demonstrates antitumor efficacy and exhibits favorable pharmacokinetic properties in a rat model.</p>Formule :C33H27N5O3Masse moléculaire :541.60(Rac)-8-Hydroxy-efavirenz
CAS :<p>(Rac)-8-Hydroxy-efavirenz is a metabolite of Efavirenz, a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in the treatment of HIV-1.</p>Formule :C14H9ClF3NO3Couleur et forme :SolidMasse moléculaire :331.674BAY 3389934
CAS :<p>BAY 3389934 is a dual inhibitor of factor IIa (factor IIa) and factor Xa (factor Xa), providing anticoagulant and organ-protective effects. It alleviates coagulopathy and organ dysfunction in baboon models of Staphylococcus aureus sepsis.</p>Formule :C26H30ClN5O7S2Couleur et forme :SolidMasse moléculaire :624.129Beloranib
CAS :<p>Beloranib is a fumagillin anticancer drug. Beloranib belongs to an angiogenesis inhibitor.</p>Formule :C29H41NO6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :499.649-cis-β-Carotene
CAS :<p>9-cis-β-Carotene, a precursor of retinal, is cleaved by beta-carotene oxygenase 1 (BCMO1) to produce 9-cis-retinal.</p>Formule :C40H56Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :536.87Gcase activator 2
CAS :<p>Gcase activator 2 is a β-glucocerebrosidase activator that induces dimerization of GCase, increases lysosomal substrate metabolism.</p>Formule :C21H24N4O2Degré de pureté :99.51% - 99.76%Couleur et forme :SolidMasse moléculaire :364.44IDH1 Inhibitor 1
CAS :<p>Oral, brain-penetrant mutant IDH1 inhibitor targeting R132H/C with IC50: 0.021/0.045μM; 2.52μM for IDH1WT.</p>Formule :C20H18F4N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :450.39ASB14780
<p>ASB14780 is a 4-phenoxy derivative and an inhibitor of cytoplasmic phospholipase cPLA2α (IC50: 20 nM).</p>Couleur et forme :SolidIDO2-IN-1
CAS :<p>IDO2-IN-1: potent oral IDO2 inhibitor, IC50 = 112 nM, for inflammatory autoimmunity research.</p>Formule :C21H21BrN10O3Couleur et forme :SolidMasse moléculaire :541.36Aripiprazole N,N-Dioxide
CAS :AripiprazoleN,N-Dioxide is a metabolite of the atypical antipsychotic drug aripiprazole, formed through its oxidation.Formule :C23H27Cl2N3O4Masse moléculaire :480.38EB-0176
<p>EB-0176: A valerian derivative; broad-spectrum antiviral; potent ER α-glucosidase I/II inhibitor; IC50s: 0.6439/0.0011 μM.</p>Formule :C23H33N5O7Couleur et forme :SolidMasse moléculaire :491.54CK1δ-IN-10
CAS :<p>CK1δ-IN-10 (Compound 85) is an inhibitor of casein kinase 1 (CK1), specifically targeting CK1δ (CSNKID), with an IC50 value of 0.255 μM.</p>Formule :C17H11F4N5Couleur et forme :SolidMasse moléculaire :361.296Carbonic anhydrase inhibitor 5
<p>Potent hCA inhibitor: targets hCA II, IX & XII with IC50s of 42.9, 47.6, & 6.7 nM respectively.</p>Formule :C24H20ClN3O3SCouleur et forme :SolidMasse moléculaire :465.95BAY 74-4113
CAS :<p>BAY 74-4113 is a DGAT1 inhibitor with an IC50 of 72 nM. It is utilized in research related to obesity.</p>Formule :C26H20F2N2O3SCouleur et forme :SolidMasse moléculaire :478.51PPARδ agonist 11
CAS :<p>Compound 11, a selective PPARδ agonist, demonstrates an EC50 of 20 nM, indicating its high affinity for PPARδ receptors. This compound efficiently reduces levels of nitric oxide (NO), as well as the pro-inflammatory cytokines TNFα and IL-6 in LPS-stimulated RAW264.7 cells via the NF-κB pathway, showcasing its anti-inflammatory properties. Additionally, Compound 11 exhibits remarkable stability in human liver microsomes and plasma. It significantly ameliorates foot edema induced by Carrageenan, displaying favorable pharmacokinetic properties with a bioavailability of approximately 100%.</p>Formule :C19H15F3N2O3S2Couleur et forme :SolidMasse moléculaire :440.46MAGL-IN-20
<p>MAGL-IN-20 (compound ±34) is a reversible inhibitor of monoacylglycerol lipase (MAGL). It exhibits significant antiproliferative activity against a range of cancer cell lines, including H460, HT29, CT-26, Huh7, and HCCLM-3.</p>Formule :C23H24N2OCouleur et forme :SolidMasse moléculaire :344.45Monoamine Oxidase B inhibitor 6
CAS :<p>Monoamine OxidaseB inhibitor 6 (Compound BT5) is a highly selective, reversible, and competitive MAO-B inhibitor capable of crossing the blood-brain barrier, with an IC50 of 0.11 μM. It exhibits antioxidant and neuroprotective properties, making it suitable for research into neurodegenerative diseases.</p>Formule :C15H15N3OSCouleur et forme :SolidMasse moléculaire :285.364Salacinol
CAS :<p>Salacinol is a naturally occurring alpha-glucosidase inhibitor isolated from an Ayurvedic traditional medicine Salacia reticulata.</p>Formule :C9H18O9S2Couleur et forme :SolidMasse moléculaire :334.37Casein kinase 1δ-IN-17
CAS :<p>Casein kinase1δ-IN-17 (compound 753) is an inhibitor of casein kinase 1δ (CK1δ). It is applicable in research related to neurodegenerative diseases.</p>Formule :C14H14N4SCouleur et forme :SolidMasse moléculaire :270.353ABD957
CAS :<p>ABD957: covalent ABHD17 depalmitoylases inhibitor, IC50 0.21µM for ABHD17B, blocks N-Ras, halts NRAS-mutant AML cell growth.</p>Formule :C27H36F3N7O5SCouleur et forme :SolidMasse moléculaire :627.68BAR-2227
CAS :<p>BAR-2227 (compound 3a) functions as an FXR agonist and a LIFR inhibitor. It is utilized in the study of liver fibrosis and inflammation.</p>Formule :C24H17Cl2NO4Couleur et forme :SolidMasse moléculaire :454.30α-Glucosidase-IN-14
<p>α-Glucosidase-IN-14 is a potent inhibitor of α-glucosidase (IC50: 5.22 μM).</p>Formule :C24H27N5O4S2Couleur et forme :SolidMasse moléculaire :513.63Thioquinapiperifil dihydrochloride
CAS :<p>Thioquinapiperifil dihydrochloride is a potent, selective PDE-5 inhibitor (IC50: 0.074 nM) for research.</p>Formule :C24H29ClN6OSDegré de pureté :98.73%Couleur et forme :SolidMasse moléculaire :485.05NAZ2329
CAS :<p>NAZ2329: Cell-permeable, targets R5 RPTPs, inhibits hPTPRZ1 (IC50=7.5 μM) & hPTPRG (IC50=4.8 μM), hampers glioblastoma growth, affects stem cell traits.</p>Formule :C21H18F3NO4S3Couleur et forme :SoildMasse moléculaire :501.56Glucosylceramide synthase-IN-3
<p>Glucosylceramide synthase-IN-3 (BZ1) is a potent, brain-accessible, oral GCS inhibitor with a 16 nM IC50, relevant for Gaucher's disease study.</p>Formule :C21H20FN3O3Couleur et forme :SolidMasse moléculaire :381.4CYP2C1/CYP2C19-IN-2
<p>CYP2C1/CYP2C19-IN-2 is a potent inhibitor of CYP2C9/CYP2C19 without liver toxicity or genotoxicity and can be used to study Zika virus (ZIKV) infection.</p>Formule :C27H28N2O6SCouleur et forme :SolidMasse moléculaire :508.59CYP2C9/CYP2C19-IN-1
<p>CYP2C9/CYP2C19-IN-1 is a potent inhibitor of CYP2C9/CYP2C19 without liver toxicity or genotoxicity and can be used to study Zika virus (ZIKV) infection.</p>Formule :C27H28N2O6SCouleur et forme :SolidMasse moléculaire :508.59PHGDH-IN-2
<p>PHGDH-IN-2: potent PHGDH inhibitor, IC50=5.2μM; hinders PHGDH cancer cell growth & serine synthesis in MDA-MB-468.</p>Formule :C22H20N4O3SCouleur et forme :SolidMasse moléculaire :420.48α-Amylase-IN-7
CAS :<p>α-Amylase-IN-7 (Compound 6e) is an inhibitor of α-Amylase, with an IC50 of 40 μM, indicating its potency. This compound shows potential as an anti-diabetic medication.</p>Formule :C18H15ClN6O2SMasse moléculaire :414.87HIF-2α-IN-7
CAS :<p>HIF-2α-IN-7 is a hypoxia inducible factor 2α (HIF-2α) inhibitor.</p>Formule :C18H9F6NO2Couleur et forme :SolidMasse moléculaire :385.26TMX-4116
CAS :<p>TMX-4116 is a CK1α degrader targeting multiple cell lines with DC50s below 200 nM, used in multiple myeloma research and protein degradation strategy studies.</p>Formule :C17H19N5O4SCouleur et forme :SolidMasse moléculaire :389.43(E)-10-Hydroxynortriptyline maleate
CAS :<p>(E)-10-Hydroxy Nortriptyline maleate, a derivative of antidepressant Nortriptyline, eases depression symptoms.</p>Formule :C23H25NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :395.4559(S)-HETE
CAS :<p>9(S)-HETE is an enantiomer of (±)9-HETE, not an enzymatic product, and doesn't promote cell adhesion like 12(S)-HETE. Identified by chiral HPLC.</p>Formule :C20H32O3Couleur et forme :SolidMasse moléculaire :320.47LRAT-IN-1
CAS :<p>LRAT-IN-1 (compound 1) is an inhibitor of lecithin retinol acyltransferase (LRAT) with an IC50 value of 21.1 μM. This compound works by inhibiting the esterification of retinol to form retinyl esters, thereby increasing the availability of retinol in the skin to deliver anti-aging benefits. LRAT-IN-1 is under investigation for its potential use as an anti-aging ingredient in cosmetics.</p>Formule :C27H47N5O5S2Couleur et forme :SolidMasse moléculaire :585.82MDL-100240
CAS :<p>MDL-100240 inhibits ACE/neprilysin, effective against hypertension-induced heart/vascular changes.</p>Formule :C26H28N2O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :480.58Casein Kinase II Inhibitor IV Hydrochloride
CAS :<p>Casein Kinase II Inhibitor IV HCl promotes keratinocyte differentiation, potential for skin disorder therapy.</p>Formule :C24H24ClN5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :465.93RORγt/DHODH-IN-3
<p>RORγt/DHODH-IN-3 (compound (S)-14d) is a potent, orally active dual inhibitor of RORγt (IC50: 0.098 μM) and DHODH (IC50: 0.432 μM).RORγt/DHODH-IN-1 has</p>Formule :C24H26ClF6N3O3SCouleur et forme :SolidMasse moléculaire :585.99NNC 55-0396
CAS :<p>NNC 55-0396: Selective T-type calcium channel blocker, IC50 6.8 μM, inhibits human ovarian cancer cell growth.</p>Formule :C30H40Cl2FN3O2Degré de pureté :99.00%Couleur et forme :SolidMasse moléculaire :564.56JTT-553
CAS :<p>JTT-553 is a DGAT1 inhibitor with an IC50 of 2.38 nM. It effectively reduces plasma levels of glucose, insulin, non-esterified fatty acids (NEFA), total cholesterol (TC), and liver triglycerides (TG). JTT-553 enhances insulin-dependent glucose absorption and glucose intolerance in the adipose tissue of diet-induced obese (DIO) mice. In KK-Ay mice, it lowers TNF-α mRNA levels and elevates GLUT4 mRNA levels in adipose tissue. By contributing to weight loss, JTT-553 improves insulin resistance in adipose tissue and overall glucose metabolism. This compound is useful for research on obesity and type 2 diabetes mellitus (T2DM).</p>Formule :C25H27F3N4O3Couleur et forme :SolidMasse moléculaire :488.50PDE5-IN-8
CAS :<p>PDE5-IN-8 (compound 2) is an inhibitor of PDEs.</p>Formule :C22H20ClN3O2Couleur et forme :SolidMasse moléculaire :393.87Atorvastatin 3-Deoxyhept-2E-Enoic Acid
CAS :Atorvastatin 3-Deoxyhept-2E-Enoic Acid, an impurity in Atorvastatin, lowers blood lipids as an HMG-CoA reductase inhibitor.Formule :C33H33FN2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :540.62PTP1B-IN-18
<p>PTP1B-IN-18 is an orally active, fully mixed protein tyrosine phosphatase 1B (PTP1B) inhibitor (Ki: 35.2 μM).PTP1B-IN-18 can be used to study type 2 diabetes.</p>Formule :C26H19N3O4SCouleur et forme :SolidMasse moléculaire :469.51RORγt inhibitor 4
CAS :<p>RORγt inhibitor 4 (Compound 9a) is an orally active RORγt inhibitor capable of penetrating the central nervous system. It has been shown to improve experimental autoimmune encephalomyelitis.</p>Formule :C22H16Cl2F3NO4SCouleur et forme :SolidMasse moléculaire :518.333LU 2443
CAS :<p>LU 2443 is an orally active antiepileptic agent that is extensively absorbed, with up to 18% remaining unabsorbed in rats. The active half-life in plasma is 13.17 hours.</p>Formule :C9H8N2S2Couleur et forme :SolidMasse moléculaire :208.3Magnesium ionophore III
CAS :<p>Magnesium ionophore III (ETH 4030) is an ion carrier that regulates intracellular magnesium ion concentrations. It enhances cellular functions and metabolic activities by increasing the permeability of cell membranes to magnesium ions. Additionally, Magnesium ionophore III is utilized in research to explore the significance of magnesium ions in biological processes and their impact on cellular physiology.</p>Formule :C30H58N4O4Couleur et forme :SolidMasse moléculaire :538.81Calcium 2-hydroxypropanoate pentahydrate
CAS :<p>Calcium 2-hydroxypropanoate (pentahydrate) acts as an activator of the hydroxyl-carboxylic acid receptor 1 (HCAR1) and serves as an epigenetic regulator that induces lysine residue lactylation. This compound, a glycolysis end product, bridges the gap between glycolysis and oxidative phosphorylation and functions as a tumor metabolite with immunoprotective effects of lactate in antitumor immunity.</p>Formule :C3H5O3CaH2OCouleur et forme :SolidMasse moléculaire :154.147CYP121A1-IN-1
<p>CYP121A1-IN-1: Strong inhibitor for CYP121A1, hinders Mycobacterium tuberculosis growth (MIC 90 ~6.25 μM), reduces mycocyclosin synthesis.</p>Formule :C22H20N4OCouleur et forme :SolidMasse moléculaire :356.42Docosapentaenoic acid (22n-3) sodium
CAS :<p>Docosapentaenoic acid (22n-3) sodium is a component of phospholipids. It exhibits inhibitory activity against α-amylase and α-glucosidase, with IC50 values of 17 μg/mL and 22 μg/mL, respectively. Additionally, Docosapentaenoic acid 22n-3 sodium enhances cell viability and has mild anti-inflammatory effects.</p>Formule :C22H34NaO2Couleur et forme :SolidMasse moléculaire :353.494ATX inhibitor 22
<p>ATX inhibitor 22 is a novel inhibitor of ATX (autotaxin) (IC50: 218.9 μM) that lacks inhibitory activity against LPAR1.</p>Formule :C19H17Cl3F2N2O4SCouleur et forme :SolidMasse moléculaire :513.77GSK2945 hydrochloride
<p>GSK2945 HCl is a specific Rev-erbα antagonist, EC50: 21.5 μM (mouse), 20.8 μM (human), increases cholesterol 7α-hydroxylase.</p>Formule :C20H19Cl3N2O2SCouleur et forme :SolidMasse moléculaire :457.87-Hydroxy-4-phenylcoumarin
CAS :<p>7-Hydroxy-4-phenylcoumarin is a dual inhibitor of ALDH-2 and MAO, with IC50 values of 1.5 µM and 0.5 µM, respectively.</p>Formule :C15H10O3Couleur et forme :SolidMasse moléculaire :238.2382R,4R-Sacubitril
CAS :<p>2R,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is used in combination with valsartan for the treatment of patients with heart failure.</p>Formule :C24H29NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :411.49CK1δ-IN-6
CAS :<p>CK1δ-IN-6 (Compound 303) is an inhibitor of Casein kinase 1δ, with potential applications in Alzheimer's disease research.</p>Formule :C23H17N3O4Couleur et forme :SolidMasse moléculaire :399.399HIV-1 inhibitor-40
<p>HIV-1 inhibitor-40 (4ab) is a potent NNRTI (EC50: 1.9 nM), non-toxic in vivo, and a sensitive CYP inhibitor.</p>Formule :C25H18N6O2Couleur et forme :SolidMasse moléculaire :434.45ACLY-IN-1
CAS :ACLY-IN-1 (compound 55) is a potent ACLY inhibitor with an IC50 of 8.3 nM, and it can be utilized in hyperlipidemia research.Formule :C20H12BrClF2N2O4SCouleur et forme :SolidMasse moléculaire :529.74RORγt inverse agonist 29
<p>RORγt inverse agonist 29 is a potent, selective, orally active RORγt inverse agonist with an IC50 value of 21 nM.</p>Formule :C25H24N2O5SCouleur et forme :SolidMasse moléculaire :464.53PNPLA3 modifier 1
CAS :<p>PNPLA3 Modifier 1 (Compound 10), a modifier of patatin-like phospholipase domain-containing protein 3 (pnpla3), exhibits a geometric mean EC50 of 4.9 nM.</p>Formule :C16H19ClF2N2O4SCouleur et forme :SolidMasse moléculaire :408.85HIF-1α-IN-5
<p>HIF-1α-IN-5 is an inhibitor of HIF-1α with an IC 50 value of 24 nM in HEK293T cells that also inhibits the activity of MAO-A.</p>Formule :C16H15N3O2Couleur et forme :SolidMasse moléculaire :281.31DEL-I25
CAS :<p>DEL-I25 is an effective activator of GPX4 that protects cells from ferroptosis (iron-dependent cell death).</p>Formule :C21H23N5O3Couleur et forme :SolidMasse moléculaire :393.44Deltasonamide 2 hydrochloride
<p>Deltasonamide 2 hydrochloride is a competitive high-affinity PDEδ inhibitor with a Kd of approximately 385 pM.</p>Formule :C30H40Cl2N6O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :683.71(Rac)-OSMI-1
<p>(Rac)-OSMI-1, a racemate, inhibits OGT (IC50: 2.7 μM) affecting O-GlcNAcylation without changing surface glycans.</p>Formule :C28H25N3O6S2Couleur et forme :SolidMasse moléculaire :563.64Fusarisetin A
CAS :<p>Fusarisetin A, a pentacyclic fungal metabolite, is an acinar morphogenesis inhibitor .</p>Formule :C22H31NO5Couleur et forme :SolidMasse moléculaire :389.49IDO1-IN-13
<p>IDO1-IN-13 is a potent IDO1 inhibitor (IC50: 61.6 nM, EC50: 30 nM in HeLa) that reduces kyn/trp ratio by 51% in SK-OV-3 tumors.</p>Formule :C20H16BrN5O2SCouleur et forme :SolidMasse moléculaire :470.34Nomelidine
CAS :Nomelidine, the active N-demethylated metabolite of zimelidine, has been used as an antidepressant and analgesic.Formule :C15H15BrN2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :303.20PDE4-IN-6
<p>PDE4-IN-6: Potent PDE4 inhibitor, IC50 - 0.125μM (B), 0.43μM (D), anti-inflammatory, for arthritis research.</p>Formule :C25H20FNO5SCouleur et forme :SolidMasse moléculaire :465.498-Hydroxychlorpromazine
CAS :<p>8-Hydroxychlorpromazine is a metabolite of Chlorpromazine that can enhance the hyperglycemic response following glucose loading, suggesting a possible synergistic role in Chlorpromazine-induced glucose metabolism disorders. It holds potential for research into metabolic diseases.</p>Formule :C17H19ClN2OSCouleur et forme :SolidMasse moléculaire :334.864LEQ803
CAS :<p>LEQ803 (N-DesmethylRibociclib) is a metabolite of the CDK4/6 inhibitor Ribociclib, produced through metabolism by CYP3A4. This compound holds potential applications in the field of oncology.</p>Formule :C22H28N8OCouleur et forme :SolidMasse moléculaire :420.511PF-07202954
CAS :<p>PF-07202954, a weakly basic diacylglycerol O-acyltransferase 2 (DGAT2) inhibitor, exhibits an inhibition concentration half-maximum (IC50) of 10 nM against</p>Formule :C22H23FN6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :438.45SID 24785302
CAS :<p>SID 24785302 is an inhibitor of hexokinase, which can suppress glycolysis, regulate mitochondrial function, and ultimately inhibit the replication of mutant mitochondrial DNA.</p>Formule :C14H12N2O3S2Couleur et forme :SolidMasse moléculaire :320.387Zaragozic acid C
CAS :<p>Zaragozic acid C is an effective inhibitor of squalene synthase.</p>Formule :C40H50O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :754.82PHD2-IN-4
CAS :<p>PHD2-IN-4 (compound 1) is an inhibitor of PHD2, with an IC50 of 4 nM. It is utilized in research related to chronic kidney disease.</p>Formule :C21H19N5O3Couleur et forme :SolidMasse moléculaire :389.407
