Métabolisme
Les inhibiteurs du métabolisme sont des composés qui interfèrent avec les voies métaboliques, modifiant ainsi la production et l'utilisation de l'énergie au sein des cellules. Ces inhibiteurs sont utilisés pour étudier la régulation du métabolisme, le rôle des voies métaboliques dans des maladies telles que le cancer et le diabète, et pour développer de nouvelles stratégies thérapeutiques. Les inhibiteurs du métabolisme peuvent cibler diverses enzymes et processus impliqués dans la glycolyse, l'oxydation des acides gras et d'autres fonctions métaboliques. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de métabolisme de haute qualité pour soutenir vos recherches en biochimie, troubles métaboliques et développement de médicaments.
Sous-catégories appartenant à la catégorie "Métabolisme"
- AhR(41 produits)
- Aminopeptidase(67 produits)
- CETP(18 produits)
- Anhydrase carbonique(178 produits)
- Caséine Kinase(130 produits)
- DHFR(33 produits)
- Décarboxylase(4 produits)
- Déshydrogénase(270 produits)
- FAAH(64 produits)
- FXR(58 produits)
- Facteur Xa(80 produits)
- Synthase des acides gras(33 produits)
- Ferroptose(215 produits)
- GR(3 produits)
- GSNOR(3 produits)
- Glucokinase(54 produits)
- Prolyl-Hydroxylase de HIF/HIF(142 produits)
- HMG-CoA Réductase(33 produits)
- Hydroxylase(30 produits)
- IDO(82 produits)
- LDL(8 produits)
- Lipase(97 produits)
- Lipides(59 produits)
- Lipoxygénase(125 produits)
- MAO(87 produits)
- MPO(2 produits)
- NAMPT(36 produits)
- P450(6 produits)
- PAI-1(25 produits)
- PDE(166 produits)
- PED(1 produits)
- PKM(15 produits)
- PPAR(164 produits)
- Phospholipase(82 produits)
- ROR(42 produits)
- Récepteur de rétinoïdes(29 produits)
- SGK(11 produits)
- Thioredoxine(12 produits)
- Transférase(30 produits)
- Tansporteur(42 produits)
- UGT(4 produits)
- Inhibiteurs de la xanthine oxydase (XO)(9 produits)
Affichez 34 plus de sous-catégories
8626 produits trouvés pour "Métabolisme"
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Indoluidin E
<p>Indoluidin E selectively inhibits DHODH and has an inhibitory effect on cancer cell growth.</p>Formule :C28H30N4O2Couleur et forme :SolidMasse moléculaire :454.568-Hydroxychlorpromazine
CAS :<p>8-Hydroxychlorpromazine is a metabolite of Chlorpromazine that can enhance the hyperglycemic response following glucose loading, suggesting a possible synergistic role in Chlorpromazine-induced glucose metabolism disorders. It holds potential for research into metabolic diseases.</p>Formule :C17H19ClN2OSCouleur et forme :SolidMasse moléculaire :334.864PDE4-IN-6
<p>PDE4-IN-6: Potent PDE4 inhibitor, IC50 - 0.125μM (B), 0.43μM (D), anti-inflammatory, for arthritis research.</p>Formule :C25H20FNO5SCouleur et forme :SolidMasse moléculaire :465.49SID 24785302
CAS :<p>SID 24785302 is an inhibitor of hexokinase, which can suppress glycolysis, regulate mitochondrial function, and ultimately inhibit the replication of mutant mitochondrial DNA.</p>Formule :C14H12N2O3S2Couleur et forme :SolidMasse moléculaire :320.387Asimicin
CAS :<p>Asimicin is a effective complex I inhibitor.</p>Formule :C37H66O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :622.92Atorvastatin 3-Deoxyhept-2E-Enoic Acid
CAS :<p>Atorvastatin 3-Deoxyhept-2E-Enoic Acid, an impurity in Atorvastatin, lowers blood lipids as an HMG-CoA reductase inhibitor.</p>Formule :C33H33FN2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :540.62BPU17
CAS :<p>BPU17 interacts with PHB1 and disrupts the PHB1-PHB2 interaction, causing slight mitochondrial dysfunction. This damage hinders transcription dependent on SRF/CArG-box, thereby inhibiting epithelial-mesenchymal transition (EMT) in retinal pigment epithelial cells (RPEs). BPU17 has demonstrated anti-fibrotic activity in vivo. It holds potential as a research agent for anti-angiogenic age-related macular degeneration (nAMD).</p>Formule :C12H13ClN2O2Couleur et forme :SolidMasse moléculaire :252.703-Benzylidenecamphor
CAS :<p>3-Benzylidenecamphor, a UV absorber, is noted for its excellent photostability and antioxidant activity. It is extensively utilized in sunscreen products to shield the skin from UV damage. Additionally, 3-Benzylidenecamphor is used in cosmetics to enhance product shelf life and safety.</p>Formule :C17H20OCouleur et forme :SolidMasse moléculaire :240.34Ranosidenib
CAS :<p>Ranolisib is an isocitrate dehydrogenase (IDH) inhibitor known for its antitumor activity.</p>Formule :C15H16F9N5OCouleur et forme :SolidMasse moléculaire :453.31Nampt-IN-14
CAS :<p>Nampt-IN-14 (example 3) is an effective NAMPT inhibitor with an IC50 of 0.2 nM, suited for use in the synthesis of antibody-drug conjugates (ADCs).</p>Formule :C33H35N7O2Couleur et forme :SolidMasse moléculaire :561.68Inosine 5′-diphosphate sodium
CAS :<p>Inosine 5'-diphosphate sodium, a purine ribonucleoside diphosphate with inosine as its nucleobase, plays a role in intracellular energy metabolism and signal transduction processes.</p>Formule :C10H13N4Na3O12P2Couleur et forme :SolidMasse moléculaire :512.15LASSBio-1632
<p>LASSBio-1632: Novel anti-asthmatic, blocks PDE4A/D, reduces AHR & lung TNF-α, crosses BBB.</p>Formule :C18H20N2O6SCouleur et forme :SolidMasse moléculaire :392.4313(R)-HODE
CAS :<p>13(R)-HODE, produced from linoleic acid, inhibits platelet aggregation (IC50=2.7μM) and is found in bovine endothelial cells.</p>Formule :C18H32O3Couleur et forme :SolidMasse moléculaire :296.44MDL-100240
CAS :<p>MDL-100240 inhibits ACE/neprilysin, effective against hypertension-induced heart/vascular changes.</p>Formule :C26H28N2O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :480.583β,7β-Dihydroxy-5-cholestenoic acid
CAS :<p>3β,7β-Dihydroxy-5-cholestenoic acid is a C27 acid whose levels are elevated in Niemann-Pick Type C and B diseases, leading to toxicity in ocular motor neurons. It is synthesized by the enzymatic action of hydroxysteroid 11-β dehydrogenase 1 from 3β-hydroxy-7-oxocholest-5-en-(25R)26-enoic acid (3βH,7O-CA).</p>Formule :C27H44O4Couleur et forme :SolidMasse moléculaire :432.64Lumirubin
CAS :<p>Lumirubin is a water-soluble photoproduct of bilirubin formed in vivo during phototherapy.</p>Formule :C33H36N4O6Couleur et forme :SolidMasse moléculaire :584.66AZ513
CAS :<p>AZ513 is a reversible FAAH inhibitor, exhibiting an IC50 of 551 nM for human FAAH and 27 nM for rat FAAH. It inhibits the hydrolysis of arachidonoyl ethanolamide in HEK293 cells transfected with human FAAH, with an IC50 of 360 nM.</p>Formule :C14H9Cl2N3OCouleur et forme :SolidMasse moléculaire :306.147JTT-553
CAS :<p>JTT-553 is a DGAT1 inhibitor with an IC50 of 2.38 nM. It effectively reduces plasma levels of glucose, insulin, non-esterified fatty acids (NEFA), total cholesterol (TC), and liver triglycerides (TG). JTT-553 enhances insulin-dependent glucose absorption and glucose intolerance in the adipose tissue of diet-induced obese (DIO) mice. In KK-Ay mice, it lowers TNF-α mRNA levels and elevates GLUT4 mRNA levels in adipose tissue. By contributing to weight loss, JTT-553 improves insulin resistance in adipose tissue and overall glucose metabolism. This compound is useful for research on obesity and type 2 diabetes mellitus (T2DM).</p>Formule :C25H27F3N4O3Couleur et forme :SolidMasse moléculaire :488.50PLAP-IN-1
CAS :<p>PLAP-IN-1: Potent, selective inhibitor of PLAP, IC50 of 32 nM; doesn't notably inhibit TNAP.</p>Formule :C25H21Cl2N3O5Couleur et forme :SoildMasse moléculaire :514.36Propofol sulfate sodium
CAS :<p>Propofolsulfate (sodium) is a metabolite of Propofol.</p>Formule :C12H17NaO4SCouleur et forme :SolidMasse moléculaire :280.316FAAH/MAGL-IN-1
<p>FAAH/MAGL-IN-1 (SIH 3) inhibits FAAH & MAGL with IC50 of 31 & 29 nM, useful in neuropathic pain research.</p>Formule :C15H9Cl2N3O3Couleur et forme :SolidMasse moléculaire :350.16IMR687
CAS :<p>IMR687: a PDE9 inhibitor that could improve memory in Alzheimer's by slowing cGMP hydrolysis.</p>Formule :C21H26N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :394.47FXIa-IN-8
<p>FXIa-IN-8: potent FXIa blocker (IC50: 14.2 nM), anti-thrombotic, low bleeding/toxicity risk.</p>Couleur et forme :SolidTabimorelin hemifumarate
CAS :<p>orally active ghrelin receptor (GHS-R1a) agonist</p>Formule :C32H40N403C4H404Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :586.72Gcase activator 2
CAS :<p>Gcase activator 2 is a β-glucocerebrosidase activator that induces dimerization of GCase, increases lysosomal substrate metabolism.</p>Formule :C21H24N4O2Degré de pureté :99.51% - 99.76%Couleur et forme :SolidMasse moléculaire :364.447-Hydroxy-4-phenylcoumarin
CAS :<p>7-Hydroxy-4-phenylcoumarin is a dual inhibitor of ALDH-2 and MAO, with IC50 values of 1.5 µM and 0.5 µM, respectively.</p>Formule :C15H10O3Couleur et forme :SolidMasse moléculaire :238.238Nampt-IN-13
CAS :<p>Nampt-IN-13 (example 58m) is an NAMPT inhibitor used in the synthesis of antibody-drug conjugates (ADCs).</p>Formule :C24H30N6O2Couleur et forme :SolidMasse moléculaire :434.53BMS-185354
CAS :<p>BMS-185354 is a selective RARγ activator with an EC50 value of 28 nM, offering potential for cancer research.</p>Formule :C26H27NO3Couleur et forme :SolidMasse moléculaire :401.497sEH inhibitor-2
<p>SEH inhibitor-2 is an orally active sEH blocker (IC50=0.9 nM) with predicted 71.2-88.4% absorption, potentially aiding cardiovascular health.</p>Formule :C23H18N4O3Couleur et forme :SolidMasse moléculaire :398.41Z57346765
CAS :<p>Z57346765 is a specific PGK1 inhibitor that inhibits PGK1-dependent cell proliferation by decreasing the metabolic enzyme activity of PGK1 during glycolysis.</p>Formule :C17H18N4ODegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :294.3511-trans Leukotriene E4
CAS :<p>Slow isomerization of the C-11 double bond of LTE4 leads to the formation of 11-trans LTE4. 11-trans LTE4 is equipotent to LTE4 in contracting guinea pig ileum.</p>Formule :C23H37NO5SCouleur et forme :SolidMasse moléculaire :439.61PDHK-IN-3
<p>PDHK-IN-3 (compound 7) is a potent inhibitor of pyruvate dehydrogenase kinase(PDHK) with IC50s of 0.21 and 1.54 μM for PDHK2 and PDHK4, respectively [1].</p>Formule :C17H16N2O2Couleur et forme :SolidMasse moléculaire :280.32LEQ803
CAS :<p>LEQ803 (N-DesmethylRibociclib) is a metabolite of the CDK4/6 inhibitor Ribociclib, produced through metabolism by CYP3A4. This compound holds potential applications in the field of oncology.</p>Formule :C22H28N8OCouleur et forme :SolidMasse moléculaire :420.511PF-07202954
CAS :<p>PF-07202954, a weakly basic diacylglycerol O-acyltransferase 2 (DGAT2) inhibitor, exhibits an inhibition concentration half-maximum (IC50) of 10 nM against</p>Formule :C22H23FN6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :438.45Carbonic anhydrase inhibitor 10
<p>CA inhibitor 10 targets MCF-7 cells, IC50: 11.9 μM; potent h CA IX inhibitor, Ki: 6.2 nM. Anti-cancer research.</p>Formule :C14H17N5O3SCouleur et forme :SolidMasse moléculaire :335.382R,4R-Sacubitril
CAS :<p>2R,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is used in combination with valsartan for the treatment of patients with heart failure.</p>Formule :C24H29NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :411.49PDHK-IN-4
<p>PDHK-IN-4 inhibits PDHK2 (IC50: 0.0051 μM) & PDHK4 (IC50: 0.0122 μM), with potential for cancer research.</p>Formule :C24H25N5O3Couleur et forme :SolidMasse moléculaire :431.49RORγt inhibitor 2
CAS :<p>RORγt Inhibitor 2, a potent inhibitor of RORγt, exhibits an IC50 of 9.2 nM and is utilized in the study of cancer, inflammation, or autoimmune diseases that are</p>Formule :C31H33F5N2O7SCouleur et forme :SolidMasse moléculaire :672.66α-Glucosidase-IN-14
<p>α-Glucosidase-IN-14 is a potent inhibitor of α-glucosidase (IC50: 5.22 μM).</p>Formule :C24H27N5O4S2Couleur et forme :SolidMasse moléculaire :513.63ATUX-8385
CAS :<p>ATUX-8385 is a potent activator of PP2A. It binds to the PR65 subunit and holds promise for research into cancer and chronic diseases, including Alzheimer's disease and chronic obstructive pulmonary disease (COPD).</p>Formule :C24H20F5N3O4SCouleur et forme :SolidMasse moléculaire :541.49PTP1B-IN-18
<p>PTP1B-IN-18 is an orally active, fully mixed protein tyrosine phosphatase 1B (PTP1B) inhibitor (Ki: 35.2 μM).PTP1B-IN-18 can be used to study type 2 diabetes.</p>Formule :C26H19N3O4SCouleur et forme :SolidMasse moléculaire :469.51Lufironil
CAS :<p>Lufironil (HOE 077) is an inhibitor of prolyl 4-hydroxylase, designed for investigating chronic liver conditions such as alcoholic hepatitis and cirrhosis.</p>Formule :C13H19N3O4Couleur et forme :SolidMasse moléculaire :281.31Vimirogant hydrochloride
<p>Vimirogant (VTP-43742) HCl: Oral, selective RORγt inhibitor (IC50: 17 nM, Ki: 3.5 nM), >1000x selectivity over RORα/β, targets Th17, not Th1/2/Treg.</p>Formule :C27H36ClF3N4O3SCouleur et forme :SolidMasse moléculaire :588.21487CAII-IN-1
<p>CAII-IN-1 (3n) is a selective bovine CA-II inhibitor with 10.3 μM IC50, used in carbonic anhydrase disorder studies.</p>Formule :C19H21FN4SCouleur et forme :SolidMasse moléculaire :356.46FXIa-IN-6
CAS :<p>FXIa-IN-6: Potent, selective FXIa inhibitor (Ki=0.3 nM); strong PK with high oral bioavailability, low clearance preclinically.</p>Formule :C31H29ClF2N4O4Couleur et forme :SolidMasse moléculaire :595.04NTPDase-IN-2
CAS :<p>NTPDase-IN-2 inhibits h-NTPDase-2/-8 (IC50: 0.04, 2.27 µM), non-competitive for h-NTPDase-1/-2 (Km: 74 µM); useful in cancer, immune, bacterial research.</p>Formule :C24H20FN3OS2Couleur et forme :SolidMasse moléculaire :449.56GW461484A
CAS :<p>GW461484A is a small molecule inhibitor targeting Candida albicans Yck2, exhibiting an IC50 of 0.11 µM. It has a MIC80 of 12.5 µM against C. albicans. GW461484A shows potential for research into fungal diseases, including drug-resistant Candida infections.</p>Formule :C19H14FN3Couleur et forme :SolidMasse moléculaire :303.333Glucokinase activator 7
CAS :<p>Glucokinase activator7 is an activator of glucose kinase (Glucokinase) and can be utilized in research on diabetes and hyperglycemia [refer to compound on page 176].</p>Formule :C14H13N3O2SCouleur et forme :SolidMasse moléculaire :287.337RO5101576
CAS :<p>RO5101576 is a potent antagonist of LTB4 receptor.</p>Formule :C36H38O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :630.75GJG057
CAS :<p>GJG057 is a highly efficient and selective Leukotriene C4 synthase (LTC4S) inhibitor with an IC50 of 44 nM in human whole blood LTC4 release assays and oral activity. It demonstrates anti-inflammatory efficacy in a mouse asthma exacerbation model and can be used for the treatment of allergic inflammation.</p>Formule :C21H21F5N4O2Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :456.41PHD2-IN-4
CAS :<p>PHD2-IN-4 (compound 1) is an inhibitor of PHD2, with an IC50 of 4 nM. It is utilized in research related to chronic kidney disease.</p>Formule :C21H19N5O3Couleur et forme :SolidMasse moléculaire :389.40711β-HSD2-IN-2
CAS :<p>11β-HSD2-IN-2 (compound 3) is a selective 17β-HSD2 (17β-hydroxysteroid dehydrogenase type 2) inhibitor with an IC50 of 300 nM, studying osteoporosis.</p>Formule :C22H21NO2Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :331.41FXR agonist 12
CAS :<p>FXR agonist12 (Compound C7) is an orally active FXR agonist. It downregulates bile acid synthesis-related genes and upregulates bile acid transport-related genes in HepG2 cells. FXR agonist12 alleviates ANIT-induced cholestasis and reduces liver damage and fibrosis in a mouse model of NASH.</p>Formule :C26H44O3Couleur et forme :SolidMasse moléculaire :404.626ZK159222
CAS :<p>ZK159222 is an effective 1α,25-(OH)2D3 receptor (VDR) agonist. ZK159222 has a partial agonistic character.</p>Formule :C32H48O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :512.72Etoricoxib N1'-oxide
CAS :<p>EtoricoxibN1'-oxide is a metabolite of Etoricoxib. It does not inhibit COX-1 and does not significantly inhibit COX-2.</p>Formule :C18H15ClN2O3SCouleur et forme :SolidMasse moléculaire :374.841HIF-2α-IN-7
CAS :<p>HIF-2α-IN-7 is a hypoxia inducible factor 2α (HIF-2α) inhibitor.</p>Formule :C18H9F6NO2Couleur et forme :SolidMasse moléculaire :385.26hMAO-B/MB-COMT-IN-2
<p>Dual inhibitor hMAO-B/MB-COMT-IN-2 targets hMAO-B (IC50: 4.27μM) & MB-COMT (IC50: 2.69μM), aids in neurodegenerative research.</p>Formule :C17H18N2O3Couleur et forme :SolidMasse moléculaire :298.34Cilazaprilat
CAS :<p>Cilazaprilat is the active metabolite of cilazapril, a pyridazine angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.</p>Formule :C20H27N3O5Couleur et forme :SolidMasse moléculaire :389.45Implitapide
CAS :<p>Implitapide is an inhibitor of microsomal triglyceride transfer protein (MTP).</p>Formule :C35H37N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :531.69Xanthosine-5'-monophosphate
CAS :<p>Xanthosine 5'-monophosphate is produced from inosine monophosphate (IMP) through the catalytic action of inosine monophosphate dehydrogenase (IMPDH).</p>Formule :C10H13N4O9PCouleur et forme :SolidMasse moléculaire :364.21LXR agonist 2
<p>LXR agonist 2 is a potent agonist of the LXR (liver X receptor). LXR agonist 2 stabilises NCOA1 (coactivator), which in turn agonises the LXR.</p>Formule :C35H40ClN3O3Couleur et forme :SolidMasse moléculaire :586.16GK420
CAS :<p>GK420 (AVX420) is a potent inhibitor of cytoplasmic phospholipase A2α (cPLA2α), with an XI(50) value of 0.0016. It effectively inhibits the release of arachidonic acid, with an EC50 of 0.09 μM. GK420 plays a significant role in cancer research.</p>Formule :C20H25NO5SCouleur et forme :SolidMasse moléculaire :391.481Morocromen
CAS :<p>Morocromen is a 2-benzamidobenzoic acid derivative characterized by its ability to enhance coronary activity.</p>Formule :C21H27N3O5Couleur et forme :SolidMasse moléculaire :401.46GSK864
CAS :<p>GSK864 is an inhibitor of isocitrate dehydrogenase 1 (IDH1) mutant. GSK864 inhibits IDH1 mutants R132C, R132H, and R132G (IC50: 8.8, 15.2, and 16.6 nM).</p>Formule :C30H31FN6O4Degré de pureté :97.07%Couleur et forme :SolidMasse moléculaire :558.6ATX inhibitor 22
<p>ATX inhibitor 22 is a novel inhibitor of ATX (autotaxin) (IC50: 218.9 μM) that lacks inhibitory activity against LPAR1.</p>Formule :C19H17Cl3F2N2O4SCouleur et forme :SolidMasse moléculaire :513.77Lipid HTO12
CAS :<p>Lipid HTO12 is an ionizable lipid used for forming lipid nanoparticles (LNP). It facilitates the delivery of siRNA and mRNA.</p>Formule :C41H83NO4Couleur et forme :SolidMasse moléculaire :654.102JTZ-951 HCl
CAS :<p>JTZ-951 is a potent and orally active inhibitor of hypoxia inducible factor prolyl hydroxylase (PHD).</p>Formule :C17H17ClN4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :376.79CYP1B1-IN-2
<p>CYP1B1-IN-2 (compound 9j) is a highly potent and selective inhibitor of CYP1B1, a cytochrome P450 enzyme. It exhibits an IC50 value of 0.52 nM [1].</p>Formule :C20H11F3O2Couleur et forme :SolidMasse moléculaire :340.3Casein kinase 1δ-IN-23
CAS :<p>Casein kinase1δ-IN-23 (compound 423) is an effective inhibitor of casein kinase1δ. It is applicable in research related to neurodegenerative diseases such as Alzheimer's disease.</p>Formule :C19H15N3O3SCouleur et forme :SolidMasse moléculaire :365.406α-Amylase-IN-12
CAS :<p>α-Amylase-IN-12 (Compound 5e) is an α-amylase inhibitor with an IC50 of 0.15 mM, functioning through a mixed inhibition mode. It exhibits an IC50 of 9.40 mM against α-glucosidase. This compound enhances glucose uptake in yeast cells and demonstrates significant anti-glycation activity at high concentrations. α-Amylase-IN-12 is applicable for diabetes research.</p>Formule :C16H11NO4Couleur et forme :SolidMasse moléculaire :281.263HIF-2α-IN-5
CAS :<p>HIF-2α-IN-5 is a potent HIF-2α inhibitor with an IC 50 of < 50 nM [1].</p>Formule :C15H12F4O3S2Couleur et forme :SolidMasse moléculaire :380.38hCAII-IN-4
CAS :<p>hCAII-IN-4 (Compound 12j) is a potent inhibitor of human carbonic anhydrase II (hCA II), exhibiting an inhibitory concentration (IC50) of 7.78 μM.</p>Formule :C31H23NO9Couleur et forme :SolidMasse moléculaire :553.52Enpp-1-IN-12
<p>ENPP1-IN-12 is a potent, oral ENPP1 inhibitor with a Ki of 41 nM and anti-tumor properties.</p>Formule :C17H19N5O3SCouleur et forme :SolidMasse moléculaire :373.43(±)-HIP-B
CAS :<p>(±)-HIP-B is an excitatory amino acid transporter blocker.</p>Formule :C6H8N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :172.143,3'-[Dithiobis[2,1-ethanediyl(methylimino)]]bis[1-propanol]
CAS :<p>The compound 3,3'-[Dithiobis[2,1-ethanediyl(methylimino)]]bis[1-propanol] is an SS-cleavable, proton-activated lipid-like substance (SSPalm) that facilitates the delivery of plasmid DNA.</p>Formule :C12H28N2O2S2Couleur et forme :SolidMasse moléculaire :296.493Diacylglycerol acyltransferase inhibitor-2
CAS :<p>Diacylglycerolacyltransferaseinhibitor-2 (Example 8) acts as an inhibitor for diacylglycerol acyltransferase 2 (DGAT2), exhibiting an IC50 value of 3.7 nM.</p>Formule :C21H20FN5O4Couleur et forme :SolidMasse moléculaire :425.41MAGL-IN-18
CAS :<p>MAGL-IN-18 (compound 118) serves as a highly potent inhibitor of Monoacylglycerol lipase (MAGL), demonstrating an IC 50 value of 0.03nM.</p>Formule :C23H28F3N7OCouleur et forme :SolidMasse moléculaire :475.51L 671776
CAS :<p>L 671776 is an inositol monophosphatase inhibitor.</p>Formule :C23H32O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :388.53-Oxochenodeoxycholic acid
CAS :3-Oxochenodeoxycholic acid is an endogenous metabolite detectable in feces and may serve as a diagnostic marker for various diseases, including COVID-19.Formule :C24H38O4Masse moléculaire :390.556Lipid PPz-2R1
CAS :Lipid PPz-2R1 is an ionizable cationic lipid employed in crafting lipid nanoparticles (LNPs) for mRNA delivery both in vitro and in vivo. LNPs with lipid PPz-2R1, encapsulating an mRNA reporter, target the lungs preferentially over the heart, liver, spleen, and kidneys in mice. Additionally, these LNPs, when encapsulating mRNA encoding phosphatase and tensin homolog (PTEN), enhance PTEN protein levels in PTEN-deficient Lewis lung carcinoma (LLC) cells. In an orthotopic murine LLC model, these Lipid PPz-2R1-containing LNPs, carrying PTEN mRNA, reduce tumor growth either when administered alone or alongside an antibody against programmed cell death protein 1 (PD-1).Formule :C48H94N2O4Masse moléculaire :763.27Cephapirin lactone
CAS :Cephapirinlactone is a metabolite of the antibiotic Cephapirin.Formule :C15H13N3O4S2Masse moléculaire :363.41h15-LOX-2 inhibitor 3
CAS :<p>Compound 13, identified as h15-LOX-2 inhibitor 3, exhibits inhibitory activity against h15-LOX, with IC50 and Ki values of 25 μM and 15.1 μM, respectively.</p>Formule :C22H13N5O3Couleur et forme :SolidMasse moléculaire :395.37hCAI/II/XII-IN-1
CAS :<p>hCAI/II/XII-IN-1 (compound 7) is an inhibitor of human carbonic anhydrases hCAI, hCAII, and hCAXII, with Ki values of 78.5 nM, 9.1 nM, 605 nM, 7.7 nM, and 3.7 nM.</p>Formule :C12H12N2O2SCouleur et forme :SolidMasse moléculaire :248.301HSD17B13-IN-40
CAS :HSD17B13-IN-40 (compound 6) serves as a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), exhibiting an IC50 value of less than 0.1 μM using estradiol as substrates. This compound is significant in the treatment of nonalcoholic fatty liver diseases (NAFLDs), including nonalcoholic steatohepatitis (NASH) [1].Formule :C23H14Cl2F3N3O3Masse moléculaire :508.28OH-α-PVP TFA
CAS :OH-α-PVP (OH-α-Pyrrolidinovalerophenone) TFA is a metabolite of α-pyrrolidinovalerophenone, which is a synthetic cathinone stimulant.Formule :C17H24F3NO3Masse moléculaire :347.37SelB-1
CAS :<p>SelB-1 acts as a dual inhibitor of Topoisomerase I/II (TopoisomeraseI/II), exhibiting anticancer activity suitable for research on prostate and colon cancers. Additionally, SelB-1 can induce the expression of autophagy (autophagy) genes and lipid peroxidation while reducing GSH levels.</p>Formule :C32H24O5Couleur et forme :SolidMasse moléculaire :488.53ZSH-2208
CAS :<p>ZSH-2208 is a retinoic acid A analogue that inhibits tumour cell proliferation and survival through RARγ-TNFAIP3 and retinoid receptors.</p>Formule :C20H18O3SDegré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :338.42OSI-413 free base
CAS :<p>OSI-413 (free base) (CP 373413) is the primary metabolite of Erlotinib. Erlotinib (CP-358774) acts as a direct EGFR tyrosine kinase inhibitor with an IC50 of 2 nM against human EGFR.</p>Formule :C21H21N3O4Couleur et forme :SolidMasse moléculaire :379.409MK-3168 (12C)
CAS :<p>MK-3168 (12C) functions as a FAAH inhibitor, exhibiting IC50 values of 1.0 nM, 5.5 nM, and 1.7 nM for human, rhesus, and rat respectively. It demonstrates effective brain uptake and FAAH-specific signaling. Additionally, 11 C MK-3168 is applicable as a FAAH PET tracer.</p>Formule :C21H21ClN4OSCouleur et forme :SolidMasse moléculaire :412.94α-Glucosylrutin
CAS :<p>α-Glucosylrutin is an effective antioxidant known for its activity in scavenging free radicals. Due to its high epidermal bioavailability, it is commonly utilized in studies related to skin aging.</p>Formule :C33H40O21Couleur et forme :SolidMasse moléculaire :772.66BAY 3389934
CAS :<p>BAY 3389934 is a dual inhibitor of factor IIa (factor IIa) and factor Xa (factor Xa), providing anticoagulant and organ-protective effects. It alleviates coagulopathy and organ dysfunction in baboon models of Staphylococcus aureus sepsis.</p>Formule :C26H30ClN5O7S2Couleur et forme :SolidMasse moléculaire :624.129Urobilin hydrochloride
CAS :<p>Urobilin hydrochloride, a metabolic byproduct of Hemoglobin, is excreted through urine and feces in various mammals. It also serves as an indicator of human waste contamination.</p>Formule :C33H43ClN4O6Couleur et forme :SolidMasse moléculaire :627.17RWJ 22108
CAS :<p>RWJ 22108 is a bronchial-selective calcium channel (calcium channel) blocker that exhibits an IC50 of 5.7 nM in dog bronchial smooth muscle calcium-dependent contractions.</p>Formule :C27H30ClFN2O4SCouleur et forme :SolidMasse moléculaire :533.06Valerate sodium
CAS :<p>Valerate sodium is a potential Carbonic anhydrase 1/2 inhibitor for biochemical experiments.</p>Formule :C5H9NaO2Degré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :124.11CA IX-IN-1
<p>CA IX-IN-1 (compound 12g) is a potent and highly selective hCA IX inhibitor (IC50: 7 nM) that exhibits antitumour effects.</p>Formule :C16H22N4O8SCouleur et forme :SolidMasse moléculaire :430.43IDO1-IN-25
CAS :<p>IDO1-IN-25, a dual inhibitor of IDO1/TDO2, showcases IC50 values of 0.17 μM for IDO1 and 3.2 μM for TDO2. It effectively suppresses NO production in RAW264.7 cells following stimulation with lipopolysaccharide (LPS). Additionally, IDO1-IN-25 demonstrates anti-inflammatory properties in a mouse ear edema model of acute inflammation induced by croton oil.</p>Formule :C14H8Cl3NO2SCouleur et forme :SolidMasse moléculaire :360.64Falecalcitriol
CAS :<p>Falecalcitriol is an analog of calcitriol. It has a higher potency both in vivo and in vitro systems, which is longer duration of action in vivo.</p>Formule :C27H38F6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :524.58Carbonic anhydrase inhibitor 3
<p>Carbonic anhydrase inhibitor 3 (compound 11g) is an inhibitor of carbonic anhydrase II that reduces the intraocular pressure in glaucomatous rabbits [1].</p>Formule :C15H17N3O3SCouleur et forme :SolidMasse moléculaire :319.38ZK168281
CAS :<p>ZK168281 is a 1α,25(OH)2D3 analog, VDR antagonist with 0.1 nM Kd, and blocks receptor CoA interaction.</p>Formule :C32H46O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :510.70PTP1B-IN-17
<p>PTP1B-IN-17, a benzimidazole derivative, inhibits PTP1B (Ki: 30.2 μM) and may help study type 2 diabetes.</p>Formule :C26H19N3O4SCouleur et forme :SolidMasse moléculaire :469.51
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