Métabolisme

<p>Selective inhibitor of Ca2+-calmodulin-dependent protein phosphatase (calcineurin) (IC50 ~ 10 μM). Does not inhibit PP1, PP2A or CaM kinase II (IC50 &gt; 100 mM).</p>

<p>Z-Pro-prolinal, an orally active PREP inhibitor, IC50: 0.4 nM in porcine.</p>

<p>Mitochondrial inhibitor 49 (respiration-IN-1 hydrobromide, IC50=8.8 mg/mL) from US20110301180A1 reduces platelet respiration.</p>

<p>sPLA2 inhibitor 3 (Compound 6c) functions as a potent α-glucosidase inhibitor (IC50= 0.0953 µM) and has potential applications in diabetes research.</p>

<p>POPG sodium salt is a phospholipid and a component of biological membranes and can be used to study the function of biological membranes.</p>

<p>a1,3GalT (GGTA1) synthesizes α-gal glycan by adding galactose from UDP to glycoproteins.</p>

<p>Guanosine triphosphate tritris (GTP tritris) serves as a crucial enhancer in myocyte differentiation, playing an essential role in regulating miRNA-muscle regulatory factors. It promotes the release of exosomes rich in guanine and guanine-derived molecules, and is considered an activation precursor for RNA synthesis. In mitochondrial functionality, GTP is involved in the entry of proteins into the matrix, which is vital for various regulatory pathways. It initiates peptide synthesis by facilitating the binding of formylmethionine-tRNA to the ribosome, and aids in polypeptide chain elongation. Additionally, GTP acts as a carrier for phosphates and pyrophosphates, channeling chemical energy into specific biosynthetic pathways. It activates signal transduction G proteins, regulates cellular processes such as proliferation and differentiation, and its hydrolysis by small GTPases (including Ras and Rho) is indispensable for both proliferation and apoptosis. Furthermore, the small GTPase Rab assists in vesicle docking, fusion, and formation. Beyond signal transduction, GTP is also an energy-rich precursor in the biosynthesis of DNA and RNA enzymes.</p>

<p>Febuxostat impurity 6 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K i of 0.6 nM [1] .</p>

<p>RMC-3943 is a potent SHP2 allosteric inhibitor with an IC50 of 2.19 nM.</p>

<p>7-Hydroxydichloromethotrexate is a methotrexate metabolite.</p>

<p>6α-hydroxy Paclitaxel (6α-OH-PTX) is a major metabolite of the anticancer compound paclitaxel and is partially cytotoxic.</p>

<p>TDC, a PLP-dependent enzyme, removes carboxyl groups from tyrosine, producing tyramine and CO2, found in plants, insects, and microbes.</p>

<p>Sphingomyelin phosphodiesterase, a hydrolase, converts sphingomyelin into phosphocholine and ceramide, affecting cellular processes and cholesterol metabolism.</p>

<p>D-myo-Inositol-1,4,5-triphosphate tripotassium is a second messenger in the intracellular signaling system that induces Ca2+ mobilization.</p>

<p>TDI-11055 is a chromatin reader 11-19 leukemia inhibitor and can be used to study acute myeloid leukemia (AML).</p>

<p>Perfluorobutane is a gas that is colorless.</p>

<p>FA-Ala-Arg is a dipeptide featuring a furylacryloyl group that degrades to yield arginine.</p>

<p>Daprodustat (GSK1278863) is a HIF-prolyl hydroxylase inhibitor.</p>

<p>α-Glucosidase-IN-75 (compound 13) is an inhibitor of α-glucosidase, exhibiting an IC50 value of 3.81 μM. It is employed in the study of cardiovascular diseases induced by high glucose levels.</p>

<p>BMT-297376, the optimized Linrodostat, is a potent IDO1 inhibitor.</p>