Métabolisme
Les inhibiteurs du métabolisme sont des composés qui interfèrent avec les voies métaboliques, modifiant ainsi la production et l'utilisation de l'énergie au sein des cellules. Ces inhibiteurs sont utilisés pour étudier la régulation du métabolisme, le rôle des voies métaboliques dans des maladies telles que le cancer et le diabète, et pour développer de nouvelles stratégies thérapeutiques. Les inhibiteurs du métabolisme peuvent cibler diverses enzymes et processus impliqués dans la glycolyse, l'oxydation des acides gras et d'autres fonctions métaboliques. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de métabolisme de haute qualité pour soutenir vos recherches en biochimie, troubles métaboliques et développement de médicaments.
Sous-catégories appartenant à la catégorie "Métabolisme"
- AhR(41 produits)
- Aminopeptidase(67 produits)
- CETP(18 produits)
- Anhydrase carbonique(178 produits)
- Caséine Kinase(130 produits)
- DHFR(33 produits)
- Décarboxylase(4 produits)
- Déshydrogénase(270 produits)
- FAAH(64 produits)
- FXR(58 produits)
- Facteur Xa(80 produits)
- Synthase des acides gras(33 produits)
- Ferroptose(215 produits)
- GR(3 produits)
- GSNOR(3 produits)
- Glucokinase(54 produits)
- Prolyl-Hydroxylase de HIF/HIF(142 produits)
- HMG-CoA Réductase(33 produits)
- Hydroxylase(30 produits)
- IDO(82 produits)
- LDL(8 produits)
- Lipase(97 produits)
- Lipides(59 produits)
- Lipoxygénase(125 produits)
- MAO(87 produits)
- MPO(2 produits)
- NAMPT(36 produits)
- P450(6 produits)
- PAI-1(25 produits)
- PDE(166 produits)
- PED(1 produits)
- PKM(15 produits)
- PPAR(164 produits)
- Phospholipase(82 produits)
- ROR(42 produits)
- Récepteur de rétinoïdes(29 produits)
- SGK(11 produits)
- Thioredoxine(12 produits)
- Transférase(30 produits)
- Tansporteur(42 produits)
- UGT(4 produits)
- Inhibiteurs de la xanthine oxydase (XO)(9 produits)
Affichez 34 plus de sous-catégories
8626 produits trouvés pour "Métabolisme"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
3-Hydroxycarbofuran
CAS :<p>3-Hydroxycarbofuran, a principal metabolite of Carbofuran, acts as a reversible inhibitor of acetylcholinesterase (AChE) [1].</p>Formule :C12H15NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :237.25PDE5-IN-42
CAS :<p>PDE5-IN-42 is a selective inhibitor of second-generation phosphodiesterase type 5 (PDE5).</p>Formule :C23H31N7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :453.541-Stearoyl-2-hydroxy-sn-glycero-3-PG sodium
CAS :<p>1-Stearoyl-2-hydroxy-sn-glycero-3-PG, a lysophospholipid characterized by the presence of stearic acid (18:0) at the sn-1 position, finds application in the creation of micelles, liposomes, and various artificial membranes, including those utilized in lipid-based drug delivery systems.</p>Formule :C24H48NaO9PCouleur et forme :SolidMasse moléculaire :534.60312(R)-HEPE
CAS :<p>12(R)-HEPE, a monohydroxy fatty acid derived from EPA in the eggs of the sea urchin S. purpuratus, has a biological activity that, while not extensively documented, may resemble that of 12(R)-HETE (Catalog No.34560).</p>Formule :C20H30O3Couleur et forme :SolidMasse moléculaire :318.5Sulforhodamine 101 DHPE
CAS :<p>Sulforhodamine 101 DHPE, a fluorescent probe, results from the conjugation of sulforhodamine 101, a red fluorescent dye with excitation/emission spectra of 586/605 nm, to the phospholipid 1,2-dipalmitoyl-sn-glycero-3-PE. It effectively integrates into phospholipid bilayers and is utilized for imaging solid supported lipid bilayers, detecting protein-ligand interactions on bilayers, and monitoring lipid probe colocalization in liposomes through resonance energy transfer (RET).</p>Formule :C74H117N4O14PS2Couleur et forme :SolidMasse moléculaire :1381.86YM17E
CAS :<p>YM17E is an inhibitor of ACAT with IC50 of 44 nM in rabbit liver microsomes in vitro.</p>Formule :C40H56N6O2Degré de pureté :99.29%Couleur et forme :SolidMasse moléculaire :652.91RORγt modulator 4
CAS :<p>RORγt modulator 4 is a RORγt modulator that regulates IL-17A production activity in cells derived from mouse spleen.</p>Formule :C26H27N3O4SCouleur et forme :SolidMasse moléculaire :477.58ICMT-IN-19
CAS :<p>ICMT-IN-19 (compound 53) serves as a potent inhibitor of ICMT, demonstrating an IC50 value of 0.026 μM [1].</p>Formule :C21H26N2O3Couleur et forme :SolidMasse moléculaire :354.44C82
CAS :<p>C82 acts as an inhibitor of Mycobacterium tuberculosis (Mtb) cyclic dinucleotide phosphodiesterase (CdnP), with an IC50 value of 17.5 µM. This particular enzyme is responsible for breaking down cyclic di-AMP (c-di-AMP) into adenosine 5'-monophosphate (AMP). Notably, C82 demonstrates selectivity for Mtb CdnP over other bacterial cyclic dinucleotide phosphodiesterases (CDN PDEs) such as Yybt, RocR, and Group B Streptococcus (GBS) CdnP, as well as the mammalian CDN PDE ENPP1, and the viral CDN PDE poxin, showing effectiveness at a concentration of 200 µM.</p>Formule :C17H17N3O3SCouleur et forme :SolidMasse moléculaire :343.4ACT-606559
<p>ACT-606559, a metabolite of ACT451840, is a novel chemical compound exhibiting antimalarial properties. It is utilized in malaria research.</p>Formule :C47H52N6O3Couleur et forme :SolidMasse moléculaire :748.95(±)-2'-hydroxy Ceramide (d18:0/18:0)
CAS :<p>"(±)-2'-Hydroxy Ceramide (d18:0/18:0) is a sphingomyelin derivative isolated from mammalian platelets upon ADP stimulation [1]."</p>Formule :C36H73NO4Couleur et forme :SolidMasse moléculaire :583.983KD-026
CAS :<p>KD-026 (SLx 4090), a microsomal triglyceride transfer protein (MTP) inhibitor(IC50 = 8.0 nM), is used in type 2 diabetes studies.</p>Formule :C31H25F3N2O4Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :546.54JTT 551
CAS :<p>JTT 551: Selective PTP1B inhibitor for type 2 diabetes research; Ki=0.22μM for PTP1B, 9.3μM for TCPTP.</p>Formule :C34H43N3O3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :605.85N-Palmitoyl Taurine
CAS :<p>N-Palmitoyl taurine, an amino-acyl endocannabinoid prominent in rat brain lipidomics profiling, accompanies multiple arachidonoyl amino acids isolated from bovine brain, including N-arachidonoylethanolamine (NADA) and N-arachidonoyl serine (ARA-S). Mass spectral lipidomic analysis of rat brain additionally revealed a series of fatty acyl amides with taurine. The function of N-Palmitoyl taurine is under investigation.</p>Formule :C18H37NO4SCouleur et forme :SolidMasse moléculaire :363.6ICMT-IN-37
CAS :<p>ICMT-IN-37 (compound 41) serves as an inhibitor of ICMT with an IC50 value of 0.308 μM [1].</p>Formule :C22H28ClNOCouleur et forme :SolidMasse moléculaire :357.921,2-Dilauroyl-sn-glycero-3-PA sodium
CAS :<p>DLPA is a phosphatidic acid (PA) that incorporates the medium-chain lauric acid (12:0).</p>Formule :C27H52O8PNaCouleur et forme :SolidMasse moléculaire :558.661,2-Dipropionyl-sn-glycero-3-PC
CAS :<p>1,2-Dipropionyl-sn-glycero-3-phosphocholine (PC) is a phospholipid characterized by the presence of propionic acid at its sn-1 and sn-2 positions. This compound has applications in the investigation of interactions between water and the phosphocholine headgroup in aqueous solutions.</p>Formule :C14H28NO8PCouleur et forme :SolidMasse moléculaire :369.4FR-190809
CAS :<p>FR-190809 is a nonadrenotoxic and orally efficacious inhibitor of acyl-CoA:cholesterol O-acyltransferase (ACAT) (IC50: 45 nM).</p>Formule :C29H34FN3O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :603.73KRP-109
CAS :<p>KRP-109, a neutrophil elastase (NE) inhibitor, acts by decreasing expression of TGF-ß Signal Related Genes.</p>Formule :C26H30N4O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :510.547Dieicosanoin
CAS :<p>Dieicosanoin is a diacylglycerol that incorporates arachidic acid, a saturated long-chain fatty acid featuring a 20-carbon backbone. This acid is derivable from sources such as peanut butter and anaerobic fungi [1] [2].</p>Formule :C43H84O5Couleur et forme :SolidMasse moléculaire :681.12 (Monomer)L791943
CAS :<p>L791943 is a selective, potent) inhibitor of Phosphodiesterase-4 (PDE4,IC50 of 4.2 nM).</p>Formule :C24H17F10NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :573.38QH536
CAS :<p>QH536 degrades HMGCR (EC50: 0.22 μM), has anti-inflammatory properties, and avoids cholesterol buildup; useful for cardiovascular and NASH research.</p>Formule :C33H49N3O3Couleur et forme :SolidMasse moléculaire :535.76GSK2647544
CAS :<p>GSK2647544 inhibits Lp-PLA2, a pro-inflammatory enzyme from macrophages, orally active, calcium-independent.</p>Formule :C24H18ClF3N4O3Couleur et forme :SolidMasse moléculaire :502.87ICMT-IN-38
CAS :<p>ICMT-IN-38 (Compound 42) is an ICMT inhibitor, demonstrating an IC50 value of 0.049 μM [1].</p>Formule :C22H28ClNOCouleur et forme :SolidMasse moléculaire :357.92MAGL-IN-6
CAS :<p>MAGL-IN-6, a powerful MAGL blocker, IC50 at 4.71 nM, may assist in neurological disease research.</p>Formule :C24H19F3N4OCouleur et forme :SolidMasse moléculaire :436.43Lateritin
CAS :<p>Lateritin (Bassiatin) is An Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor and a platelet aggregation inhibitor from the mycelial cake of Gibberella</p>Formule :C15H19NO3Degré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :261.32RB 101
CAS :<p>RB 101 suppresses enkephalinase and aminopeptidases; biologically cleaved at disulfide to produce inhibitors of both aminopeptidase N and neutral endopeptidase.</p>Formule :C31H38N2O3S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :582.84ML395
CAS :<p>ML395 is a potent, selective PLD2 allosteric inhibitor with potent antiviral activity (IC50 =360 nM).</p>Formule :C26H29N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :443.54L-869298
CAS :<p>L-869298 is a potent and selective inhibitor of PDE4.</p>Formule :C23H18F8N2O4SCouleur et forme :SolidMasse moléculaire :570.45Siguazodan
CAS :<p>Siguazodan (SKF 94836) is an effective, selective, orally active phosphodiesterase III ((PDE-III)) inhibitor with an IC50 of 117 nM.</p>Formule :C14H16N6ODegré de pureté :99.62% - 99.87%Couleur et forme :SolidMasse moléculaire :284.32C12-113
CAS :<p>C12-113, a lipidoid delivery agent, effectively transfects siRNA into cells and, when combined with additional lipids, forms lipid nanoparticles (LNPs). These LNPs facilitate the delivery of mRNA encoding the spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in mice [1] [2].</p>Formule :C53H111N3O4Couleur et forme :SolidMasse moléculaire :854.47Oseltamivir acid methyl ester
CAS :<p>Oseltamivir acid methyl ester, a CES1-convertible neuraminidase inhibitor, serves as an antiviral prodrug.</p>Formule :C15H26N2O4Degré de pureté :98.78%Couleur et forme :SolidMasse moléculaire :298.38cKK-E15
CAS :<p>cKK-E15, a peptide-lipid, is instrumental in formulating LNP3 alongside C14PEG2000, unmodified cholesterol, and DOPE [1].</p>Formule :C72H144N4O6Couleur et forme :SolidMasse moléculaire :1161.94ICMT-IN-21
CAS :<p>ICMT-IN-21 (compound 6ag) is an ICMT inhibitor with an IC50 value of 8.8 µM, featuring sulfonamide-modified farnesyl cysteine (SMFC).</p>Formule :C22H33NO4S3Couleur et forme :SolidMasse moléculaire :471.7Lp-PLA2-IN-2
CAS :<p>Lp-PLA2-IN-2 is a selective and potent lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC50 0f 120 nM for recombinant human Lp-PLA2.</p>Formule :C19H23FN2O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :394.46Biliverdin
CAS :<p>Biliverdin, produced through the oxidation of bilirubin, can also be synthesized through a non-protoporphyrin pathway in Corynebacterium glutamicum [1].</p>Formule :C33H34N4O6Couleur et forme :SolidMasse moléculaire :582.65Prostaglandin H2
CAS :<p>Prostaglandin H2 (PGH2), initially isolated from the incubation of arachidonic acid with ovine seminal vesicle microsomes, acts as a potent vasoconstrictor. It serves as the precursor for all 2-series prostaglandins (PGs) and thromboxanes (TXs). Moreover, as a TP receptor agonist, PGH2 irreversibly aggregates human platelets at concentrations of 50-100 ng/ml.</p>Formule :C20H32O5Couleur et forme :SolidMasse moléculaire :352.4711,2-Dioleoyl-3-Docosohexaenoyl-rac-glycerol
CAS :<p>1,2-Dioleoyl-3-docosohexaenoyl-rac-glycerol, a triacylglycerol, consists of oleic acid at the sn-1 and sn-2 positions and docosahexaenoic acid at the sn-3 position. This compound has been identified in human breast milk.</p>Formule :C61H102O6Couleur et forme :SolidMasse moléculaire :931.46LFHP-1c
CAS :<p>LFHP-1c, a neuroprotective PGAM5 inhibitor, demonstrates efficacy in preserving blood-brain barrier integrity following ischemic stroke.</p>Formule :C55H64N6O4Degré de pureté :98.07%Couleur et forme :SolidMasse moléculaire :873.13UK-157147
CAS :<p>UK-157147 is a substrate for UGT1A1(Km: 105 μM).</p>Formule :C23H24N2O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :472.51L-690488
CAS :<p>L-690488 has more effective cell penetration than L-690330. L-690488 is a prodrug of L-690330 and is a selective inositol monophosphatase (IMPase) inhibitor.</p>Formule :C32H52O16P2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :754.69ATX inhibitor 15
CAS :<p>ATX inhibitor 15, an indole-based carbamate, has a 2.17 nM IC50 against ATX, suppresses pro-fibrotic genes, and protects against mouse lung fibrosis.</p>Formule :C27H32ClN5O4SCouleur et forme :SolidMasse moléculaire :558.09AZD-1656
CAS :<p>AZD-1656 is a glucokinase activator (GKA) that can cause dose-limiting hypoglycemia in normal animals used in embryofetal development studies and type 2</p>Formule :C24H26N6O5Degré de pureté :97.07% - 99.37%Couleur et forme :SolidMasse moléculaire :478.59(E),11(E)-Conjugated Linoleic Acid
CAS :<p>9(E),11(E)-Conjugated Linoleic Acid (9(E),11(E)-CLA) belongs to a group of eight geometric isomers of linoleic acid, characterized by adjacent double bonds. This specific isomer, 9,11 all-trans linoleic acid, was first discovered in ground beef and is found in various dairy products as well. Notably, it has been shown to decrease mammary tumors in rats with dietary inclusion as minimal as 0.1%. [Matreya, LLC. Catalog No. 1181]</p>Formule :C18H32O2Couleur et forme :SolidMasse moléculaire :280.452VU0155069 hydrochloride
CAS :<p>VU0155069 hydrochloride (CAY10593 hydrochloride) is a potent and selective inhibitor of phospholipase D (PLD), exhibiting IC50 values of 46 nM for PLD1 and 933 nM for PLD2. It effectively inhibits the migration of both human and mouse breast cancer cell lines [1] [2].</p>Formule :C26H28Cl2N4O2Couleur et forme :SolidMasse moléculaire :499.43N-Methyl Palbociclib
CAS :<p>N-Methyl Palbociclib is an impurity of the orally active selective CDK4 and CDK6 inhibitor Palbociclib (PD 0332991).</p>Formule :C25H31N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :461.56GLUT4 activator 1
CAS :<p>GLUT4 activator 1 is a potent glucose transporter type 4 (GLUT4) translocation activator (EC50: 0.14 μM).</p>Formule :C23H21FN4O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :452.51-Deazaadenosine
CAS :<p>1-Deazaadenosine, an adenosine deaminase inhibitor (Ki: 0.66 μM), may treat cancer, particularly lymphoproliferative disorders.</p>Formule :C11H14N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :266.25II-B08
CAS :<p>II-B08 is a cell-permeable SHP2 inhibitor (IC50 = 5.5 µM). II-B08 blocks growth factor stimulated ERK1/2 activation and hematopoietic progenitor proliferation.</p>Formule :C33H27N5O4Couleur et forme :SolidMasse moléculaire :557.6M-0002
CAS :<p>M-0002, a vasopressin V2 receptor antagonist, is used potentially for the treatment of ascites.</p>Formule :C32H29Cl2N3O3Couleur et forme :SolidMasse moléculaire :574.5CoPoP
CAS :<p>CoPoP, a liposome-based vaccine adjuvant, holds potential for application in cancer research [1].</p>Formule :C57H80CoN5O9PCouleur et forme :SolidMasse moléculaire :1069.18BMS-962212
CAS :<p>BMS-962212: reversible, selective FXIa blocker, well-tolerated, quick PD effect, rapid clearance, alters clotting time/activity.</p>Formule :C32H28ClFN8O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :659.07IDO-IN-9
CAS :<p>IDO-IN-9 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.011 μM (Kinase) and 0.0018 μM (Hela Cell).</p>Formule :C13H13BrFN7O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :446.251,2-Dioleoyl-3-Stearoyl-rac-glycerol
CAS :<p>1,2-Dioleoyl-3-stearoyl-rac-glycerol, a triacylglycerol, features oleic acid at the sn-1 and sn-2 positions and stearic acid at the sn-3 position. This compound is present in sunflower, corn, and soybean oils, as well as in ostrich oil.</p>Formule :C57H106O6Couleur et forme :SolidMasse moléculaire :887.45Glycosidase-IN-2
CAS :<p>Glycosidase-IN-2 is a glycosidase inhibitor with hypoglycemic activity.</p>Formule :C13H23NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :273.331,3-Dipalmitoyl glycero-2-PE
CAS :<p>1,3-Dipalmitoyl glycero-2-phosphatidylethanolamine is a phospholipid incorporating saturated long-chain (16:0) stearic acid at the sn-1 and sn-3 positions, with phosphatidylethanolamine (PE) at the sn-2 position. Phosphatidylethanolamines, critical components of biological membranes, play essential structural and functional roles. Various PE types are instrumental in forming micelles, liposomes, and other synthetic membranes.</p>Formule :C37H74NO8PCouleur et forme :SolidMasse moléculaire :691.972COX-2-IN-30
CAS :<p>COX-2-IN-30, a benzenesulfonamide derivative, is an orally active, dual inhibitor of cyclooxygenase-2 (COX-2; IC50 = 49 nM) and cyclooxygenase-1 (COX-1; IC50 =</p>Formule :C17H16N6O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :384.41JNJ-10258859
CAS :JNJ-10258859 is a potent, and selective phosphodiesterase type 5 inhibitor with a K(i) of 0.23 nM.Formule :C30H24N4O3Couleur et forme :SolidMasse moléculaire :488.54ICMT-IN-29
CAS :<p>ICMT-IN-29, also known as compound 66, effectively inhibits ICMT with an IC50 value of 0.019 μM [1].</p>Formule :C20H27NO2SCouleur et forme :SolidMasse moléculaire :345.53-Oxo Atorvastatin
CAS :<p>3-Oxo Atorvastatin is an impurity of Atorvastatin. Atorvastatin is an HMG-CoA reductase inhibitor and has the ability to effectively decrease blood lipids.</p>Formule :C33H33FN2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :556.62AMC Arachidonoyl Amide
CAS :<p>Arachidonoyl amide (AMC-AA) is a fatty acid amide among several that serve to quantify fatty acid amide hydrolase (FAAH) activity. FAAH, with its relative lack of selectivity, processes various amide head groups beyond ethanolamine, the head group of its primary endogenous substrate, anandamide (AEA). The interaction of AMC-AA with FAAH leads to the liberation of fluorescent aminomethyl coumarin, which has an absorption peak at 360 nm and emission at 465 nm. This fluorescence release facilitates the rapid and efficient assessment of FAAH activity through the utilization of either a standard cuvette or a microplate fluorometer.</p>Formule :C30H39NO3Couleur et forme :SolidMasse moléculaire :461.6ZK824859
CAS :<p>ZK824859 is an oral uPA inhibitor with IC50s: 79 nM (uPA), 1580 nM (tPA), 1330 nM (plasmin).</p>Formule :C23H22F2N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :428.439(Z),11(E)-Conjugated Linoleic Acid methyl ester
CAS :<p>9(Z),11(E)-Conjugated Linoleic Acid Methyl Ester, identified in lemon grass (C. flexuosus), serves as a standard for quantifying conjugated linoleic acids in thermally stressed olive oil and trans fats in bakery products. [Matreya, LLC. Catalog No. 1255]</p>Formule :C19H34O2Couleur et forme :SolidMasse moléculaire :294.479DPM-1001 trihydrochloride
<p>DPM-1001 trihydrochloride: Potent PTP1B inhibitor, IC50 100 nM, oral, non-competitive, anti-diabetic.</p>Formule :C35H60Cl3N3O3Couleur et forme :SolidMasse moléculaire :677.23Monohydroxy Melphalan hydrochloride
CAS :<p>Monohydroxy melphalan, a degradation product and DNA alkylating agent derived from melphalan, results from melphalan hydrolysis in aqueous solutions such as cell culture medium and human plasma. It enhances DNA adducts in ML-1 myeloblastic leukemia cells based on concentration and induces cytotoxicity with an IC50 value of 28.1 μg/ml.</p>Formule :C13H19ClN2O3HClCouleur et forme :SolidMasse moléculaire :359.68S-Benzylglutathione
CAS :<p>S-Benzylglutathione acts as a competitive inhibitor of glutathionase and undergoes conversion by rat kidney microsomes into its cysteine derivatives.</p>Formule :C17H23N3O6SCouleur et forme :SolidMasse moléculaire :397.45(Rac)-Lonafarnib
CAS :<p>(Rac)-Lonafarnib is a racemic FTase inhibitor, effective against H-ras, K-ras, N-ras (IC50: 1.9, 5.2, 2.8 nM), and has anti-HDV properties.</p>Formule :C27H31Br2ClN4O2Couleur et forme :SolidMasse moléculaire :638.82Edaglitazone
CAS :<p>Edaglitazone (R-483) is a PPARγ agonist with antiplatelet activity that can be used in studies of diabetes and obesity.</p>Formule :C24H20N2O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :464.56Glyoxalase I inhibitor 3
CAS :<p>Compound 22g: potent GLO1 inhibitor; IC50=0.011 μM; potential for depression, anxiety research.</p>Formule :C22H21N3O3Couleur et forme :SolidMasse moléculaire :375.42FXIa-IN-1
CAS :<p>FXIa-IN-1 is a potent β-lactam covalent heparin-derived factor XIa (fXIa) inhibitor.</p>Formule :C20H19F3N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :452.38CJ-463
CAS :<p>CJ-463, a selective uPA blocker, shows strong anti-tumor effect, especially at 100mg/kg, potentially treating lung cancer.</p>Formule :C21H27N5O6SCouleur et forme :SolidMasse moléculaire :477.531-Palmitoyl-3-Stearoyl-rac-glycerol
CAS :<p>1-Palmitoyl-3-stearoyl-rac-glycerol, a diacylglycerol, features palmitic acid at the sn-1 position and stearic acid at the sn-3 position. This compound appears in palm-based diacylglycerols derived from palm stearin, palm mid fraction, palm oil, and palm olein, as well as in extracts of wheat bran and brewer's spent grain.</p>Formule :C37H72O5Couleur et forme :SolidMasse moléculaire :596.96JW 618
CAS :<p>JW 618 is a selective inhibitor of ABHD6, demonstrating inhibition concentrations (IC50 values) of 38 nM for mouse ABHD6 and 13 nM for rat ABHD6, indicating its potent activity across species [1].</p>Formule :C17H14F6N2O2Couleur et forme :SolidMasse moléculaire :392.3FXa-IN-1
CAS :<p>FXa-IN-1, an FXa blocker: IC50=3 nM, Ki=0.7 nM, orally available, long half-life, for thrombosis research.</p>Formule :C24H18F5N5OCouleur et forme :SolidMasse moléculaire :487.4215-deoxy-Δ12,14-Prostaglandin D2
CAS :<p>15-deoxy-Δ12,14-Prostaglandin D2 (15-deoxy-Δ12,14-PGD2) is a PGD2 metabolite functioning as an agonist for the PGD2 receptor 2 (DP2), with a binding affinity (Ki) of 50 nM for the mouse DP2 receptor expressed in HEK293 cell membranes. It activates eosinophils with an EC50 of 8 nM and enhances the recruitment of steroid receptor coactivator-1 (SRC-1) to peroxisome proliferator-activated receptor γ (PPARγ), initiating PPARγ-mediated transcription at 5 µM concentration. Furthermore, it exhibits cytotoxicity towards L1210 murine leukemia cells with an IC50 of 0.3 µg/ml and displays weaker inhibition of ADP-induced platelet aggregation than PGD2, with an IC50 of 320 ng/ml.</p>Formule :C20H30O4Couleur et forme :SolidMasse moléculaire :334.456Thioquinapiperifil
CAS :<p>Thioquinapiperifil is a type of phosphodiesterase-5 (PDE-5) inhibitor found in dietary supplements.</p>Formule :C24H28N6OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :448.58EMD638683 S-Form
CAS :<p>EMD638683 is a highly selective SGK1 inhibitor with IC50 of 3 μM. EMD638683 S-Form is the S-form of EMD638683.</p>Formule :C18H18F2N2O4Couleur et forme :SolidMasse moléculaire :364.34Prostaglandin F2α-1-glyceryl ester
CAS :<p>Prostaglandin F2α-1-glyceryl ester undergoes oxidation via 15-hydroxyprostaglandin dehydrogenase (15-HPGDH) [1].</p>Formule :C23H40O7Couleur et forme :SolidMasse moléculaire :428.566SH-BC-893
CAS :<p>SH-BC-893: Oral anti-cancer sphingolipid analog, prevents ceramide-related mitochondrial issues, and tackles diet-related obesity.</p>Formule :C19H32ClNOCouleur et forme :SolidMasse moléculaire :325.92Iomazenil
CAS :<p>Iomazenil is an antagonist and partial inverse agonist of benzodiazepine and potential therapy for alcohol abuse.</p>Formule :C15H14IN3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :411.19ICMT-IN-9
CAS :<p>ICMT-IN-9 (compound 47) is a potent ICMT inhibitor with an IC50 value of 0.16 μM [1].</p>Formule :C22H28FNO2Couleur et forme :SolidMasse moléculaire :357.46BI-11634
CAS :<p>BI-11634 is a factor Xa inhibitor.</p>Formule :C22H23ClN4NaO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :465.89BIO-32546
CAS :<p>BIO-32546 (S-isomer) is a highly potent regulator of autotaxin (ATX) with an IC50 value of 1 nM.</p>Formule :C28H31F6NO3Degré de pureté :98.03%Couleur et forme :SolidMasse moléculaire :543.541-Isopropyltryptophan
CAS :<p>1-Isopropyltryptophan (1-IsoPT), an IDO1 inhibitor, suppresses the expression of IDO-1 and IDO-2 mRNA induced by IFN-γ stimulation [1].</p>Formule :C14H18N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :246.3FTI-2153
CAS :<p>FTI-2153 inhibits farnesyltransferase with 1.4 nM IC50, >3000x more effective on H-Ras than Rap1A.</p>Formule :C25H30N4O3SCouleur et forme :SolidMasse moléculaire :466.6FASN-IN-1
CAS :<p>FASN-in-1 is an effective, specific inhibitor of fatty acid synthase (FASN), a compound specifically designed to target and inhibit the activity of the enzyme</p>Formule :C18H25N3O3S2Degré de pureté :99.92% - >99.99%Couleur et forme :SolidMasse moléculaire :395.54Diflumidone sodium
CAS :<p>Diflumidone sodium is a non-steroidal agent with anti-inflammatory activity.</p>Formule :C14H10F2NNaO3SCouleur et forme :SolidMasse moléculaire :333.29CAXII-IN-1
CAS :<p>CAXII-IN-1, antitumor, selectively inhibits CA XII with Ki of 3.8 nM for hCA XII and 56 nM for hCA IX.</p>Formule :C13H7Cl2NO3SCouleur et forme :SolidMasse moléculaire :328.17LNP Lipid-8
CAS :<p>LNP Lipid-8 (11-A-M), an ionizable lipid, is utilized in lipid nanoparticles (LNP) for siRNA delivery to T cells without ligand targeting. When loaded with GFP siRNA (siGFP), it significantly silences the GFP gene in a mouse model [1].</p>Formule :C42H71NO7Couleur et forme :SolidMasse moléculaire :702.02LY-338979
CAS :<p>LY-338979 is an impurity of pemetrexedone.</p>Formule :C20H21N5O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :443.41Z-Pro-Pro-CHO
CAS :<p>Z-Pro-Pro-CHO acts as a prolyl oligopeptidase inhibitor with half-maximal inhibitory concentrations (IC50) of 0.16 μM for human prolyl oligopeptidase and 0.01</p>Formule :C18H22N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :330.38DHODH-IN-22
CAS :<p>DHODH-IN-22: potent, selective DHODH inhibitor, orally active, IC50: 0.3 nM, for AML research.</p>Formule :C21H21ClF4N6O5Couleur et forme :SolidMasse moléculaire :548.88Palmitoleic Acid sodium
CAS :<p>Palmitoleic acid, an ω-7 monounsaturated fatty acid found in macadamia and sea buckthorn oils, enhances both basal and insulin-stimulated glucose uptake, as well as Glut4 protein levels in 3T3-L1 adipocytes at a 200 µM concentration. Ex vivo, at a dosage of 300 mg/kg per day, it significantly increases glucose uptake and both aerobic and anaerobic glycolysis, while decreasing de novo fatty acid synthesis and the activity of lipogenic enzymes, specifically ATP citrate lyase (ACL) and glucose-6-phosphate dehydrogenase (G6PDH), in isolated murine adipocytes. Furthermore, the dietary administration of palmitoleic acid at 300 mg/kg mitigates high-fat diet-induced insulin resistance and liver inflammation in mice.</p>Formule :C16H29O2NaCouleur et forme :SolidMasse moléculaire :276.39BMS-185411
CAS :<p>BMS-185411 is a bio-active chemical.</p>Formule :C26H23NO3Couleur et forme :SolidMasse moléculaire :397.47AZD7687
CAS :<p>AZD7687: Selective DGAT1 inhibitor, IC50 of 80 nM. In vitro reduces postprandial TAG. In vivo significant GI side effects at >5 mg/day dose.</p>Formule :C21H25N3O3Couleur et forme :SolidMasse moléculaire :367.44FR-234938
CAS :<p>FR-234938 is a non-nucleoside adenosine deaminase inhibitor with anti-inflammatory activity.</p>Formule :C19H21N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :323.39PHD-IN-1
CAS :<p>PHD-IN-1 (compound 80) serves as a potent PHD2 inhibitor, exhibiting an IC50 value of ≤5 nM.</p>Formule :C24H23N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :441.49Dasatinib analog-1
CAS :<p>Dasatinib analog-1 (compound 5826) demonstrates inhibition of CYP3A4 activity, presenting a K_i value of 5.4 μM, and effectively prevents the formation of glutathione adducts [1].</p>Formule :C22H25ClFN7O2SCouleur et forme :SolidMasse moléculaire :506(S,R)-WT IDH1 Inhibitor 2
CAS :<p>(S,R)-WT IDH1 Inhibitor 2: selectively targets mutant IDH1; IC50 - R132G: 2.9 nM, R132C: 3.8 nM, R132H: 4.6 nM, WT: 46 nM; potential for AML treatment.</p>Formule :C28H28FN5O3Couleur et forme :SolidMasse moléculaire :501.559-OAHSA
CAS :<p>Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are a class of endogenous lipids whose levels are modulated by fasting and high-fat diets and are linked to insulin sensitivity. These compounds typically consist of a C-16 or C-18 fatty acid, such as palmitoleic, palmitic, oleic, or stearic acid, esterified to a hydroxylated C-16 or C-18 lipid. One specific form of FAHFA, known as 9-OAHSA, involves the esterification of oleic acid to 9-hydroxy stearic acid. Within the FAHFA family, OAHSAs notably represent the predominant form found in the serum of glucose-tolerant AG4OX mice, which uniquely overexpress the Glut4 glucose transporter in adipose tissue.</p>Formule :C36H68O4Couleur et forme :SolidMasse moléculaire :564.936RORγt inverse agonist 26
CAS :<p>RORγt inverse agonist 26, a potent reverse agonist of RORγt, effectively modulates Th17 cell differentiation and suppresses IL-17 production.</p>Formule :C27H21F7N2O5SCouleur et forme :SolidMasse moléculaire :618.52N-Desethyl Brinzolamide oxalate
CAS :<p>N-Desethyl Brinzolamide oxalate functions as a dual inhibitor targeting Carbonic anhydrase II and Carbonic anhydrase IV, exhibiting inhibitory concentrations (IC50) of 1.28 nM and 128 nM, respectively [1].</p>Formule :C12H19N3O9S3Couleur et forme :SolidMasse moléculaire :445.49Ac-VDVAD-CHO
CAS :<p>Ac-VDVAD-CHO is an inhibitor of caspase-2 and caspase-3 (IC50: 46 nM for caspase-2 and 15 nM for caspase-3) [1].</p>Formule :C23H37N5O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :543.57Yonkenafil
CAS :<p>Yonkenafil, a PDE5 inhibitor, may reduce stroke damage and aid in Alzheimer's treatment.</p>Formule :C24H33N5O4SCouleur et forme :SolidMasse moléculaire :487.61IDO1/TDO-IN-6
CAS :<p>IDO1/TDO-IN-6 (compound 11) is a dual inhibitor targeting IDO1 and TDO, exhibiting IC50 values of 2.25 μM for IDO1 and 2.89 μM for TDO.</p>Formule :C20H17NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :351.351-Myristoyl-2-Linoleoyl-3-Oleoyl-rac-glycerol
CAS :<p>1-Myristoyl-2-linoleoyl-3-oleoyl-rac-glycerol, a triacylglycerol, features myristic acid, linoleic acid, and oleic acid at the sn-1, sn-2, and sn-3 positions, respectively. This compound is prevalent in mature human milk, infant formula fats, and butterfat.</p>Formule :C53H96O6Couleur et forme :SolidMasse moléculaire :829.33Miglustat hydrochloride
CAS :<p>Miglustat hydrochloride (N-Butyldeoxynojirimycin hydrochloride) is an inhibitor of glucosylceramide synthase and can be used for studies about Type I Gaucher</p>Formule :C10H22ClNO4Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :255.74BMS-654457
CAS :<p>BMS-654457 is a small-molecule, reversible inhibitor of factor XIa (FXIa; Kis: 0.2 and 0.42 nM for human and rabbit FXIa).</p>Formule :C36H37N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :603.71JTV-803 mesylate
CAS :<p>JTV-803 inhibits factor Xa (K(i) 0.019 µM, IC(50) 0.081 µM), 100x more selective vs thrombin, extends clotting times dose-dependently.</p>Formule :C23H31N5O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :505.59S-Fcme
CAS :<p>S-Fcme activates multidrug resistance transporter by boosting ATPase activity and competing for drug binding.</p>Formule :C19H33NO2SCouleur et forme :SolidMasse moléculaire :339.54GNE-618
CAS :<p>GNE-618 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (IC50: 6 nM).</p>Formule :C21H15F3N4O3SCouleur et forme :SolidMasse moléculaire :460.43Dioleyldimethylammonium chloride
CAS :<p>Dioleyldimethylammonium chloride (DODAC) is a cationic lipid utilized as a transfection reagent [1].</p>Formule :C38H76ClNCouleur et forme :SolidMasse moléculaire :582.47ICMT-IN-25
CAS :<p>ICMT-IN-25 (compound 37) serves as a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), exhibiting an IC50 value of 0.025 μM [1].</p>Formule :C21H26ClNOCouleur et forme :SolidMasse moléculaire :343.89E-5324
CAS :<p>E-5324 is potent cholesterol acyltransferase (ACAT) inhibitor (IC50s: 44 to 190 nM).</p>Formule :C26H34N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :434.5714,15-Epoxyeicosatrienoic acid
CAS :<p>14,15-Epoxyeicosatrienoic acid (14,15-EET), derived from Arachidonic acid metabolism, significantly inhibits platelet aggregation in vivo and enhances</p>Formule :C20H32O3Couleur et forme :SolidMasse moléculaire :320.47HSD17B13-IN-2
CAS :<p>HSD17B13-IN-2 (compound 1) serves as a potent inhibitor of hydroxysteroid 17ß-dehydrogenase 13 (HSD17B13) with demonstrable activity in cellular experiments [1</p>Formule :C21H23F2NO4Couleur et forme :SolidMasse moléculaire :391.41C16 1-Deoxyceramide (m18:1/16:0)
CAS :<p>C16 1-Deoxyceramide (m18:1/16:0) is a lipid molecule that can be used in life science related research. The CAS number of C16 1-Deoxyceramide (m18:1/16:0) is 1246298-56-5.</p>Formule :C34H67NO2Couleur et forme :SolidMasse moléculaire :521.9Methyl γ-Linolenyl Fluorophosphonate
CAS :<p>MγLnFP, an analog of methyl arachidonyl fluozophosphonate (MAFP), holds significance in pharmacological research due to its potential as an inhibitor of phospholipases, FAAH, and its role as a CB receptor ligand. However, the properties and effects of the γ-linolenyl variant of MAFP remain to be fully explored.</p>Formule :C19H34FO2PCouleur et forme :SolidMasse moléculaire :344.451sPLA2 inhibitor 1
CAS :<p>KH064 is a sPLA2-IIA inhibitor of oral activity.</p>Formule :C31H37NO4Couleur et forme :SolidMasse moléculaire :487.63WT IDH1 Inhibitor 2
CAS :<p>WT IDH1 Inhibitor 2 blocks wild-type and R132H mutant IDH1 (IC50: 120 nM); related to GSK321.</p>Formule :C28H28FN5O3Couleur et forme :SolidMasse moléculaire :501.55DORI
CAS :<p>DORI, a cationic lipid, efficiently delivers plasmid DNA in vitro, exhibiting lower cytotoxicity and high transfection efficiency [1].</p>Formule :C43H82BrNO5Couleur et forme :SolidMasse moléculaire :773.02Quercetin 7-glucuronide
CAS :<p>Quercetin 7-glucuronide (Quercetin 7-O-β-glucuronide), a Quercetin metabolite found in Madagascarian Uncarina species, has the capability to inhibit LDL</p>Formule :C21H18O13Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :478.36AR453588 hydrochloride
CAS :<p>AR453588 hydrochloride is an orally bioavailable anti-diabetic glucokinase activator (EC50: 42 nM) with anti-hyperglycemic activity.</p>Formule :C25H26ClN7O2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :556.1Benzoic acid lithium
CAS :<p>Lithium benzoate, an aromatic alcohol present in numerous plants, commonly serves as an additive in food, beverages, cosmetics, and various other products. This compound exhibits antibacterial and antifungal properties, functioning effectively as a preservative [1].</p>Formule :C7H5LiO2Couleur et forme :SolidMasse moléculaire :128.06Gisadenafil besylate
CAS :<p>Gisadenafil besylate (UK 369003-26) is a potent and orally active PDE5 inhibitor, for lower urinary tract symptoms associated with benign prostatic hyperplasia.</p>Formule :C29H39N7O8S2Couleur et forme :SolidMasse moléculaire :677.79GSK321
CAS :<p>GSK321 is an IDH1 inhibitor that prevents cytoplasmic glutamine reductive carboxylation.GSK321 is used in the study of leukemia.</p>Formule :C28H28FN5O3Degré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :501.55GSK2324
CAS :<p>GSK2324 is a potent FXR agonist for the treatment of NAFLD by controlling hepatic lipids through reduced uptake and selective reduction of fatty acid synthesis.</p>Formule :C29H22Cl2N2O4Degré de pureté :98.09% - 99.02%Couleur et forme :SolidMasse moléculaire :533.4Clocortolone pivalate
CAS :<p>Clocortolone pivalate, a synthetic steroid, treats dermatitis and psoriasis.</p>Formule :C27H36ClFO5Couleur et forme :SolidMasse moléculaire :495.02Darodipine
CAS :<p>Darodipine (PY-108068) is a dihydropyridine type Ca+2 antagonist.</p>Formule :C19H21N3O5Degré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :371.39Xanthine oxidase-IN-1
CAS :<p>Xanthine oxidase-IN-1 is an effective inhibitor of xanthine oxidase with an IC50 value of 6.5 nM.</p>Formule :C16H8F2N2O3Degré de pureté :97.36% - 99.22%Couleur et forme :SolidMasse moléculaire :314.24Enpp-1-IN-16
CAS :<p>Enpp-1-IN-16 is an ENPP1 inhibitor, yo anti-cancer activity.Enpp-1-IN-16 can be used to study insulin resistance and chondrocalcinosis.</p>Formule :C23H32N4O4Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :428.52h-NTPDase-IN-2
CAS :<p>h-NTPDase-IN-2 is a broad-spectrum NTPDase inhibitor that inhibits multiple h-NTPDas isoforms.</p>Formule :C19H16N4SDegré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :332.42Varespladib methyl
CAS :<p>Varespladib methyl (LY333013), a bioavailable prodrug of Varespladib, is a selective group II secretory phospholipase A2 inhibitor.</p>Formule :C22H22N2O5Degré de pureté :99.42% - 99.97%Couleur et forme :SolidMasse moléculaire :394.42Ranirestat
CAS :<p>Ranirestat (AS-3201) is an AR inhibitor with neuroprotective properties that improves peripheral nerve dysfunction in rats with advanced diabetic polyneuropathy</p>Formule :C17H11BrFN3O4Degré de pureté :98.83% - 99.44%Couleur et forme :SolidMasse moléculaire :420.19ALDH2 modulator 1
CAS :<p>ALDH2 modulator 1 is a potent and orally active modulator of acetaldehyde dehydrogenase-2 (ALDH2), which reduces blood alcohol levels in mice.</p>Formule :C18H18ClFN2O3Degré de pureté :99.68%Couleur et forme :SoildMasse moléculaire :364.8WAY-620147
CAS :<p>WAY-620147 inhibits Monoamine Oxidase and can be used for the study of neurological disorders.</p>Formule :C12H16BrN3O2Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :314.18Mitiperstat
CAS :<p>Mitiperstat, a strong MPO inhibitor, helps prevent heart failure and coronary artery disease.</p>Formule :C15H15ClN4OSDegré de pureté :98.36%Couleur et forme :SolidMasse moléculaire :334.82DGAT-1 inhibitor 2
CAS :<p>DGAT-1 inhibitor 2: effective against obesity, targets enzyme in triglyceride synthesis for diabetes treatment.</p>Formule :C24H28N4O3Degré de pureté :98.36%Couleur et forme :SolidMasse moléculaire :420.5Cudetaxestat
CAS :<p>Cudetaxestat (BLD-0409) is a potent inhibitor of orally active autotaxin.</p>Formule :C21H15Cl2F2N3O2SDegré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :482.337-BIA
CAS :<p>7-BIA is a receptor-type protein tyrosine phosphatase D (PTPRD) inhibitor with anti-addictive properties and can be used in the study of neuropathic pain.</p>Formule :C15H18O6Degré de pureté :≥98% - ≥98%Couleur et forme :SolidMasse moléculaire :294.3Rilapladib
CAS :<p>Rilapladib (SB 659032) is a selective inhibitor of Lipoprotein-Associated Phospholipase A2(Lp-PLA2, IC50 = 230 pM) and an antagonist of the platelet activating</p>Formule :C40H38F5N3O3SDegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :735.8Calcium channel-modulator-1
CAS :<p>Calcium channel-modulator-1 is a calcium channel-modulator (IC50:0.8 μM) with specialisation to block aortic constriction.</p>Formule :C26H24Cl2N2O7SDegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :579.45NEP-IN-1
CAS :<p>NEP-IN-1 is an inhibitor of neutral endopeptidase (NEP, IC50 = 2 nM) and can be used in studies about female sexual arousal disorders.</p>Formule :C21H30ClNO4Degré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :395.92TPN171
CAS :<p>TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6, which has the potential for the treatment of pulmonary</p>Formule :C24H35N5O3Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :441.57CCT365623
CAS :<p>CCT365623: oral Lysyl Oxidase inhibitor, potent, selective, good pharmacokinetics, anti-metastatic.</p>Formule :C18H17NO4S3Degré de pureté :97.299% - 99.49%Couleur et forme :SolidMasse moléculaire :407.53PA452
CAS :<p>PA452 is a selective antagonist of retinoic X receptor (RXR) and suppresses the effect of Retinoic acid on Th1/Th2 development.</p>Formule :C26H37N3O3Degré de pureté :97.14%Couleur et forme :SolidMasse moléculaire :439.59Inolitazone
CAS :<p>Inolitazone (RS5444) a high-affinity PPARγ agonist. Inolitazone exhibits IC50 for growth inhibition is ~0.8 nM in vitro.</p>Formule :C27H26N4O4SDegré de pureté :99.41% - 99.53%Couleur et forme :SolidMasse moléculaire :502.58Cis-22a
CAS :<p>Cis-22a: selective TRPV6 inhibitor (IC50=0.32μM), halts T47D breast cancer cell growth.</p>Formule :C24H30F3N3O2Degré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :449.51CB29
CAS :<p>CB29 is a specific inhibitor of aldehyde dehydrogenase 3A1 (ALDH3A1).</p>Formule :C15H15N3O5SDegré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :349.36PDE9-IN-(S)-C33
CAS :<p>PDE9-IN-(S)-C33: potent PDE9 inhibitor with 11 nM IC50, for CNS diseases and diabetes study.</p>Formule :C18H20ClN5ODegré de pureté :98.75%Couleur et forme :SolidMasse moléculaire :357.84AMG 579
CAS :<p>AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM).</p>Formule :C25H23N5O3Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :441.48PXS-6302 hydrochloride
CAS :<p>PXS-6302 hydrochloride is a potent irreversible lysine oxidase (LOX) inhibitor, inhibiting Bovine LOX, rh LOXL1, rh LOXL2, rh LOXL3, and rh LOXL4 with IC50 of 3</p>Formule :C10H11ClF3NO2SDegré de pureté :99.89%Couleur et forme :SoildMasse moléculaire :301.71BI-3231
CAS :<p>BI-3231 is a hydroxysteroid 17ß-dehydrogenase 13 HSD17B13 inhibitor that inhibits hHSD17B13 .BI-3231 can be used to study cirrhosis.</p>Formule :C16H14F2N4O3SDegré de pureté :98.2%Couleur et forme :SolidMasse moléculaire :380.374A3-SC8
CAS :<p>4A3-SC8 is a modular, degradable dendrimer facilitating the extension of survival in aggressive liver cancer models through the delivery of small RNAs [1].</p>Formule :C75H139N3O16S4Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :1467.18ML400
CAS :<p>ML400 (CID73050863) is an allosteric inhibitor of LMPTP with an EC50 of 1μM. ML400 displays good cell-based activity and rodent pharmacokinetics.</p>Formule :C24H29N3ODegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :375.51WAY-297848
CAS :<p>WAY-297848 is a novel glucokinase activator for the prevention or treatment of hyperglycemia, diabetes mellitus, obesity, dyslipidemia, and metabolic syndrome.</p>Formule :C13H13ClN2O2SDegré de pureté :98.19%Couleur et forme :SolidMasse moléculaire :296.77HIF-2α agonist 2
CAS :HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α.Formule :C13H8Br2N2O2SDegré de pureté :98.87%Couleur et forme :SoildMasse moléculaire :416.09RS 8359
CAS :<p>RS 8359 is a selective MAO-A reversible inhibitor with a 2200:1 A:B ratio, exhibiting antidepressant effects.</p>Formule :C14H12N4ODegré de pureté :99.3%Couleur et forme :SolidMasse moléculaire :252.27p-Ethynylphenylalanine
CAS :<p>p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine), a tryptophan hydroxylase (TPH) inhibitor, is competitive, effective, selective, and reversible, with a Ki of</p>Formule :C11H11NO2Degré de pureté :97.57%Couleur et forme :SolidMasse moléculaire :189.21Setileuton
CAS :<p>Setileuton (MK0633) is a specific 5-LOX inhibitor and can be used in research on asthma and atherosclerosis.</p>Formule :C22H17F4N3O4Degré de pureté :98.85% - 99.35%Couleur et forme :SolidMasse moléculaire :463.38Ecopladib
CAS :<p>Ecopladib inhibits cPLA2α with IC50 of 0.15 μM (micelles) & 0.11 μM (rat blood).</p>Formule :C39H33Cl3N2O5SDegré de pureté :95.15%Couleur et forme :SolidMasse moléculaire :748.11NPAS3-IN-1
CAS :<p>NPAS3-IN-1 is an NPAS3-ARNT heterodimerization inhibitor that regulates NPAS3 transcription by modulating the heterodimerization of NPAS3 with ARNT.</p>Formule :C10H5N3O2S3Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :295.36ER 50891
CAS :<p>ER-50891 is a potent RARα antagonist, countering retinoic acid inhibition and aiding BMP2-induced osteoblast differentiation.</p>Formule :C29H24N2O2Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :432.51KB-74935
CAS :<p>KB-74935: enzyme inhibitor, mineralocorticoid blocker, treats cholesterol, hypolipidemia, neurological issues, Alzheimer's.</p>Formule :C19H18ClF4N3O3SDegré de pureté :99.4%Couleur et forme :SolidMasse moléculaire :479.88OGT 2115
CAS :<p>OGT 2115 blocks heparanase (IC50=0.4µM), cleaving heparan sulfate; antiangiogenic (IC50=1µM).</p>Formule :C24H16BrFN2O4Degré de pureté :97.17%Couleur et forme :SolidMasse moléculaire :495.3Dechloro Rivaroxaban
CAS :<p>Dechloro Rivaroxaban is a Factor Xa inhibitor that inhibits free FXa and plasminogen and fibrin-associated FXa activity in humans.</p>Formule :C19H19N3O5SDegré de pureté :98.63%Couleur et forme :SolidMasse moléculaire :401.44Fluspirilene
CAS :<p>Fluspirilene is a long-acting antipsychotic for schizophrenia, inhibiting L-type calcium channels (IC50: 0.03 μM).</p>Formule :C29H31F2N3ODegré de pureté :99.59%Couleur et forme :SolidMasse moléculaire :475.57TP-10
CAS :<p>TP-10 is a selective inhibitor of PDE10A against other PDEs with IC50 of 0.8 nM.</p>Formule :C26H19F3N4ODegré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :460.45Mutant IDH1-IN-2
CAS :<p>Mutant IDH1-IN-2 is a inhibitor of mutant Isocitrate dehydrogenase (IDH) proteins, with IC50 of 16.6 nM in Fluorescence biochemical assay, IC50 of ＜22 nM in LS-</p>Formule :C24H31F2N5O2Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :459.53Nomelidine
CAS :Nomelidine, the active N-demethylated metabolite of zimelidine, has been used as an antidepressant and analgesic.Formule :C15H15BrN2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :303.20CK2 inhibitor 3
<p>CK2 inhibitor 3: potent CK2 blocker, IC50 of 280 nM, suppresses tumor cell growth, highly selective among 320 kinases.</p>Formule :C13H9BrN4O3SCouleur et forme :SolidMasse moléculaire :381.2Zaragozic acid C
CAS :<p>Zaragozic acid C is an effective inhibitor of squalene synthase.</p>Formule :C40H50O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :754.82Miaosporone A
<p>Miaosporone A: angucyclic quinone, cytotoxic to MCF-7, NCI-H187, Vero cells; anti-TB and anti-malaria with IC50 of 2.4 μM, 2.5 μM.</p>Formule :C19H18O5Couleur et forme :SolidMasse moléculaire :326.34LDHA-IN-5
CAS :<p>LDHA-IN-5 is a novel and potent inhibitor targeting both glycolate oxidase (GO) and lactate dehydrogenase A (LDHA), designed for the treatment of primary</p>Formule :C27H22FN7O6S3Couleur et forme :SolidMasse moléculaire :655.7CAII-IN-2
<p>CAII-IN-2 (3g): potent, selective CA-II inhibitor; IC50-12.1 μM for bovine CA-II; valuable in CA-related disorder research.</p>Formule :C18H19BrN4SCouleur et forme :SolidMasse moléculaire :403.34RORγt modulator 5
CAS :<p>RORγt modulator 5, a potent RORγt modulator, exhibits a dissociation constant (K_i) of <100 nM.</p>Formule :C27H22F5N3O6SCouleur et forme :SolidMasse moléculaire :611.54hCAII-IN-3
<p>hCAII-IN-3 inhibits key hCA isoforms with Ki: hCA I (403.8 nM), hCA II (5.1 nM), hCA IX (10.2 nM), hCA XII (5.2 nM); shows anticancer potential.</p>Formule :C17H21N3O3SCouleur et forme :SolidMasse moléculaire :347.43Keto lovastatin
CAS :<p>Keto lovastatin is an impurity of lovastatin with antibacterial properties. Lovastatin is a cell-permeable HMG-CoA reductase (HMG-CoA reductase) inhibitor used to reduce cholesterol levels.</p>Formule :C24H34O6Couleur et forme :SolidMasse moléculaire :418.523RORγt inverse agonist 32
CAS :<p>RORγt inverse agonist 32 (compound b14) exhibits oral activity and can be utilized in inflammatory research studies.</p>Formule :C24H28F3NO5SCouleur et forme :SolidMasse moléculaire :499.54FXR/CES2 modulator 1
CAS :<p>Compound LE-77, known as FXR/CES2 modulator 1, functions as a dual regulator that activates FXR and inhibits CES2. It effectively mitigates the intestinal toxicity of irinotecan.</p>Formule :C27H21Cl2NO5Couleur et forme :SolidMasse moléculaire :510.36α-Glucosidase-IN-12
<p>α-Glucosidase-IN-12 is a potent inhibitor of α-glucosidase (IC50: 10.20 μM).</p>Formule :C25H30N4O4S2Couleur et forme :SolidMasse moléculaire :514.66IDO1-IN-14
<p>IDO1-IN-14 is an IDO1 enzyme inhibitor with an IC50 of 396.9 nM and suppresses HeLa cell activity with an EC50 of 3393 nM.</p>Formule :C18H12Cl2FN3O2Couleur et forme :SolidMasse moléculaire :392.21Raloxifene N-Oxide
CAS :<p>Raloxifene N-Oxide is a Raloxifene oxidative degradation product.</p>Formule :C28H27NO5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :489.58FTI-2148
CAS :<p>FTI-2148 blocks RAS-related FT-1 & GGT-1; IC50: 1.4 nM & 1.7 μM.</p>Formule :C24H28N4O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :452.57Darlifarnib
CAS :<p>Darlifarnib (Compound (S)-058) is an inhibitor of farnesyl transferase and geranylgeranyltransferase, with IC50 values of ≤ 10 nM and > 1000 nM, respectively. It exhibits high metabolic stability in human and mouse liver microsomes, with a half-life of over 100 minutes.</p>Formule :C29H20N6OCouleur et forme :SolidMasse moléculaire :468.509Nampt-IN-15
CAS :Nampt-IN-15 (Example 3) is a Nampt inhibitor that exhibits cytotoxic effects on various cell lines, including BxPC-3, HepG2, L540cy, and MOLM-13. The respective IC50 values for these cell lines are 38.5 nM, 8 nM, 8.5 nM, and 7 nM.Formule :C24H30N4O2Couleur et forme :SolidMasse moléculaire :406.52JA2
CAS :<p>JA2 is an inhibitor of metalloendopeptidase 24.15 that enhances the hypotensive response to bradykinin in rats.</p>Formule :C33H38N4O8Couleur et forme :SolidMasse moléculaire :618.68hMAO-B/MB-COMT-IN-1
<p>Dual hMAO-B/MB-COMT inhibitor, IC50: 2.5 μΜ (hMAO-B), 3.84 μΜ (MB-COMT); potential in Parkinson's research.</p>Formule :C16H19NO3Couleur et forme :SolidMasse moléculaire :273.33NTPDase-IN-2
CAS :<p>NTPDase-IN-2 inhibits h-NTPDase-2/-8 (IC50: 0.04, 2.27 µM), non-competitive for h-NTPDase-1/-2 (Km: 74 µM); useful in cancer, immune, bacterial research.</p>Formule :C24H20FN3OS2Couleur et forme :SolidMasse moléculaire :449.56Fonadelpar
CAS :<p>Fonadelpar is an agonist of PPARδ. It also is used in the research of neuroparalytic keratopathy.</p>Formule :C25H23F3N2O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :504.52Lecufexor
CAS :<p>Lecufexor is an agonist of the farnesoid X receptor (FXR).</p>Formule :C32H21Cl3N2O5Couleur et forme :SolidMasse moléculaire :619.88DPM-1003
CAS :<p>DPM-1003 is an allosteric inhibitor of PTP1B, targeting the non-catalytic, disordered C-terminal segment of the PTP1B protein, and has shown beneficial effects in reducing pulmonary inflammation in mice.</p>Formule :C35H57N3O3Couleur et forme :SolidMasse moléculaire :567.845Ranosidenib
CAS :<p>Ranolisib is an isocitrate dehydrogenase (IDH) inhibitor known for its antitumor activity.</p>Formule :C15H16F9N5OCouleur et forme :SolidMasse moléculaire :453.31Nampt-IN-14
CAS :<p>Nampt-IN-14 (example 3) is an effective NAMPT inhibitor with an IC50 of 0.2 nM, suited for use in the synthesis of antibody-drug conjugates (ADCs).</p>Formule :C33H35N7O2Couleur et forme :SolidMasse moléculaire :561.68Inosine 5′-diphosphate sodium
CAS :<p>Inosine 5'-diphosphate sodium, a purine ribonucleoside diphosphate with inosine as its nucleobase, plays a role in intracellular energy metabolism and signal transduction processes.</p>Formule :C10H13N4Na3O12P2Couleur et forme :SolidMasse moléculaire :512.15Nampt-IN-13
CAS :<p>Nampt-IN-13 (example 58m) is an NAMPT inhibitor used in the synthesis of antibody-drug conjugates (ADCs).</p>Formule :C24H30N6O2Couleur et forme :SolidMasse moléculaire :434.53ALOX15-IN-1
<p>ALOX15-IN-1 (8b) inhibits rabbit/human ALOX15; IC50: 0.04 μM for LA, 2.06 μM for AA.</p>Formule :C24H31N3O5SCouleur et forme :SolidMasse moléculaire :473.59Propofol sulfate sodium
CAS :<p>Propofolsulfate (sodium) is a metabolite of Propofol.</p>Formule :C12H17NaO4SCouleur et forme :SolidMasse moléculaire :280.316BRD7539
CAS :<p>BRD7539B: PfDHODH inhibitor, IC50 0.033μM; selective vs HsDHODH, IC50 >50μM.</p>Formule :C23H22FN3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :391.44BMS-185354
CAS :<p>BMS-185354 is a selective RARγ activator with an EC50 value of 28 nM, offering potential for cancer research.</p>Formule :C26H27NO3Couleur et forme :SolidMasse moléculaire :401.497
