Métabolisme

Les inhibiteurs du métabolisme sont des composés qui interfèrent avec les voies métaboliques, modifiant ainsi la production et l'utilisation de l'énergie au sein des cellules. Ces inhibiteurs sont utilisés pour étudier la régulation du métabolisme, le rôle des voies métaboliques dans des maladies telles que le cancer et le diabète, et pour développer de nouvelles stratégies thérapeutiques. Les inhibiteurs du métabolisme peuvent cibler diverses enzymes et processus impliqués dans la glycolyse, l'oxydation des acides gras et d'autres fonctions métaboliques. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de métabolisme de haute qualité pour soutenir vos recherches en biochimie, troubles métaboliques et développement de médicaments.

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ROR1-IN-1
CAS :
- 3053223-31-4
ROR1-IN-1 (Compound 19h) is an inhibitor of receptor tyrosine kinase-like orphan receptor 1 (ROR1) with a Ki of 0.10 μM. It inhibits the proliferation of cancer cell lines H1975, A549, and MDA-MB-231, with IC50 values of 0.36 μM, 1.37 μM, and 0.47 μM, respectively. In mice, ROR1-IN-1 demonstrates antitumor efficacy and exhibits favorable pharmacokinetic properties in a rat model.
Formule :C₃₃H₂₇N₅O₃
Masse moléculaire :541.60
Ref: TM-T210170
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Lipid HTO12
CAS :
- 3047222-45-4
Lipid HTO12 is an ionizable lipid used for forming lipid nanoparticles (LNP). It facilitates the delivery of siRNA and mRNA.
Formule :C₄₁H₈₃NO₄
Couleur et forme :Solid
Masse moléculaire :654.102
Ref: TM-TCL-01114
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Casein kinase 1δ-IN-26
CAS :
- 756857-71-3
Casein kinase1δ-IN-26 (compound 505) is a potent inhibitor of casein kinase 1δ. This compound is applicable in research related to neurodegenerative disorders such as Alzheimer’s disease.
Formule :C₁₆H₁₃N₃O₄S
Couleur et forme :Solid
Masse moléculaire :343.357
Ref: TM-T204859
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TAP311
TAP311 is an inhibitor of cholesteryl ester transfer protein (CETP)(IC50 of 62 nM).
Formule :C₃₄H₄₀F₆N₆O₄
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :710.71
Ref: TM-T13079
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P053
CAS :
- 2748196-63-4
P053: potent, selective CerS1 inhibitor, IC50 = 0.5µM, curbs muscle fat oxidation, affects body fat.
Formule :C₁₈H₂₁Cl₂NO₂
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :354.27
Ref: TM-T12342
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α-Amylase-IN-7
CAS :
- 3049575-16-5
α-Amylase-IN-7 (Compound 6e) is an inhibitor of α-Amylase, with an IC50 of 40 μM, indicating its potency. This compound shows potential as an anti-diabetic medication.
Formule :C₁₈H₁₅ClN₆O₂S
Masse moléculaire :414.87
Ref: TM-T210159
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Myxothiazol
CAS :
- 76706-55-3
Myxothiazol blocks mitochondrial complex III and triggers SESN2, a gene important for stress response.
Formule :C₂₅H₃₃N₃O₃S₂
Couleur et forme :Solid
Masse moléculaire :487.68
Ref: TM-T68731
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Lipid 11
CAS :
- 2758820-82-3
Lipid 11 (Compound Lipid 1) is a cationic lipid designed for nucleic acid delivery. It forms lipid nanoparticles (LNPs) through electrostatic interactions with nucleic acids, such as ceDNA. By using its cationic amine groups, Lipid 11 complexes with negatively charged nucleic acids, enabling cellular uptake and release of the nucleic acid cargo. Lipid 11 shows potential for use in the development of gene therapy drug delivery systems.
Formule :C₄₃H₈₅NO₄
Couleur et forme :Solid
Masse moléculaire :680.14
Ref: TM-TCL-01218
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Implitapide
CAS :
- 177469-96-4
Implitapide is an inhibitor of microsomal triglyceride transfer protein (MTP).
Formule :C₃₅H₃₇N₃O₂
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :531.69
Ref: TM-T15570
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Carbonic anhydrase inhibitor 4
CA inhibitor 4, photoprobe; targets hCA I-XIV; Ki: 640-1166 nM.
Formule :C₂₁H₁₈N₂O₄S
Couleur et forme :Solid
Masse moléculaire :394.44
Ref: TM-T61829
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AD015
CAS :
- 177741-43-4
AD015 is a dual inhibitor of angiotensin-converting enzyme (ACE) and neprilysin (NEP), effectively inhibiting NEP, nACE, and cACE with IC50 values of 0.009, 0.019, and 0.0008 μM, respectively.
Formule :C₂₃H₂₆N₂O₄S
Couleur et forme :Solid
Masse moléculaire :426.53
Ref: TM-T207211
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Cilazaprilat
CAS :
- 90139-06-3
Cilazaprilat is the active metabolite of cilazapril, a pyridazine angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.
Formule :C₂₀H₂₇N₃O₅
Couleur et forme :Solid
Masse moléculaire :389.45
Ref: TM-T68412
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α-Amylase/α-Glucosidase-IN-19
CAS :
- 223505-23-5
α-Amylase/α-Glucosidase-IN-19 (compound 10) is a dual inhibitor of α-amylase and α-glucosidase, with an IC50 of 170.7 μM and 60.37 μM, respectively.
Formule :C₁₇H₁₄BrClN₂O
Couleur et forme :Solid
Masse moléculaire :377.663
Ref: TM-T206992
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DDO-3733
CAS :
- 2923531-63-7
DDO-3733 is a conformational activator of Protein Phosphatase 5 (PP5) that functions independently of TRP, facilitating the dephosphorylation of downstream substrates.
Formule :C₁₀H₆F₂N₂OS
Couleur et forme :Solid
Masse moléculaire :240.23
Ref: TM-T200216
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D-Citrulline
CAS :
- 13594-51-9
D-Citrulline (H-D-Cit-OH), a stereoisomer of L-citrulline, effectively reduces cardiac contractile dysfunction caused by polymorphonuclear leukocyte (PMN) in isolated perfused rat hearts undergoing ischemia/reperfusion. This protective effect is mediated through a non-NO-mediated mechanism.
Formule :C₆H₁₃N₃O₃
Couleur et forme :Solid
Masse moléculaire :175.19
Ref: TM-T200340
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5-LOX/MAOs-IN-1
CAS :
- 33865-93-9
Compound 3, known as 5-LOX/MAOs-IN-1, acts as an inhibitor of 5-LOX/MAOs and is an effective free radical scavenger, displaying antioxidant characteristics. It has demonstrated neuroprotective effects in cell models damaged by oxidative stress and is capable of activating the neurogenesis microenvironment in adult mouse neural stem cells. This compound is utilized in research focused on neurodegenerative diseases.
Formule :C₁₈H₁₈N₂O₂
Couleur et forme :Solid
Masse moléculaire :294.35
Ref: TM-T200298
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Cgs 25155
CAS :
- 150126-87-7
Cgs 25155 is an orally active inhibitor of NEP 24.11.
Formule :C₂₅H₃₄N₂O₆S
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :490.61
Ref: TM-T25231
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6′SLN
CAS :
- 64364-50-7
6′SLN is a characteristic glycan found on the surface of cancer-related extracellular vesicles (EVs) and serves as the primary form of protein glycosylation within EVs. Additionally, 6′SLN, a derivative of sialic acid, interacts with hemagglutinins (HAs) from both human and avian influenza strains, making it relevant in the study of anti-influenza drugs.
Formule :C₂₅H₄₂N₂O₁₉
Couleur et forme :Solid
Masse moléculaire :674.6
Ref: TM-T200406
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IDO1-IN-25
CAS :
- 2841467-86-3
IDO1-IN-25, a dual inhibitor of IDO1/TDO2, showcases IC50 values of 0.17 μM for IDO1 and 3.2 μM for TDO2. It effectively suppresses NO production in RAW264.7 cells following stimulation with lipopolysaccharide (LPS). Additionally, IDO1-IN-25 demonstrates anti-inflammatory properties in a mouse ear edema model of acute inflammation induced by croton oil.
Formule :C₁₄H₈Cl₃NO₂S
Couleur et forme :Solid
Masse moléculaire :360.64
Ref: TM-T200055
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L 668411
CAS :
- 112965-15-8
L 668411, the 2,3-ditritiated methyl ester of L 659699, inhibits HMG-CoA synthase.
Formule :C₁₉H₃₀O₅
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :338.44
Ref: TM-T24320
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L 671776
CAS :
- 134313-74-9
L 671776 is an inositol monophosphatase inhibitor.
Formule :C₂₃H₃₂O₅
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :388.5
Ref: TM-T24326
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20-HEDE
CAS :
- 240427-90-1
20-HEDE (WIT 002) is a 20-hydroxyeicosatetraenoic acid (20-HETE) antagonist.
Formule :C₂₀H₃₆O₃
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :324.50
Ref: TM-T13343
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RWJ 22108
CAS :
- 112769-37-6
RWJ 22108 is a bronchial-selective calcium channel (calcium channel) blocker that exhibits an IC50 of 5.7 nM in dog bronchial smooth muscle calcium-dependent contractions.
Formule :C₂₇H₃₀ClFN₂O₄S
Couleur et forme :Solid
Masse moléculaire :533.06
Ref: TM-T89985
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Etoricoxib N1'-oxide
CAS :
- 325855-74-1
EtoricoxibN1'-oxide is a metabolite of Etoricoxib. It does not inhibit COX-1 and does not significantly inhibit COX-2.
Formule :C₁₈H₁₅ClN₂O₃S
Couleur et forme :Solid
Masse moléculaire :374.841
Ref: TM-TYD-02100
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Urobilin hydrochloride
CAS :
- 28925-89-5
Urobilin hydrochloride, a metabolic byproduct of Hemoglobin, is excreted through urine and feces in various mammals. It also serves as an indicator of human waste contamination.
Formule :C₃₃H₄₃ClN₄O₆
Couleur et forme :Solid
Masse moléculaire :627.17
Ref: TM-T200243
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Deltasonamide 2 hydrochloride
Deltasonamide 2 hydrochloride is a competitive high-affinity PDEδ inhibitor with a Kd of approximately 385 pM.
Formule :C₃₀H₄₀Cl₂N₆O₄S₂
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :683.71
Ref: TM-T10994L
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α-Glucosylrutin
CAS :
- 130603-71-3
α-Glucosylrutin is an effective antioxidant known for its activity in scavenging free radicals. Due to its high epidermal bioavailability, it is commonly utilized in studies related to skin aging.
Formule :C₃₃H₄₀O₂₁
Couleur et forme :Solid
Masse moléculaire :772.66
Ref: TM-T200289
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MK-3168 (12C)
CAS :
- 1242441-26-4
MK-3168 (12C) functions as a FAAH inhibitor, exhibiting IC50 values of 1.0 nM, 5.5 nM, and 1.7 nM for human, rhesus, and rat respectively. It demonstrates effective brain uptake and FAAH-specific signaling. Additionally, 11 C MK-3168 is applicable as a FAAH PET tracer.
Formule :C₂₁H₂₁ClN₄OS
Couleur et forme :Solid
Masse moléculaire :412.94
Ref: TM-T200270
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SelB-1
CAS :
- 2674058-66-1
SelB-1 acts as a dual inhibitor of Topoisomerase I/II (TopoisomeraseI/II), exhibiting anticancer activity suitable for research on prostate and colon cancers. Additionally, SelB-1 can induce the expression of autophagy (autophagy) genes and lipid peroxidation while reducing GSH levels.
Formule :C₃₂H₂₄O₅
Couleur et forme :Solid
Masse moléculaire :488.53
Ref: TM-T89905
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h15-LOX-2 inhibitor 3
CAS :
- 1164515-84-7
Compound 13, identified as h15-LOX-2 inhibitor 3, exhibits inhibitory activity against h15-LOX, with IC50 and Ki values of 25 μM and 15.1 μM, respectively.
Formule :C₂₂H₁₃N₅O₃
Couleur et forme :Solid
Masse moléculaire :395.37
Ref: TM-T200110
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MAGL-IN-18
CAS :
- 3036792-74-9
MAGL-IN-18 (compound 118) serves as a highly potent inhibitor of Monoacylglycerol lipase (MAGL), demonstrating an IC 50 value of 0.03nM.
Formule :C₂₃H₂₈F₃N₇O
Couleur et forme :Solid
Masse moléculaire :475.51
Ref: TM-T200343
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Diacylglycerol acyltransferase inhibitor-2
CAS :
- 2186700-48-9
Diacylglycerolacyltransferaseinhibitor-2 (Example 8) acts as an inhibitor for diacylglycerol acyltransferase 2 (DGAT2), exhibiting an IC50 value of 3.7 nM.
Formule :C₂₁H₂₀FN₅O₄
Couleur et forme :Solid
Masse moléculaire :425.41
Ref: TM-T89852
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RORγt inhibitor 2
CAS :
- 2673278-10-7
RORγt Inhibitor 2, a potent inhibitor of RORγt, exhibits an IC50 of 9.2 nM and is utilized in the study of cancer, inflammation, or autoimmune diseases that are
Formule :C₃₁H₃₃F₅N₂O₇S
Couleur et forme :Solid
Masse moléculaire :672.66
Ref: TM-T72595
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PDHK-IN-4
PDHK-IN-4 inhibits PDHK2 (IC50: 0.0051 μM) & PDHK4 (IC50: 0.0122 μM), with potential for cancer research.
Formule :C₂₄H₂₅N₅O₃
Couleur et forme :Solid
Masse moléculaire :431.49
Ref: TM-T62407
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Z21090
CAS :
- 2992690-71-6
Z21090 (ZL40) is a highly effective inhibitor of PDE 4, exhibiting an IC 50 value of 37.4 nM, and possesses oral bioavailability. It is significant in the study of alcohol-related diseases [1].
Formule :C₁₂H₁₄ClN₃O₃
Couleur et forme :Solid
Masse moléculaire :283.71
Ref: TM-T87655
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SAL-0010042
CAS :
- 521298-46-4
SAL-0010042 is an inhibitor of Plasmodium phosphodiesterase β (PDEβ), effectively blocking the hydrolysis of cAMP and cGMP in gametocytes with an IC50 of 48.9 nM, thereby activating PKG and inhibiting the growth and development of Plasmodium (IC50s for 3D7 and Dd2 are 142 nM and 218 nM, respectively). It also inhibits hPDE5 and hPDE6 with IC50 values of 632 nM and 73 nM, respectively.
Formule :C₁₅H₁₅FN₄O
Couleur et forme :Solid
Masse moléculaire :286.304
Ref: TM-T204533
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PDHK-IN-3
PDHK-IN-3 (compound 7) is a potent inhibitor of pyruvate dehydrogenase kinase(PDHK) with IC50s of 0.21 and 1.54 μM for PDHK2 and PDHK4, respectively [1].
Formule :C₁₇H₁₆N₂O₂
Couleur et forme :Solid
Masse moléculaire :280.32
Ref: TM-T60527
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DX-9065A HCl hydrate
CAS :
- 155204-81-2
DX-9065a: Competitive fXa/prothrombinase inhibitor; blocks proinflammatory events; Ki ~10-20 nM.
Formule :C₂₆H₃₉ClN₄O₈
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :571.06
Ref: TM-T27224
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TS010
TS010 is a highly potent inhibitor of GLO-I, with an IC50 value of 0.57 μM. It holds significant promise for advancements in cancer research [1].
Formule :C₁₆H₁₂N₄O₄S
Couleur et forme :Solid
Masse moléculaire :356.36
Ref: TM-T61279
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ent-8-iso-15(S)-Prostaglandin F2α
CAS :
- 214748-66-0
Isoprostanes are produced by the non-enzymatic, free radical peroxidation of phospholipid-esterified arachidonic acid.
Formule :C₂₀H₃₄O₅
Couleur et forme :Solid
Masse moléculaire :354.48
Ref: TM-T35990
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Asimicin
CAS :
- 102989-24-2
Asimicin is a effective complex I inhibitor.
Formule :C₃₇H₆₆O₇
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :622.92
Ref: TM-T25115
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Keto lovastatin
CAS :
- 96497-73-3
Keto lovastatin is an impurity of lovastatin with antibacterial properties. Lovastatin is a cell-permeable HMG-CoA reductase (HMG-CoA reductase) inhibitor used to reduce cholesterol levels.
Formule :C₂₄H₃₄O₆
Couleur et forme :Solid
Masse moléculaire :418.523
Ref: TM-T204532
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ALOX15-IN-1
ALOX15-IN-1 (8b) inhibits rabbit/human ALOX15; IC50: 0.04 μM for LA, 2.06 μM for AA.
Formule :C₂₄H₃₁N₃O₅S
Couleur et forme :Solid
Masse moléculaire :473.59
Ref: TM-T63075
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Lp-PLA2-IN-10
Lp-PLA2-IN-10, a potent Lp-PLA2 inhibitor, may research neurodegenerative and cardiovascular diseases.
Formule :C₂₁H₁₅F₅N₄O₄
Couleur et forme :Solid
Masse moléculaire :482.36
Ref: TM-T63192
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Porphobilinogen
CAS :
- 487-90-1
Porphobilinogen act as a phytotoxin, a metabotoxin, and a neurotoxin.
Formule :C₁₀H₁₄N₂O₄
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :226.23
Ref: TM-T19130
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(2S,4S)-Sacubitril
CAS :
- 149709-63-7
(2S,4S)-Sacubitril (Sacubitril Impurity C) is a stereoisomer derived from Sacubitril which is a potent NEP inhibitor.
Formule :C₂₄H₂₉NO₅
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :411.49
Ref: TM-T19114
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α-Glucosidase-IN-19
Alpha-Glucosidase-IN-19 (Compound 6B) is an orally active alpha-glucosidase inhibitor (IC50: 3.63 μM) with antidiabetic effects.
Formule :C₃₁H₂₅NOS
Couleur et forme :Solid
Masse moléculaire :459.6
Ref: TM-T62891
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CIT-ALD
CAS :
- 211800-31-6
CIT-ALD is an aldehyde intermediate formed during the metabolism of Citalopram. It has potential applications in the research of neurological disorders.
Formule :C₁₈H₁₄FNO₂
Masse moléculaire :295.31
Ref: TM-TYD-02191
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RORγt modulator 5
CAS :
- 2119042-65-6
RORγt modulator 5, a potent RORγt modulator, exhibits a dissociation constant (K_i) of <100 nM.
Formule :C₂₇H₂₂F₅N₃O₆S
Couleur et forme :Solid
Masse moléculaire :611.54
Ref: TM-T72596
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7-APB hydrochloride
CAS :
- 286834-86-4
7-APB hydrochloride is a benzofuran compound and serves as a metabolite of 7-MAPB.
Formule :C₁₁H₁₄ClNO
Couleur et forme :Solid
Masse moléculaire :211.688
Ref: TM-TYD-02081
+ Info
Carbonic anhydrase inhibitor 5
Potent hCA inhibitor: targets hCA II, IX & XII with IC50s of 42.9, 47.6, & 6.7 nM respectively.
Formule :C₂₄H₂₀ClN₃O₃S
Couleur et forme :Solid
Masse moléculaire :465.95
Ref: TM-T62976
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hCAII-IN-5
CAS :
- 2816080-16-5
hCAII-IN-5 (compound 12h) is a potent, selective inhibitor of human carbonic anhydrase II (hCA II) with an inhibition constant (IC50) of 4.55 µM [1].
Formule :C₂₉H₁₈N₂O₇
Couleur et forme :Solid
Masse moléculaire :506.46
Ref: TM-T63467
+ Info
FTI 276 TFA
CAS :
- 1217471-51-6
FTI 276 TFA targets plasmodium falciparum & humans, inhibits PFT with IC50s: 0.9 nM (parasite) & 0.5 nM (human).
Formule :C₂₃H₂₈F₃N₃O₅S₂
Couleur et forme :Solid
Masse moléculaire :547.61
Ref: TM-T11331
+ Info
TMX-4116
CAS :
- 2766385-56-0
TMX-4116 is a CK1α degrader targeting multiple cell lines with DC50s below 200 nM, used in multiple myeloma research and protein degradation strategy studies.
Formule :C₁₇H₁₉N₅O₄S
Couleur et forme :Solid
Masse moléculaire :389.43
Ref: TM-T61754
+ Info
PDE4-IN-14
CAS :
- 2231329-25-0
PDE4-IN-14 (Compound 1) serves as an inhibitor of phosphodiesterase 4 (PDE4), applicable in research concerning diseases associated with PDE4, including
Formule :C₁₉H₂₀F₂N₄O₃S
Couleur et forme :Solid
Masse moléculaire :422.45
Ref: TM-T79624
+ Info
Lipoxin A5
CAS :
- 110657-98-2
LXA5 is made from EPA by leukocytes, contracts guinea pig lungs like LXA4/LXB4, but doesn't dilate aorta.
Formule :C₂₀H₃₀O₅
Couleur et forme :Solid
Masse moléculaire :350.45
Ref: TM-T37459
+ Info
Enpp-1-IN-11
Enpp-1-IN-11 inhibits ENPP1 with a 45 nM Ki, is plasma stable, and has low clearance in human/mouse livers, potentially aiding cancer research.
Formule :C₁₅H₁₅N₅O₃S
Couleur et forme :Solid
Masse moléculaire :345.38
Ref: TM-T61136
+ Info
Nampt-IN-14
CAS :
- 2369099-57-8
Nampt-IN-14 (example 3) is an effective NAMPT inhibitor with an IC50 of 0.2 nM, suited for use in the synthesis of antibody-drug conjugates (ADCs).
Formule :C₃₃H₃₅N₇O₂
Couleur et forme :Solid
Masse moléculaire :561.68
Ref: TM-T201172
+ Info
Ranosidenib
CAS :
- 2301974-60-5
Ranolisib is an isocitrate dehydrogenase (IDH) inhibitor known for its antitumor activity.
Formule :C₁₅H₁₆F₉N₅O
Couleur et forme :Solid
Masse moléculaire :453.31
Ref: TM-T201237
+ Info
CK1δ-IN-5
CAS :
- 956753-89-2
CK1δ-IN-5 (Compound 24) is an inhibitor of casein kinase 1δ (CK1δ) and can be used in the study of neurodegenerative diseases.
Formule :C₂₂H₂₁N₅
Couleur et forme :Solid
Masse moléculaire :355.436
Ref: TM-T205270
+ Info
IRX5010
CAS :
- 856683-59-5
IRX5010 (IRX4647F), an analogue of IRX4647, serves as a highly selective RARγ nuclear receptor agonist. It effectively inhibits the growth of EMT-6 triple-negative breast cancer.
Formule :C₂₄H₂₆FNO₃
Couleur et forme :Solid
Masse moléculaire :395.466
Ref: TM-T205243
+ Info
Nampt-IN-15
CAS :
- 2222981-61-3
Nampt-IN-15 (Example 3) is a Nampt inhibitor that exhibits cytotoxic effects on various cell lines, including BxPC-3, HepG2, L540cy, and MOLM-13. The respective IC50 values for these cell lines are 38.5 nM, 8 nM, 8.5 nM, and 7 nM.
Formule :C₂₄H₃₀N₄O₂
Couleur et forme :Solid
Masse moléculaire :406.52
Ref: TM-T201167
+ Info
CK1δ-IN-7
CAS :
- 882220-11-3
CK1δ-IN-7 (Compound 488) is an inhibitor of casein kinase 1δ (CK1δ).
Formule :C₂₃H₂₃N₅O
Couleur et forme :Solid
Masse moléculaire :385.462
Ref: TM-T205150
+ Info
DDO-3055
CAS :
- 1842340-93-5
DDO-3055 is an orally active PHD2 inhibitor utilized in studies related to anemia associated with chronic kidney disease.
Formule :C₁₇H₁₃ClN₂O₅
Couleur et forme :Solid
Masse moléculaire :360.749
Ref: TM-T205089
+ Info
GKA50 quarterhydrate
GKA50 quarterhydrate: glucokinase activator, EC50 of 33 nM, boosts insulin, cuts glucose in rats.
Formule :C₂₆H₃₀N₂O₇
Couleur et forme :Solid
Masse moléculaire :469.01
Ref: TM-T63019
+ Info
Ro 23-9358
CAS :
- 153125-17-8
Ro 23-9358 is a potent inhibitor of secretory phospholipase A2, exhibiting anti-inflammatory properties.
Formule :C₃₀H₅₁NO₆
Couleur et forme :Solid
Masse moléculaire :521.729
Ref: TM-T204941
+ Info
BPU17
CAS :
- 2198977-68-1
BPU17 interacts with PHB1 and disrupts the PHB1-PHB2 interaction, causing slight mitochondrial dysfunction. This damage hinders transcription dependent on SRF/CArG-box, thereby inhibiting epithelial-mesenchymal transition (EMT) in retinal pigment epithelial cells (RPEs). BPU17 has demonstrated anti-fibrotic activity in vivo. It holds potential as a research agent for anti-angiogenic age-related macular degeneration (nAMD).
Formule :C₁₂H₁₃ClN₂O₂
Couleur et forme :Solid
Masse moléculaire :252.70
Ref: TM-T200681
+ Info
CYP2C9/CYP2C19-IN-1
CYP2C9/CYP2C19-IN-1 is a potent inhibitor of CYP2C9/CYP2C19 without liver toxicity or genotoxicity and can be used to study Zika virus (ZIKV) infection.
Formule :C₂₇H₂₈N₂O₆S
Couleur et forme :Solid
Masse moléculaire :508.59
Ref: TM-T63496
+ Info
E234G HYPE-IN-1
CAS :
- 1341007-95-1
Compound I2.10 (E234G HYPE-IN-1) functions as an AMPylase inhibitor and exhibits low cytotoxicity toward human cell lines [1].
Formule :C₁₄H₉N₅O₂
Couleur et forme :Solid
Masse moléculaire :279.25
Ref: TM-T86314
+ Info
3-Benzylidenecamphor
CAS :
- 15087-24-8
3-Benzylidenecamphor, a UV absorber, is noted for its excellent photostability and antioxidant activity. It is extensively utilized in sunscreen products to shield the skin from UV damage. Additionally, 3-Benzylidenecamphor is used in cosmetics to enhance product shelf life and safety.
Formule :C₁₇H₂₀O
Couleur et forme :Solid
Masse moléculaire :240.34
Ref: TM-T201251
+ Info
GW461484A
CAS :
- 401815-65-4
GW461484A is a small molecule inhibitor targeting Candida albicans Yck2, exhibiting an IC50 of 0.11 µM. It has a MIC80 of 12.5 µM against C. albicans. GW461484A shows potential for research into fungal diseases, including drug-resistant Candida infections.
Formule :C₁₉H₁₄FN₃
Couleur et forme :Solid
Masse moléculaire :303.333
Ref: TM-T206361
+ Info
Casein kinase 1δ-IN-16
CAS :
- 851467-69-1
Casein kinase1δ-IN-16 (compound 506) is an inhibitor of casein kinase 1δ (CK1δ). This compound is applicable in research related to neurodegenerative diseases.
Formule :C₁₇H₁₂N₄S₂
Couleur et forme :Solid
Masse moléculaire :336.434
Ref: TM-T204851
+ Info
3'-Hydroxy Repaglinide
CAS :
- 874908-14-2
'3'-Hydroxy Repaglinide, a CYP2C8 metabolite of Repaglinide, treats type II diabetes.
Formule :C₂₇H₃₆N₂O₅
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :468.59
Ref: TM-T13497
+ Info
O-Desmethyl Brinzolamide hydrochloride
CAS :
- 2967475-56-3
O-Desmethyl Brinzolamide hydrochloride (compound 6a), a potent metabolite derived from Brinzolamide, serves as a carbonic anhydrase (CA) inhibitor. It exhibits a dissociation constant (Kd) of 0.136 nM for CA II and an inhibitory concentration (IC50) of 165 nM for CA IV [1].
Formule :C₁₁H₂₀ClN₃O₅S₃
Couleur et forme :Solid
Masse moléculaire :405.94
Ref: TM-T87055
+ Info
WAY-606344
CAS :
- 380423-28-9
WAY-606344 (Compound 97) is an inhibitor of Casein kinase 1δ and shows potential for Alzheimer's disease research.
Formule :C₁₄H₈ClN₃O₂
Couleur et forme :Solid
Masse moléculaire :285.685
Ref: TM-T205317
+ Info
hCA XII/II/IX-IN-1
hCA XII/II/IX-IN-1 inhibits hCA I/II/IX/XII (IC50: 2.6, 0.004, 0.005, 0.001 μM) with anticancer properties.
Formule :C₂₅H₃₄N₄O₇S
Couleur et forme :Solid
Masse moléculaire :534.63
Ref: TM-T63764
+ Info
Nampt activator-4
CAS :
- 2847156-05-0
Nampt activator-4, a positive allosteric modulator (N-PAM) of nicotinamide phosphoribosyltransferase (NAMPT), has an EC50 of 0.058 μM and can enhance nicotinamide adenine dinucleotide (NAD+) levels in cells [1].
Formule :C₂₆H₂₂F₃N₇OS
Couleur et forme :Solid
Masse moléculaire :537.56
Ref: TM-T86957
+ Info
SMase-IN-1
CAS :
- 33017-85-5
SMase-IN-1 (Compound 4) is a bacterial sphingomyelinase (SMase) inhibitor with an IC50 value of 6.43 µM against Bacillus cereus SMase. It also inhibits eqBuChE with an inhibition rate of 59.50% at a concentration of 50 µM. SMase-IN-1 forms a complex with Cu2+ through bio-metal interactions and can inhibit hemolysis of sheep red blood cells induced by Bacillus cereus.
Formule :C₈H₅ClN₂OS
Couleur et forme :Solid
Masse moléculaire :212.656
Ref: TM-T204131
+ Info
ABHD antagonist 1
CAS :
- 3034510-10-3
ABHD antagonist 1 is an inhibitor of ABHD6 (α/β-Hydrolase domain containing 6), involved in modulating biochemical pathways affected by ABHD6, thereby influencing cell function and inflammatory responses. This compound is applicable for research in fields such as pain, neurological disorders, inflammatory diseases, autoimmune diseases, metabolic disorders, and cancer.
Formule :C₁₉H₂₀BrN₃O₃S
Couleur et forme :Solid
Masse moléculaire :450.35
Ref: TM-T88145
+ Info
BRD2879
CAS :
- 1304750-47-7
BRD2879 is a potent and cell-active inhibitor of IDH1-R132H (IC50 = 50 nM).
Formule :C₃₀H₃₈FN₃O₅S
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :571.70
Ref: TM-T26898
+ Info
Salacinol
CAS :
- 200399-47-9
Salacinol is a naturally occurring alpha-glucosidase inhibitor isolated from an Ayurvedic traditional medicine Salacia reticulata.
Formule :C₉H₁₈O₉S₂
Couleur et forme :Solid
Masse moléculaire :334.37
Ref: TM-T70002
+ Info
RORγt inverse agonist 32
CAS :
- 2301159-96-4
RORγt inverse agonist 32 (compound b14) exhibits oral activity and can be utilized in inflammatory research studies.
Formule :C₂₄H₂₈F₃NO₅S
Couleur et forme :Solid
Masse moléculaire :499.54
Ref: TM-T200887
+ Info
CAII-IN-3
CAII-IN-3, a thiosemicarbazone, potently inhibits CA-II with an IC50 of 13.4 μM.
Formule :C₁₈H₁₈F₂N₄S
Couleur et forme :Solid
Masse moléculaire :360.42
Ref: TM-T61340
+ Info
CK1δ-IN-6
CAS :
- 565167-37-5
CK1δ-IN-6 (Compound 303) is an inhibitor of Casein kinase 1δ, with potential applications in Alzheimer's disease research.
Formule :C₂₃H₁₇N₃O₄
Couleur et forme :Solid
Masse moléculaire :399.399
Ref: TM-T205075
+ Info
EB-0150
EB-0150 inhibits ER α-Glu I/II (IC50: 0.73/0.0337 μM), is an N-substituted valerian with antiviral effects, and has drug discovery potential.
Formule :C₁₉H₃₀N₆O₇
Couleur et forme :Solid
Masse moléculaire :454.48
Ref: TM-T62793
+ Info
GJG057
CAS :
- 2761767-18-2
GJG057 is a highly efficient and selective Leukotriene C4 synthase (LTC4S) inhibitor with an IC50 of 44 nM in human whole blood LTC4 release assays and oral activity. It demonstrates anti-inflammatory efficacy in a mouse asthma exacerbation model and can be used for the treatment of allergic inflammation.
Formule :C₂₁H₂₁F₅N₄O₂
Degré de pureté :99.8%
Couleur et forme :Solid
Masse moléculaire :456.41
Ref: TM-T205247
+ Info
CAII-IN-1
CAII-IN-1 (3n) is a selective bovine CA-II inhibitor with 10.3 μM IC50, used in carbonic anhydrase disorder studies.
Formule :C₁₉H₂₁FN₄S
Couleur et forme :Solid
Masse moléculaire :356.46
Ref: TM-T61292
+ Info
UGT1A1-IN-1
CAS :
- 2097024-37-6
UGT1A1-IN-1 (compound 2) acts as a non-competitive inhibitor of UGT1A1, effectively inhibiting the 1-O-glucuronidation process mediated by UGT1A1 with a Ki value of 5.02 μM. This compound binds to the same ligand-binding site on UGT1A1 as bilirubin and additionally functions as a 'turn-on' fluorescent probe substrate for UGT1A1 [1].
Formule :C₂₂H₁₉NO₃
Couleur et forme :Solid
Masse moléculaire :345.39
Ref: TM-T87592
+ Info
Anticancer agent 78
Anticancer agent 78: anti-aromatase (IC50=0.9 μM), cytotoxic, potential in breast cancer research.
Formule :C₁₉H₁₄BrNO₄
Couleur et forme :Solid
Masse moléculaire :400.22
Ref: TM-T61919
+ Info
RORγt inhibitor 4
CAS :
- 1426803-07-7
RORγt inhibitor 4 (Compound 9a) is an orally active RORγt inhibitor capable of penetrating the central nervous system. It has been shown to improve experimental autoimmune encephalomyelitis.
Formule :C₂₂H₁₆Cl₂F₃NO₄S
Couleur et forme :Solid
Masse moléculaire :518.333
Ref: TM-T205045
+ Info
Rivaroxaban diol
CAS :
- 1160170-00-2
Rivaroxabandiol is a metabolite of Rivaroxaban, which is a potent and selective direct inhibitor of coagulation factor Xa (FXa) with an IC50 of 0.7 nM and a Ki of 0.4 nM.
Formule :C₁₉H₂₀ClN₃O₆S
Couleur et forme :Solid
Masse moléculaire :453.897
Ref: TM-TYD-02008
+ Info
HSD17B13-IN-40
CAS :
- 2770246-06-3
HSD17B13-IN-40 (compound 6) serves as a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), exhibiting an IC50 value of less than 0.1 μM using estradiol as substrates. This compound is significant in the treatment of nonalcoholic fatty liver diseases (NAFLDs), including nonalcoholic steatohepatitis (NASH) [1].
Formule :C₂₃H₁₄Cl₂F₃N₃O₃
Masse moléculaire :508.28
Ref: TM-T86630
+ Info
sEH inhibitor-1
TCPU (sEH inhibitor-1) is a potent oral human sEH blocker with IC50s of 0.4 nM (human) and 5.3 nM (mouse).
Couleur et forme :Solid
Ref: TM-T64291
+ Info
7-Hydroxy-4-phenylcoumarin
CAS :
- 2555-30-8
7-Hydroxy-4-phenylcoumarin is a dual inhibitor of ALDH-2 and MAO, with IC50 values of 1.5 µM and 0.5 µM, respectively.
Formule :C₁₅H₁₀O₃
Couleur et forme :Solid
Masse moléculaire :238.238
Ref: TM-T205432
+ Info
OH-α-PVP TFA
CAS :
- 1797986-63-0
OH-α-PVP (OH-α-Pyrrolidinovalerophenone) TFA is a metabolite of α-pyrrolidinovalerophenone, which is a synthetic cathinone stimulant.
Formule :C₁₇H₂₄F₃NO₃
Masse moléculaire :347.37
Ref: TM-TN11134
+ Info
4-Acetylphenylboronic acid
CAS :
- 149104-90-5
4-Acetylphenylboronic acid acts as an effective inhibitor targeting carbonic anhydrase II (CAII), displaying inhibitory concentrations (IC50) of 246 μM for bovine CAII (bCA II) and 281.40 μM for human CAII (hCA II).
Formule :C₈H₉BO₃
Couleur et forme :Solid
Masse moléculaire :163.97
Ref: TM-T88721
+ Info
hCAVII/IX-IN-1
CAS :
- 1300714-76-4
hCAVII/IX-IN-1 (compound 4) functions as an inhibitor of hCAVII/IX, exhibiting Ki values of 56.5 nM and 38.2 nM, respectively. It is applicable in the field of cancer research.
Formule :C₇H₇N₃O₂S₂
Couleur et forme :Solid
Masse moléculaire :229.279
Ref: TM-T204621
+ Info
Complex III-IN-2
Complex III-IN-2 inhibits complex III, with antifungal EC50: 29.31 mg/L vs R. solani, 29.98 mg/L vs S. sclerotiorum.
Formule :C₁₅H₂₁ClN₂O₂S
Couleur et forme :Solid
Masse moléculaire :328.86
Ref: TM-T60949
+ Info
RXR antagonist 1
RXR antagonist 1 is a Retinoid X Receptor (RXR) modulator that exhibits high RXR antagonism (pA2: 8.06). RXR antagonist 1 can be used to study type 2 diabetes.
Formule :C₂₈H₃₃F₃N₂O₃
Couleur et forme :Solid
Masse moléculaire :502.57
Ref: TM-T63415
+ Info
LTA4H-IN-2
CAS :
- 2851480-52-7
LTA4H-IN-2 (compound (S)-2) acts as an orally active inhibitor targeting Leukotriene A4 Hydrolase, exhibiting potent activity with an IC 50 of less than 3 nM [1].
Formule :C₂₀H₁₉FN₆O₂
Couleur et forme :Solid
Masse moléculaire :394.4
Ref: TM-T86827
+ Info
CGS 24592
CAS :
- 147923-04-4
CGS-24592 is an orally active, selective, and potent inhibitor of neutral endopeptidase 24.11 (NEP), with an IC50 value of 1.6 nmol/L. It reduces the degradation of atrial natriuretic peptide (ANP), thereby increasing plasma ANP concentration and lowering blood pressure. CGS-24592 shows potential for research in cardiovascular diseases such as hypertension and congestive heart failure.
Formule :C₁₉H₂₃N₂O₆P
Couleur et forme :Solid
Masse moléculaire :406.37
Ref: TM-T206087
+ Info
Bestatin methyl ester
CAS :
- 65322-89-6
Bestatin methyl ester (600, 900 µM; 24 h) inhibits spore cell differentiation in Dictyostelium discoideum.
Formule :C₁₇H₂₆N₂O₄
Couleur et forme :Solid
Masse moléculaire :322.4
Ref: TM-T88754
+ Info
2-Amino-5-methyl-5-hexenoic acid
CAS :
- 73322-75-5
2-Amino-5-methyl-5-hexenoic acid ((S)-2-Amino-5-methylhex-5-enoic acid) acts as a methionine analog, competing with methionine and thereby hindering cell growth. This compound inhibits protein synthesis in Salmonella typhimurium TA1535 and Escherichia coli K-12 without affecting the synthesis of DNA or RNA.
Formule :C₇H₁₃NO₂
Couleur et forme :Solid
Masse moléculaire :143.184
Ref: TM-T205170
+ Info
ABT-046
CAS :
- 1031336-60-3
ABT-046 is an orally active, selective, and highly efficient Diacylglycerol Acyltransferase 1 (DGAT-1) inhibitor that can be used in metabolic disease research.
Formule :C₂₀H₂₂N₄O₂
Degré de pureté :98.13%
Couleur et forme :Solid
Masse moléculaire :350.41
Ref: TM-T14085
+ Info
PTP1B-IN-19
PTP1B-IN-19, a benzimidazole, selectively inhibits protein tyrosine phosphatase 1B with a Ki of 23.3 μM, potential for type 2 diabetes research.
Formule :C₂₆H₁₉N₃O₄S
Couleur et forme :Solid
Masse moléculaire :469.51
Ref: TM-T63023
+ Info
Lunacalcipol
CAS :
- 250384-82-8
Lunacalcipol is used for the treatment of Secondary Hyperparathyroidism.
Formule :C₂₈H₄₂O₄S
Couleur et forme :Solid
Masse moléculaire :474.7
Ref: TM-T32952
+ Info
Squalestatin 3
CAS :
- 142505-92-8
Squalestatin 3 is an inhibitor of squalene synthase.
Formule :C₂₅H₃₀O₁₃
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :538.5
Ref: TM-T24826
+ Info
9(S)-HETE
CAS :
- 107656-13-3
9(S)-HETE is an enantiomer of (±)9-HETE, not an enzymatic product, and doesn't promote cell adhesion like 12(S)-HETE. Identified by chiral HPLC.
Formule :C₂₀H₃₂O₃
Couleur et forme :Solid
Masse moléculaire :320.47
Ref: TM-T37411
+ Info
Casein Kinase II Inhibitor IV Hydrochloride
CAS :
- 2320347-54-2
Casein Kinase II Inhibitor IV HCl promotes keratinocyte differentiation, potential for skin disorder therapy.
Formule :C₂₄H₂₄ClN₅O₃
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :465.93
Ref: TM-T10687L
+ Info
ZK824859 hydrochloride
ZK824859 hydrochloride: oral uPA inhibitor with IC50 of 79 nM (uPA), 1580 nM (tPA), 1330 nM (fibrin).
Formule :C₂₃H₂₃ClF₂N₂O₄
Couleur et forme :Solid
Masse moléculaire :464.89
Ref: TM-T62961
+ Info
β-Glucuronidase/hCAII-IN-1
CAS :
- 2816080-17-6
β-Glucuronidase/hCAII-IN-2 (Compound 12e) is a compound that effectively inhibits both β-glucuronidase and human Carbonic Anhydrase II (hCA II), exhibiting IC50
Formule :C₃₀H₂₁NO₉
Couleur et forme :Solid
Masse moléculaire :539.49
Ref: TM-T63805
+ Info
hCAIX/XII-IN-15
CAS :
- 69141-46-4
hCAIX/XII-IN-15 (Compound 17β) is an inhibitor of hCA IX and hCA XII, exhibiting Ki values of 0.42 and 4.37 μM, respectively. It demonstrates a pro-apoptotic effect in multiple myeloma cells.
Formule :C₁₇H₁₈O₄S
Couleur et forme :Solid
Masse moléculaire :318.387
Ref: TM-T206751
+ Info
4-(4-Bromophenyl)-4-hydroxypiperidine
CAS :
- 57988-58-6
4-(4-Bromophenyl)-4-hydroxypiperidine (BPHP) is a metabolite of Bromperidol (BRO), produced through the N-dealkylation of BRO.
Formule :C₁₁H₁₄BrNO
Couleur et forme :Solid
Masse moléculaire :256.139
Ref: TM-TYD-02042
+ Info
A-800141
CAS :
- 681245-85-2
A-800141 is an orally active and selective MetAP2 inhibitor with an IC50 of 12 nM, while showing weaker inhibitory activity against MetAP1 (IC50: 36 μM). GAPDH can serve as a biomarker for monitoring the inhibition of MetAP2 by A-800141. This compound exhibits anti-angiogenic and anticancer properties in various xenograft tumor models.
Formule :C₂₄H₃₀N₂O₄S
Couleur et forme :Solid
Masse moléculaire :442.571
Ref: TM-T204983
+ Info
HIV-1 inhibitor-40
HIV-1 inhibitor-40 (4ab) is a potent NNRTI (EC50: 1.9 nM), non-toxic in vivo, and a sensitive CYP inhibitor.
Formule :C₂₅H₁₈N₆O₂
Couleur et forme :Solid
Masse moléculaire :434.45
Ref: TM-T62452
+ Info
CK2 inhibitor 3
CK2 inhibitor 3: potent CK2 blocker, IC50 of 280 nM, suppresses tumor cell growth, highly selective among 320 kinases.
Formule :C₁₃H₉BrN₄O₃S
Couleur et forme :Solid
Masse moléculaire :381.2
Ref: TM-T61629
+ Info
(Rac)-OSMI-1
(Rac)-OSMI-1, a racemate, inhibits OGT (IC50: 2.7 μM) affecting O-GlcNAcylation without changing surface glycans.
Formule :C₂₈H₂₅N₃O₆S₂
Couleur et forme :Solid
Masse moléculaire :563.64
Ref: TM-T63988
+ Info
Fusarisetin A
CAS :
- 1300041-53-5
Fusarisetin A, a pentacyclic fungal metabolite, is an acinar morphogenesis inhibitor .
Formule :C₂₂H₃₁NO₅
Couleur et forme :Solid
Masse moléculaire :389.49
Ref: TM-T72867
+ Info
IDO1-IN-13
IDO1-IN-13 is a potent IDO1 inhibitor (IC50: 61.6 nM, EC50: 30 nM in HeLa) that reduces kyn/trp ratio by 51% in SK-OV-3 tumors.
Formule :C₂₀H₁₆BrN₅O₂S
Couleur et forme :Solid
Masse moléculaire :470.34
Ref: TM-T63034
+ Info
HIF-1/2α-IN-1
HIF-1/2α-IN-1, an orally active compound, functions as an inhibitor of HIF-2α.
Formule :C₁₇H₁₆N₆O₄
Couleur et forme :Solid
Masse moléculaire :368.35
Ref: TM-T61442
+ Info
hMAO-B/MB-COMT-IN-1
Dual hMAO-B/MB-COMT inhibitor, IC50: 2.5 μΜ (hMAO-B), 3.84 μΜ (MB-COMT); potential in Parkinson's research.
Formule :C₁₆H₁₉NO₃
Couleur et forme :Solid
Masse moléculaire :273.33
Ref: TM-T60489
+ Info
Homodestcardin
CAS :
- 917382-84-4
Homodestcardin: cyclic depsipeptide from T. roseum with immunosuppressant properties; inhibits mouse T cell proliferation.
Formule :C₃₂H₅₅N₅O₇
Couleur et forme :Solid
Masse moléculaire :621.81
Ref: TM-T68351
+ Info
PDE4-IN-5
PDE4-IN-5: potent PDE4 inhibitor, IC50 = 3.1 nM, superb skin penetration, anti-psoriasis effect.
Formule :C₂₁H₂₈N₂O₃
Couleur et forme :Solid
Masse moléculaire :356.46
Ref: TM-T61295
+ Info
ZK168281
CAS :
- 186371-96-0
ZK168281 is a 1α,25(OH)2D3 analog, VDR antagonist with 0.1 nM Kd, and blocks receptor CoA interaction.
Formule :C₃₂H₄₆O₅
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :510.70
Ref: TM-T13404
+ Info
Turoctocog alfa
CAS :
- 1192451-26-5
Turoctocog alfa: recombinant FVIII from CHO cells for hemophilia A study.
Couleur et forme :Solid
Ref: TM-T64298
+ Info
Lp-PLA2-IN-5
CAS :
- 2738877-85-3
Lp-PLA2-IN-5 inhibits Lp-PLA2 and PAF-AH, potentially useful in Alzheimer's and atherosclerosis studies.
Formule :C₂₃H₁₈F₅N₃O₄
Couleur et forme :Solid
Masse moléculaire :495.4
Ref: TM-T63345
+ Info
PKR-IN-1
CAS :
- 3057531-75-3
PKR-IN-1 (Compound 5s) is a pyruvate kinase (PK) inhibitor with antifungal properties, exhibiting an EC50 of 0.21 μg/mL against Rhizoctonia solani (R. solani).
Formule :C₉HCl₅N₄OS₂
Couleur et forme :Solid
Masse moléculaire :422.525
Ref: TM-T206852
+ Info
Calcipotriol Impurity C
CAS :
- 113082-99-8
Calcipotriol Impurity C is the impurity of Calcipotriol. Calcipotriol is a VDR-like receptors ligand.
Formule :C₂₇H₄₀O₃
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :412.614
Ref: TM-T13590
+ Info
FXIa-IN-8
FXIa-IN-8: potent FXIa blocker (IC50: 14.2 nM), anti-thrombotic, low bleeding/toxicity risk.
Couleur et forme :Solid
Ref: TM-T64257
+ Info
LXRβ agonist-3
CAS :
- 2413308-63-9
LXRβ agonist-3 is a potent and selective LXRβ (liver X receptor β) agonist (EC50: 0.095 μM).
Formule :C₃₀H₃₃N₃O₆S
Couleur et forme :Solid
Masse moléculaire :563.66
Ref: TM-T63989
+ Info
PTP1B-IN-18
PTP1B-IN-18 is an orally active, fully mixed protein tyrosine phosphatase 1B (PTP1B) inhibitor (Ki: 35.2 μM).PTP1B-IN-18 can be used to study type 2 diabetes.
Formule :C₂₆H₁₉N₃O₄S
Couleur et forme :Solid
Masse moléculaire :469.51
Ref: TM-T63022
+ Info
Lufironil
CAS :
- 128075-79-6
Lufironil (HOE 077) is an inhibitor of prolyl 4-hydroxylase, designed for investigating chronic liver conditions such as alcoholic hepatitis and cirrhosis.
Formule :C₁₃H₁₉N₃O₄
Couleur et forme :Solid
Masse moléculaire :281.31
Ref: TM-T207410
+ Info
ATUX-8385
CAS :
- 2088956-86-7
ATUX-8385 is a potent activator of PP2A. It binds to the PR65 subunit and holds promise for research into cancer and chronic diseases, including Alzheimer's disease and chronic obstructive pulmonary disease (COPD).
Formule :C₂₄H₂₀F₅N₃O₄S
Couleur et forme :Solid
Masse moléculaire :541.49
Ref: TM-T204196
+ Info
SGK1-IN-3
SGK1-IN-3: Potent oral inhibitor of SGK1, may target osteoarthritis.
Formule :C₂₃H₂₀Cl₂N₆O₃S
Couleur et forme :Solid
Masse moléculaire :531.41
Ref: TM-T63741
+ Info
ICMT-IN-55
CAS :
- 1313602-77-5
ICMT-IN-55 (compound 31) acts as an ICMT inhibitor, exhibiting an IC50 value of 90 nM [1].
Formule :C₂₂H₂₆F₃NO₂
Couleur et forme :Solid
Masse moléculaire :393.44
Ref: TM-T86702
+ Info
Antidiabetic agent 5
CAS :
- 2152667-21-3
Compound S1 (antidiabetic agent 5) is an antidiabetic agent that effectively inhibits the enzymes α-glucosidase and α-amylase, demonstrating IC50 values of 3.91 µM and 8.89 µM, respectively. It reduces sugar levels and holds potential for type-II diabetes research [1].
Formule :C₁₇H₁₅N₃O₄S
Couleur et forme :Solid
Masse moléculaire :357.38
Ref: TM-T85678
+ Info
NAMPT activator-6
CAS :
- 2237267-86-4
NAMPT activator-6, a regulatory molecule for the optical control system of NAMPT and NAD+, can be used to design efficient photoswitchable proteolysis-targeting chimeras (PS-PROTACs) for light-dependent, reversible regulation of NAMPT and NAD+, thereby reducing toxicity associated with inhibitor-based PS-PROTACs. This enables antitumor activity and in vivo modulation of NAMPT and NAD+ through optical manipulation [1].
Formule :C₁₇H₂₁N₅O₃S
Couleur et forme :Solid
Masse moléculaire :375.45
Ref: TM-T86958
+ Info
Zaragozic acid C
CAS :
- 146389-62-0
Zaragozic acid C is an effective inhibitor of squalene synthase.
Formule :C₄₀H₅₀O₁₄
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :754.82
Ref: TM-T24710
+ Info
ZK159222
CAS :
- 156965-15-0
ZK159222 is an effective 1α,25-(OH)2D3 receptor (VDR) agonist. ZK159222 has a partial agonistic character.
Formule :C₃₂H₄₈O₅
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :512.72
Ref: TM-T17292
+ Info
GPX4-IN-15
CAS :
- 3032966-42-7
GPX4-IN-15 (Compound C1) is an inhibitor of GPX4, demonstrating an inhibition rate of 19.8% at a concentration of 1 μM. This compound effectively inhibits the proliferation of cancer cell lines MDA-MB-468, BT-549, and MDA-MB-231, with IC50 values of 0.86 μM, 0.96 μM, and 0.48 μM respectively.
Formule :C₁₇H₁₅Cl₂NO₄
Couleur et forme :Solid
Masse moléculaire :368.21
Ref: TM-T201732
+ Info
WR 199507 trihydrobromide
CAS :
- 57514-28-0
WR 199507 trihydrobromide is a primary aminoquinoline metabolite that induces the formation of methemoglobin in canine erythrocyte lysates.
Formule :C₁₅H₂₄Br₃N₃O₂
Couleur et forme :Solid
Masse moléculaire :518.08
Ref: TM-T201764
+ Info
Perfluorohexane sulfonamide
CAS :
- 41997-13-1
Perfluorohexane sulfonamide (FHxSA) serves as an inhibitor of carbonic anhydrase (CA), effectively inhibiting bovine CA and human CAII with IC50 values of 0.122 and 1.38 μM, respectively. Additionally, it acts as a delayed-action insecticide for controlling red imported fire ants (Solenopsis invicta). Furthermore, Perfluorohexane sulfonamide is considered a potential environmental pollutant.
Formule :C₆H₂F₁₃NO₂S
Couleur et forme :Solid
Masse moléculaire :399.13
Ref: TM-T201506
+ Info
KY-455
CAS :
- 178469-71-1
KY-455 is a novel acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor. It demonstrates inhibition of ACAT in rabbit intestines, liver, macrophages, and adrenal glands with IC50 values of 0.4, 0.9, 2.9, and 4.1 μmol/L, respectively.
Formule :C₂₀H₃₂N₂O
Couleur et forme :Solid
Masse moléculaire :316.48
Ref: TM-T201482
+ Info
Emopamil
CAS :
- 78370-13-5
Emopamil, a calcium channel inhibitor, reduces neuronal damage caused by ischemia.
Formule :C₂₃H₃₀N₂
Couleur et forme :Solid
Masse moléculaire :334.5
Ref: TM-T201608
+ Info
MD 770222
CAS :
- 70133-35-6
MD 770222, the principal plasma O-demethylated metabolite of Cimoxatone, is an orally active selective and reversible inhibitor of MAO A. The potency of MD 770222 is lower than that of Cimoxatone.
Formule :C₁₈H₁₆N₂O₄
Couleur et forme :Solid
Masse moléculaire :324.33
Ref: TM-T201612
+ Info
Estradiol 3-glucuronide
CAS :
- 15270-30-1
Estradiol 3-glucuronide is an immunogen with antigenic properties. The antiserum induced in rabbits exhibits high affinity and specificity for Estradiol 3-glucuronide. This compound shows promise for use in research involving radioimmunoassay.
Formule :C₂₄H₃₂O₈
Couleur et forme :Solid
Masse moléculaire :448.51
Ref: TM-T201862
+ Info
7PPD-Q
CAS :
- 2894124-00-4
7PPD-Q is a substituted p-phenylenediamine antioxidant derivative. It exhibits toxicity towards the bacterium V. fischeri (EC50= 14.9 mg/L).
Formule :C₁₉H₂₄N₂O₂
Couleur et forme :Solid
Masse moléculaire :312.41
Ref: TM-T201775
+ Info
Utibaprilat
CAS :
- 109683-79-6
Utibaprilat is the primary degradation product of Utibapril and functions as an ACE inhibitor.
Formule :C₂₀H₂₇N₃O₅S
Couleur et forme :Solid
Masse moléculaire :421.51
Ref: TM-T201545
+ Info
MGAT2-IN-1
CAS :
- 1800025-30-2
MGAT2-IN-1 is an orally active monoacylglycerol acyltransferase (MGAT2)inhibitor (human and mouse MGAT2 with IC50 of 7.8 and 2.4 nM , respectively).
Formule :C₂₇H₂₁ClF₅N₇O₃S
Couleur et forme :Solid
Masse moléculaire :654.01
Ref: TM-T12028
+ Info
α-Hydroxy alprazolam
CAS :
- 37115-43-8
α-Hydroxy alprazolam (U 40125), the primary metabolite of α-Hydroxy alprazolam, possesses pharmacological activity accounting for 60% of that of Alprazolam.
Formule :C₁₇H₁₃ClN₄O
Couleur et forme :Solid
Masse moléculaire :324.76
Ref: TM-T201680
+ Info
Beloranib
CAS :
- 251111-30-5
Beloranib is a fumagillin anticancer drug. Beloranib belongs to an angiogenesis inhibitor.
Formule :C₂₉H₄₁NO₆
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :499.64
Ref: TM-T19871
+ Info
S-15176
CAS :
- 148089-70-7
S-15176 is an inhibitor of the mitochondrial permeability transition pore (PTP). It effectively suppresses mitochondrial swelling induced by tert-butyl hydroperoxide, with an IC50 value of 45.7 μM. S-15176 prevents the opening of PTP, thus averting the dissipation of mitochondrial membrane potential and the oxidation of NAD(P)H, while enhancing mitochondrial calcium loading capacity. It holds potential for research into ischemia-reperfusion injury.
Formule :C₃₁H₄₈N₂O₄S
Couleur et forme :Solid
Masse moléculaire :544.79
Ref: TM-T207660
+ Info
FXR agonist 12
CAS :
- 1831862-88-4
FXR agonist12 (Compound C7) is an orally active FXR agonist. It downregulates bile acid synthesis-related genes and upregulates bile acid transport-related genes in HepG2 cells. FXR agonist12 alleviates ANIT-induced cholestasis and reduces liver damage and fibrosis in a mouse model of NASH.
Formule :C₂₆H₄₄O₃
Couleur et forme :Solid
Masse moléculaire :404.626
Ref: TM-T205709
+ Info
Propofol sulfate sodium
CAS :
- 2748343-63-5
Propofolsulfate (sodium) is a metabolite of Propofol.
Formule :C₁₂H₁₇NaO₄S
Couleur et forme :Solid
Masse moléculaire :280.316
Ref: TM-TYD-02096
+ Info
QGC583
CAS :
- 2417001-25-1
QGC583 is an effective and selective AminopeptidaseA (APA) inhibitor, demonstrating an IC50 of 4 nM. It inhibits APA activity in the brain, kidneys, and heart of rats.
Formule :C₁₃H₂₀NO₅P
Couleur et forme :Solid
Masse moléculaire :301.28
Ref: TM-T200621
+ Info
DGAT2-IN-3
CAS :
- 3037141-61-7
DGAT2-IN-3 (compound 9) is an inhibitor of DGAT2 with an IC50 value of 0.4 nM. It is utilized in research related to fatty liver disease, diabetes, and cardiovascular diseases.
Formule :C₂₁H₂₀F₄N₄O₅S
Couleur et forme :Solid
Masse moléculaire :516.47
Ref: TM-T200747
+ Info
Carbonic anhydrase inhibitor 3
Carbonic anhydrase inhibitor 3 (compound 11g) is an inhibitor of carbonic anhydrase II that reduces the intraocular pressure in glaucomatous rabbits [1].
Formule :C₁₅H₁₇N₃O₃S
Couleur et forme :Solid
Masse moléculaire :319.38
Ref: TM-T60848
+ Info
BAR-2227
CAS :
- 2409154-23-8
BAR-2227 (compound 3a) functions as an FXR agonist and a LIFR inhibitor. It is utilized in the study of liver fibrosis and inflammation.
Formule :C₂₄H₁₇Cl₂NO₄
Couleur et forme :Solid
Masse moléculaire :454.30
Ref: TM-T200662
+ Info
(rel)-Mirogabalin
CAS :
- 1138244-97-9
(rel)-Mirogabalin ((rel)-DS5565) is an inhibitor of voltage-dependent calcium channels, specifically targeting the α2δ-1 subunit.
Formule :C₁₂H₁₉NO₂
Couleur et forme :Solid
Masse moléculaire :209.28
Ref: TM-T200506
+ Info
Xanthosine-5'-monophosphate
CAS :
- 523-98-8
Xanthosine 5'-monophosphate is produced from inosine monophosphate (IMP) through the catalytic action of inosine monophosphate dehydrogenase (IMPDH).
Formule :C₁₀H₁₃N₄O₉P
Couleur et forme :Solid
Masse moléculaire :364.21
Ref: TM-T201502
+ Info
Z57346765
CAS :
- 1016340-64-9
Z57346765 is a specific PGK1 inhibitor that inhibits PGK1-dependent cell proliferation by decreasing the metabolic enzyme activity of PGK1 during glycolysis.
Formule :C₁₇H₁₈N₄O
Degré de pureté :99.85%
Couleur et forme :Solid
Masse moléculaire :294.35
Ref: TM-T87659
+ Info
PRL3-CNNM4 interaction-IN-1
CAS :
- 40133-06-0
PRL3-CNNM4 interaction-IN-1 (Compound C28d52) is an inhibitor of the PRL3-CNNM4 interaction that also suppresses CNNM inhibition mediated by PRL. This compound exhibits favorable pharmacokinetic and drug metabolism properties.
Formule :C₈H₈O₂S
Couleur et forme :Solid
Masse moléculaire :168.21
Ref: TM-T200840
+ Info
4-Hydroxyclonidine
CAS :
- 57101-48-1
4-Hydroxyclonidine is a metabolite of Clonidine. It is equally effective as Clonidine in displacing labeled Clonidine from antibodies.
Formule :C₉H₉Cl₂N₃O
Couleur et forme :Solid
Masse moléculaire :246.093
Ref: TM-TYD-01857
+ Info
PENAO
CAS :
- 1192411-43-0
PENAO is a potent mitochondrial toxin for tumor cells. It deactivates the mitochondria of tumor cells by targeting the adenine nucleotide translocase in the cell membrane.
Formule :C₁₃H₁₉AsN₂O₅S
Couleur et forme :Solid
Masse moléculaire :390.29
Ref: TM-T207680
+ Info
m-APTA
CAS :
- 86072-47-1
m-APTA (5'-S-(3-aminophenyl)-5'-thioadenosine) is a selective chemoprotective agent targeting methylthioadenosine phosphorylase (MTAP). It can be converted into adenine, which is a crucial step in shielding normal cells from the toxicity of nucleobase analogs (NBA). m-APTA holds potential for research in MTAP-deficient cancers.
Formule :C₁₆H₁₈N₆O₃S
Couleur et forme :Solid
Masse moléculaire :374.418
Ref: TM-T206811
+ Info
Deamino-NAD sodium
CAS :
- 104809-38-3
Deamino-NAD sodium, a structural analog of NAD+, serves as a substrate for rabbit muscle glyceraldehyde 3-phosphate dehydrogenase (GPDH) in glycolysis. It exhibits a Km of 2300 pm and a Kd of 112 pm.
Formule :C₂₁H₂₅N₆NaO₁₅P₂
Couleur et forme :Solid
Masse moléculaire :686.39
Ref: TM-T200588
+ Info
FTI-2148
CAS :
- 251577-09-0
FTI-2148 blocks RAS-related FT-1 & GGT-1; IC50: 1.4 nM & 1.7 μM.
Formule :C₂₄H₂₈N₄O₃S
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :452.57
Ref: TM-T11330L
+ Info
Anticancer agent 142
CAS :
- 2948338-60-9
Compound 142 (also known as Compound 235) is a PTPN inhibitor with potential applications in cancer research [1].
Formule :C₁₃H₁₄BrF₂N₂O₇PS₂
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :523.26
Ref: TM-T79843
+ Info
11-Mercaptoundecanoate-NHS
CAS :
- 240125-70-6
11-Mercaptoundecanoate-NHS is a lipid utilized in the synthesis of Linkers.
Formule :C₁₅H₂₅NO₄S
Couleur et forme :Solid
Masse moléculaire :315.428
Ref: TM-TYD-02063
+ Info
α-Glucosidase-IN-17
CAS :
- 2820424-84-6
α-Glucosidase-IN-17 (Compound 12B) is a potent and orally active inhibitor of α-glucosidase, demonstrating antidiabetic activity with an inhibitory
Formule :C₃₀H₂₇NO₂S
Couleur et forme :Solid
Masse moléculaire :465.61
Ref: TM-T62972
+ Info
Thioquinapiperifil dihydrochloride
CAS :
- 204077-66-7
Thioquinapiperifil dihydrochloride is a potent, selective PDE-5 inhibitor (IC50: 0.074 nM) for research.
Formule :C₂₄H₂₉ClN₆OS
Degré de pureté :98.73%
Couleur et forme :Solid
Masse moléculaire :485.05
Ref: TM-T9773
+ Info
ATX inhibitor 22
ATX inhibitor 22 is a novel inhibitor of ATX (autotaxin) (IC50: 218.9 μM) that lacks inhibitory activity against LPAR1.
Formule :C₁₉H₁₇Cl₃F₂N₂O₄S
Couleur et forme :Solid
Masse moléculaire :513.77
Ref: TM-T63564
+ Info
CA IX-IN-3
CAS :
- 333413-02-8
CAIX-IN-3 (Compound 27) is a selective and potent inhibitor of carbonic anhydrase IX (CAIX), with an IC50 of 0.48 nM.
Formule :C₂₁H₁₉N₅O₄S₂
Couleur et forme :Solid
Masse moléculaire :469.537
Ref: TM-T204606
+ Info
Diacylglycerol acyltransferase inhibitor-1
CAS :
- 1610800-25-3
Diacylglycerol Acyltransferase Inhibitor-1, a diacylglycerol acyltransferase (DGAT1) inhibitor, effectively suppresses the activity of DGAT1.
Formule :C₂₁H₂₃N₅O₂
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :377.44
Ref: TM-T11037
+ Info
Docosapentaenoic acid (22n-3) sodium
CAS :
- 2983837-44-9
Docosapentaenoic acid (22n-3) sodium is a component of phospholipids. It exhibits inhibitory activity against α-amylase and α-glucosidase, with IC50 values of 17 μg/mL and 22 μg/mL, respectively. Additionally, Docosapentaenoic acid 22n-3 sodium enhances cell viability and has mild anti-inflammatory effects.
Formule :C₂₂H₃₄NaO₂
Couleur et forme :Solid
Masse moléculaire :353.494
Ref: TM-T206225
+ Info
PFM046
CAS :
- 3053859-57-4
PFM046 is an antagonist of the liver X receptor (LXR), effectively inhibiting the activation of LXRα and LXRβ, with IC50 values of 2.04 μM and 1.58 μM respectively. It reduces the expression of SCD1 and FASN while increasing ABCA1 expression, and demonstrates antitumor activity in mouse models.
Formule :C₂₉H₄₂O₂
Couleur et forme :Solid
Masse moléculaire :422.643
Ref: TM-T204254
+ Info
NR1H4 activator 1
CAS :
- 2242855-68-9
NR1H4 activator 1 is a potent and selective agonist of Famesoid X Receptor (FXR).
Formule :C₃₄H₅₃NO₇S
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :619.85
Ref: TM-T12251
+ Info
Danifexor
CAS :
- 2648738-68-3
Danifexor is an agonist of the farnesoid X receptor (Farnesoid X receptor).
Formule :C₂₉H₂₀Cl₂N₂O₅
Couleur et forme :Solid
Masse moléculaire :547.386
Ref: TM-T206509
+ Info
DOCP
CAS :
- 1360461-57-9
DOCP (2-((2,3-Bis(oleoyloxy)propyl)dimethylammonio)ethyl hydrogen phosphate) is a lipid characterized by an opposite charge orientation compared to traditional phosphatidylcholine (PC) lipids, featuring quaternary ammonium near the bilayer interface and phosphate groups projecting into the aqueous environment. This unique structure of iPC lipids presents an excellent opportunity to investigate the biophysical characteristics and biological activities influenced by the reversal of surface charges on bilayers.
Formule :C₄₃H₈₂NO₈P
Couleur et forme :Solid
Masse moléculaire :772.09
Ref: TM-T201007
+ Info
Mibefradil
CAS :
- 116644-53-2
Mibefradil is a calcium channel blocker with moderate selectivity for T-type Ca2+ channels (IC50s: 2.7 μM and 18.6 μM for T-type and L-type currents).
Formule :C₂₉H₃₈FN₃O₃
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :495.63
Ref: TM-TQ0153
+ Info
Tovinontrine
CAS :
- 2062661-53-2
Tovinontrine (IMR-687) (IMR-687) is a potent and selective inhibitor of phosphodiesterase-9 (PDE9), designed to target sickle cell disease treatment.
Formule :C₂₁H₂₆N₆O₂
Degré de pureté :98.14%
Couleur et forme :Solid
Masse moléculaire :394.47
Ref: TM-T61833
+ Info
LEQ803
CAS :
- 1211441-59-6
LEQ803 (N-DesmethylRibociclib) is a metabolite of the CDK4/6 inhibitor Ribociclib, produced through metabolism by CYP3A4. This compound holds potential applications in the field of oncology.
Formule :C₂₂H₂₈N₈O
Couleur et forme :Solid
Masse moléculaire :420.511
Ref: TM-T206449
+ Info
Casein kinase 1δ-IN-23
CAS :
- 729579-66-2
Casein kinase1δ-IN-23 (compound 423) is an effective inhibitor of casein kinase1δ. It is applicable in research related to neurodegenerative diseases such as Alzheimer's disease.
Formule :C₁₉H₁₅N₃O₃S
Couleur et forme :Solid
Masse moléculaire :365.406
Ref: TM-T204385
+ Info
Glycerophosphoglycerol
CAS :
- 6418-92-4
Glycerophosphoglycerol is a precursor in phospholipid synthesis. By enhancing phospholipid formation, it aids in the reconstruction and proliferation of membrane structures in tumor cells. Glycerophosphoglycerol holds promise for research in breast cancer cells.
Formule :C₆H₁₅O₈P
Couleur et forme :Solid
Masse moléculaire :246.15
Ref: TM-TXB-00776
+ Info
CP 524515
CAS :
- 262352-13-6
CP 524515 is a potent inhibitor of cholesterol ester transfer protein (CETP), which results in increased levels of high-density lipoprotein cholesterol.
Formule :C₂₇H₂₇F₉N₂O₄
Couleur et forme :Solid
Masse moléculaire :614.5
Ref: TM-T204330
+ Info
4-MDM
CAS :
- 834-14-0
4-MDM (4-Methoxydiphenylmethane) is an orally active anti-inflammatory compound that selectively enhances the aminopeptidase activity of leukotriene A4 hydrolase (LTA4H). By promoting the degradation of proline-glycine-proline by LTA4H, 4-MDM reduces neutrophil recruitment in the lungs, alleviating inflammation without affecting the epoxide hydrolase activity of LTA4H. This compound is useful for research in pulmonary diseases.
Formule :C₁₄H₁₄O
Couleur et forme :Solid
Masse moléculaire :198.26
Ref: TM-T204132
+ Info
CYP11B1-IN-2
CYP11B1-IN-2 selectively inhibits human and rat CYP11B1 (IC50: 9/25 nM) orally to research cortisol-related diseases.
Couleur et forme :Solid
Ref: TM-T64249
+ Info
PF-07202954
CAS :
- 2639372-47-5
PF-07202954, a weakly basic diacylglycerol O-acyltransferase 2 (DGAT2) inhibitor, exhibits an inhibition concentration half-maximum (IC50) of 10 nM against
Formule :C₂₂H₂₃FN₆O₃
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :438.45
Ref: TM-T79764
+ Info
Yck2-IN-1
CAS :
- 401816-26-0
Yck2-IN-1 (Compound 2a) is an inhibitor of the fungus Candida albicans Yck2. It has an IC50 of approximately 80 nM for Yck2 and an MIC80 of 12.5 µM for C. albicans, demonstrating good metabolic stability [66% remaining in mouse liver microsomes]. In a mouse model with drug-resistant Candida, Yck2-IN-1 significantly reduced fungal load in the kidneys. Yck2-IN-1 shows potential for research in antifungal infection treatments.
Formule :C₁₉H₁₁FN₄
Couleur et forme :Solid
Masse moléculaire :314.316
Ref: TM-T206070
+ Info
2R,4S-Sacubitril
CAS :
- 761373-05-1
2R,4S-Sacubitril (Sacubitril Enantiomer) is the impurity of Sacubitril which is a neprilysin inhibitor.
Formule :C₂₄H₂₈NO₅₁Ca
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :430.49
Ref: TM-T19112
+ Info
AD011
AD011, a cACE/NEP inhibitor derived from lenopril-tryptophan, may offer strong anti-hypertensive, cardioprotective benefits.
Formule :C₂₇H₃₃N₃O₅
Couleur et forme :Solid
Masse moléculaire :479.57
Ref: TM-T63160
+ Info
Casein kinase 1δ-IN-17
CAS :
- 450394-66-8
Casein kinase1δ-IN-17 (compound 753) is an inhibitor of casein kinase 1δ (CK1δ). It is applicable in research related to neurodegenerative diseases.
Formule :C₁₄H₁₄N₄S
Couleur et forme :Solid
Masse moléculaire :270.353
Ref: TM-T204832
+ Info
PPARδ agonist 11
CAS :
- 2982696-04-6
Compound 11, a selective PPARδ agonist, demonstrates an EC50 of 20 nM, indicating its high affinity for PPARδ receptors. This compound efficiently reduces levels of nitric oxide (NO), as well as the pro-inflammatory cytokines TNFα and IL-6 in LPS-stimulated RAW264.7 cells via the NF-κB pathway, showcasing its anti-inflammatory properties. Additionally, Compound 11 exhibits remarkable stability in human liver microsomes and plasma. It significantly ameliorates foot edema induced by Carrageenan, displaying favorable pharmacokinetic properties with a bioavailability of approximately 100%.
Formule :C₁₉H₁₅F₃N₂O₃S₂
Couleur et forme :Solid
Masse moléculaire :440.46
Ref: TM-T200543
+ Info
BAY 74-4113
CAS :
- 791593-56-1
BAY 74-4113 is a DGAT1 inhibitor with an IC50 of 72 nM. It is utilized in research related to obesity.
Formule :C₂₆H₂₀F₂N₂O₃S
Couleur et forme :Solid
Masse moléculaire :478.51
Ref: TM-T207624
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EB-0176
EB-0176: A valerian derivative; broad-spectrum antiviral; potent ER α-glucosidase I/II inhibitor; IC50s: 0.6439/0.0011 μM.
Formule :C₂₃H₃₃N₅O₇
Couleur et forme :Solid
Masse moléculaire :491.54
Ref: TM-T63303
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IDO2-IN-1
CAS :
- 2803768-09-2
IDO2-IN-1: potent oral IDO2 inhibitor, IC50 = 112 nM, for inflammatory autoimmunity research.
Formule :C₂₁H₂₁BrN₁₀O₃
Couleur et forme :Solid
Masse moléculaire :541.36
Ref: TM-T63814
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RWJ-445167
CAS :
- 226566-43-4
RWJ-445167 is a thrombin and factor Xa dual inhibitor(Ki of 4.0 nM and 230 nM, respectively), with potent antithrombotic activity.
Formule :C₁₈H₂₄N₆O₅S
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :436.49
Ref: TM-T12782
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ASB14780
ASB14780 is a 4-phenoxy derivative and an inhibitor of cytoplasmic phospholipase cPLA2α (IC50: 20 nM).
Couleur et forme :Solid
Ref: TM-T64237
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DC360
CAS :
- 2324152-25-0
DC360 is a synthetic analog of all-trans retinoic acid (ATRA) that can induce the expression of RARβ. It is useful for studies characterizing the retinoic acid signaling pathway.
Formule :C₂₃H₂₃NO₂
Couleur et forme :Solid
Masse moléculaire :345.434
Ref: TM-T204562
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11β-HSD2-IN-2
CAS :
- 1834601-37-4
11β-HSD2-IN-2 (compound 3) is a selective 17β-HSD2 (17β-hydroxysteroid dehydrogenase type 2) inhibitor with an IC50 of 300 nM, studying osteoporosis.
Formule :C₂₂H₂₁NO₂
Degré de pureté :99.61%
Couleur et forme :Solid
Masse moléculaire :331.41
Ref: TM-T85382