Métabolisme
Les inhibiteurs du métabolisme sont des composés qui interfèrent avec les voies métaboliques, modifiant ainsi la production et l'utilisation de l'énergie au sein des cellules. Ces inhibiteurs sont utilisés pour étudier la régulation du métabolisme, le rôle des voies métaboliques dans des maladies telles que le cancer et le diabète, et pour développer de nouvelles stratégies thérapeutiques. Les inhibiteurs du métabolisme peuvent cibler diverses enzymes et processus impliqués dans la glycolyse, l'oxydation des acides gras et d'autres fonctions métaboliques. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de métabolisme de haute qualité pour soutenir vos recherches en biochimie, troubles métaboliques et développement de médicaments.
Sous-catégories appartenant à la catégorie "Métabolisme"
- AhR(42 produits)
- Aminopeptidase(76 produits)
- CETP(20 produits)
- Anhydrase carbonique(196 produits)
- Caséine Kinase(138 produits)
- DHFR(30 produits)
- Décarboxylase(4 produits)
- Déshydrogénase(302 produits)
- FAAH(64 produits)
- FXR(62 produits)
- Facteur Xa(87 produits)
- Synthase des acides gras(37 produits)
- Ferroptose(227 produits)
- GR(3 produits)
- GSNOR(3 produits)
- Glucokinase(56 produits)
- Prolyl-Hydroxylase de HIF/HIF(146 produits)
- HMG-CoA Réductase(34 produits)
- Hydroxylase(36 produits)
- IDO(84 produits)
- LDL(7 produits)
- Lipase(107 produits)
- Lipides(62 produits)
- Lipoxygénase(133 produits)
- MAO(85 produits)
- MPO(2 produits)
- NAMPT(40 produits)
- P450(6 produits)
- PAI-1(26 produits)
- PDE(170 produits)
- PED(1 produits)
- PKM(17 produits)
- PPAR(170 produits)
- Phospholipase(85 produits)
- ROR(47 produits)
- Récepteur de rétinoïdes(20 produits)
- SGK(10 produits)
- Thioredoxine(12 produits)
- Transférase(30 produits)
- Tansporteur(43 produits)
- UGT(4 produits)
- Inhibiteurs de la xanthine oxydase (XO)(9 produits)
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9200 produits trouvés pour "Métabolisme"
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1-Myristoyl-2-Linoleoyl-3-Palmitoyl-rac-glycerol
CAS :1-Myristoyl-2-linoleoyl-3-palmitoyl-rac-glycerol, a triacylglycerol comprising myristic, linoleic, and palmitic acids at the sn-1, sn-2, and sn-3 positions respectively, is present in palm and vegetable oils.Formule :C51H94O6Couleur et forme :SolidMasse moléculaire :803.29Ramipril Diketopiperazine Acid
CAS :Ramipril diketopiperazine acid represents a potential impurity identified within commercial ramipril formulations.Formule :C21H26N2O4Couleur et forme :SolidMasse moléculaire :370.445-methyl Chrysene
CAS :5-Methylchrysene, a carcinogenic polycyclic aromatic hydrocarbon with four fused rings, functions as an aryl hydrocarbon receptor agonist. It is generated through the incomplete combustion of organic matter and primarily detected in gasoline exhaust and tobacco smoke. Additionally, 5-Methylchrysene can be converted into mutagenic metabolites by cytochrome P450 enzymes 1A1 and 1B1.Formule :C19H14Couleur et forme :SolidMasse moléculaire :242.3hUP1-IN-1 potassium
CAS :hUP1-IN-1 potassium (compound 6a), a hUP1 inhibitor, demonstrates inhibitory activity with Ki and Kis values of 375 nM and 635 nM, respectively. It achieves 70% inhibition of hUP1-catalyzed reactions at a concentration of 1 μM. This compound is utilized in cancer research [1].Formule :C7H5KN2O2Couleur et forme :SolidMasse moléculaire :188.231,3-Dioleoyl-2-Octanoyl Glycerol
CAS :1,3-Dioleoyl-2-octanoyl glycerol, a triacylglycerol, features oleic acid at the sn-1 and sn-3 positions and octanoic acid at the sn-2 position. Its utility lies in the characterization of R. oryzae lipase functionality, specifically for regiodistribution analysis of fats that comprise medium- and short-chain fatty acids.Formule :C47H86O6Couleur et forme :SolidMasse moléculaire :747.1810(Z)-Heptadecenoic Acid methyl ester
CAS :Methyl 10(Z)-heptadecenoate, a minor fatty acid methyl ester (FAME) component of biodiesel, is the ester derivative of cis-10-heptadecenoic acid.Formule :C18H34O2Couleur et forme :SolidMasse moléculaire :282.468FASN-IN-1
CAS :FASN-in-1 is an effective, specific inhibitor of fatty acid synthase (FASN), a compound specifically designed to target and inhibit the activity of the enzymeFormule :C18H25N3O3S2Degré de pureté :99.92% - >99.99%Couleur et forme :SolidMasse moléculaire :395.547-hydroxy Etodolac
CAS :7-Hydroxy Etodolac, an inactive metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor etodolac, serves no active function in the drug's pharmacological effects.Formule :C17H21NO4Couleur et forme :SolidMasse moléculaire :303.35α-HNJNAc
CAS :α-HNJNAc is a potent, competitive hexosaminidases inhibitor that does not interfer with other glycosidases [1].Formule :C9H18N2O5Couleur et forme :SolidMasse moléculaire :234.25Descarbonyl Lacosamide
CAS :Descarbonyl-lacosamide is a potential impurity in commercial lacosamide preparations. It is a degradation product that forms under acidic conditions.Formule :C11H16N2O2Couleur et forme :SolidMasse moléculaire :208.2613'-hydroxy Lidocaine
CAS :3'-Hydroxy Lidocaine, an active metabolite of Lidocaine, is produced through the metabolism by the cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4.Formule :C14H22N2O2Couleur et forme :SolidMasse moléculaire :250.3421,3-Dioleoyl Glycerol
CAS :1,3-Dioleoyl glycerol, a diacylglycerol with oleic acid at the sn-1 and sn-3 positions, activates protein kinase C (PKC) by approximately 30% at a concentration of 50 μM.Formule :C39H72O5Couleur et forme :SolidMasse moléculaire :620.991-Aminodecylidene bis-Phosphonic Acid
CAS :1-Aminodecylidenebis-phosphonic acid, with its potent inhibitory effect on acid sphingomyelinase (IC50= 20 nM), shows selectivity by being less effective against neutral sphingomyelinase (IC50= >100 μM). Additionally, it entirely prevents dexamethasone-induced apoptosis in HepG2 cells.Formule :C10H25NO6P2Couleur et forme :SolidMasse moléculaire :317.261-Arachidonoyl Glycerol
CAS :2-Arachidonoylglycerol (2-AG) is identified as a more potent endogenous cannabinoid ligand compared to its analogue, 1-Arachidonoylglycerol (1-AG), exhibiting 10 to 100 times the ligand binding affinity and agonist activity at the CB1 receptor, thus making it a natural ligand. However, 2-AG's chemical instability leads to rapid isomerization to 1-AG (also referred to as 1(3)-AG) both in vitro and in vivo. This isomerization process, where 1-AG becomes a frequent contaminant in synthetic 1-AG preparations, significantly decreases their cannabinergic potency. Furthermore, 1-AG is characterized as a weak CB1 receptor agonist with potential for other pharmacological effects.Formule :C23H38O4Couleur et forme :SolidMasse moléculaire :378.611α-Hydroxyprogesterone
CAS :11alpha-Hydroxyprogesterone, an inactive analogue of 11beta-Hydroxyprogesterone, serves as an experimental control. Meanwhile, 11beta-Hydroxyprogesterone functions as a potent inhibitor of 11β-Hydroxysteroid dehydrogenase and activates the human mineralocorticoid receptor in COS-7 cells, with an effective dose (ED)50 of 10 nM.Formule :C21H30O3Couleur et forme :SolidMasse moléculaire :330.468Therapeutic agent-1
CAS :Therapeutic Agent-1, a heteroaryl compound, serves as an enzyme replacement therapy to enhance glucocerebrosidase activity in the treatment of Gaucher disease [Formule :C18H20N6Couleur et forme :SolidMasse moléculaire :320.39Sezolamide
CAS :Sezolamide is a carbonic anhydrase inhibitor.Formule :C11H18N2O4S3Couleur et forme :SolidMasse moléculaire :338.47N-desethyl-N-methyl Vardenafil
CAS :N-Desethyl-N-methyl Vardenafil, a potential impurity in commercial vardenafil preparations, functions as a phosphodiesterase 5 (PDE5) inhibitor, similar to its parent compound. With an IC50 value of 2 nM, it exhibits potent inhibitory activity against PDE5.Formule :C22H30N6O4SCouleur et forme :SolidMasse moléculaire :474.58Albuterol methyl ether
CAS :Salbutamol (albuterol), a selective β2-adrenergic partial agonist, serves as a bronchodilator widely used in various clinical scenarios and to counteract doping abuse. Its process impurity, Albuterol methyl ether, may be present in urine samples, highlighting the importance of detection and chemical analysis.Formule :C14H23NO3Couleur et forme :SolidMasse moléculaire :253.31,2-Dioleoyl-3-Lauroyl-rac-glycerol
CAS :1,2-Dioleoyl-3-lauroyl-rac-glycerol, a triacylglycerol, comprises oleic acid at the sn-1 and sn-2 positions and lauric acid at the sn-3 position. It is identified in the date seed oil and the fat body of male B. lapidarius bumblebees.Formule :C51H94O6Couleur et forme :SolidMasse moléculaire :803.291-Palmitoyl-2-Linoleoyl-sn-glycero-3-PC
CAS :1-Palmitoyl-2-Linoleoyl-sn-glycero-3-phosphatidylcholine (PC) is a phospholipid characterized by the incorporation of palmitic (16:0) and linoleic (18:2) acids at the sn-1 and sn-2 positions, respectively. It is utilized in the creation of micelles, liposomes, and various artificial membranes, playing a significant role in research on lipid peroxidation.Formule :C42H80NO8PCouleur et forme :SolidMasse moléculaire :758.07512(Z),15(Z)-Heneicosadienoic Acid
CAS :12(Z),15(Z)-Heneicosadienoic acid, an ω-6 very long-chain polyunsaturated fatty acid, serves as a positional isomer of heneicosadienoic acid, which is scarcely found in living organisms.Formule :C21H38O2Couleur et forme :SolidMasse moléculaire :322.533MK-8666
CAS :MK-8666, a partial GPCR agonist targeting GPR40, may treat type 2 diabetes by enhancing insulin secretion and lowering glucose safely.Formule :C29H31NO6SCouleur et forme :SolidMasse moléculaire :521.62R-1663
CAS :R-1663 inhibits factor Xa, prolongs clotting, reduces thrombin without affecting bleed time; more effective on peak than ETP.Formule :C24H21ClF3N5O3Couleur et forme :SolidMasse moléculaire :519.9Indeloxazine
CAS :Indeloxazine is a cerebral activator and anticonvulsant.Formule :C14H17NO2Couleur et forme :SolidMasse moléculaire :231.29SNAP-7941
CAS :SNAP-7941: Selective MCH1 receptor antagonist with potential anxiolytic, antidepressant, and appetite-suppressing qualities.Formule :C31H37F2N5O6Couleur et forme :SolidMasse moléculaire :613.65Fulvestrant 3-β-D-Glucuronide
CAS :Fulvestrant 3-β-D-Glucuronide，Fulvestrant的代谢产物，为葡萄糖醛酸结合物，属于纯抗雌激素类固醇。该化合物可应用于乳腺癌研究领域。Formule :C38H55F5O9SCouleur et forme :SolidMasse moléculaire :782.9EOS (d18:1/30:0/18:2)
CAS :EOS (d18:1/30:0/18:2) is a lipid molecule that can be used in life science related research. The CAS number of EOS (d18:1/30:0/18:2) is 97040-38-5.Formule :C66H125NO5Couleur et forme :SolidMasse moléculaire :1012.7GYKI-16084
CAS :GYKI-16084 is a postsynaptic alpha2 receptor blocker with potential efficacy in the treatment of benign prostatic hyperplasia.Formule :C16H19N3O3Couleur et forme :SolidMasse moléculaire :301.341,2-Distearoyl-3-Palmitoyl-rac-glycerol
CAS :1,2-Distearoyl-3-palmitoyl-rac-glycerol, a triacylglycerol, features stearic acid at the sn-1 and sn-2 positions and palmitic acid at the sn-3 position. This compound is identified in cocoa butter, lard, and cod liver oil.Formule :C55H106O6Couleur et forme :SolidMasse moléculaire :863.43TMC-649128
CAS :TMC-649128, a RNA polymerase NS5B inhibitor, is used for the treatment of HCV infection.Formule :C18H26N6O6Couleur et forme :SolidMasse moléculaire :422.44(±)11(12)-EpETE
CAS :Eicosapentaenoic acid (EPA) is metabolized into epoxyeicosatetraenoic acids (EpETE) by multiple cytochrome P450 isoforms. The predominant compound of this epoxygenase pathway, (±)17(18)-EpETE, induces relaxation in vascular and airway smooth muscles through its action on large conductance Ca2+-activated K+ (BKCa) channels, specifically by binding to the BKα channel subunits. Another notable epoxygenase pathway derivative, (±)11(12)-EpETE, also generated from EPA via CYP450 activity in both in vitro and in vivo studies, has biological and physiological roles that are yet to be fully elucidated.Formule :C20H30O3Couleur et forme :SolidMasse moléculaire :318.51-Stearoyl-2-Eicosapentaenoyl-sn-glycero-3-PC
CAS :1-Stearoyl-2-eicosapentaenoyl-sn-glycero-3-PC is a phospholipid comprising stearic acid and eicosapentaenoic acid at the sn-1 and sn-2 positions, respectively, identified in human red blood cells (RBCs).Formule :C46H82NO8PCouleur et forme :SolidMasse moléculaire :808.12Deleobuvir sodium
CAS :Deleobuvir sodium (BI207127), a hepatitis C NS5B inhibitor, showed promise in some trials but was discontinued in 2013 due to insufficient efficacy.Formule :C34H32BrN6NaO3Couleur et forme :SolidMasse moléculaire :675.56AZD2716
CAS :AZD2716 is an effective selective phospholipase A2 inhibitor for the treatment of coronary artery and cardiovascular disease.Formule :C24H23NO3Couleur et forme :SolidMasse moléculaire :373.44l-Primaquine
CAS :l-Primaquine is used to treat and prevent malaria and to treat Pneumocystis pneumonia.Formule :C15H21N3OCouleur et forme :SolidMasse moléculaire :259.35TAS2R14 agonist-1
CAS :TAS2R14 agonist is a potent partial agonist of TAS2R14, displaying an EC50 value of 116.6 ± 23.6 nM [1].Formule :C15H9F6N5Couleur et forme :SolidMasse moléculaire :373.26Sezolamide hydrochloride
CAS :Sezolamide hydrochloride is a potent topical carbonic anhydrase inhibitor.Formule :C11H19ClN2O4S3Couleur et forme :SolidMasse moléculaire :374.931-Stearoyl-2-Palmitoyl-3-Oleoyl-rac-glycerol
CAS :1-Stearoyl-2-palmitoyl-3-oleoyl-rac-glycerol is a triacylglycerol comprising stearic acid (at the sn-1 position), palmitic acid (at the sn-2 position), and oleic acid (at the sn-3 position), identified in bovine milk.Formule :C55H104O6Couleur et forme :SolidMasse moléculaire :861.41Difethialone
CAS :Difethialone is an anticoagulant rodenticide and a vitamin K antagonist.Formule :C31H23BrO2SCouleur et forme :SolidMasse moléculaire :539.48N-Formyl-L-histidine
CAS :N-Formyl-L-histidine is a competitive inhibitor of L-histidine deaminase (Ki = 4.26 mM) and also binds to histidine-tRNA synthetase (Ki = 4.6 μM).Formule :C7H9N3O3Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :183.16Z-Pro-Pro-CHO
CAS :Z-Pro-Pro-CHO acts as a prolyl oligopeptidase inhibitor with half-maximal inhibitory concentrations (IC50) of 0.16 μM for human prolyl oligopeptidase and 0.01Formule :C18H22N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :330.38Curcumin-β-D-glucuronide
CAS :Curcumin-β-D-glucuronide, a principal metabolite detected in hepatic tissue and portal blood following oral consumption of Curcumin, is utilized in colon cancerFormule :C27H28O12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :544.5Tiracizine HCl
CAS :Tiracizine HCl, a new class I antiarrhythmic drug, was studied in patients with ischemic heart disease and shown to decrease myocardial contractile function.Formule :C21H26ClN3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :403.9Aladotrilat
CAS :Aladotrilat is an inhibitor of neutral endopeptidase. Its prodrug is aladrotril.Formule :C14H17NO5SCouleur et forme :SolidMasse moléculaire :311.35Glycosidase-IN-2
CAS :Glycosidase-IN-2 is a glycosidase inhibitor with hypoglycemic activity.Formule :C13H23NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :273.33Kelatorphan
CAS :Kelatorphan is an enkephalin degrading enzyme full inhibitor.Formule :C14H18N2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :294.3Diflumidone sodium
CAS :Diflumidone sodium is a non-steroidal agent with anti-inflammatory activity.Formule :C14H10F2NNaO3SCouleur et forme :SolidMasse moléculaire :333.29A 79175
CAS :A 79175 is a 5-lipoxygenase inhibitor that increases bone formation.Formule :C15H13FN2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :304.27M-0002
CAS :M-0002, a vasopressin V2 receptor antagonist, is used potentially for the treatment of ascites.Formule :C32H29Cl2N3O3Couleur et forme :SolidMasse moléculaire :574.5
