Métabolisme
Les inhibiteurs du métabolisme sont des composés qui interfèrent avec les voies métaboliques, modifiant ainsi la production et l'utilisation de l'énergie au sein des cellules. Ces inhibiteurs sont utilisés pour étudier la régulation du métabolisme, le rôle des voies métaboliques dans des maladies telles que le cancer et le diabète, et pour développer de nouvelles stratégies thérapeutiques. Les inhibiteurs du métabolisme peuvent cibler diverses enzymes et processus impliqués dans la glycolyse, l'oxydation des acides gras et d'autres fonctions métaboliques. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de métabolisme de haute qualité pour soutenir vos recherches en biochimie, troubles métaboliques et développement de médicaments.
Sous-catégories appartenant à la catégorie "Métabolisme"
- AhR(41 produits)
- Aminopeptidase(67 produits)
- CETP(18 produits)
- Anhydrase carbonique(178 produits)
- Caséine Kinase(130 produits)
- DHFR(33 produits)
- Décarboxylase(4 produits)
- Déshydrogénase(271 produits)
- FAAH(64 produits)
- FXR(58 produits)
- Facteur Xa(80 produits)
- Synthase des acides gras(33 produits)
- Ferroptose(215 produits)
- GR(3 produits)
- GSNOR(3 produits)
- Glucokinase(54 produits)
- Prolyl-Hydroxylase de HIF/HIF(142 produits)
- HMG-CoA Réductase(33 produits)
- Hydroxylase(30 produits)
- IDO(82 produits)
- LDL(8 produits)
- Lipase(98 produits)
- Lipides(58 produits)
- Lipoxygénase(124 produits)
- MAO(87 produits)
- MPO(2 produits)
- NAMPT(36 produits)
- P450(6 produits)
- PAI-1(25 produits)
- PDE(166 produits)
- PED(1 produits)
- PKM(15 produits)
- PPAR(165 produits)
- Phospholipase(82 produits)
- ROR(42 produits)
- Récepteur de rétinoïdes(29 produits)
- SGK(11 produits)
- Thioredoxine(12 produits)
- Transférase(30 produits)
- Tansporteur(42 produits)
- UGT(4 produits)
- Inhibiteurs de la xanthine oxydase (XO)(9 produits)
Affichez 34 plus de sous-catégories
8628 produits trouvés pour "Métabolisme"
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Rivaroxaban diol
CAS :<p>Rivaroxabandiol is a metabolite of Rivaroxaban, which is a potent and selective direct inhibitor of coagulation factor Xa (FXa) with an IC50 of 0.7 nM and a Ki of 0.4 nM.</p>Formule :C19H20ClN3O6SCouleur et forme :SolidMasse moléculaire :453.897PDE4-IN-6
<p>PDE4-IN-6: Potent PDE4 inhibitor, IC50 - 0.125μM (B), 0.43μM (D), anti-inflammatory, for arthritis research.</p>Formule :C25H20FNO5SCouleur et forme :SolidMasse moléculaire :465.49TS010
<p>TS010 is a highly potent inhibitor of GLO-I, with an IC50 value of 0.57 μM. It holds significant promise for advancements in cancer research [1].</p>Formule :C16H12N4O4SCouleur et forme :SolidMasse moléculaire :356.36LXRβ agonist-2
CAS :LXRβ agonist-2 is a highly potent and β-selective liver X receptor (LXRβ) agonist with EC50 of 7 nM.Formule :C32H31F6N3O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :683.59PD-224378
CAS :<p>PD-224378 is the lactam form of glycamine (β-isomer), produced through a Maillard reaction between pregabalin and lactose.</p>Formule :C20H35NO11Couleur et forme :SolidMasse moléculaire :465.492Nampt-IN-13
CAS :Nampt-IN-13 (example 58m) is an NAMPT inhibitor used in the synthesis of antibody-drug conjugates (ADCs).Formule :C24H30N6O2Couleur et forme :SolidMasse moléculaire :434.53CA IX-IN-1
<p>CA IX-IN-1 (compound 12g) is a potent and highly selective hCA IX inhibitor (IC50: 7 nM) that exhibits antitumour effects.</p>Formule :C16H22N4O8SCouleur et forme :SolidMasse moléculaire :430.43Ketomethylenebestatin
CAS :<p>Ketomethylenebestatin, a weaker carba-analog of aminopeptidase inhibitor bestatin, is 10x less potent.</p>Formule :C17H25NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :307.38Beloranib
CAS :<p>Beloranib is a fumagillin anticancer drug. Beloranib belongs to an angiogenesis inhibitor.</p>Formule :C29H41NO6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :499.64Casein kinase 1δ-IN-23
CAS :<p>Casein kinase1δ-IN-23 (compound 423) is an effective inhibitor of casein kinase1δ. It is applicable in research related to neurodegenerative diseases such as Alzheimer's disease.</p>Formule :C19H15N3O3SCouleur et forme :SolidMasse moléculaire :365.406CK1δ-IN-8
CAS :<p>CK1δ-IN-8 (Compound 429) is a CK1δ inhibitor suitable for Alzheimer's disease research.</p>Formule :C14H9N3O2S2Couleur et forme :SolidMasse moléculaire :315.37hDHODH-IN-10
<p>hDHODH-IN-10: selective oral inhibitor of hDHODH (IC50: 10.9 nM); blocks cancer cell growth, aids cancer research.</p>Formule :C21H15ClF4N2O4Couleur et forme :SolidMasse moléculaire :470.8Casein kinase 1δ-IN-19
CAS :<p>Casein kinase1δ-IN-19 (compound 492) is a potent inhibitor of casein kinase 1δ. It is utilized in research related to neurodegenerative disorders, such as Alzheimer's disease.</p>Formule :C21H19N5O3Couleur et forme :SolidMasse moléculaire :389.407hMAO-B/MB-COMT-IN-2
<p>Dual inhibitor hMAO-B/MB-COMT-IN-2 targets hMAO-B (IC50: 4.27μM) & MB-COMT (IC50: 2.69μM), aids in neurodegenerative research.</p>Formule :C17H18N2O3Couleur et forme :SolidMasse moléculaire :298.34ERAP1 modulator-2
CAS :<p>ERAP1 modulator-2 (compound 10) is a potent ERAP1 inhibitor with an IC50 value of less than 100 nM.</p>Formule :C22H25F3N2O4SCouleur et forme :SolidMasse moléculaire :470.505Dopaminechrome
CAS :<p>Dopaminechrome (DACHR) is an oxidation product of dopamine that promotes the generation of H2O2 at mitochondrial complex I in the brain in a concentration- and respiration-dependent manner. It possesses neurotoxic properties and can be utilized in Parkinson's disease research.</p>Formule :C8H7NO2Couleur et forme :SolidMasse moléculaire :149.1477-Hydroxy-4-phenylcoumarin
CAS :<p>7-Hydroxy-4-phenylcoumarin is a dual inhibitor of ALDH-2 and MAO, with IC50 values of 1.5 µM and 0.5 µM, respectively.</p>Formule :C15H10O3Couleur et forme :SolidMasse moléculaire :238.23811-Mercaptoundecanoate-NHS
CAS :<p>11-Mercaptoundecanoate-NHS is a lipid utilized in the synthesis of Linkers.</p>Formule :C15H25NO4SCouleur et forme :SolidMasse moléculaire :315.428Quinapril
CAS :<p>Quinapril is an orally active, non-peptide, and non-thiol angiotensin-converting enzyme (ACE) inhibitor. It primarily blocks the conversion of angiotensin I to angiotensin II in both plasma and tissues. Upon enzymatic hydrolysis, Quinapril is converted into the pharmacologically active Quinaprilat and is effective in hypertension models.</p>Formule :C25H30N2O5Couleur et forme :SolidMasse moléculaire :438.516α-Glucosidase-IN-17
CAS :<p>α-Glucosidase-IN-17 (Compound 12B) is a potent and orally active inhibitor of α-glucosidase, demonstrating antidiabetic activity with an inhibitory</p>Formule :C30H27NO2SCouleur et forme :SolidMasse moléculaire :465.61CP 524515
CAS :<p>CP 524515 is a potent inhibitor of cholesterol ester transfer protein (CETP), which results in increased levels of high-density lipoprotein cholesterol.</p>Formule :C27H27F9N2O4Couleur et forme :SolidMasse moléculaire :614.5Benfooxythiamine
CAS :<p>Benfooxythiamine is a transketolase (TKT) inhibitor that suppresses SARS-CoV-2 replication and enhances the activity of the glycolysis inhibitor 2DG. It exhibits antiviral properties.</p>Formule :C19H22N3O7PSCouleur et forme :SolidMasse moléculaire :467.433Mutant IDH1-IN-3
CAS :<p>Mutant IDH1-IN-3 (Compound 1) is a selective allosteric inhibitor targeting the mutant isocitrate dehydrogenase 1 (IDH1), with an IC50 of 13 nM for R132HIDH1. It effectively suppresses the production of D-2-hydroxyglutarate (2HG) in cells and is applicable for research in oncology.</p>Formule :C22H30N4OCouleur et forme :SolidMasse moléculaire :366.5PFM046
CAS :<p>PFM046 is an antagonist of the liver X receptor (LXR), effectively inhibiting the activation of LXRα and LXRβ, with IC50 values of 2.04 μM and 1.58 μM respectively. It reduces the expression of SCD1 and FASN while increasing ABCA1 expression, and demonstrates antitumor activity in mouse models.</p>Formule :C29H42O2Couleur et forme :SolidMasse moléculaire :422.643O-Desmethyl Brinzolamide hydrochloride
CAS :<p>O-Desmethyl Brinzolamide hydrochloride (compound 6a), a potent metabolite derived from Brinzolamide, serves as a carbonic anhydrase (CA) inhibitor. It exhibits a dissociation constant (Kd) of 0.136 nM for CA II and an inhibitory concentration (IC50) of 165 nM for CA IV [1].</p>Formule :C11H20ClN3O5S3Couleur et forme :SolidMasse moléculaire :405.94Anticancer agent 78
<p>Anticancer agent 78: anti-aromatase (IC50=0.9 μM), cytotoxic, potential in breast cancer research.</p>Formule :C19H14BrNO4Couleur et forme :SolidMasse moléculaire :400.22Casein kinase 1δ-IN-30
CAS :<p>Casein kinase1δ-IN-30 (Compound 581) is an inhibitor of casein kinase 1δ (CK1δ). It can be utilized in research related to neurodegenerative diseases.</p>Formule :C18H15BrN6O2SCouleur et forme :SolidMasse moléculaire :459.32Anticancer agent 142
CAS :<p>Compound 142 (also known as Compound 235) is a PTPN inhibitor with potential applications in cancer research [1].</p>Formule :C13H14BrF2N2O7PS2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :523.26D-Citrulline
CAS :D-Citrulline (H-D-Cit-OH), a stereoisomer of L-citrulline, effectively reduces cardiac contractile dysfunction caused by polymorphonuclear leukocyte (PMN) in isolated perfused rat hearts undergoing ischemia/reperfusion. This protective effect is mediated through a non-NO-mediated mechanism.Formule :C6H13N3O3Couleur et forme :SolidMasse moléculaire :175.19Complex III-IN-1
<p>Complex III-IN-1 inhibits complex III, has antifungal properties, and an EC50 of 18.53 mg/L against S. sclerotiorum.</p>Formule :C14H20ClNO2S2Couleur et forme :SolidMasse moléculaire :333.9HSD17B13-IN-32
CAS :HSD17B13-IN-32 (Compound 67) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤0.1 μM for estradiol. It can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) [1].Formule :C23H15Cl2N5O3Masse moléculaire :480.3DDO-3733
CAS :<p>DDO-3733 is a conformational activator of Protein Phosphatase 5 (PP5) that functions independently of TRP, facilitating the dephosphorylation of downstream substrates.</p>Formule :C10H6F2N2OSCouleur et forme :SolidMasse moléculaire :240.23LU 2443
CAS :<p>LU 2443 is an orally active antiepileptic agent that is extensively absorbed, with up to 18% remaining unabsorbed in rats. The active half-life in plasma is 13.17 hours.</p>Formule :C9H8N2S2Couleur et forme :SolidMasse moléculaire :208.3PDE4B/7A-IN-2
CAS :<p>5-HT1A/5-HT7 antagonist; 5-HT1A Ki=8 nM, 5-HT7 Ki=451 nM; PDE4B IC50=80.4 μM, PDE7A IC50=151.3 μM; stronger than escitalopram.</p>Formule :C25H35N3O2Couleur et forme :SolidMasse moléculaire :409.56DSM705 hydrochloride
<p>DSM705 hydrochloride: potent antimalarial, pyrrole-based DHODH inhibitor effective against Plasmodium, non-toxic to mammalian DHODH.</p>Formule :C19H20ClF3N6OCouleur et forme :SolidMasse moléculaire :440.85IDH1 Inhibitor 1
CAS :<p>Oral, brain-penetrant mutant IDH1 inhibitor targeting R132H/C with IC50: 0.021/0.045μM; 2.52μM for IDH1WT.</p>Formule :C20H18F4N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :450.39SDX-7539
CAS :<p>SDX-7539 is a selective MetAP2 inhibitor that inhibits the proliferation of HUVEC, with an IC50 of 120 μM. It has demonstrated antitumor activity in xenografted NSCLC in athymic nude mice.</p>Formule :C23H38N2O5Masse moléculaire :422.56trans-Doxercalciferol
CAS :<p>trans-Doxercalciferol is an isomer of Doxercalciferol. Doxercalciferol is an activator of the Vitamin D receptor and prevents renal disease.</p>Formule :C28H44O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :412.65RORγt/DHODH-IN-1
CAS :RORγt/DHODH-IN-1 (compound (R)-14d) is a potent, orally active dual inhibitor of RORγt (IC50: 0.083 μM) and DHODH (IC50: 0.172 μM), which exhibits significantFormule :C24H26ClF6N3O3SCouleur et forme :SolidMasse moléculaire :585.99PDE5-IN-8
CAS :<p>PDE5-IN-8 (compound 2) is an inhibitor of PDEs.</p>Formule :C22H20ClN3O2Couleur et forme :SolidMasse moléculaire :393.87MK-3168 (12C)
CAS :<p>MK-3168 (12C) functions as a FAAH inhibitor, exhibiting IC50 values of 1.0 nM, 5.5 nM, and 1.7 nM for human, rhesus, and rat respectively. It demonstrates effective brain uptake and FAAH-specific signaling. Additionally, 11 C MK-3168 is applicable as a FAAH PET tracer.</p>Formule :C21H21ClN4OSCouleur et forme :SolidMasse moléculaire :412.94PKR Inhibitor, negative control
CAS :<p>The PKR Inhibitor, negative control, is an inactive structural analog of RNA-dependent protein kinase (PKR) inhibitors, serving as a negative control. Additionally, it can inhibit LK-induced neuronal death, demonstrating significant neuroprotective properties.</p>Formule :C15H8Cl3NO2Masse moléculaire :340.59ZSH-2208
CAS :ZSH-2208 is a retinoic acid A analogue that inhibits tumour cell proliferation and survival through RARγ-TNFAIP3 and retinoid receptors.Formule :C20H18O3SDegré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :338.42Mucidin
CAS :<p>Mucidin is an antifungal antibiotic that inhibits electron transfer reactions within the mitochondrial respiratory chain's cytochrome bc1 complex.</p>Formule :C16H18O3Masse moléculaire :258.31VHR-IN-1
CAS :<p>VHR-IN-1 (Compound SA1) is an effective and selective VHR phosphatase inhibitor with an IC50 of 18 nM. It hinders the proliferation of cervical cancer cells, demonstrating antitumor activity.</p>Formule :C28H22ClN3O5S3Couleur et forme :SolidMasse moléculaire :612.139HIF-1α-IN-5
<p>HIF-1α-IN-5 is an inhibitor of HIF-1α with an IC 50 value of 24 nM in HEK293T cells that also inhibits the activity of MAO-A.</p>Formule :C16H15N3O2Couleur et forme :SolidMasse moléculaire :281.312,4-Dihydroxybutanoic acid
CAS :2,4-Dihydroxybutanoic acid is typically not found in extracts of normal human urine and is present only in trace amounts in newborns, while cases of succinic semialdehyde dehydrogenase deficiency consistently exhibit elevated levels of this metabolite.Formule :C4H8O4Couleur et forme :SolidMasse moléculaire :120.10AD012
<p>AD012, a dual cACE/NEP inhibitor, leverages lenopril-tryptophan for potential anti-hypertensive and cardioprotective benefits.</p>Formule :C25H32N2O6Couleur et forme :SolidMasse moléculaire :456.53α-Glucosidase-IN-43
CAS :<p>α-Glucosidase-IN-43 (compound AS14) is an α-glucosidase inhibitor with an IC50 of 4.32 μM, demonstrating acute blood-glucose-lowering properties. It is safe and effective in vivo, showing no toxicity to normal fibroblasts in mice and can ameliorate diabetes induced by streptozotocin in rats. α-Glucosidase-IN-43 is applicable for research on postprandial hyperglycemia in diabetic patients.</p>Formule :C27H31N3O4Masse moléculaire :461.55Carbonic anhydrase inhibitor 19
CAS :<p>Carbonic anhydrase inhibitor19 (compound 26a) targets glaucoma-associated isozymes hCA II and hCA XII, with inhibition constants (Kis) of 9.4 nM and 6.7 nM, respectively. This compound is effective in reducing intraocular pressure.</p>Formule :C23H25N3O6S2Masse moléculaire :503.59
