Métabolisme
Les inhibiteurs du métabolisme sont des composés qui interfèrent avec les voies métaboliques, modifiant ainsi la production et l'utilisation de l'énergie au sein des cellules. Ces inhibiteurs sont utilisés pour étudier la régulation du métabolisme, le rôle des voies métaboliques dans des maladies telles que le cancer et le diabète, et pour développer de nouvelles stratégies thérapeutiques. Les inhibiteurs du métabolisme peuvent cibler diverses enzymes et processus impliqués dans la glycolyse, l'oxydation des acides gras et d'autres fonctions métaboliques. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de métabolisme de haute qualité pour soutenir vos recherches en biochimie, troubles métaboliques et développement de médicaments.
Sous-catégories appartenant à la catégorie "Métabolisme"
- AhR(41 produits)
- Aminopeptidase(67 produits)
- CETP(18 produits)
- Anhydrase carbonique(178 produits)
- Caséine Kinase(130 produits)
- DHFR(33 produits)
- Décarboxylase(4 produits)
- Déshydrogénase(271 produits)
- FAAH(64 produits)
- FXR(58 produits)
- Facteur Xa(80 produits)
- Synthase des acides gras(33 produits)
- Ferroptose(215 produits)
- GR(3 produits)
- GSNOR(3 produits)
- Glucokinase(54 produits)
- Prolyl-Hydroxylase de HIF/HIF(142 produits)
- HMG-CoA Réductase(33 produits)
- Hydroxylase(30 produits)
- IDO(82 produits)
- LDL(8 produits)
- Lipase(98 produits)
- Lipides(58 produits)
- Lipoxygénase(124 produits)
- MAO(87 produits)
- MPO(2 produits)
- NAMPT(36 produits)
- P450(6 produits)
- PAI-1(25 produits)
- PDE(166 produits)
- PED(1 produits)
- PKM(15 produits)
- PPAR(165 produits)
- Phospholipase(82 produits)
- ROR(42 produits)
- Récepteur de rétinoïdes(29 produits)
- SGK(11 produits)
- Thioredoxine(12 produits)
- Transférase(30 produits)
- Tansporteur(42 produits)
- UGT(4 produits)
- Inhibiteurs de la xanthine oxydase (XO)(9 produits)
Affichez 34 plus de sous-catégories
8628 produits trouvés pour "Métabolisme"
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Darlifarnib
CAS :<p>Darlifarnib (Compound (S)-058) is an inhibitor of farnesyl transferase and geranylgeranyltransferase, with IC50 values of ≤ 10 nM and > 1000 nM, respectively. It exhibits high metabolic stability in human and mouse liver microsomes, with a half-life of over 100 minutes.</p>Formule :C29H20N6OCouleur et forme :SolidMasse moléculaire :468.509Carbonic anhydrase inhibitor 3
<p>Carbonic anhydrase inhibitor 3 (compound 11g) is an inhibitor of carbonic anhydrase II that reduces the intraocular pressure in glaucomatous rabbits [1].</p>Formule :C15H17N3O3SCouleur et forme :SolidMasse moléculaire :319.38RWJ-445167
CAS :<p>RWJ-445167 is a thrombin and factor Xa dual inhibitor(Ki of 4.0 nM and 230 nM, respectively), with potent antithrombotic activity.</p>Formule :C18H24N6O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :436.49Phospho-L-arginine
CAS :<p>Phospho-L-arginine is a derivative of arginine.</p>Formule :C6H15N4O5PMasse moléculaire :254.18NAZ2329
CAS :<p>NAZ2329: Cell-permeable, targets R5 RPTPs, inhibits hPTPRZ1 (IC50=7.5 μM) & hPTPRG (IC50=4.8 μM), hampers glioblastoma growth, affects stem cell traits.</p>Formule :C21H18F3NO4S3Couleur et forme :SoildMasse moléculaire :501.56PENAO
CAS :<p>PENAO is a potent mitochondrial toxin for tumor cells. It deactivates the mitochondria of tumor cells by targeting the adenine nucleotide translocase in the cell membrane.</p>Formule :C13H19AsN2O5SCouleur et forme :SolidMasse moléculaire :390.29Carbonic anhydrase inhibitor 5
<p>Potent hCA inhibitor: targets hCA II, IX & XII with IC50s of 42.9, 47.6, & 6.7 nM respectively.</p>Formule :C24H20ClN3O3SCouleur et forme :SolidMasse moléculaire :465.95RORγt modulator 5
CAS :<p>RORγt modulator 5, a potent RORγt modulator, exhibits a dissociation constant (K_i) of <100 nM.</p>Formule :C27H22F5N3O6SCouleur et forme :SolidMasse moléculaire :611.54α-Glucosidase-IN-17
CAS :<p>α-Glucosidase-IN-17 (Compound 12B) is a potent and orally active inhibitor of α-glucosidase, demonstrating antidiabetic activity with an inhibitory</p>Formule :C30H27NO2SCouleur et forme :SolidMasse moléculaire :465.61Diethylumbelliferyl phosphate
CAS :<p>Diethylumbelliferyl phosphate (DEUP) is a potent and selective inhibitor of cholesterol esterase that does not inhibit protein kinase A activity in vitro. It disrupts steroidogenesis by blocking cholesterol transport to mitochondria in steroidogenic cells, with an IC50 of 11.6 μM. This compound may also limit the absorption of dietary cholesterol.</p>Formule :C14H17O6PCouleur et forme :SolidMasse moléculaire :312.25NSC 828467
<p>NSC 828467 is one of the top five CA-IX inhibitors with significant in vitro anticancer activity (IC50: 27.2 nM).</p>Formule :C21H19N9O2SCouleur et forme :SolidMasse moléculaire :461.5Calcium 2-hydroxypropanoate pentahydrate
CAS :Calcium 2-hydroxypropanoate (pentahydrate) acts as an activator of the hydroxyl-carboxylic acid receptor 1 (HCAR1) and serves as an epigenetic regulator that induces lysine residue lactylation. This compound, a glycolysis end product, bridges the gap between glycolysis and oxidative phosphorylation and functions as a tumor metabolite with immunoprotective effects of lactate in antitumor immunity.Formule :C3H5O3CaH2OCouleur et forme :SolidMasse moléculaire :154.1477-APB hydrochloride
CAS :<p>7-APB hydrochloride is a benzofuran compound and serves as a metabolite of 7-MAPB.</p>Formule :C11H14ClNOCouleur et forme :SolidMasse moléculaire :211.688(S)-CPP sodium
CAS :<p>(S)-CPP sodium serves as an inhibitor of the branched-chain α-keto acid dehydrogenase complex (BCKDC) kinase, commonly referred to as BDK or keto acid dehydrogenase kinase. As a negative regulator of BCKDC activity, (S)-CPP (IC50 of 6.3 μM) inhibits BDK, which activates the complex, leading to a significant reduction in the levels of leucine/isoleucine and valine in the plasma of wild-type mice.</p>Formule :C9H8ClNaO2Couleur et forme :SolidMasse moléculaire :206.60TAK-828F
CAS :<p>TAK-828F: potent, selective RORγt inverse agonist. Oral. IC50=1.9 nM; reporter gene IC50=6.1 nM.</p>Formule :C28H32FN3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :509.57Glucosylceramide synthase-IN-4
CAS :<p>Glucosylceramide Synthase-IN-4 (compound 12) serves as a potent inhibitor of glucosylceramide synthase (GCS), exhibiting an IC50 of 6.8 nM. It demonstrates superior pharmacokinetic properties and robust stability in human hepatocytes. Additionally, this compound is noted for its effective CNS penetration and acceptable PXR selectivity [1].</p>Formule :C22H18F5N3O3Couleur et forme :SolidMasse moléculaire :467.392,4-Dihydroxybutanoic acid
CAS :2,4-Dihydroxybutanoic acid is typically not found in extracts of normal human urine and is present only in trace amounts in newborns, while cases of succinic semialdehyde dehydrogenase deficiency consistently exhibit elevated levels of this metabolite.Formule :C4H8O4Couleur et forme :SolidMasse moléculaire :120.10AChE/BChE-IN-23
<p>AChE/BChE-IN-23 (Compound 6e) is a dual inhibitor of acetylcholinesterase and butyrylcholinesterase, exhibiting IC50 values of 0.91 μM for AChE, 1.19 μM for eqBChE, and 1.01 μM for hBChE. This compound also demonstrates antioxidant properties and inhibits the aggregation of Aβ1-42 and Tau proteins. Moreover, AChE/BChE-IN-23 prevents the activation of microglial cells by inhibiting the release of reactive oxygen species and mitochondrial damage. Additionally, it reduces the levels of the NLRP3 inflammasome in human microglial cells and reverses memory impairment in mice induced by scopolamine.</p>Formule :C19H21N5O3Couleur et forme :SolidMasse moléculaire :367.4MAGL-IN-20
<p>MAGL-IN-20 (compound ±34) is a reversible inhibitor of monoacylglycerol lipase (MAGL). It exhibits significant antiproliferative activity against a range of cancer cell lines, including H460, HT29, CT-26, Huh7, and HCCLM-3.</p>Formule :C23H24N2OCouleur et forme :SolidMasse moléculaire :344.45FXR agonist 9
CAS :<p>FXR agonist9 (compound 26) is a selective, orally active partial agonist of FXR with an EC50 of 0.09 µM (maximum efficacy of 75.13%). It ameliorates the pathological features of fatty liver disease in mice induced by HFD and CCl4-related metabolic dysfunction.</p>Formule :C28H30N2O5Couleur et forme :SolidMasse moléculaire :474.55Lp-PLA2-IN-6
CAS :<p>Lp-PLA2-IN-6: Potent tetracyclic inhibitor of rhLp-PLA2, with pIC50 of 10.0, and potential in neurodegenerative research.</p>Formule :C25H21F5N4O3Couleur et forme :SolidMasse moléculaire :520.457PPD-Q
CAS :<p>7PPD-Q is a substituted p-phenylenediamine antioxidant derivative. It exhibits toxicity towards the bacterium V. fischeri (EC50= 14.9 mg/L).</p>Formule :C19H24N2O2Couleur et forme :SolidMasse moléculaire :312.41Glycerophosphoglycerol
CAS :<p>Glycerophosphoglycerol is a precursor in phospholipid synthesis. By enhancing phospholipid formation, it aids in the reconstruction and proliferation of membrane structures in tumor cells. Glycerophosphoglycerol holds promise for research in breast cancer cells.</p>Formule :C6H15O8PCouleur et forme :SolidMasse moléculaire :246.15SAL-0010042
CAS :<p>SAL-0010042 is an inhibitor of Plasmodium phosphodiesterase β (PDEβ), effectively blocking the hydrolysis of cAMP and cGMP in gametocytes with an IC50 of 48.9 nM, thereby activating PKG and inhibiting the growth and development of Plasmodium (IC50s for 3D7 and Dd2 are 142 nM and 218 nM, respectively). It also inhibits hPDE5 and hPDE6 with IC50 values of 632 nM and 73 nM, respectively.</p>Formule :C15H15FN4OCouleur et forme :SolidMasse moléculaire :286.304Emopamil
CAS :<p>Emopamil, a calcium channel inhibitor, reduces neuronal damage caused by ischemia.</p>Formule :C23H30N2Couleur et forme :SolidMasse moléculaire :334.5KY-455
CAS :<p>KY-455 is a novel acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor. It demonstrates inhibition of ACAT in rabbit intestines, liver, macrophages, and adrenal glands with IC50 values of 0.4, 0.9, 2.9, and 4.1 μmol/L, respectively.</p>Formule :C20H32N2OCouleur et forme :SolidMasse moléculaire :316.487-hydroxychlorpromazine
CAS :<p>7-Hydroxychlorpromazine, an active metabolite of Chlorpromazine, can reversibly counteract the suppression of regionally dense dopaminergic neurons induced by Amphetamine.</p>Formule :C17H19ClN2OSCouleur et forme :SolidMasse moléculaire :334.86CA IX-IN-1
<p>CA IX-IN-1 (compound 12g) is a potent and highly selective hCA IX inhibitor (IC50: 7 nM) that exhibits antitumour effects.</p>Formule :C16H22N4O8SCouleur et forme :SolidMasse moléculaire :430.43Morocromen
CAS :<p>Morocromen is a 2-benzamidobenzoic acid derivative characterized by its ability to enhance coronary activity.</p>Formule :C21H27N3O5Couleur et forme :SolidMasse moléculaire :401.46SGK1-IN-3
<p>SGK1-IN-3: Potent oral inhibitor of SGK1, may target osteoarthritis.</p>Formule :C23H20Cl2N6O3SCouleur et forme :SolidMasse moléculaire :531.41ZK824859 hydrochloride
<p>ZK824859 hydrochloride: oral uPA inhibitor with IC50 of 79 nM (uPA), 1580 nM (tPA), 1330 nM (fibrin).</p>Formule :C23H23ClF2N2O4Couleur et forme :SolidMasse moléculaire :464.89MDL-100240
CAS :<p>MDL-100240 inhibits ACE/neprilysin, effective against hypertension-induced heart/vascular changes.</p>Formule :C26H28N2O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :480.58LRAT-IN-1
CAS :<p>LRAT-IN-1 (compound 1) is an inhibitor of lecithin retinol acyltransferase (LRAT) with an IC50 value of 21.1 μM. This compound works by inhibiting the esterification of retinol to form retinyl esters, thereby increasing the availability of retinol in the skin to deliver anti-aging benefits. LRAT-IN-1 is under investigation for its potential use as an anti-aging ingredient in cosmetics.</p>Formule :C27H47N5O5S2Couleur et forme :SolidMasse moléculaire :585.82Magnesium ionophore III
CAS :<p>Magnesium ionophore III (ETH 4030) is an ion carrier that regulates intracellular magnesium ion concentrations. It enhances cellular functions and metabolic activities by increasing the permeability of cell membranes to magnesium ions. Additionally, Magnesium ionophore III is utilized in research to explore the significance of magnesium ions in biological processes and their impact on cellular physiology.</p>Formule :C30H58N4O4Couleur et forme :SolidMasse moléculaire :538.81Cgs 25155
CAS :<p>Cgs 25155 is an orally active inhibitor of NEP 24.11.</p>Formule :C25H34N2O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :490.61Cilazaprilat
CAS :<p>Cilazaprilat is the active metabolite of cilazapril, a pyridazine angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.</p>Formule :C20H27N3O5Couleur et forme :SolidMasse moléculaire :389.45DOCP
CAS :DOCP (2-((2,3-Bis(oleoyloxy)propyl)dimethylammonio)ethyl hydrogen phosphate) is a lipid characterized by an opposite charge orientation compared to traditional phosphatidylcholine (PC) lipids, featuring quaternary ammonium near the bilayer interface and phosphate groups projecting into the aqueous environment. This unique structure of iPC lipids presents an excellent opportunity to investigate the biophysical characteristics and biological activities influenced by the reversal of surface charges on bilayers.Formule :C43H82NO8PCouleur et forme :SolidMasse moléculaire :772.09Sphingomyelin (d18:1/12:0)
CAS :Sphingomyelin (d18:1/12:0) is a polar lipid known for its role in modulating cell signal transduction. It plays a critical role in cell membranes, influencing their fluidity and stability. Additionally, sphingomyelin (d18:1/12:0) is involved in lipid metabolism and has potential in promoting neuronal cell growth. This compound is essential for the functioning and development of the nervous system.Formule :C35H71N2O6PCouleur et forme :SolidMasse moléculaire :646.92DS44470011
CAS :<p>DS44470011 is an inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) with oral bioavailability. It enhances the release of erythropoietin (EPO) from cells and is utilized in research related to renal anemia.</p>Formule :C21H19N3O4Couleur et forme :SolidMasse moléculaire :377.39ABT-046
CAS :<p>ABT-046 is an orally active, selective, and highly efficient Diacylglycerol Acyltransferase 1 (DGAT-1) inhibitor that can be used in metabolic disease research.</p>Formule :C20H22N4O2Degré de pureté :98.13%Couleur et forme :SolidMasse moléculaire :350.41Rostratin A
CAS :<p>Rostratin A, a disulfide from Exserohilum rostratum, is cytotoxic to HCT-116 cells with an IC50 of 8.5 μg/mL.</p>Formule :C18H24N2O6S2Couleur et forme :SolidMasse moléculaire :428.52LTA4H-IN-3
CAS :<p>LTA4H-IN-3 (compound 9) functions as an inhibitor of LTA4H, demonstrating an IC50 of 28 nM [1].</p>Formule :C17H15ClN4O3Couleur et forme :SolidMasse moléculaire :358.78ZSH-2208
CAS :ZSH-2208 is a retinoic acid A analogue that inhibits tumour cell proliferation and survival through RARγ-TNFAIP3 and retinoid receptors.Formule :C20H18O3SDegré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :338.42VHR-IN-1
CAS :<p>VHR-IN-1 (Compound SA1) is an effective and selective VHR phosphatase inhibitor with an IC50 of 18 nM. It hinders the proliferation of cervical cancer cells, demonstrating antitumor activity.</p>Formule :C28H22ClN3O5S3Couleur et forme :SolidMasse moléculaire :612.139Lipid HTO12
CAS :<p>Lipid HTO12 is an ionizable lipid used for forming lipid nanoparticles (LNP). It facilitates the delivery of siRNA and mRNA.</p>Formule :C41H83NO4Couleur et forme :SolidMasse moléculaire :654.102Carbonic anhydrase inhibitor 8
<p>R-13, a carbonic anhydrase inhibitor, has Ki of 60.7 nM (hCA I), 320.7 nM (hCA II), and 2298 nM (hCA IV).</p>Formule :C20H25N3O4SCouleur et forme :SolidMasse moléculaire :403.5PDE5-IN-8
CAS :<p>PDE5-IN-8 (compound 2) is an inhibitor of PDEs.</p>Formule :C22H20ClN3O2Couleur et forme :SolidMasse moléculaire :393.87E234G HYPE-IN-1
CAS :<p>Compound I2.10 (E234G HYPE-IN-1) functions as an AMPylase inhibitor and exhibits low cytotoxicity toward human cell lines [1].</p>Formule :C14H9N5O2Couleur et forme :SolidMasse moléculaire :279.25Epoxykynin
CAS :<p>Epoxykynin is a potent soluble epoxide hydrolase (sEH) inhibitor [1].</p>Formule :C19H20BrF3N2O2Couleur et forme :SolidMasse moléculaire :445.27PDHK-IN-5
<p>PDHK-IN-5, potent PDHK2 (0.006 μM IC50) & PDHK4 (0.0329 μM IC50) inhibitor, may be explored for cancer and diabetes treatment.</p>Formule :C30H31N5O2Couleur et forme :SolidMasse moléculaire :493.6
