Métabolisme
Les inhibiteurs du métabolisme sont des composés qui interfèrent avec les voies métaboliques, modifiant ainsi la production et l'utilisation de l'énergie au sein des cellules. Ces inhibiteurs sont utilisés pour étudier la régulation du métabolisme, le rôle des voies métaboliques dans des maladies telles que le cancer et le diabète, et pour développer de nouvelles stratégies thérapeutiques. Les inhibiteurs du métabolisme peuvent cibler diverses enzymes et processus impliqués dans la glycolyse, l'oxydation des acides gras et d'autres fonctions métaboliques. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de métabolisme de haute qualité pour soutenir vos recherches en biochimie, troubles métaboliques et développement de médicaments.
Sous-catégories appartenant à la catégorie "Métabolisme"
- AhR(41 produits)
- Aminopeptidase(67 produits)
- CETP(18 produits)
- Anhydrase carbonique(178 produits)
- Caséine Kinase(130 produits)
- DHFR(33 produits)
- Décarboxylase(4 produits)
- Déshydrogénase(271 produits)
- FAAH(64 produits)
- FXR(58 produits)
- Facteur Xa(80 produits)
- Synthase des acides gras(33 produits)
- Ferroptose(215 produits)
- GR(3 produits)
- GSNOR(3 produits)
- Glucokinase(54 produits)
- Prolyl-Hydroxylase de HIF/HIF(142 produits)
- HMG-CoA Réductase(33 produits)
- Hydroxylase(30 produits)
- IDO(82 produits)
- LDL(8 produits)
- Lipase(98 produits)
- Lipides(58 produits)
- Lipoxygénase(124 produits)
- MAO(87 produits)
- MPO(2 produits)
- NAMPT(36 produits)
- P450(6 produits)
- PAI-1(25 produits)
- PDE(166 produits)
- PED(1 produits)
- PKM(15 produits)
- PPAR(165 produits)
- Phospholipase(82 produits)
- ROR(42 produits)
- Récepteur de rétinoïdes(29 produits)
- SGK(11 produits)
- Thioredoxine(12 produits)
- Transférase(30 produits)
- Tansporteur(42 produits)
- UGT(4 produits)
- Inhibiteurs de la xanthine oxydase (XO)(9 produits)
Affichez 34 plus de sous-catégories
8628 produits trouvés pour "Métabolisme"
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PF-06795071
CAS :<p>PF-06795071 is an effective and selective covalent inhibitor of MAGL (IC50: 3 nM).</p>Formule :C18H17F4N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :399.34Lipoxin A5
CAS :<p>LXA5 is made from EPA by leukocytes, contracts guinea pig lungs like LXA4/LXB4, but doesn't dilate aorta.</p>Formule :C20H30O5Couleur et forme :SolidMasse moléculaire :350.45Etiocholanolone glucuronide
CAS :<p>Etiocholanolone glucuronide (Etio-G) is a metabolite of Etiocholanolone, produced through the catalysis by UDP glucuronosyltransferase in the liver. Etiocholanolone glucuronide shows potential for research in metabolic-related diseases.</p>Formule :C25H38O8Couleur et forme :SolidMasse moléculaire :466.564Anticancer agent 78
<p>Anticancer agent 78: anti-aromatase (IC50=0.9 μM), cytotoxic, potential in breast cancer research.</p>Formule :C19H14BrNO4Couleur et forme :SolidMasse moléculaire :400.22Inosine 5′-diphosphate sodium
CAS :<p>Inosine 5'-diphosphate sodium, a purine ribonucleoside diphosphate with inosine as its nucleobase, plays a role in intracellular energy metabolism and signal transduction processes.</p>Formule :C10H13N4Na3O12P2Couleur et forme :SolidMasse moléculaire :512.15Nampt-IN-14
CAS :<p>Nampt-IN-14 (example 3) is an effective NAMPT inhibitor with an IC50 of 0.2 nM, suited for use in the synthesis of antibody-drug conjugates (ADCs).</p>Formule :C33H35N7O2Couleur et forme :SolidMasse moléculaire :561.68FXR/HSD17B13 modulator 1
CAS :<p>FXR/HSD17B13 modulator 1 (compound 6) is an effective modulator of FXR/HSD17B13, playing a significant role in studies related to metabolic dysfunction-associated steatohepatitis (MASH).</p>Formule :C26H19Cl2NO4Couleur et forme :SolidMasse moléculaire :480.339Ranosidenib
CAS :<p>Ranolisib is an isocitrate dehydrogenase (IDH) inhibitor known for its antitumor activity.</p>Formule :C15H16F9N5OCouleur et forme :SolidMasse moléculaire :453.31NTPDase-IN-1
<p>NTPDase-IN-1 selectively inhibits NTPDases 1, 2, 8 with IC50 of 0.05, 0.23, 0.54 μM. Non-competitive, K m 21 μM, used in cancer, immune, infection research.</p>Formule :C18H25N3OS2Couleur et forme :SolidMasse moléculaire :363.54SDX-7539
CAS :<p>SDX-7539 is a selective MetAP2 inhibitor that inhibits the proliferation of HUVEC, with an IC50 of 120 μM. It has demonstrated antitumor activity in xenografted NSCLC in athymic nude mice.</p>Formule :C23H38N2O5Masse moléculaire :422.56RORγt inhibitor 4
CAS :<p>RORγt inhibitor 4 (Compound 9a) is an orally active RORγt inhibitor capable of penetrating the central nervous system. It has been shown to improve experimental autoimmune encephalomyelitis.</p>Formule :C22H16Cl2F3NO4SCouleur et forme :SolidMasse moléculaire :518.333IDH1 Inhibitor 1
CAS :<p>Oral, brain-penetrant mutant IDH1 inhibitor targeting R132H/C with IC50: 0.021/0.045μM; 2.52μM for IDH1WT.</p>Formule :C20H18F4N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :450.39GSK2945 hydrochloride
<p>GSK2945 HCl is a specific Rev-erbα antagonist, EC50: 21.5 μM (mouse), 20.8 μM (human), increases cholesterol 7α-hydroxylase.</p>Formule :C20H19Cl3N2O2SCouleur et forme :SolidMasse moléculaire :457.8HIF-1/2α-IN-1
<p>HIF-1/2α-IN-1, an orally active compound, functions as an inhibitor of HIF-2α.</p>Formule :C17H16N6O4Couleur et forme :SolidMasse moléculaire :368.35IDO2-IN-1
CAS :<p>IDO2-IN-1: potent oral IDO2 inhibitor, IC50 = 112 nM, for inflammatory autoimmunity research.</p>Formule :C21H21BrN10O3Couleur et forme :SolidMasse moléculaire :541.36JA2
CAS :JA2 is an inhibitor of metalloendopeptidase 24.15 that enhances the hypotensive response to bradykinin in rats.Formule :C33H38N4O8Couleur et forme :SolidMasse moléculaire :618.68Dihydrokainic acid
CAS :EAAT2(GLT1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptakeFormule :C10H17NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :215.25BAY 74-4113
CAS :<p>BAY 74-4113 is a DGAT1 inhibitor with an IC50 of 72 nM. It is utilized in research related to obesity.</p>Formule :C26H20F2N2O3SCouleur et forme :SolidMasse moléculaire :478.51MGAT2-IN-1
CAS :MGAT2-IN-1 is an orally active monoacylglycerol acyltransferase (MGAT2)inhibitor (human and mouse MGAT2 with IC50 of 7.8 and 2.4 nM , respectively).Formule :C27H21ClF5N7O3SCouleur et forme :SolidMasse moléculaire :654.01hCAII-IN-3
<p>hCAII-IN-3 inhibits key hCA isoforms with Ki: hCA I (403.8 nM), hCA II (5.1 nM), hCA IX (10.2 nM), hCA XII (5.2 nM); shows anticancer potential.</p>Formule :C17H21N3O3SCouleur et forme :SolidMasse moléculaire :347.43ABT-046
CAS :<p>ABT-046 is an orally active, selective, and highly efficient Diacylglycerol Acyltransferase 1 (DGAT-1) inhibitor that can be used in metabolic disease research.</p>Formule :C20H22N4O2Degré de pureté :98.13%Couleur et forme :SolidMasse moléculaire :350.41ACLY-IN-1
CAS :ACLY-IN-1 (compound 55) is a potent ACLY inhibitor with an IC50 of 8.3 nM, and it can be utilized in hyperlipidemia research.Formule :C20H12BrClF2N2O4SCouleur et forme :SolidMasse moléculaire :529.74hCAII-IN-4
CAS :hCAII-IN-4 (Compound 12j) is a potent inhibitor of human carbonic anhydrase II (hCA II), exhibiting an inhibitory concentration (IC50) of 7.78 μM.Formule :C31H23NO9Couleur et forme :SolidMasse moléculaire :553.52hMAO-B/MB-COMT-IN-2
<p>Dual inhibitor hMAO-B/MB-COMT-IN-2 targets hMAO-B (IC50: 4.27μM) & MB-COMT (IC50: 2.69μM), aids in neurodegenerative research.</p>Formule :C17H18N2O3Couleur et forme :SolidMasse moléculaire :298.34Carbonic anhydrase inhibitor 2
CAS :<p>Compound 7c inhibits carbonic anhydrase II, lowering intraocular pressure in glaucomatous rabbits.</p>Formule :C12H16N4O6SCouleur et forme :SolidMasse moléculaire :344.34BRD2879
CAS :<p>BRD2879 is a potent and cell-active inhibitor of IDH1-R132H (IC50 = 50 nM).</p>Formule :C30H38FN3O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :571.70Ro 23-9358
CAS :<p>Ro 23-9358 is a potent inhibitor of secretory phospholipase A2, exhibiting anti-inflammatory properties.</p>Formule :C30H51NO6Couleur et forme :SolidMasse moléculaire :521.729Diacylglycerol acyltransferase inhibitor-2
CAS :<p>Diacylglycerolacyltransferaseinhibitor-2 (Example 8) acts as an inhibitor for diacylglycerol acyltransferase 2 (DGAT2), exhibiting an IC50 value of 3.7 nM.</p>Formule :C21H20FN5O4Couleur et forme :SolidMasse moléculaire :425.41Oxythiamine diphosphate ammonium
<p>Oxythiamin diphosphate ammonium is a potent inhibitor of transketolase (TK).</p>Couleur et forme :SolidPPARδ agonist 11
CAS :<p>Compound 11, a selective PPARδ agonist, demonstrates an EC50 of 20 nM, indicating its high affinity for PPARδ receptors. This compound efficiently reduces levels of nitric oxide (NO), as well as the pro-inflammatory cytokines TNFα and IL-6 in LPS-stimulated RAW264.7 cells via the NF-κB pathway, showcasing its anti-inflammatory properties. Additionally, Compound 11 exhibits remarkable stability in human liver microsomes and plasma. It significantly ameliorates foot edema induced by Carrageenan, displaying favorable pharmacokinetic properties with a bioavailability of approximately 100%.</p>Formule :C19H15F3N2O3S2Couleur et forme :SolidMasse moléculaire :440.46L 731735
CAS :<p>L 731735 is a farnesyltransferase inhibitor.</p>Formule :C19H40N4O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :420.61FTI-2153 TFA
<p>FTI-2153 TFA inhibits farnesyltransferase with high selectivity (IC50: 1.4 nM), over 3000x more than Rap1A processing.</p>Formule :C27H31F3N4O5SCouleur et forme :SolidMasse moléculaire :580.62α-Amylase/α-Glucosidase-IN-19
CAS :<p>α-Amylase/α-Glucosidase-IN-19 (compound 10) is a dual inhibitor of α-amylase and α-glucosidase, with an IC50 of 170.7 μM and 60.37 μM, respectively.</p>Formule :C17H14BrClN2OCouleur et forme :SolidMasse moléculaire :377.663DC360
CAS :<p>DC360 is a synthetic analog of all-trans retinoic acid (ATRA) that can induce the expression of RARβ. It is useful for studies characterizing the retinoic acid signaling pathway.</p>Formule :C23H23NO2Couleur et forme :SolidMasse moléculaire :345.434CAII-IN-3
<p>CAII-IN-3, a thiosemicarbazone, potently inhibits CA-II with an IC50 of 13.4 μM.</p>Formule :C18H18F2N4SCouleur et forme :SolidMasse moléculaire :360.42FR 901537
CAS :<p>FR 901537 is a new aromatase inhibitor with antitumor effects.</p>Formule :C23H29N3O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :507.62Casein kinase 1δ-IN-19
CAS :<p>Casein kinase1δ-IN-19 (compound 492) is a potent inhibitor of casein kinase 1δ. It is utilized in research related to neurodegenerative disorders, such as Alzheimer's disease.</p>Formule :C21H19N5O3Couleur et forme :SolidMasse moléculaire :389.407Rivaroxaban diol
CAS :<p>Rivaroxabandiol is a metabolite of Rivaroxaban, which is a potent and selective direct inhibitor of coagulation factor Xa (FXa) with an IC50 of 0.7 nM and a Ki of 0.4 nM.</p>Formule :C19H20ClN3O6SCouleur et forme :SolidMasse moléculaire :453.897sEH inhibitor-1
<p>TCPU (sEH inhibitor-1) is a potent oral human sEH blocker with IC50s of 0.4 nM (human) and 5.3 nM (mouse).</p>Couleur et forme :SolidhCAVII/IX-IN-1
CAS :<p>hCAVII/IX-IN-1 (compound 4) functions as an inhibitor of hCAVII/IX, exhibiting Ki values of 56.5 nM and 38.2 nM, respectively. It is applicable in the field of cancer research.</p>Formule :C7H7N3O2S2Couleur et forme :SolidMasse moléculaire :229.279RXR antagonist 1
<p>RXR antagonist 1 is a Retinoid X Receptor (RXR) modulator that exhibits high RXR antagonism (pA2: 8.06). RXR antagonist 1 can be used to study type 2 diabetes.</p>Formule :C28H33F3N2O3Couleur et forme :SolidMasse moléculaire :502.57Yck2-IN-1
CAS :<p>Yck2-IN-1 (Compound 2a) is an inhibitor of the fungus Candida albicans Yck2. It has an IC50 of approximately 80 nM for Yck2 and an MIC80 of 12.5 µM for C. albicans, demonstrating good metabolic stability [66% remaining in mouse liver microsomes]. In a mouse model with drug-resistant Candida, Yck2-IN-1 significantly reduced fungal load in the kidneys. Yck2-IN-1 shows potential for research in antifungal infection treatments.</p>Formule :C19H11FN4Couleur et forme :SolidMasse moléculaire :314.316Lunacalcipol
CAS :<p>Lunacalcipol is used for the treatment of Secondary Hyperparathyroidism.</p>Formule :C28H42O4SCouleur et forme :SolidMasse moléculaire :474.7β-Glucuronidase/hCAII-IN-1
CAS :<p>β-Glucuronidase/hCAII-IN-2 (Compound 12e) is a compound that effectively inhibits both β-glucuronidase and human Carbonic Anhydrase II (hCA II), exhibiting IC50</p>Formule :C30H21NO9Couleur et forme :SolidMasse moléculaire :539.49A-800141
CAS :<p>A-800141 is an orally active and selective MetAP2 inhibitor with an IC50 of 12 nM, while showing weaker inhibitory activity against MetAP1 (IC50: 36 μM). GAPDH can serve as a biomarker for monitoring the inhibition of MetAP2 by A-800141. This compound exhibits anti-angiogenic and anticancer properties in various xenograft tumor models.</p>Formule :C24H30N2O4SCouleur et forme :SolidMasse moléculaire :442.571CK2 inhibitor 3
<p>CK2 inhibitor 3: potent CK2 blocker, IC50 of 280 nM, suppresses tumor cell growth, highly selective among 320 kinases.</p>Formule :C13H9BrN4O3SCouleur et forme :SolidMasse moléculaire :381.2Casein kinase 1δ-IN-23
CAS :<p>Casein kinase1δ-IN-23 (compound 423) is an effective inhibitor of casein kinase1δ. It is applicable in research related to neurodegenerative diseases such as Alzheimer's disease.</p>Formule :C19H15N3O3SCouleur et forme :SolidMasse moléculaire :365.406PDE4-IN-5
<p>PDE4-IN-5: potent PDE4 inhibitor, IC50 = 3.1 nM, superb skin penetration, anti-psoriasis effect.</p>Formule :C21H28N2O3Couleur et forme :SolidMasse moléculaire :356.46FXIa-IN-8
<p>FXIa-IN-8: potent FXIa blocker (IC50: 14.2 nM), anti-thrombotic, low bleeding/toxicity risk.</p>Couleur et forme :SolidGcase activator 2
CAS :<p>Gcase activator 2 is a β-glucocerebrosidase activator that induces dimerization of GCase, increases lysosomal substrate metabolism.</p>Formule :C21H24N4O2Degré de pureté :99.51% - 99.76%Couleur et forme :SolidMasse moléculaire :364.44
