Métabolisme
Les inhibiteurs du métabolisme sont des composés qui interfèrent avec les voies métaboliques, modifiant ainsi la production et l'utilisation de l'énergie au sein des cellules. Ces inhibiteurs sont utilisés pour étudier la régulation du métabolisme, le rôle des voies métaboliques dans des maladies telles que le cancer et le diabète, et pour développer de nouvelles stratégies thérapeutiques. Les inhibiteurs du métabolisme peuvent cibler diverses enzymes et processus impliqués dans la glycolyse, l'oxydation des acides gras et d'autres fonctions métaboliques. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de métabolisme de haute qualité pour soutenir vos recherches en biochimie, troubles métaboliques et développement de médicaments.
Sous-catégories appartenant à la catégorie "Métabolisme"
- AhR(41 produits)
- Aminopeptidase(67 produits)
- CETP(18 produits)
- Anhydrase carbonique(178 produits)
- Caséine Kinase(130 produits)
- DHFR(33 produits)
- Décarboxylase(4 produits)
- Déshydrogénase(271 produits)
- FAAH(64 produits)
- FXR(58 produits)
- Facteur Xa(80 produits)
- Synthase des acides gras(33 produits)
- Ferroptose(215 produits)
- GR(3 produits)
- GSNOR(3 produits)
- Glucokinase(54 produits)
- Prolyl-Hydroxylase de HIF/HIF(142 produits)
- HMG-CoA Réductase(33 produits)
- Hydroxylase(30 produits)
- IDO(82 produits)
- LDL(8 produits)
- Lipase(98 produits)
- Lipides(58 produits)
- Lipoxygénase(124 produits)
- MAO(87 produits)
- MPO(2 produits)
- NAMPT(36 produits)
- P450(6 produits)
- PAI-1(25 produits)
- PDE(166 produits)
- PED(1 produits)
- PKM(15 produits)
- PPAR(164 produits)
- Phospholipase(82 produits)
- ROR(42 produits)
- Récepteur de rétinoïdes(29 produits)
- SGK(11 produits)
- Thioredoxine(12 produits)
- Transférase(30 produits)
- Tansporteur(42 produits)
- UGT(4 produits)
- Inhibiteurs de la xanthine oxydase (XO)(9 produits)
Affichez 34 plus de sous-catégories
8626 produits trouvés pour "Métabolisme"
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FTI-2148
CAS :<p>FTI-2148 blocks RAS-related FT-1 & GGT-1; IC50: 1.4 nM & 1.7 μM.</p>Formule :C24H28N4O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :452.573'-Hydroxy Repaglinide
CAS :<p>'3'-Hydroxy Repaglinide, a CYP2C8 metabolite of Repaglinide, treats type II diabetes.</p>Formule :C27H36N2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.59LDHA-IN-5
CAS :<p>LDHA-IN-5 is a novel and potent inhibitor targeting both glycolate oxidase (GO) and lactate dehydrogenase A (LDHA), designed for the treatment of primary</p>Formule :C27H22FN7O6S3Couleur et forme :SolidMasse moléculaire :655.7Ro 23-9358
CAS :<p>Ro 23-9358 is a potent inhibitor of secretory phospholipase A2, exhibiting anti-inflammatory properties.</p>Formule :C30H51NO6Couleur et forme :SolidMasse moléculaire :521.729BT-114143
CAS :<p>BT-114143 is a plasminogen activator inhibitor with an IC50 of 8.42 μM. It is applicable in research related to hemorrhagic diseases caused by excessive fibrinolysis, including traumatic bleeding, severe menorrhagia, postpartum hemorrhage, and complications of hemophilia.</p>Formule :C8H11N2O3PCouleur et forme :SolidMasse moléculaire :214.158Casein kinase 1δ-IN-30
CAS :<p>Casein kinase1δ-IN-30 (Compound 581) is an inhibitor of casein kinase 1δ (CK1δ). It can be utilized in research related to neurodegenerative diseases.</p>Formule :C18H15BrN6O2SCouleur et forme :SolidMasse moléculaire :459.32CB30865
CAS :CB30865 (ZM 242421) is a selective and highly effective nicotinamide phosphoribosyltransferase (Nampt) inhibitor with potential antitumor activity.Formule :C26H22BrN5O2Degré de pureté :99.04%Couleur et forme :SolidMasse moléculaire :516.39Casein kinase 1δ-IN-16
CAS :<p>Casein kinase1δ-IN-16 (compound 506) is an inhibitor of casein kinase 1δ (CK1δ). This compound is applicable in research related to neurodegenerative diseases.</p>Formule :C17H12N4S2Couleur et forme :SolidMasse moléculaire :336.434CK1δ-IN-8
CAS :<p>CK1δ-IN-8 (Compound 429) is a CK1δ inhibitor suitable for Alzheimer's disease research.</p>Formule :C14H9N3O2S2Couleur et forme :SolidMasse moléculaire :315.37(3S,17S)-FD-895
CAS :<p>(3S,17S)-FD-895 is an analogue of FD-895. It inhibits the growth of HCT116 cells and shows splicing-modulating activity. This compound can be utilized in cancer research.</p>Formule :C31H50O9Couleur et forme :SolidMasse moléculaire :566.723BRD2879
CAS :<p>BRD2879 is a potent and cell-active inhibitor of IDH1-R132H (IC50 = 50 nM).</p>Formule :C30H38FN3O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :571.70GW461484A
CAS :<p>GW461484A is a small molecule inhibitor targeting Candida albicans Yck2, exhibiting an IC50 of 0.11 µM. It has a MIC80 of 12.5 µM against C. albicans. GW461484A shows potential for research into fungal diseases, including drug-resistant Candida infections.</p>Formule :C19H14FN3Couleur et forme :SolidMasse moléculaire :303.333SMase-IN-1
CAS :<p>SMase-IN-1 (Compound 4) is a bacterial sphingomyelinase (SMase) inhibitor with an IC50 value of 6.43 µM against Bacillus cereus SMase. It also inhibits eqBuChE with an inhibition rate of 59.50% at a concentration of 50 µM. SMase-IN-1 forms a complex with Cu2+ through bio-metal interactions and can inhibit hemolysis of sheep red blood cells induced by Bacillus cereus.</p>Formule :C8H5ClN2OSCouleur et forme :SolidMasse moléculaire :212.656Carbonic anhydrase inhibitor 2
CAS :<p>Compound 7c inhibits carbonic anhydrase II, lowering intraocular pressure in glaucomatous rabbits.</p>Formule :C12H16N4O6SCouleur et forme :SolidMasse moléculaire :344.34hMAO-B/MB-COMT-IN-2
<p>Dual inhibitor hMAO-B/MB-COMT-IN-2 targets hMAO-B (IC50: 4.27μM) & MB-COMT (IC50: 2.69μM), aids in neurodegenerative research.</p>Formule :C17H18N2O3Couleur et forme :SolidMasse moléculaire :298.34DSM705 hydrochloride
<p>DSM705 hydrochloride: potent antimalarial, pyrrole-based DHODH inhibitor effective against Plasmodium, non-toxic to mammalian DHODH.</p>Formule :C19H20ClF3N6OCouleur et forme :SolidMasse moléculaire :440.85CYP1B1-IN-2
<p>CYP1B1-IN-2 (compound 9j) is a highly potent and selective inhibitor of CYP1B1, a cytochrome P450 enzyme. It exhibits an IC50 value of 0.52 nM [1].</p>Formule :C20H11F3O2Couleur et forme :SolidMasse moléculaire :340.3TNP-470
CAS :<p>TNP-470 is a methionine aminopeptidase-2 inhibitor. TNP-470 is also an angiogenesis inhibitor.</p>Formule :C19H28ClNO6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :401.88(2S,4S)-Sacubitril
CAS :<p>(2S,4S)-Sacubitril (Sacubitril Impurity C) is a stereoisomer derived from Sacubitril which is a potent NEP inhibitor.</p>Formule :C24H29NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :411.49hCAII-IN-4
CAS :hCAII-IN-4 (Compound 12j) is a potent inhibitor of human carbonic anhydrase II (hCA II), exhibiting an inhibitory concentration (IC50) of 7.78 μM.Formule :C31H23NO9Couleur et forme :SolidMasse moléculaire :553.52Falecalcitriol
CAS :<p>Falecalcitriol is an analog of calcitriol. It has a higher potency both in vivo and in vitro systems, which is longer duration of action in vivo.</p>Formule :C27H38F6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :524.58ATX inhibitor 22
<p>ATX inhibitor 22 is a novel inhibitor of ATX (autotaxin) (IC50: 218.9 μM) that lacks inhibitory activity against LPAR1.</p>Formule :C19H17Cl3F2N2O4SCouleur et forme :SolidMasse moléculaire :513.77hCAII-IN-3
<p>hCAII-IN-3 inhibits key hCA isoforms with Ki: hCA I (403.8 nM), hCA II (5.1 nM), hCA IX (10.2 nM), hCA XII (5.2 nM); shows anticancer potential.</p>Formule :C17H21N3O3SCouleur et forme :SolidMasse moléculaire :347.43LEQ803
CAS :<p>LEQ803 (N-DesmethylRibociclib) is a metabolite of the CDK4/6 inhibitor Ribociclib, produced through metabolism by CYP3A4. This compound holds potential applications in the field of oncology.</p>Formule :C22H28N8OCouleur et forme :SolidMasse moléculaire :420.511JTT-553
CAS :<p>JTT-553 is a DGAT1 inhibitor with an IC50 of 2.38 nM. It effectively reduces plasma levels of glucose, insulin, non-esterified fatty acids (NEFA), total cholesterol (TC), and liver triglycerides (TG). JTT-553 enhances insulin-dependent glucose absorption and glucose intolerance in the adipose tissue of diet-induced obese (DIO) mice. In KK-Ay mice, it lowers TNF-α mRNA levels and elevates GLUT4 mRNA levels in adipose tissue. By contributing to weight loss, JTT-553 improves insulin resistance in adipose tissue and overall glucose metabolism. This compound is useful for research on obesity and type 2 diabetes mellitus (T2DM).</p>Formule :C25H27F3N4O3Couleur et forme :SolidMasse moléculaire :488.50Mitochondrial-IN-1
CAS :<p>Mitochondrial-IN (C458) is a potent inhibitor of mitochondrial complex I. It offers significant protection against Aβ toxicity, exhibits favorable pharmacokinetic properties, and has minimal off-target effects.</p>Formule :C22H30N2OCouleur et forme :SolidMasse moléculaire :338.49AZ513
CAS :<p>AZ513 is a reversible FAAH inhibitor, exhibiting an IC50 of 551 nM for human FAAH and 27 nM for rat FAAH. It inhibits the hydrolysis of arachidonoyl ethanolamide in HEK293 cells transfected with human FAAH, with an IC50 of 360 nM.</p>Formule :C14H9Cl2N3OCouleur et forme :SolidMasse moléculaire :306.147(Rac)-8-Hydroxy-efavirenz
CAS :<p>(Rac)-8-Hydroxy-efavirenz is a metabolite of Efavirenz, a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in the treatment of HIV-1.</p>Formule :C14H9ClF3NO3Couleur et forme :SolidMasse moléculaire :331.674ZK824859 hydrochloride
<p>ZK824859 hydrochloride: oral uPA inhibitor with IC50 of 79 nM (uPA), 1580 nM (tPA), 1330 nM (fibrin).</p>Formule :C23H23ClF2N2O4Couleur et forme :SolidMasse moléculaire :464.89hCAIX/XII-IN-15
CAS :<p>hCAIX/XII-IN-15 (Compound 17β) is an inhibitor of hCA IX and hCA XII, exhibiting Ki values of 0.42 and 4.37 μM, respectively. It demonstrates a pro-apoptotic effect in multiple myeloma cells.</p>Formule :C17H18O4SCouleur et forme :SolidMasse moléculaire :318.387Buspirone N-oxide
CAS :<p>Buspirone N-oxide (Bu N-oxide) is a metabolite of Buspirone. Buspirone is an orally active 5-HT1A receptor agonist and a dopamine D2 (dopamine D2) autoreceptor antagonist. It is an anxiolytic agent used for research in generalized anxiety disorder.</p>Formule :C21H31N5O3Couleur et forme :SolidMasse moléculaire :401.5035-Carboxy-2′-deoxycytidine
CAS :<p>5-Carboxy-2′-deoxycytidine is a metabolite of Trifluridine.</p>Formule :C10H13N3O6Couleur et forme :SolidMasse moléculaire :271.22711β-HSD2-IN-2
CAS :<p>11β-HSD2-IN-2 (compound 3) is a selective 17β-HSD2 (17β-hydroxysteroid dehydrogenase type 2) inhibitor with an IC50 of 300 nM, studying osteoporosis.</p>Formule :C22H21NO2Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :331.41Lumirubin
CAS :<p>Lumirubin is a water-soluble photoproduct of bilirubin formed in vivo during phototherapy.</p>Formule :C33H36N4O6Couleur et forme :SolidMasse moléculaire :584.66MDL-100240
CAS :<p>MDL-100240 inhibits ACE/neprilysin, effective against hypertension-induced heart/vascular changes.</p>Formule :C26H28N2O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :480.58Atorvastatin 3-Deoxyhept-2E-Enoic Acid
CAS :Atorvastatin 3-Deoxyhept-2E-Enoic Acid, an impurity in Atorvastatin, lowers blood lipids as an HMG-CoA reductase inhibitor.Formule :C33H33FN2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :540.62Desmonomethylpromazine
CAS :<p>Desmonomethylpromazine is a demethylated metabolite of Promazine that can penetrate the brain. It enters red blood cells and tissues via passive diffusion and is distributed in organs such as the lungs, liver, and kidneys in rats.</p>Formule :C16H18N2SCouleur et forme :SolidMasse moléculaire :270.39P5SA-2
CAS :<p>P5SA-2 is a selective allosteric activator of PPP5C, functioning by modulating the structure of the PPP5C phosphatase domain. At a concentration of 100 μM, it can enhance PPP5C activity by 3.2-fold, with an apparent affinity constant of 7.8 μM. P5SA-2 is applicable in research related to cancer and Alzheimer's disease.</p>Formule :C17H15ClN2O3Couleur et forme :SolidMasse moléculaire :330.766PDE4-IN-6
<p>PDE4-IN-6: Potent PDE4 inhibitor, IC50 - 0.125μM (B), 0.43μM (D), anti-inflammatory, for arthritis research.</p>Formule :C25H20FNO5SCouleur et forme :SolidMasse moléculaire :465.49SGK1-IN-6
CAS :<p>SGK1-IN-6 (compound 12f) is an SGK1 inhibitor with an IC50 value of 0.39 μM. In PC3 xenograft models using BALB/c nude mice, SGK1-IN-6 effectively hinders tumor growth without causing any observable toxicity.</p>Formule :C30H30F3N5O4Couleur et forme :SolidMasse moléculaire :581.5868-Hydroxychlorpromazine
CAS :<p>8-Hydroxychlorpromazine is a metabolite of Chlorpromazine that can enhance the hyperglycemic response following glucose loading, suggesting a possible synergistic role in Chlorpromazine-induced glucose metabolism disorders. It holds potential for research into metabolic diseases.</p>Formule :C17H19ClN2OSCouleur et forme :SolidMasse moléculaire :334.864Casein kinase 1δ-IN-18
CAS :<p>Casein kinase1δ-IN-18 (compound 660) is an inhibitor of casein kinase 1δ (CK1δ), which can be utilized for research in neurodegenerative diseases.</p>Formule :C16H12ClN3O2S2Couleur et forme :SolidMasse moléculaire :377.868GlcCer (d18:1/18:0)
CAS :<p>GlcCer (d18:1/18:0) (C18 Glucosyl(β) ceramide (d18:1/18:0)) is a sphingolipid with potential applications in research on Parkinson's disease and Lewy body dementia.</p>Formule :C42H81NO8Couleur et forme :SolidMasse moléculaire :728.094RORγt inverse agonist 34
CAS :<p>RORγt inverse agonist 34 (compound 5a) is an inverse agonist for RORγt, exhibiting an IC50 of 0.094 μM for the inhibition of RORγt-LBD. This compound is utilized in psoriasis research.</p>Formule :C31H37N3O3SCouleur et forme :SolidMasse moléculaire :531.709CK2-IN-3
<p>CK2-IN-3: potent, selective CK2 inhibitor; Kd=12 nM, IC50: 1.51 μM (CK2α), 7.64 μM (CK2α'). For cancer research.</p>Formule :C22H26N4O7Couleur et forme :SolidMasse moléculaire :458.46IMR687
CAS :<p>IMR687: a PDE9 inhibitor that could improve memory in Alzheimer's by slowing cGMP hydrolysis.</p>Formule :C21H26N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :394.47FAAH/MAGL-IN-3
<p>FAAH/MAGL-IN-3 irreversibly inhibits FAAH (IC50: 179 nM) & MAGL (IC50: 759 nM) with low PAMPA permeability.</p>Formule :C21H25N3O6SCouleur et forme :SolidMasse moléculaire :447.5FR 901537
CAS :<p>FR 901537 is a new aromatase inhibitor with antitumor effects.</p>Formule :C23H29N3O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :507.62AXKO-0046
<p>AXKO-0046 is an indole derivative and small-molecule LDHB selective inhibitor.</p>Formule :C25H33N3Couleur et forme :SolidMasse moléculaire :375.55Lp(a)-IN-5
CAS :<p>Lp(a)-IN-5 (Compound A) is an orally active inhibitor of lipoprotein (a) [Lp(a)]. It effectively inhibits the assembly of Apo(a) and ApoB proteins, with an IC50 value of 0.41 nM. Lp(a)-IN-5 shows potential for research into diseases associated with elevated plasma Lp(a) levels, such as cardiovascular diseases.</p>Formule :C43H56N4O7Couleur et forme :SolidMasse moléculaire :740.927
