Métabolisme
Les inhibiteurs du métabolisme sont des composés qui interfèrent avec les voies métaboliques, modifiant ainsi la production et l'utilisation de l'énergie au sein des cellules. Ces inhibiteurs sont utilisés pour étudier la régulation du métabolisme, le rôle des voies métaboliques dans des maladies telles que le cancer et le diabète, et pour développer de nouvelles stratégies thérapeutiques. Les inhibiteurs du métabolisme peuvent cibler diverses enzymes et processus impliqués dans la glycolyse, l'oxydation des acides gras et d'autres fonctions métaboliques. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de métabolisme de haute qualité pour soutenir vos recherches en biochimie, troubles métaboliques et développement de médicaments.
Sous-catégories appartenant à la catégorie "Métabolisme"
- AhR(41 produits)
- Aminopeptidase(67 produits)
- CETP(18 produits)
- Anhydrase carbonique(178 produits)
- Caséine Kinase(130 produits)
- DHFR(33 produits)
- Décarboxylase(4 produits)
- Déshydrogénase(271 produits)
- FAAH(64 produits)
- FXR(58 produits)
- Facteur Xa(80 produits)
- Synthase des acides gras(33 produits)
- Ferroptose(215 produits)
- GR(3 produits)
- GSNOR(3 produits)
- Glucokinase(54 produits)
- Prolyl-Hydroxylase de HIF/HIF(142 produits)
- HMG-CoA Réductase(33 produits)
- Hydroxylase(30 produits)
- IDO(82 produits)
- LDL(8 produits)
- Lipase(98 produits)
- Lipides(58 produits)
- Lipoxygénase(124 produits)
- MAO(87 produits)
- MPO(2 produits)
- NAMPT(36 produits)
- P450(6 produits)
- PAI-1(25 produits)
- PDE(166 produits)
- PED(1 produits)
- PKM(15 produits)
- PPAR(164 produits)
- Phospholipase(82 produits)
- ROR(42 produits)
- Récepteur de rétinoïdes(29 produits)
- SGK(11 produits)
- Thioredoxine(12 produits)
- Transférase(30 produits)
- Tansporteur(42 produits)
- UGT(4 produits)
- Inhibiteurs de la xanthine oxydase (XO)(9 produits)
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8626 produits trouvés pour "Métabolisme"
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IDX375
CAS :IDX375 is a non-nucleoside inhibitor that selectively targets the HCV NS5B enzyme. It shows promising selectivity for genotypes 1a and 1b. The structure and binding sites of IDX375 have been confirmed through X-ray co-crystallization studies.Formule :C24H37N4O6PSCouleur et forme :SolidMasse moléculaire :540.61AD012
<p>AD012, a dual cACE/NEP inhibitor, leverages lenopril-tryptophan for potential anti-hypertensive and cardioprotective benefits.</p>Formule :C25H32N2O6Couleur et forme :SolidMasse moléculaire :456.531-Phenylethanamine
CAS :<p>1-Phenylethanamine, a potential central nervous system stimulant related to β-phenylethylamine (β-phenylethylamine), exhibits diminished glycogenolysis activity in the brain due to its benzene ring being replaced by an indole group. This reduction in activity makes it useful for investigating how the chemical structure of phenylethylamine derivatives influences their effects on the central nervous system. Additionally, 1-Phenylethanamine is also utilized in the synthesis of the tyrosine kinase (tyrosine kinase) inhibitor CLM3.</p>Formule :C8H11NCouleur et forme :SolidMasse moléculaire :121.18PTP1B-IN-16
<p>PTP1B-IN-16: selective benzimidazole inhibitor of PTP1B, Ki: 12.6 μM, potential for type 2 diabetes research.</p>Formule :C26H18ClN3O4SCouleur et forme :SolidMasse moléculaire :503.96PAT-347
CAS :<p>PAT-347 is a potent inhibitor of Autotaxin, an enzyme linked to cell survival and diseases like cancer and fibrosis.</p>Formule :C28H21ClF2N2O3SCouleur et forme :SolidMasse moléculaire :538.996-trans-12-epi-Leukotriene B4
CAS :<p>6-trans-12-epi-Leukotriene B4, a metabolite of arachidonic acid, serves as a potent anti-inflammatory agent.</p>Formule :C20H32O4Couleur et forme :SolidMasse moléculaire :336.471,2-Dipentadecanoyl-rac-glycerol
CAS :<p>1,2-Dipentadecanoyl-rac-glycerol (DG(15:0/15:0/0:0)) is a compound referenced in studies examining the effect of insulin on the content of 1,2-diacylglycerol in rat hearts. Insulin is observed to increase the amount of 1,2-diacylglycerol containing specific fatty acid compositions in the heart, which may be linked to cardiac contractility.</p>Formule :C33H64O5Couleur et forme :SolidMasse moléculaire :540.86Oxoprolintane
CAS :<p>Oxoprolintane is a metabolite of the psychoactive compound Prolintane. It exhibits activity in modulating the central nervous system and may serve as a potential neuroprotective agent. Oxoprolintane shows promise for research in the field of neurological disorders.</p>Formule :C15H21NOCouleur et forme :SolidMasse moléculaire :231.333sEH inhibitor-1
<p>TCPU (sEH inhibitor-1) is a potent oral human sEH blocker with IC50s of 0.4 nM (human) and 5.3 nM (mouse).</p>Couleur et forme :SolidRivaroxaban diol
CAS :<p>Rivaroxabandiol is a metabolite of Rivaroxaban, which is a potent and selective direct inhibitor of coagulation factor Xa (FXa) with an IC50 of 0.7 nM and a Ki of 0.4 nM.</p>Formule :C19H20ClN3O6SCouleur et forme :SolidMasse moléculaire :453.897Diacylglycerol acyltransferase inhibitor-2
CAS :<p>Diacylglycerolacyltransferaseinhibitor-2 (Example 8) acts as an inhibitor for diacylglycerol acyltransferase 2 (DGAT2), exhibiting an IC50 value of 3.7 nM.</p>Formule :C21H20FN5O4Couleur et forme :SolidMasse moléculaire :425.41Morocromen
CAS :<p>Morocromen is a 2-benzamidobenzoic acid derivative characterized by its ability to enhance coronary activity.</p>Formule :C21H27N3O5Couleur et forme :SolidMasse moléculaire :401.46LXRα agonist 1
CAS :<p>LXRα agonist 1 (Compound 40) is a selective activator of LXRα, with an EC50 of 42 nM, and also demonstrates some activation effects on LXRβ, with an EC50 of 266 nM. It promotes target gene transcription by stabilizing the ligand-binding domain (LBD) of LXRα. When combined with the Raf inhibitor Sorafenib, LXRα agonist 1 shows significant antitumor activity in liver cancer cells. This compound is applicable in research focused on lipotoxicity-related cancers.</p>Formule :C28H27N3O2Couleur et forme :SolidMasse moléculaire :437.533α-Amylase/α-Glucosidase-IN-7
CAS :<p>α-Amylase/α-Glucosidase-IN-7 (Compound 3f) serves as a competitive inhibitor for the enzymes α-glucosidase and α-amylase, exhibiting IC50 values of 18.52 µM and 20.25 µM, respectively. Additionally, it effectively inhibits AChE and BChE, with IC50 values of 9.25 µM and 10.06 µM, respectively. This compound is useful in research related to diabetes and Alzheimer's [1].</p>Formule :C15H9Cl2FN2OSCouleur et forme :SolidMasse moléculaire :355.21MAGL-IN-18
CAS :<p>MAGL-IN-18 (compound 118) serves as a highly potent inhibitor of Monoacylglycerol lipase (MAGL), demonstrating an IC 50 value of 0.03nM.</p>Formule :C23H28F3N7OCouleur et forme :SolidMasse moléculaire :475.51Rosiptor acetate
CAS :<p>Rosiptor (AQX-1125) activates SHIP1, inhibits Akt, and reduces inflammation and allergy in rodents.</p>Formule :C22H39NO4Degré de pureté :98%Couleur et forme :Solid PowderMasse moléculaire :381.55h15-LOX-2 inhibitor 3
CAS :<p>Compound 13, identified as h15-LOX-2 inhibitor 3, exhibits inhibitory activity against h15-LOX, with IC50 and Ki values of 25 μM and 15.1 μM, respectively.</p>Formule :C22H13N5O3Couleur et forme :SolidMasse moléculaire :395.37BLT-4
CAS :<p>BLT-4 is a specific and reversible inhibitor of scavenger receptor class B type I (SR-BI). It effectively blocks the SR-BI-mediated transfer of lipids between high-density lipoprotein (HDL) and cells.</p>Formule :C18H16N2O2Couleur et forme :SolidMasse moléculaire :292.332α-Amylase-IN-12
CAS :<p>α-Amylase-IN-12 (Compound 5e) is an α-amylase inhibitor with an IC50 of 0.15 mM, functioning through a mixed inhibition mode. It exhibits an IC50 of 9.40 mM against α-glucosidase. This compound enhances glucose uptake in yeast cells and demonstrates significant anti-glycation activity at high concentrations. α-Amylase-IN-12 is applicable for diabetes research.</p>Formule :C16H11NO4Couleur et forme :SolidMasse moléculaire :281.263ATX inhibitor 12
<p>Oral ATX inhibitor 12 (IC50: 1.72 nM) at 60 mg/kg prevents lung damage in C57Bl/6J mice.</p>Formule :C30H34FN5O2Couleur et forme :SolidMasse moléculaire :515.62SelB-1
CAS :<p>SelB-1 acts as a dual inhibitor of Topoisomerase I/II (TopoisomeraseI/II), exhibiting anticancer activity suitable for research on prostate and colon cancers. Additionally, SelB-1 can induce the expression of autophagy (autophagy) genes and lipid peroxidation while reducing GSH levels.</p>Formule :C32H24O5Couleur et forme :SolidMasse moléculaire :488.531-Stearoyl-sn-glycerol 3-phosphate sodium
CAS :1-Stearoyl-sn-glycerol 3-phosphate sodium, a biologically active phospholipid, plays a crucial role in regulating cell motility, proliferation, invasion, survival, and the production of growth factors through interactions with G protein-coupled receptors (GPCR). Synthesized during the formation of membrane phospholipids, this compound typically has a low plasma concentration (approximately 100nM) and originates from various cell types, including activated platelets, epithelial cells, leukocytes, neuronal cells, and tumor cells. Its distinctive structure features stearic acid at the sn-1 position and a hydroxyl group at the sn-2 position.Formule :C21H42NaO7PCouleur et forme :SolidMasse moléculaire :460.52Anticancer agent 142
CAS :<p>Compound 142 (also known as Compound 235) is a PTPN inhibitor with potential applications in cancer research [1].</p>Formule :C13H14BrF2N2O7PS2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :523.26RORγ-IN-2
CAS :<p>RORγ-IN-2 (Compound 22) is an inhibitor of RORγ, with a Ki value of 16.6 nM for hRORγ. It is useful for research in IL-17-dependent autoimmune diseases.</p>Formule :C28H32F3N5O4S2Couleur et forme :SolidMasse moléculaire :623.71TNP-470
CAS :<p>TNP-470 is a methionine aminopeptidase-2 inhibitor. TNP-470 is also an angiogenesis inhibitor.</p>Formule :C19H28ClNO6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :401.88IDO1 ligand-1
CAS :<p>IDO1ligand-1 is the target protein ligand for PROTAC NU227326, which is utilized for degrading IDO1.</p>Formule :C29H34FN3O2Couleur et forme :SolidMasse moléculaire :475.598MK-3168 (12C)
CAS :<p>MK-3168 (12C) functions as a FAAH inhibitor, exhibiting IC50 values of 1.0 nM, 5.5 nM, and 1.7 nM for human, rhesus, and rat respectively. It demonstrates effective brain uptake and FAAH-specific signaling. Additionally, 11 C MK-3168 is applicable as a FAAH PET tracer.</p>Formule :C21H21ClN4OSCouleur et forme :SolidMasse moléculaire :412.94EB-0150
<p>EB-0150 inhibits ER α-Glu I/II (IC50: 0.73/0.0337 μM), is an N-substituted valerian with antiviral effects, and has drug discovery potential.</p>Formule :C19H30N6O7Couleur et forme :SolidMasse moléculaire :454.48α-Glucosylrutin
CAS :α-Glucosylrutin is an effective antioxidant known for its activity in scavenging free radicals. Due to its high epidermal bioavailability, it is commonly utilized in studies related to skin aging.Formule :C33H40O21Couleur et forme :SolidMasse moléculaire :772.66ICMT-IN-55
CAS :ICMT-IN-55 (compound 31) acts as an ICMT inhibitor, exhibiting an IC50 value of 90 nM [1].Formule :C22H26F3NO2Couleur et forme :SolidMasse moléculaire :393.44CK1δ-IN-7
CAS :<p>CK1δ-IN-7 (Compound 488) is an inhibitor of casein kinase 1δ (CK1δ).</p>Formule :C23H23N5OCouleur et forme :SolidMasse moléculaire :385.462GSK 366
CAS :GSK 366 is a potent kynurenine-3-monooxygenase (KMO) inhibitor (IC50s: 0.7 nM and 2.3 nM for P. fluorescens-KMO and human KMO).Formule :C17H16ClN3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :361.78Antidiabetic agent 5
CAS :<p>Compound S1 (antidiabetic agent 5) is an antidiabetic agent that effectively inhibits the enzymes α-glucosidase and α-amylase, demonstrating IC50 values of 3.91 µM and 8.89 µM, respectively. It reduces sugar levels and holds potential for type-II diabetes research [1].</p>Formule :C17H15N3O4SCouleur et forme :SolidMasse moléculaire :357.38BMS-341400 mesylate
CAS :<p>BMS-341400 mesylate (Compound 6) is an orally active selective phosphodiesterase 5 (PDE5) inhibitor with an IC50 value of 0.3 nM and is useful in the study of erectile dysfunction.</p>Formule :C24H26ClN9O5SCouleur et forme :SolidMasse moléculaire :588.039CAII-IN-3
<p>CAII-IN-3, a thiosemicarbazone, potently inhibits CA-II with an IC50 of 13.4 μM.</p>Formule :C18H18F2N4SCouleur et forme :SolidMasse moléculaire :360.42RORγt inverse agonist 34
CAS :<p>RORγt inverse agonist 34 (compound 5a) is an inverse agonist for RORγt, exhibiting an IC50 of 0.094 μM for the inhibition of RORγt-LBD. This compound is utilized in psoriasis research.</p>Formule :C31H37N3O3SCouleur et forme :SolidMasse moléculaire :531.709FTI-2153 TFA
<p>FTI-2153 TFA inhibits farnesyltransferase with high selectivity (IC50: 1.4 nM), over 3000x more than Rap1A processing.</p>Formule :C27H31F3N4O5SCouleur et forme :SolidMasse moléculaire :580.623β,7β-Dihydroxy-5-cholestenoic acid
CAS :<p>3β,7β-Dihydroxy-5-cholestenoic acid is a C27 acid whose levels are elevated in Niemann-Pick Type C and B diseases, leading to toxicity in ocular motor neurons. It is synthesized by the enzymatic action of hydroxysteroid 11-β dehydrogenase 1 from 3β-hydroxy-7-oxocholest-5-en-(25R)26-enoic acid (3βH,7O-CA).</p>Formule :C27H44O4Couleur et forme :SolidMasse moléculaire :432.64DOCP
CAS :DOCP (2-((2,3-Bis(oleoyloxy)propyl)dimethylammonio)ethyl hydrogen phosphate) is a lipid characterized by an opposite charge orientation compared to traditional phosphatidylcholine (PC) lipids, featuring quaternary ammonium near the bilayer interface and phosphate groups projecting into the aqueous environment. This unique structure of iPC lipids presents an excellent opportunity to investigate the biophysical characteristics and biological activities influenced by the reversal of surface charges on bilayers.Formule :C43H82NO8PCouleur et forme :SolidMasse moléculaire :772.09Urobilin hydrochloride
CAS :<p>Urobilin hydrochloride, a metabolic byproduct of Hemoglobin, is excreted through urine and feces in various mammals. It also serves as an indicator of human waste contamination.</p>Formule :C33H43ClN4O6Couleur et forme :SolidMasse moléculaire :627.17NAMPT activator-6
CAS :<p>NAMPT activator-6, a regulatory molecule for the optical control system of NAMPT and NAD+, can be used to design efficient photoswitchable proteolysis-targeting chimeras (PS-PROTACs) for light-dependent, reversible regulation of NAMPT and NAD+, thereby reducing toxicity associated with inhibitor-based PS-PROTACs. This enables antitumor activity and in vivo modulation of NAMPT and NAD+ through optical manipulation [1].</p>Formule :C17H21N5O3SCouleur et forme :SolidMasse moléculaire :375.45sEH inhibitor-4
<p>Compound B15: potent sEH inhibitor (0.03 nm), reduces inflammation & pain.</p>Formule :C27H28Cl2N4O3Couleur et forme :SolidMasse moléculaire :527.44Glucokinase activator 8
CAS :<p>Glucokinase activator8 is an activator of glucose kinase (glucokinase).</p>Formule :C14H13N3O2SCouleur et forme :SolidMasse moléculaire :287.337trans-Doxercalciferol
CAS :<p>trans-Doxercalciferol is an isomer of Doxercalciferol. Doxercalciferol is an activator of the Vitamin D receptor and prevents renal disease.</p>Formule :C28H44O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :412.65Arphamenine A
CAS :<p>Arphamenine A is an inhibitor of aminopeptidase B (aminopeptidaseB) found in HMG361-CF4 of Actinomadura azurea. It exhibits inhibitory effects against Sarcoma 180 and invasive micropapillary carcinoma (IMC).</p>Formule :C16H24N4O3Couleur et forme :SolidMasse moléculaire :320.387RWJ 22108
CAS :<p>RWJ 22108 is a bronchial-selective calcium channel (calcium channel) blocker that exhibits an IC50 of 5.7 nM in dog bronchial smooth muscle calcium-dependent contractions.</p>Formule :C27H30ClFN2O4SCouleur et forme :SolidMasse moléculaire :533.06PDE4B-IN-3
<p>PDE4B-IN-3 is a potent inhibitor of PDE4B (IC50: 0.94 μM) and exhibits anti-inflammatory effects.</p>Formule :C30H35N3O4S2Couleur et forme :SolidMasse moléculaire :565.75L 731735
CAS :<p>L 731735 is a farnesyltransferase inhibitor.</p>Formule :C19H40N4O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :420.61IRX5010
CAS :<p>IRX5010 (IRX4647F), an analogue of IRX4647, serves as a highly selective RARγ nuclear receptor agonist. It effectively inhibits the growth of EMT-6 triple-negative breast cancer.</p>Formule :C24H26FNO3Couleur et forme :SolidMasse moléculaire :395.466(S)-Dexfadrostat
CAS :(S)-Dexfadrostat ((S)-Fadrozole), an aromatase inhibitor, exhibits an IC 50 of 4.6 nM in in vitro assays using human placental microsomes. It is applicable for research on estrogen-dependent breast cancer, gynecomastia, and systemic lupus erythematosus.Formule :C14H13N3Couleur et forme :SolidMasse moléculaire :223.27
