Métabolisme
Les inhibiteurs du métabolisme sont des composés qui interfèrent avec les voies métaboliques, modifiant ainsi la production et l'utilisation de l'énergie au sein des cellules. Ces inhibiteurs sont utilisés pour étudier la régulation du métabolisme, le rôle des voies métaboliques dans des maladies telles que le cancer et le diabète, et pour développer de nouvelles stratégies thérapeutiques. Les inhibiteurs du métabolisme peuvent cibler diverses enzymes et processus impliqués dans la glycolyse, l'oxydation des acides gras et d'autres fonctions métaboliques. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de métabolisme de haute qualité pour soutenir vos recherches en biochimie, troubles métaboliques et développement de médicaments.
Sous-catégories appartenant à la catégorie "Métabolisme"
- AhR(41 produits)
- Aminopeptidase(67 produits)
- CETP(18 produits)
- Anhydrase carbonique(178 produits)
- Caséine Kinase(130 produits)
- DHFR(33 produits)
- Décarboxylase(4 produits)
- Déshydrogénase(271 produits)
- FAAH(64 produits)
- FXR(58 produits)
- Facteur Xa(80 produits)
- Synthase des acides gras(33 produits)
- Ferroptose(215 produits)
- GR(3 produits)
- GSNOR(3 produits)
- Glucokinase(54 produits)
- Prolyl-Hydroxylase de HIF/HIF(142 produits)
- HMG-CoA Réductase(33 produits)
- Hydroxylase(30 produits)
- IDO(82 produits)
- LDL(8 produits)
- Lipase(98 produits)
- Lipides(58 produits)
- Lipoxygénase(124 produits)
- MAO(87 produits)
- MPO(2 produits)
- NAMPT(36 produits)
- P450(6 produits)
- PAI-1(25 produits)
- PDE(166 produits)
- PED(1 produits)
- PKM(15 produits)
- PPAR(164 produits)
- Phospholipase(82 produits)
- ROR(42 produits)
- Récepteur de rétinoïdes(29 produits)
- SGK(11 produits)
- Thioredoxine(12 produits)
- Transférase(30 produits)
- Tansporteur(42 produits)
- UGT(4 produits)
- Inhibiteurs de la xanthine oxydase (XO)(9 produits)
Affichez 34 plus de sous-catégories
8626 produits trouvés pour "Métabolisme"
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MAGL-IN-20
<p>MAGL-IN-20 (compound ±34) is a reversible inhibitor of monoacylglycerol lipase (MAGL). It exhibits significant antiproliferative activity against a range of cancer cell lines, including H460, HT29, CT-26, Huh7, and HCCLM-3.</p>Formule :C23H24N2OCouleur et forme :SolidMasse moléculaire :344.45Utibaprilat
CAS :<p>Utibaprilat is the primary degradation product of Utibapril and functions as an ACE inhibitor.</p>Formule :C20H27N3O5SCouleur et forme :SolidMasse moléculaire :421.51FXR agonist 9
CAS :<p>FXR agonist9 (compound 26) is a selective, orally active partial agonist of FXR with an EC50 of 0.09 µM (maximum efficacy of 75.13%). It ameliorates the pathological features of fatty liver disease in mice induced by HFD and CCl4-related metabolic dysfunction.</p>Formule :C28H30N2O5Couleur et forme :SolidMasse moléculaire :474.554-Hexen-3-one
CAS :<p>4-Hexen-3-one inhibits the growth of H. pylori in the ATCC 43526 strain and TDR strain. Additionally, this compound suppresses urease activity.</p>Formule :C6H10OCouleur et forme :SolidMasse moléculaire :98.14DX-9065A HCl hydrate
CAS :<p>DX-9065a: Competitive fXa/prothrombinase inhibitor; blocks proinflammatory events; Ki ~10-20 nM.</p>Formule :C26H39ClN4O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :571.06Estradiol 3-glucuronide
CAS :<p>Estradiol 3-glucuronide is an immunogen with antigenic properties. The antiserum induced in rabbits exhibits high affinity and specificity for Estradiol 3-glucuronide. This compound shows promise for use in research involving radioimmunoassay.</p>Formule :C24H32O8Couleur et forme :SolidMasse moléculaire :448.51MD 770222
CAS :<p>MD 770222, the principal plasma O-demethylated metabolite of Cimoxatone, is an orally active selective and reversible inhibitor of MAO A. The potency of MD 770222 is lower than that of Cimoxatone.</p>Formule :C18H16N2O4Couleur et forme :SolidMasse moléculaire :324.33Perfluorohexane sulfonamide
CAS :<p>Perfluorohexane sulfonamide (FHxSA) serves as an inhibitor of carbonic anhydrase (CA), effectively inhibiting bovine CA and human CAII with IC50 values of 0.122 and 1.38 μM, respectively. Additionally, it acts as a delayed-action insecticide for controlling red imported fire ants (Solenopsis invicta). Furthermore, Perfluorohexane sulfonamide is considered a potential environmental pollutant.</p>Formule :C6H2F13NO2SCouleur et forme :SolidMasse moléculaire :399.13WR 199507 trihydrobromide
CAS :<p>WR 199507 trihydrobromide is a primary aminoquinoline metabolite that induces the formation of methemoglobin in canine erythrocyte lysates.</p>Formule :C15H24Br3N3O2Couleur et forme :SolidMasse moléculaire :518.08GPX4-IN-15
CAS :<p>GPX4-IN-15 (Compound C1) is an inhibitor of GPX4, demonstrating an inhibition rate of 19.8% at a concentration of 1 μM. This compound effectively inhibits the proliferation of cancer cell lines MDA-MB-468, BT-549, and MDA-MB-231, with IC50 values of 0.86 μM, 0.96 μM, and 0.48 μM respectively.</p>Formule :C17H15Cl2NO4Couleur et forme :SolidMasse moléculaire :368.21Fluopimomide
CAS :<p>Fluopimomide (LH2010A), a powerful insecticide, is extensively utilized in the control of agricultural pests. It adversely affects the growth, locomotor behavior, reproduction, and lifespan of nematodes. Concurrently, it leads to increased production of reactive oxygen species (ROS), accumulation of lipids and lipofuscins, as well as a rise in malondialdehyde content. Additionally, Fluopimomide inhibits the antioxidant system of nematodes.</p>Formule :C15H8ClF7N2O2Couleur et forme :SolidMasse moléculaire :416.68IDH1 Inhibitor 1
CAS :<p>Oral, brain-penetrant mutant IDH1 inhibitor targeting R132H/C with IC50: 0.021/0.045μM; 2.52μM for IDH1WT.</p>Formule :C20H18F4N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :450.39ASB14780
<p>ASB14780 is a 4-phenoxy derivative and an inhibitor of cytoplasmic phospholipase cPLA2α (IC50: 20 nM).</p>Couleur et forme :SolidIDO2-IN-1
CAS :<p>IDO2-IN-1: potent oral IDO2 inhibitor, IC50 = 112 nM, for inflammatory autoimmunity research.</p>Formule :C21H21BrN10O3Couleur et forme :SolidMasse moléculaire :541.36EB-0176
<p>EB-0176: A valerian derivative; broad-spectrum antiviral; potent ER α-glucosidase I/II inhibitor; IC50s: 0.6439/0.0011 μM.</p>Formule :C23H33N5O7Couleur et forme :SolidMasse moléculaire :491.54BAY 74-4113
CAS :<p>BAY 74-4113 is a DGAT1 inhibitor with an IC50 of 72 nM. It is utilized in research related to obesity.</p>Formule :C26H20F2N2O3SCouleur et forme :SolidMasse moléculaire :478.51TS010
<p>TS010 is a highly potent inhibitor of GLO-I, with an IC50 value of 0.57 μM. It holds significant promise for advancements in cancer research [1].</p>Formule :C16H12N4O4SCouleur et forme :SolidMasse moléculaire :356.36PPARδ agonist 11
CAS :<p>Compound 11, a selective PPARδ agonist, demonstrates an EC50 of 20 nM, indicating its high affinity for PPARδ receptors. This compound efficiently reduces levels of nitric oxide (NO), as well as the pro-inflammatory cytokines TNFα and IL-6 in LPS-stimulated RAW264.7 cells via the NF-κB pathway, showcasing its anti-inflammatory properties. Additionally, Compound 11 exhibits remarkable stability in human liver microsomes and plasma. It significantly ameliorates foot edema induced by Carrageenan, displaying favorable pharmacokinetic properties with a bioavailability of approximately 100%.</p>Formule :C19H15F3N2O3S2Couleur et forme :SolidMasse moléculaire :440.46Sphingomyelin (d18:1/12:0)
CAS :Sphingomyelin (d18:1/12:0) is a polar lipid known for its role in modulating cell signal transduction. It plays a critical role in cell membranes, influencing their fluidity and stability. Additionally, sphingomyelin (d18:1/12:0) is involved in lipid metabolism and has potential in promoting neuronal cell growth. This compound is essential for the functioning and development of the nervous system.Formule :C35H71N2O6PCouleur et forme :SolidMasse moléculaire :646.92IDO antagonist-1
CAS :<p>IDO antagonist-1 (compound 163), an IDO antagonist, effectively inhibits the growth of pancreatic adenocarcinoma cells in C57BL/6 mice [1].</p>Formule :C39H53N7O5Couleur et forme :SolidMasse moléculaire :699.88Casein kinase 1δ-IN-17
CAS :<p>Casein kinase1δ-IN-17 (compound 753) is an inhibitor of casein kinase 1δ (CK1δ). It is applicable in research related to neurodegenerative diseases.</p>Formule :C14H14N4SCouleur et forme :SolidMasse moléculaire :270.353AD011
<p>AD011, a cACE/NEP inhibitor derived from lenopril-tryptophan, may offer strong anti-hypertensive, cardioprotective benefits.</p>Formule :C27H33N3O5Couleur et forme :SolidMasse moléculaire :479.57ACLY Inhibitor 7
CAS :<p>ACLY Inhibitor 7 is a potent, selective hACLY inhibitor (IC50<1 nM) for metabolic disease and oncology research.</p>Formule :C21H14ClF2NO6SDegré de pureté :99.74%Couleur et forme :SoildMasse moléculaire :481.85Yck2-IN-1
CAS :<p>Yck2-IN-1 (Compound 2a) is an inhibitor of the fungus Candida albicans Yck2. It has an IC50 of approximately 80 nM for Yck2 and an MIC80 of 12.5 µM for C. albicans, demonstrating good metabolic stability [66% remaining in mouse liver microsomes]. In a mouse model with drug-resistant Candida, Yck2-IN-1 significantly reduced fungal load in the kidneys. Yck2-IN-1 shows potential for research in antifungal infection treatments.</p>Formule :C19H11FN4Couleur et forme :SolidMasse moléculaire :314.316LTA4H-IN-3
CAS :<p>LTA4H-IN-3 (compound 9) functions as an inhibitor of LTA4H, demonstrating an IC50 of 28 nM [1].</p>Formule :C17H15ClN4O3Couleur et forme :SolidMasse moléculaire :358.78Epoxykynin
CAS :<p>Epoxykynin is a potent soluble epoxide hydrolase (sEH) inhibitor [1].</p>Formule :C19H20BrF3N2O2Couleur et forme :SolidMasse moléculaire :445.27Monoamine Oxidase B inhibitor 6
CAS :<p>Monoamine OxidaseB inhibitor 6 (Compound BT5) is a highly selective, reversible, and competitive MAO-B inhibitor capable of crossing the blood-brain barrier, with an IC50 of 0.11 μM. It exhibits antioxidant and neuroprotective properties, making it suitable for research into neurodegenerative diseases.</p>Formule :C15H15N3OSCouleur et forme :SolidMasse moléculaire :285.364Alkannin
CAS :<p>Alkannin: potent, tumor-specific PKM2 inhibitor; non-inhibitory to PKM1/PKL; potential anticancer agent.</p>Formule :C16H16O5Couleur et forme :SolidMasse moléculaire :288.3(rel)-Mirogabalin
CAS :<p>(rel)-Mirogabalin ((rel)-DS5565) is an inhibitor of voltage-dependent calcium channels, specifically targeting the α2δ-1 subunit.</p>Formule :C12H19NO2Couleur et forme :SolidMasse moléculaire :209.28BAR-2227
CAS :<p>BAR-2227 (compound 3a) functions as an FXR agonist and a LIFR inhibitor. It is utilized in the study of liver fibrosis and inflammation.</p>Formule :C24H17Cl2NO4Couleur et forme :SolidMasse moléculaire :454.30DGAT2-IN-3
CAS :<p>DGAT2-IN-3 (compound 9) is an inhibitor of DGAT2 with an IC50 value of 0.4 nM. It is utilized in research related to fatty liver disease, diabetes, and cardiovascular diseases.</p>Formule :C21H20F4N4O5SCouleur et forme :SolidMasse moléculaire :516.47QGC583
CAS :<p>QGC583 is an effective and selective AminopeptidaseA (APA) inhibitor, demonstrating an IC50 of 4 nM. It inhibits APA activity in the brain, kidneys, and heart of rats.</p>Formule :C13H20NO5PCouleur et forme :SolidMasse moléculaire :301.28IMR687
CAS :<p>IMR687: a PDE9 inhibitor that could improve memory in Alzheimer's by slowing cGMP hydrolysis.</p>Formule :C21H26N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :394.47S-15176
CAS :<p>S-15176 is an inhibitor of the mitochondrial permeability transition pore (PTP). It effectively suppresses mitochondrial swelling induced by tert-butyl hydroperoxide, with an IC50 value of 45.7 μM. S-15176 prevents the opening of PTP, thus averting the dissipation of mitochondrial membrane potential and the oxidation of NAD(P)H, while enhancing mitochondrial calcium loading capacity. It holds potential for research into ischemia-reperfusion injury.</p>Formule :C31H48N2O4SCouleur et forme :SolidMasse moléculaire :544.79LTA4H-IN-2
CAS :<p>LTA4H-IN-2 (compound (S)-2) acts as an orally active inhibitor targeting Leukotriene A4 Hydrolase, exhibiting potent activity with an IC 50 of less than 3 nM [1].</p>Formule :C20H19FN6O2Couleur et forme :SolidMasse moléculaire :394.4CGS 24592
CAS :<p>CGS-24592 is an orally active, selective, and potent inhibitor of neutral endopeptidase 24.11 (NEP), with an IC50 value of 1.6 nmol/L. It reduces the degradation of atrial natriuretic peptide (ANP), thereby increasing plasma ANP concentration and lowering blood pressure. CGS-24592 shows potential for research in cardiovascular diseases such as hypertension and congestive heart failure.</p>Formule :C19H23N2O6PCouleur et forme :SolidMasse moléculaire :406.37Bestatin methyl ester
CAS :<p>Bestatin methyl ester (600, 900 µM; 24 h) inhibits spore cell differentiation in Dictyostelium discoideum.</p>Formule :C17H26N2O4Couleur et forme :SolidMasse moléculaire :322.4MGAT2-IN-1
CAS :MGAT2-IN-1 is an orally active monoacylglycerol acyltransferase (MGAT2)inhibitor (human and mouse MGAT2 with IC50 of 7.8 and 2.4 nM , respectively).Formule :C27H21ClF5N7O3SCouleur et forme :SolidMasse moléculaire :654.0111-trans Leukotriene E4
CAS :<p>Slow isomerization of the C-11 double bond of LTE4 leads to the formation of 11-trans LTE4. 11-trans LTE4 is equipotent to LTE4 in contracting guinea pig ileum.</p>Formule :C23H37NO5SCouleur et forme :SolidMasse moléculaire :439.61hCAI/II/XII-IN-1
CAS :<p>hCAI/II/XII-IN-1 (compound 7) is an inhibitor of human carbonic anhydrases hCAI, hCAII, and hCAXII, with Ki values of 78.5 nM, 9.1 nM, 605 nM, 7.7 nM, and 3.7 nM.</p>Formule :C12H12N2O2SCouleur et forme :SolidMasse moléculaire :248.301Nomelidine
CAS :Nomelidine, the active N-demethylated metabolite of zimelidine, has been used as an antidepressant and analgesic.Formule :C15H15BrN2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :303.207-APB hydrochloride
CAS :<p>7-APB hydrochloride is a benzofuran compound and serves as a metabolite of 7-MAPB.</p>Formule :C11H14ClNOCouleur et forme :SolidMasse moléculaire :211.688TAP311
TAP311 is an inhibitor of cholesteryl ester transfer protein (CETP)(IC50 of 62 nM).Formule :C34H40F6N6O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :710.71D-2-Phosphoglyceric acid
CAS :D-2-Phosphoglyceric acid is a crucial metabolic intermediate known for its role in enhancing cellular energy metabolism and regulating biosynthesis. It plays a key role in both glycolysis and photosynthesis, which are essential for cellular energy supply. Additionally, D-2-Phosphoglyceric acid serves as a biomarker for monitoring metabolic states in various organisms.Formule :C3H7O7PCouleur et forme :SolidMasse moléculaire :186.06Rostratin A
CAS :<p>Rostratin A, a disulfide from Exserohilum rostratum, is cytotoxic to HCT-116 cells with an IC50 of 8.5 μg/mL.</p>Formule :C18H24N2O6S2Couleur et forme :SolidMasse moléculaire :428.52CK2 inhibitor 3
<p>CK2 inhibitor 3: potent CK2 blocker, IC50 of 280 nM, suppresses tumor cell growth, highly selective among 320 kinases.</p>Formule :C13H9BrN4O3SCouleur et forme :SolidMasse moléculaire :381.2BLT-4
CAS :<p>BLT-4 is a specific and reversible inhibitor of scavenger receptor class B type I (SR-BI). It effectively blocks the SR-BI-mediated transfer of lipids between high-density lipoprotein (HDL) and cells.</p>Formule :C18H16N2O2Couleur et forme :SolidMasse moléculaire :292.332Rosiptor acetate
CAS :<p>Rosiptor (AQX-1125) activates SHIP1, inhibits Akt, and reduces inflammation and allergy in rodents.</p>Formule :C22H39NO4Degré de pureté :98%Couleur et forme :Solid PowderMasse moléculaire :381.55RWJ-445167
CAS :<p>RWJ-445167 is a thrombin and factor Xa dual inhibitor(Ki of 4.0 nM and 230 nM, respectively), with potent antithrombotic activity.</p>Formule :C18H24N6O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :436.49α-Hydroxy alprazolam
CAS :<p>α-Hydroxy alprazolam (U 40125), the primary metabolite of α-Hydroxy alprazolam, possesses pharmacological activity accounting for 60% of that of Alprazolam.</p>Formule :C17H13ClN4OCouleur et forme :SolidMasse moléculaire :324.76
