Métabolisme
Les inhibiteurs du métabolisme sont des composés qui interfèrent avec les voies métaboliques, modifiant ainsi la production et l'utilisation de l'énergie au sein des cellules. Ces inhibiteurs sont utilisés pour étudier la régulation du métabolisme, le rôle des voies métaboliques dans des maladies telles que le cancer et le diabète, et pour développer de nouvelles stratégies thérapeutiques. Les inhibiteurs du métabolisme peuvent cibler diverses enzymes et processus impliqués dans la glycolyse, l'oxydation des acides gras et d'autres fonctions métaboliques. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de métabolisme de haute qualité pour soutenir vos recherches en biochimie, troubles métaboliques et développement de médicaments.
Sous-catégories appartenant à la catégorie "Métabolisme"
- AhR(41 produits)
- Aminopeptidase(67 produits)
- CETP(18 produits)
- Anhydrase carbonique(178 produits)
- Caséine Kinase(130 produits)
- DHFR(33 produits)
- Décarboxylase(4 produits)
- Déshydrogénase(270 produits)
- FAAH(64 produits)
- FXR(58 produits)
- Facteur Xa(80 produits)
- Synthase des acides gras(33 produits)
- Ferroptose(215 produits)
- GR(3 produits)
- GSNOR(3 produits)
- Glucokinase(54 produits)
- Prolyl-Hydroxylase de HIF/HIF(142 produits)
- HMG-CoA Réductase(33 produits)
- Hydroxylase(30 produits)
- IDO(82 produits)
- LDL(8 produits)
- Lipase(97 produits)
- Lipides(59 produits)
- Lipoxygénase(125 produits)
- MAO(87 produits)
- MPO(2 produits)
- NAMPT(36 produits)
- P450(6 produits)
- PAI-1(25 produits)
- PDE(166 produits)
- PED(1 produits)
- PKM(15 produits)
- PPAR(164 produits)
- Phospholipase(82 produits)
- ROR(42 produits)
- Récepteur de rétinoïdes(29 produits)
- SGK(11 produits)
- Thioredoxine(12 produits)
- Transférase(30 produits)
- Tansporteur(42 produits)
- UGT(4 produits)
- Inhibiteurs de la xanthine oxydase (XO)(9 produits)
Affichez 34 plus de sous-catégories
8626 produits trouvés pour "Métabolisme"
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MD 770222
CAS :<p>MD 770222, the principal plasma O-demethylated metabolite of Cimoxatone, is an orally active selective and reversible inhibitor of MAO A. The potency of MD 770222 is lower than that of Cimoxatone.</p>Formule :C18H16N2O4Couleur et forme :SolidMasse moléculaire :324.339-cis-β-Carotene
CAS :<p>9-cis-β-Carotene, a precursor of retinal, is cleaved by beta-carotene oxygenase 1 (BCMO1) to produce 9-cis-retinal.</p>Formule :C40H56Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :536.872,4-Dihydroxybutanoic acid
CAS :<p>2,4-Dihydroxybutanoic acid is typically not found in extracts of normal human urine and is present only in trace amounts in newborns, while cases of succinic semialdehyde dehydrogenase deficiency consistently exhibit elevated levels of this metabolite.</p>Formule :C4H8O4Couleur et forme :SolidMasse moléculaire :120.10FXR/CES2 modulator 1
CAS :<p>Compound LE-77, known as FXR/CES2 modulator 1, functions as a dual regulator that activates FXR and inhibits CES2. It effectively mitigates the intestinal toxicity of irinotecan.</p>Formule :C27H21Cl2NO5Couleur et forme :SolidMasse moléculaire :510.36Cephapirin lactone
CAS :Cephapirinlactone is a metabolite of the antibiotic Cephapirin.Formule :C15H13N3O4S2Masse moléculaire :363.41Fonadelpar
CAS :<p>Fonadelpar is an agonist of PPARδ. It also is used in the research of neuroparalytic keratopathy.</p>Formule :C25H23F3N2O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :504.52CYP2C1/CYP2C19-IN-2
<p>CYP2C1/CYP2C19-IN-2 is a potent inhibitor of CYP2C9/CYP2C19 without liver toxicity or genotoxicity and can be used to study Zika virus (ZIKV) infection.</p>Formule :C27H28N2O6SCouleur et forme :SolidMasse moléculaire :508.59α-Amylase-IN-7
CAS :<p>α-Amylase-IN-7 (Compound 6e) is an inhibitor of α-Amylase, with an IC50 of 40 μM, indicating its potency. This compound shows potential as an anti-diabetic medication.</p>Formule :C18H15ClN6O2SMasse moléculaire :414.87Lecufexor
CAS :<p>Lecufexor is an agonist of the farnesoid X receptor (FXR).</p>Formule :C32H21Cl3N2O5Couleur et forme :SolidMasse moléculaire :619.88MAFP
CAS :<p>MAFP (Methyl Arachidonyl Fluorophosphonate) is an effective irreversible inhibitor of anandamide amidase.</p>Formule :C21H36FO2PCouleur et forme :SolidMasse moléculaire :370.48Carbonic anhydrase inhibitor 16
CAS :<p>Carbonic anhydrase inhibitor 16 (compound 1) is a CA I/CA II inhibitor with potential antiviral activity, used in virus infection studies.</p>Formule :C14H10N2O4SDegré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :302.31DS44470011
CAS :<p>DS44470011 is an inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) with oral bioavailability. It enhances the release of erythropoietin (EPO) from cells and is utilized in research related to renal anemia.</p>Formule :C21H19N3O4Couleur et forme :SolidMasse moléculaire :377.39MAGL-IN-19
CAS :<p>MAGL-IN-19 (compound 7o) is a highly effective and selective inhibitor of MAGL.</p>Formule :C21H26F3N3O3Couleur et forme :SolidMasse moléculaire :425.45CK1δ-IN-3
CAS :<p>CK1δ-IN-3 (compound 376) is a CK1δ (casein kinase 1δ) inhibitor that can be used to study neurodegenerative diseases such as Alzheimer's disease.</p>Formule :C24H19N3O2SDegré de pureté :99.27%Couleur et forme :SolidMasse moléculaire :413.49DOCP
CAS :<p>DOCP (2-((2,3-Bis(oleoyloxy)propyl)dimethylammonio)ethyl hydrogen phosphate) is a lipid characterized by an opposite charge orientation compared to traditional phosphatidylcholine (PC) lipids, featuring quaternary ammonium near the bilayer interface and phosphate groups projecting into the aqueous environment. This unique structure of iPC lipids presents an excellent opportunity to investigate the biophysical characteristics and biological activities influenced by the reversal of surface charges on bilayers.</p>Formule :C43H82NO8PCouleur et forme :SolidMasse moléculaire :772.09α-Glucosidase-IN-18
<p>α-Glucosidase-IN-18 (7B) is an orally active inhibitor of α-glucosidase, displaying an IC 50 value of 3.96 μM.</p>Formule :C23H19NO2SCouleur et forme :SolidMasse moléculaire :373.47D-2-Phosphoglyceric acid
CAS :D-2-Phosphoglyceric acid is a crucial metabolic intermediate known for its role in enhancing cellular energy metabolism and regulating biosynthesis. It plays a key role in both glycolysis and photosynthesis, which are essential for cellular energy supply. Additionally, D-2-Phosphoglyceric acid serves as a biomarker for monitoring metabolic states in various organisms.Formule :C3H7O7PCouleur et forme :SolidMasse moléculaire :186.06Pyrocatechol sulfate
CAS :<p>Pyrocatechol sulfate, a phenolic metabolite found in human plasma, is associated with the intake of specific foods such as berries and the state of the gut microbiome. It serves as a potential urinary biomarker for kidney function, dialysis clearance rates, whole grain consumption, and regular coffee intake. Additionally, in conjunction with other phenolic sulfates, pyrocatechol sulfate plays a role in regulating various biological functions, including those related to brain health and the rhythmic beating of cardiac cells.</p>Formule :C6H6O5SCouleur et forme :SolidMasse moléculaire :190.17Fmoc-NH-PEG6-alcohol
CAS :<p>Fmoc-NH-PEG6-alcohol, a cleavable ADC linker, is employed in the synthesis of antibody-drug conjugates (ADCs) [1].</p>Formule :C27H37NO8Couleur et forme :SolidMasse moléculaire :503.58T-3764518
CAS :<p>T-3764518 is a novel and potent inhibitor of stearoyl coenzyme A desaturase (SCD)(IC50 of 4.7 nM).</p>Formule :C20H17F6N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :473.37Calcipotriol Impurity C
CAS :<p>Calcipotriol Impurity C is the impurity of Calcipotriol. Calcipotriol is a VDR-like receptors ligand.</p>Formule :C27H40O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :412.6147PPD-Q
CAS :<p>7PPD-Q is a substituted p-phenylenediamine antioxidant derivative. It exhibits toxicity towards the bacterium V. fischeri (EC50= 14.9 mg/L).</p>Formule :C19H24N2O2Couleur et forme :SolidMasse moléculaire :312.41LTA4H-IN-3
CAS :<p>LTA4H-IN-3 (compound 9) functions as an inhibitor of LTA4H, demonstrating an IC50 of 28 nM [1].</p>Formule :C17H15ClN4O3Couleur et forme :SolidMasse moléculaire :358.78HIV-1 inhibitor-40
<p>HIV-1 inhibitor-40 (4ab) is a potent NNRTI (EC50: 1.9 nM), non-toxic in vivo, and a sensitive CYP inhibitor.</p>Formule :C25H18N6O2Couleur et forme :SolidMasse moléculaire :434.45BMS-341400 mesylate
CAS :<p>BMS-341400 mesylate (Compound 6) is an orally active selective phosphodiesterase 5 (PDE5) inhibitor with an IC50 value of 0.3 nM and is useful in the study of erectile dysfunction.</p>Formule :C24H26ClN9O5SCouleur et forme :SolidMasse moléculaire :588.039LXRβ agonist-3
CAS :<p>LXRβ agonist-3 is a potent and selective LXRβ (liver X receptor β) agonist (EC50: 0.095 μM).</p>Formule :C30H33N3O6SCouleur et forme :SolidMasse moléculaire :563.66PDE4B/7A-IN-2
CAS :<p>5-HT1A/5-HT7 antagonist; 5-HT1A Ki=8 nM, 5-HT7 Ki=451 nM; PDE4B IC50=80.4 μM, PDE7A IC50=151.3 μM; stronger than escitalopram.</p>Formule :C25H35N3O2Couleur et forme :SolidMasse moléculaire :409.56Deltasonamide 2 hydrochloride
<p>Deltasonamide 2 hydrochloride is a competitive high-affinity PDEδ inhibitor with a Kd of approximately 385 pM.</p>Formule :C30H40Cl2N6O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :683.71Epoxykynin
CAS :<p>Epoxykynin is a potent soluble epoxide hydrolase (sEH) inhibitor [1].</p>Formule :C19H20BrF3N2O2Couleur et forme :SolidMasse moléculaire :445.27NNC 55-0396
CAS :<p>NNC 55-0396: Selective T-type calcium channel blocker, IC50 6.8 μM, inhibits human ovarian cancer cell growth.</p>Formule :C30H40Cl2FN3O2Degré de pureté :99.00%Couleur et forme :SolidMasse moléculaire :564.56APOL1-IN-3
CAS :<p>APOL1-IN-3 is an APOL1 inhibitor used for kidney disease research.</p>Formule :C16H19F3N4O2SCouleur et forme :SolidMasse moléculaire :388.41Etamicastat
CAS :<p>Etamicastat can be used in the research of cardiovascular diseases.</p>Formule :C14H15F2N3OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :311.35Estradiol 3-glucuronide
CAS :<p>Estradiol 3-glucuronide is an immunogen with antigenic properties. The antiserum induced in rabbits exhibits high affinity and specificity for Estradiol 3-glucuronide. This compound shows promise for use in research involving radioimmunoassay.</p>Formule :C24H32O8Couleur et forme :SolidMasse moléculaire :448.51LU 2443
CAS :<p>LU 2443 is an orally active antiepileptic agent that is extensively absorbed, with up to 18% remaining unabsorbed in rats. The active half-life in plasma is 13.17 hours.</p>Formule :C9H8N2S2Couleur et forme :SolidMasse moléculaire :208.3TAP311
<p>TAP311 is an inhibitor of cholesteryl ester transfer protein (CETP)(IC50 of 62 nM).</p>Formule :C34H40F6N6O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :710.71HSD17B13-IN-40
CAS :HSD17B13-IN-40 (compound 6) serves as a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), exhibiting an IC50 value of less than 0.1 μM using estradiol as substrates. This compound is significant in the treatment of nonalcoholic fatty liver diseases (NAFLDs), including nonalcoholic steatohepatitis (NASH) [1].Formule :C23H14Cl2F3N3O3Masse moléculaire :508.28NTPDase-IN-1
<p>NTPDase-IN-1 selectively inhibits NTPDases 1, 2, 8 with IC50 of 0.05, 0.23, 0.54 μM. Non-competitive, K m 21 μM, used in cancer, immune, infection research.</p>Formule :C18H25N3OS2Couleur et forme :SolidMasse moléculaire :363.54AChE/BChE-IN-23
<p>AChE/BChE-IN-23 (Compound 6e) is a dual inhibitor of acetylcholinesterase and butyrylcholinesterase, exhibiting IC50 values of 0.91 μM for AChE, 1.19 μM for eqBChE, and 1.01 μM for hBChE. This compound also demonstrates antioxidant properties and inhibits the aggregation of Aβ1-42 and Tau proteins. Moreover, AChE/BChE-IN-23 prevents the activation of microglial cells by inhibiting the release of reactive oxygen species and mitochondrial damage. Additionally, it reduces the levels of the NLRP3 inflammasome in human microglial cells and reverses memory impairment in mice induced by scopolamine.</p>Formule :C19H21N5O3Couleur et forme :SolidMasse moléculaire :367.42-Amino-5-methyl-5-hexenoic acid
CAS :<p>2-Amino-5-methyl-5-hexenoic acid ((S)-2-Amino-5-methylhex-5-enoic acid) acts as a methionine analog, competing with methionine and thereby hindering cell growth. This compound inhibits protein synthesis in Salmonella typhimurium TA1535 and Escherichia coli K-12 without affecting the synthesis of DNA or RNA.</p>Formule :C7H13NO2Couleur et forme :SolidMasse moléculaire :143.184RXR antagonist 2
<p>RXR antagonist 2 is a potent antagonist of RXR (Ki: 0.391 μM, Kd: 0.281 μM). RXR antagonist 2 has shown research potential for RXR-related diseases.</p>Formule :C29H35F3N2O3Couleur et forme :SolidMasse moléculaire :516.6PKM2-IN-9
CAS :<p>PKM2-IN-9 (compound C1) is a potent inhibitor of PKM2, demonstrating a 75% inhibition rate at 50 μM. It plays a significant role in cancer research.</p>Formule :C24H22N4O2Couleur et forme :SolidMasse moléculaire :398.457Cgs 25155
CAS :<p>Cgs 25155 is an orally active inhibitor of NEP 24.11.</p>Formule :C25H34N2O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :490.61MAGL-IN-20
<p>MAGL-IN-20 (compound ±34) is a reversible inhibitor of monoacylglycerol lipase (MAGL). It exhibits significant antiproliferative activity against a range of cancer cell lines, including H460, HT29, CT-26, Huh7, and HCCLM-3.</p>Formule :C23H24N2OCouleur et forme :SolidMasse moléculaire :344.45FXR agonist 9
CAS :<p>FXR agonist9 (compound 26) is a selective, orally active partial agonist of FXR with an EC50 of 0.09 µM (maximum efficacy of 75.13%). It ameliorates the pathological features of fatty liver disease in mice induced by HFD and CCl4-related metabolic dysfunction.</p>Formule :C28H30N2O5Couleur et forme :SolidMasse moléculaire :474.55α-Glucosidase-IN-13
<p>α-Glucosidase-IN-13 is an inhibitor of α-glucosidase (IC50: 5.69 μM).</p>Formule :C25H28N4O3S2Couleur et forme :SolidMasse moléculaire :496.64Antidiabetic agent 5
CAS :<p>Compound S1 (antidiabetic agent 5) is an antidiabetic agent that effectively inhibits the enzymes α-glucosidase and α-amylase, demonstrating IC50 values of 3.91 µM and 8.89 µM, respectively. It reduces sugar levels and holds potential for type-II diabetes research [1].</p>Formule :C17H15N3O4SCouleur et forme :SolidMasse moléculaire :357.38E234G HYPE-IN-1
CAS :<p>Compound I2.10 (E234G HYPE-IN-1) functions as an AMPylase inhibitor and exhibits low cytotoxicity toward human cell lines [1].</p>Formule :C14H9N5O2Couleur et forme :SolidMasse moléculaire :279.25GC-IN-2
CAS :<p>GC-IN-2 (Compound 25) is an effective and selective non-sugar-based glucocerebrosidase inhibitor with an IC50 value of 6.46 μM. It is utilized in research related to Gaucher's disease.</p>Formule :C19H16N2O3SCouleur et forme :SolidMasse moléculaire :352.41EpoY
CAS :<p>EpoY (SD-142) is an irreversible inhibitor of the primary brain microtubule-associated tyrosine carboxypeptidase (TCP), a complex formed by vasohibin-1 (VASH1) and small vasohibin-binding protein (SVBP). By inhibiting TCP with an IC50 value of approximately 500 nM, EpoY effectively reduces the levels of detyrosinated α-tubulin, which is crucial for microtubule dynamics and neuronal differentiation. This inhibition results in significant differentiation defects and is linked to potential issues related to cancer and cardiomyopathy.</p>Formule :C15H17NO7Couleur et forme :SolidMasse moléculaire :323.30MRS4458
CAS :<p>MRS4458 is an effective inhibitor of the P2Y14 Receptor.</p>Formule :C24H20F3N5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :515.51
