Métabolisme

<p>Topiroxostat (FYX-051) is a selective xanthine oxidase inhibitor developed for treatment and management of hyperuricemia and gout.</p>

<p>IDO-IN-13 (GS-4361) is a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor (EC50: 17 nM).</p>

<p>Hyaluronic acid sodium (MW 10 kDa) is a low molecular sodium hyaluronate with stabilizing and restorative properties, which can slow down skin aging and promote the proliferation and differentiation of epidermal cells.</p>

<p>Eliglustat hemitartrate (Genz-112638) , with an IC50 of 24 nM, is a specific, potent, oral active glucocerebral glycosidase inhibitor.</p>

<p>Epalrestat (ONO2235), an aldose reductase inhibitor, helps manage diabetic neuropathy symptoms and slows disease progression.</p>

<p>This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Rabbit PⅠNP protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rabbit PⅠNP. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rabbit PⅠNP in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>EC5026 (BPN-19186) has the potential to relieve pain by stabilizing natural analgesic and anti-inflammatory mediators.</p>

<p>Modaline, a 2-methyl-3-piperidinopyrazine, inhibits MAO, acts as an antidepressant, and increases tryptamine convulsions and dopa-induced hyperthermia.</p>

<p>Enalapril IMpurity B ((+)-N-[1-(S)-Ethoxycarbonxyl-3-phenylpropyl]-L-alanine) is Moexipril intermediate and is the main metabolite of Imidapril.</p>

TNO155 inhibits SHP2 enzyme with an IC50 of 0.011 μM, potentially aiding cancer treatment.

<p>Cyclandelate (BS 572), a direct-acting smooth muscle relaxant, is used to dilate blood vessels.</p>

<p>1-Phenyl-1, 2-ethanediol is O-benzyl oxime ether derivatives and used as pesticides.</p>

<p>Diaveridine (AI3-23935) (DVD) is a popular antibacterial synergist that is widely used in combination with sulfonamide.</p>

<p>Denatonium benzoate, a salt with an inert anion, resembles lidocaine but has a benzyl group on its amino nitrogen.</p>

<p>OMDM-1 ((Z)-N-[(2S)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl]octadec-9-enamide) is a selective and metabolically stable anandamide cellular uptake (ACU)</p>

<p>Pumafentrine（BY 343） is a dual PDE3/PDE4 inhibitor that reduces clinical scores and TNF expression in experimental colitis in mice.</p>

<p>This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with DOPAC protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to DOPAC. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of DOPAC in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>6-Aminocaproic acid (EACA) is an antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.</p>

<p>Pramiracetam, an advanced nootropic from piracetam, enhances cognitive function post-brain trauma and treats cerebrovascular disorders.</p>

<p>Tert-Buthyl Pitavastatin is a metabolite of Pitavastatin, a potent HMG-CoA reductase inhibitor.</p>

<p>Hyaluronic acid sodium (MW 40 kDa) is a low molecule of sodium hyaluronate that penetrates into the dermis and promotes skin metabolism.</p>

<p>PKR-IN-2 is a activator of pyruvate kinase (PKR).</p>

<p>GW 7647 is an effective and highly selective PPARα agonist. GW 7647 can reduce the production of nitric oxide in macrophages. Cost-effective and quality-assured.</p>

<p>Dafadine-A, a dafadine analog, inhibits DAF-9 P450 in C. elegans and mammalian CYP27A1.</p>

<p>Cefadroxil (BL-S 578) is a Cephalosporin Antibacterial. The chemical classification of cefadroxil anhydrous is Cephalosporins.</p>

<p>Nitisinone (SC0735)(SC0735) is an enzyme 4-hydroxyphenylpyruvate dioxygenase inhibitor.</p>

<p>Opicapone (BIA 9-1067), a potent COMT inhibitor for Parkinson's studies, lowers cell ATP (IC50: 98 μM).</p>

<p>BCI ((E)-BCI) is an allosteric inhibitor of dual-specificity phosphatase (DUSP; EC50s: 13.3 and 8.0 μM for DUSP6 and DUSP1 in cells) and does not inhibit DUSP5.</p>

<p>Turosteride is a small molecule steroidal 5α-reductase (5α-reductase) inhibitor.Turosteride has antitumor activity for the treatment of oncologic diseases and</p>

<p>Dorzagliatin (HMS5552) is a dual-acting glucokinase (GK) activator. It also improves glycaemic control and pancreatic β-cell function in type 2 diabetes.</p>

<p>SBI-797812 is structurally similar to active-site directed inhibitor of NAMPT(NAMPT with EC50 of 0.37 μM).</p>

<p>Diminazene is a trypanocidal agent.</p>

<p>Imidacloprid-urea, a byproduct of imidacloprid, may alter its environmental behavior by competing for soil binding sites.</p>

<p>Trimethoprim (NSC-106568) inhibits dihydrofolate reductase, CYP2C8, and OCT2 - an antibacterial agent.</p>

<p>The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human PL. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human PL. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human PL, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human PL in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>Gabexate mesylate (FOY) inhibits thrombin, plasmin, kallikrein; used for pancreatitis, DIC, hemodialysis anticoagulant.</p>

<p>JW 642 inhibits MAGL in mouse, rat, human brains (IC50: 7.6, 14, 3.7 nM).</p>

<p>Pitavastatin lactone, a major human metabolite, potently inhibits HMG-CoA reductase with minimal hepatic microsome metabolism.</p>

<p>JZP-430 is an effective, highly selective, irreversible inhibitor of α/β-hydrolase domain 6 (ABHD6) (IC50: 44 nM).</p>

<p>Hyaluronic acid sodium (MW 20 kDa) is a low molecule of sodium hyaluronate that penetrates into the dermis and promotes skin metabolism.</p>

<p>Hyaluronic acid sodium (MW 300 kDa) is a medium molecule sodium hyaluronate that penetrates into the dermis and stimulates skin metabolism.</p>

<p>Idoxuridine (Dendrid) is an analog of DEOXYURIDINE that inhibits viral DNA synthesis. The drug is used as an antiviral agent.</p>

<p>Hyaluronic acid sodium (MW 100 kDa) is a low molecule of sodium hyaluronate that penetrates into the dermis and promotes skin metabolism.</p>

<p>CCI-006, a selective inhibitor and chemosensitizer for MLL-rearranged leukemia cells, disrupts mitochondrial respiration.</p>

<p>LG-100064 is an agonist of retinoid-X-receptor (RXR)(EC50s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ)</p>

<p>Potent, reversible, non-toxic MPO inhibitor; reduces stroke damage &amp; study aid for bronchial dysplasia.</p>

<p>Retinyl palmitate (Vitamin A palmitate) is a naturally-occurring phenyl analogue of retinol, with potential antineoplastic and chemopreventive activities.</p>

<p>Benzthiazide treats edema and hypertension by promoting diuresis and inhibiting kidney Na+/Cl- reuptake, but may reduce potassium and raise uric acid.</p>

<p>(S)-(+)-N-3-Benzylnirvanol is a cytochrome P450 CYP2C19 inhibitor with a ki value of 82.5μM for CYP2C9 and 0.25μM for CYP2C19.Cost-effective and quality-assured.</p>

<p>MitoPQ (MitoParaquat) inhibits insulin-stimulated glucose uptake and plasma membrane translocation in myotubes and can be used to study oxidative stress.</p>