Métabolisme

<p>(1S,2R)-Globalagliatin is a highly potent glucokinase (GK) activator for the study of type 2 diabetes.</p>

Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers.

Girentuximab (G250) is an anti-carbonic anhydrase IX (CAIX) monoclonal antibody with anti-cancer activity for the study of uroepithelial carcinoma PET (ZiPUP).

<p>hBChE-IN-4 (compound 40) serves as an effective activator for hCA and an inhibitor for BChE. It demonstrates affinity for various hCA subtypes with affinity constants (KA) of 266 nM for hCA I, 76.9 nM for hCA II, 918 nM for hCA IV, 893 nM for hCA VB, and 98.0 nM for hCA VII. Inhibition concentrations (IC50) for eeAChE and eqBChE are recorded at 72.1 nM and 4.2 nM, respectively. hBChE-IN-4 is non-cytotoxic and has demonstrated potential cognitive enhancement effects. It holds potential for research in neurodegenerative and other neuropsychiatric disorders.</p>

2-Methyl-1-naphthol is a prostaglandin G/H synthase and polyunsaturated fatty acid 5-lipoxygenase inhibitor, suitable for biochemical experiments.

<p>Cecropin B is a small antibacterial peptide from the giant silkmoth, Hyalophora cecropia.</p>

<p>1-Palmitoyl-2-hydroxy-sn-glycero-3-PE is a naturally occurring lysophospholipid and endogenous metabolite used in biochemical experiments</p>

<p>α-Glucosidase-IN-89 (8g) is an inhibitor of α-glucosidase, with an IC50 of 0.5 μM and a Ki of 0.46 μM.</p>

<p>BVT-2733 hydrochloride is a potent, selective, and orally active non-steroidal 11β-HSD1 inhibitor. It exhibits stronger inhibition on mouse 11β-HSD1 enzyme (IC50=96 nM) compared to the human 11β-HSD1 enzyme (IC50=3341 nM). BVT-2733 hydrochloride shows potential for research in arthritis and obesity-related diseases.</p>

<p>Fenbendazole sulfone is a minor metabolite of fenbendazole, exhibiting inhibitory activity against 7-ethoxycoumarin O-deethylase in rat liver.</p>

HIF1-IN-3 (Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-) is an effective inhibitor of HIF-1 (EC50 = 0.9 μM) and can be used in

<p>Pyrindolol, a S. alboverticillatus metabolite, inhibits bovine β-galactosidase at 2 μg/ml in acid; not effective on other species' enzymes.</p>

<p>Tauro-β-muricholic Acid sodium is a endogenous metabolite, is a competitive and reversible antagonist of farnesoid X receptor (FXR)(IC50 of 40 μM).</p>

<p>ent-Prostaglandin F2α is the enantiomer of PGF2α and is found in urine.</p>

<p>Asperglaucid A: a phthalide-like compound with strong antibacterial effects against Pseudomonas syringae pv actinidae and Bacillus cereus; MIC: 6.25 μM.</p>

<p>GLUT1-IN-1 inhibits GLUT1; cytotoxic to HeLa, A549, HepG2 (IC50: 5.49, 11.14, 8.73 μM); potential in PDT and cancer research.</p>

(Z)-7-Dodecen-1-ol counteracts the attractive properties of Z-7-dodecen-1-yl acetate.

ASP8477 is a potent and selective FAAH inhibitor. It increases anandamide levels in the brain when administered orally. In rat models of neuropathic and osteoarthritic pain, ASP8477 demonstrates significant efficacy without causing motor coordination issues. A single oral dose of ASP8477 improves thermal hyperalgesia and cold allodynia in rats with chronic constriction nerve injury. Moreover, ASP8477 restores the decreased muscle pressure threshold in a myalgia model induced by reserpine. Research indicates that ASP8477 possesses analgesic effects effective for alleviating neuropathic and functional pain, making its pharmacological properties suitable for chronic pain treatment.

Creatine Kinase (CPK/CK), Bovine Heart (CK, CPK, Creatine Phosphokinase), is a biological material or organic compound suitable for use in life sciences research.

<p>Fmoc-Tyr(3-F,tBu)-OH: Cyclic peptide with high permeability, target-specific affinity. Sourced from WO2018225864A1.</p>

S32826, a potent autotaxin inhibitor with an IC50 of 8.8 nM, blocks LPA release and targets α, β, γ isoforms.

H4PteGlu5 strongly inhibits itself and tightly binds in vivo, almost irreversibly, as a coenzyme.

FR106969 is a platelet activating factor antagonist isolated from fungus with anti-inflammatory activity.

Hypusine HCl: a unique amino acid in eukaryotes/archaea, absent in bacteria; only in eIF5A protein.

Myristoyl coenzyme A lithium, a compound marked by lithium in its myristoylated form, plays a crucial role in the biochemical mechanism of myristoylation, essential for both viral functionalities and tumor growth in colon epithelial cells. This process is predominantly governed by N-myristoyltransferase (NMT), which exhibits increased activity in colon epithelial tumors compared to normal cells. The activity of NMT is significantly influenced by the reduction of coenzyme A (CoA), a vital regulator that enhances NMT's ability to induce myristoylation, unlike its oxidized form which impedes this process. Consequently, Myristoyl coenzyme A serves as an inhibitor to the demyristoylation activity, showcasing its potential as an anticancer and antiviral agent.

<p>Reticulol is an isocoumarin derivative produced by certain species of Streptomyces.</p>

SHP2-D26: potent SHP2 degrader binding VHL-1/SHP2, neddylation & proteasome-dependent.

Anticanceragent 232 (compound 12f) is a sugar hybrid designed from 1-azide glycosides derived from d-glucose, d-galactose, and d-mannose. The IC50 values for this compound are 1.05 μM against MCF-7 cells and 18.03 μM for MDA-MB231 cells.

<p>SF2312 ammonium is the ammonium salt of SF2312, a phosphonate antibiotic and enolase inhibitor derived from the actinomycete Micromonospora and active under</p>

DSPE-PEG5000-NYZL1 is a PEG compound composed of DSPE and NYZL1, where NYZL1 specifically binds to bladder cancer tissues and cells. DSPE-PEG5000-NYZL1 is applicable for drug delivery.

H-Val-βNA, also known as L-Valine β-naphthylamide, serves as a substrate for aminopeptidase and Valine arylamidase activities.

O-desmethyl Mebeverine acid is a metabolite of Mebeverine.

<p>Cholesteryl homo-γ-linolenate is a cholesterol ester.</p>

(24R)-MC 976 is a derivative of Vitamin D3.

<p>hCA IX-IN-1 inhibits hCA I/II/IX/XII with Ki of 331.4/28.4/9.4/17.8 nM, has anticancer properties.</p>

Isomer-Turosteride, a novel 5α-reductase inhibitor, reduces prostate DHT and has anticancer properties without raising T levels.

Ciwujianoside D2 is a useful organic compound for research related to life sciences. The catalog number is T126336 and the CAS number is 114892-57-8.

Tacalcitol monohydrate(Curatoderm monohydrate), a vitamin D3 analog that promotes bone development by regulating calcium ions, can be used to study psoriasis.

<p>Pectin, a plant cell wall derived heteropolysaccharide, forms nanoparticles for delivery and acts as an antimicrobial adsorbent.</p>

<p>YF704 (compound 4w), a selective allosteric inhibitor of SHP2, exhibits antiproliferative effects and induces apoptosis in cancer cells with an IC50 of 0.25 μM.</p>

<p>Dihomo-γ-Linolenic acid methyl ester is the methyl ester form of Dihomo-γ-Linolenic acid which has anti-inflammatory and anti-proliferative effects.</p>

<p>8-Demethyl Ivabradine, a metabolite of Ivabradine, is an oral HCN channel blocker.</p>

PK-10, when combined with Fluconazole, exhibits potent synergistic antifungal activity against multiple Fluconazole-resistant Candida albicans strains.

Leucylproline is a peptide that proteolytic breakdown product by larger proteins.

Bupirimate, a systemic fungicide for powdery mildew in roses and apples, belongs to pyrimidines.

<p>N4-Acetylcytidine triphosphate sodium is efficiently used as a substrate in T7 Polymerase-catalyzed in vitro transcription.</p>

<p>CTL-12, a fatty acid synthase (FASN) inhibitor (IC50: 2.5 μM), induces apoptosis and disrupts the cell cycle at the Sub-G1/S phase.</p>

Levothyroxine acyl glucuronide (Thyroxine Acyl-β-D-glucuronide), the acyl glucuronide formation of thyroxine (T4), an endogenous metabolite.

<p>hCA/Wnt/β-catenin-IN-1 (Compd 15) serves as an inhibitor with selective affinity for hCA isoforms II, IX, and XII, exhibiting K i values of 33.6, 24.1, and 6.8</p>

CarboxypeptidaseY, Baker's yeast (S. cerevisiae) serves as a biocatalyst and is a crucial enzyme in advanced biocatalyst technology. Enzyme engineering focuses on improving the kinetics of enzyme reactions, substrate selectivity, and performance under challenging conditions, such as low or high pH. Introducing stimulus-responsive modifications to these enzymes also enables dynamic control of their activity.