Métabolisme
Les inhibiteurs du métabolisme sont des composés qui interfèrent avec les voies métaboliques, modifiant ainsi la production et l'utilisation de l'énergie au sein des cellules. Ces inhibiteurs sont utilisés pour étudier la régulation du métabolisme, le rôle des voies métaboliques dans des maladies telles que le cancer et le diabète, et pour développer de nouvelles stratégies thérapeutiques. Les inhibiteurs du métabolisme peuvent cibler diverses enzymes et processus impliqués dans la glycolyse, l'oxydation des acides gras et d'autres fonctions métaboliques. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de métabolisme de haute qualité pour soutenir vos recherches en biochimie, troubles métaboliques et développement de médicaments.
Sous-catégories appartenant à la catégorie "Métabolisme"
- AhR(42 produits)
- Aminopeptidase(76 produits)
- CETP(20 produits)
- Anhydrase carbonique(196 produits)
- Caséine Kinase(138 produits)
- DHFR(32 produits)
- Décarboxylase(4 produits)
- Déshydrogénase(302 produits)
- FAAH(64 produits)
- FXR(62 produits)
- Facteur Xa(85 produits)
- Synthase des acides gras(37 produits)
- Ferroptose(226 produits)
- GR(3 produits)
- GSNOR(3 produits)
- Glucokinase(57 produits)
- Prolyl-Hydroxylase de HIF/HIF(146 produits)
- HMG-CoA Réductase(34 produits)
- Hydroxylase(36 produits)
- IDO(84 produits)
- LDL(7 produits)
- Lipase(107 produits)
- Lipides(61 produits)
- Lipoxygénase(134 produits)
- MAO(87 produits)
- MPO(2 produits)
- NAMPT(40 produits)
- P450(6 produits)
- PAI-1(26 produits)
- PDE(169 produits)
- PED(1 produits)
- PKM(17 produits)
- PPAR(170 produits)
- Phospholipase(86 produits)
- ROR(47 produits)
- Récepteur de rétinoïdes(22 produits)
- SGK(10 produits)
- Thioredoxine(12 produits)
- Transférase(29 produits)
- Tansporteur(45 produits)
- UGT(4 produits)
- Inhibiteurs de la xanthine oxydase (XO)(9 produits)
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9182 produits trouvés pour "Métabolisme"
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CalB-10X
CalB-10X, also known as Candida antarctica lipase B (CALB), functions as a catalyst for polymer synthesis.2-Amino-5-bromo-2’-chlorobenzophenone
CAS :2-Amino-5-bromo-2’-chlorobenzophenone is an active metabolite of Phenazepam.Formule :C13H9BrClNOCouleur et forme :SolidMasse moléculaire :310.57Zopiclone impurity-1
CAS :Compound PDK0219, with CAS No. 43200-81-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0219 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Formule :C11H7ClN4O2Couleur et forme :Yellow Crystalline PowderMasse moléculaire :262.65D-Leu-Pro-Arg-Rh110-D-Pro acetate
D-Leu-Pro-Arg-Rh110-D-Pro acetate is a substrate for Factor XaI (FXIa) with binding affinity. This compound is formed by linking Rhodamine 110 to a peptide chain via a cleavable bond. The cleavage of this bond enhances the intensity of the fluorophore. D-Leu-Pro-Arg-Rh110-D-Pro acetate can be used to detect FXIa activity.Formule :C42H51N9O7·xC2H4O2FXR agonist 10
FXR agonist10 (Compound 27) acts as an agonist for FXR with an EC50 of 14.26 μM. It increases the expression of SHP and BSEP proteins while decreasing the expression of NTCP and CYP7A1 proteins. Additionally, FXR agonist10 has been shown to ameliorate ANIT-induced cholestasis in mouse models.Formule :C15H22O4Couleur et forme :SolidMasse moléculaire :266.33FPPS-IN-2
FPPS-IN-2 (compound 4a) is an effective orally active HFPPS inhibitor with an IC50 value of 1.108 µM, showing potential for use in osteoporosis research.(3R,5R)-Octahydrocurcumin
CAS :(3R,5R)-Octahydrocurcumin (Compound 7) is a metabolite of Curcumin produced by gut microbiota. It exhibits neuroprotective effects against Aβ25-35-induced cell damage in SH-SY5Y cells and possesses anti-inflammatory properties in LPS-stimulated BV-2 mouse microglia.Formule :C21H28O6Couleur et forme :SolidMasse moléculaire :376.44EHNA
CAS :EHNA is a potent and selective dual inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2) (IC50 = 4 μM) and adenosine deaminase (ADA). It exhibits concentration-dependent inhibition of cGMP-stimulated PDE2 activity, with IC50 values of 0.8 μM in humans and 2 μM in porcine myocardium, but shows limited inhibition on unstimulated PDE2. EHNA is involved in modulating various pharmacological responses, such as antiviral, antitumor, and antiarrhythmic effects.Formule :C14H23N5OCouleur et forme :SolidMasse moléculaire :277.375-Dihydrocortisone
CAS :5β-Dihydrocortisone is a sterol metabolite of cortisone produced by 5β-reductase (AKR1D1) in the liver, existing as a mixture of isomers.Formule :C21H30O5Couleur et forme :SolidMasse moléculaire :362.46[Des-Tyr1]-Met-Enkephalin
CAS :Enkephalin-met, des-tyr(1)- ccauses retrograde amnesia in rats.Formule :C18H26N4O5SCouleur et forme :White PowderMasse moléculaire :410.49CGGRGD
CAS :CGGRGD, an RGD derivative with cysteine, synthesized via solid phase and added to PCL fiber with 2-cyanobenzothiazole for ammoniation.Formule :C19H33N9O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :563.59H-Lys-Trp-OH
CAS :H-Lys-Trp-OH (KW) is an ACE inhibitory peptide with an IC 50 of 7.8 μM [1] .Formule :C17H24N4O3Masse moléculaire :332.4DL-4-Hydroxy-2-ketoglutarate
CAS :DL-4-Hydroxy-2-ketoglutarate is a gamma-keto acid and glutamic acid analogue that serves as a substrate for enzymes and a lysine analogue in metabolic studies.Formule :C5H6O6Couleur et forme :SolidMasse moléculaire :162.1ATIC-IN-1 acetate
ATIC-IN-1 acetate is an ATIC inhibitor with potential anticancer activity.Formule :C23H37N7O7Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :523.59Fmoc-Thr(GalNAc(Ac)3-β-D)-OH
CAS :Fmoc-Thr(GalNAc(Ac)3-β-D)-OH impedes the proliferation of cancer cells by selectively interacting with complex oncogenic pathways and enhancing the immuneFormule :C33H38N2O13Masse moléculaire :670.66Cecropin P1, porcine
CAS :Cecropin P1, porcine is an antibacterial peptide originally identified in moths (Hyalophora cecropia) and later in pig intestine.Formule :C147H253N45O43Couleur et forme :SolidMasse moléculaire :3338.913Cyclopentyl phenyl ketone
CAS :Cyclopentyl phenyl ketone (Benzoylcyclopentane) is used for the prevention and treatment of traumatic stress.Formule :C12H14ODegré de pureté :98.86%Couleur et forme :SolidMasse moléculaire :174.24Laidlomycin propionate
CAS :Laidlomycin propionate improves the rate of gain and feed conversion in both steers and heifers.Formule :C40H66O13Couleur et forme :SolidMasse moléculaire :754.941-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE
CAS :Phospholipid with stearic acid at sn-1, 15(S)-HETE at sn-2, formed by 15-LO in activated monocytes.Formule :C43H78NO9PCouleur et forme :SolidMasse moléculaire :784.05Clocortolone
CAS :Clocortolone, a medium-strength corticosteroid, treats dermatitis as a cream ester called clocortolone pivalate.Formule :C22H28ClFO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :410.91Crotonyl-CoA
CAS :Crotonyl-CoA: key in butyric acid fermentation, lysine and tryptophan metabolism, crucial for fatty and amino acid processing.
Formule :C25H40N7O17P3SCouleur et forme :SolidMasse moléculaire :835.61Sirtuin modulator 2
CAS :Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.Formule :C19H15N3O2SDegré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :349.41HSD17B13-IN-89
CAS :HSD17B13-IN-89 (206) acts as an inhibitor of 17β-Hydroxysteroid dehydrogenases (HSD17B13) and demonstrates potent activity with an IC 50 value of less than 0.1 μM for Estradiol. It is commonly utilized in research related to Nonalcoholic Fatty Liver Diseases (NAFLD) [1].Formule :C23H13Cl2F4N3O3Couleur et forme :SolidMasse moléculaire :526.27Bhimanone
CAS :Bhimanone is a tetrahydronaphthone compound that can be extracted from Streptomyces sp.Formule :C13H14O4Couleur et forme :SolidMasse moléculaire :234.30Adenosine 2',3'-cyclic phosphate
CAS :Adenosine 2',3'-cyclic phosphate, a 2',3'-cyclic purine nucleotide, can be degraded to 2'-AMP and 3'-AMP [1] [2].Formule :C10H12N5O6PCouleur et forme :SolidMasse moléculaire :329.211β-Hydroxydeoxycholic acid
CAS :1β-Hydroxydeoxycholic acid (1β-OH-DCA), recognized as a secondary bile acid, serves as a biomarker for CYP3A. This compound is metabolized from deoxycholic acid specifically by CYP3A4 and CYP3A7 through recombinant human CYP450 enzymes [1].Formule :C24H40O5Couleur et forme :SolidMasse moléculaire :408.57β-1,4-Galactosyltransferase 1 (Y285L)
Beta-1,4-Galactosyltransferase 1 (Y285L) is capable of enzymatically synthesizing the LacdiNAc motif. Additionally, Beta-1,4-Galactosyltransferase 1 (Y285L) can transfer GalNAc from UDP-GalNAc.5A2-SC8 TFA
5A2-SC8 TFA is an ionizable amino lipid used in lipid nanoparticles (LNPs), offering high delivery potential and low in vivo toxicity. It effectively delivers small RNAs, such as siRNA and miRNA, to tumor cells. Moreover, 5A2-SC8 TFA LNPs provide unique delivery paths for RNA within the liver, enhancing therapeutic outcomes in cancer models.Couleur et forme :Odour SolidCarbonic anhydrase inhibitor 24
Carbonic anhydrase inhibitor24 (Compound 11) is an inhibitor of human carbonic anhydrase. It exhibits Ki values of 10.7 nM and 7.5 nM against hCAs IX and XII, respectively.Formule :C16H14Cl2N2O6SMasse moléculaire :431.99496IDO-IN-15
CAS :IDO-IN-15 is an IDO1 inhibitor ( IC 50 < 0.51 nM).Formule :C29H39N5O4Couleur et forme :SolidMasse moléculaire :521.662all-trans-13,14-Dihydroretinol
CAS :All-trans-13,14-Dihydroretinol, a metabolite of all-trans-retinoic acid, is synthesized through the enzymatic action of retinol saturase on all-trans-retinoic acid.Formule :C20H32OCouleur et forme :SolidMasse moléculaire :288.47PAP-IN-1
PAP-IN-1 (compound 28) is a binuclear metallohydrolase inhibitor specific to purple acid phosphatases (PAPs) with a Ki value of 168 nM against mammalian PAP andCouleur et forme :Odour Solid5-Hydroxy-8-methoxypsoralen
CAS :5-Hydroxy-8-methoxypsoralen, a CYP inhibitor, treats psoriasis, eczema, vitiligo, and skin lymphomas with phototherapy.Formule :C12H8O5Couleur et forme :SolidMasse moléculaire :232.1911-Salicylate Glucuronide
CAS :1-Salicylate Glucuronide (Salicylic Acid b-D-O-Glucuronide) is a metabolite of salicylic acid after glucuronidation, promoting excretion.
Formule :C13H14O9Couleur et forme :SolidMasse moléculaire :314.25Ro 14-6113
CAS :Ro 14-6113 is a metabolite of temarotene, Ro 15-0778.Formule :C23H28OCouleur et forme :SolidMasse moléculaire :320.47MK-6186
CAS :MK-6186 is a novel non-nucleoside reverse transcriptase inhibitor with antiviral activity for the study of viral infections.Formule :C21H12Cl2N6ODegré de pureté :97.57%Couleur et forme :SolidMasse moléculaire :435.27me4 Peptide
The synthetic compound me4 Peptide, designed from the microexon me4 sequence of the neuronal CPEB4 protein, can inhibit the aggregation of CPEB4 and is applicable in research on autism spectrum disorder-related conditions.Formule :C101H173N47O30Couleur et forme :SolidMasse moléculaire :2525.75Razaxaban
CAS :Razaxaban (also known as BMS-561389 or DPC 906) is an oral inhibitor of Factor Xa, initially developed for the treatment of thrombosis.Formule :C24H20F4N8O2Couleur et forme :SolidMasse moléculaire :528.46(Iso)-Samixogrel
CAS :(Iso)-Samixogrel shows activity against Carbonic anhydrase and Cyclooxygenase 2.Formule :C25H25ClN2O4SDegré de pureté :98.85%Couleur et forme :SolidMasse moléculaire :484.99Longestin
CAS :Longestin, a specific phosphodiesterase (phosphodiesterase) inhibitor with antitrypanosomal activity, is derived from Streptomyces argenteolus. It is under investigation for its potential use in anti-amnesic medications.Formule :C61H88O17Couleur et forme :SolidMasse moléculaire :1093.34Febuxostat sec-butoxy acid
CAS :Febuxostat sec-butoxy acid is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K i of 0.6 nM [1] .Formule :C16H16N2O3SCouleur et forme :SolidMasse moléculaire :316.374''-C18 EGCG
4''-C18 EGCG is an effective inhibitor of α-amylase and α-glucosidase, with IC50 values of 3.74 and 0.81 μM, respectively. This compound suppresses carbohydrate-hydrolyzing enzymes, reduces oxidative stress and inflammation, and exhibits anti-diabetic activity. Moreover, 4''-C18 EGCG downregulates pro-inflammatory cytokines and demonstrates cytotoxicity at 50 μM against primary human peripheral blood mononuclear cells (PBMC), as well as non-cancerous cell lines 3T3-L1 and HEK 293.Formule :C40H54O11Couleur et forme :SolidMasse moléculaire :710.85CA Ⅱ-IN-1
CAⅡ-IN-1 (compound 2i) is an inhibitor of the CA Ⅱ isozyme, exhibiting an IC50 of 0.44 µM. This compound is utilized in metabolic research.Formule :C18H19NO6SCouleur et forme :SolidMasse moléculaire :377.41hDHODH-IN-8
CAS :hDHODH-IN-8: potent hDHODH inhibitor, IC50 = 16 nM, antiproliferative, soluble, may research lymphoma.Formule :C21H15F6N3O4Degré de pureté :98%Couleur et forme :SoildMasse moléculaire :487.35Folitixorin calcium, (6R)-
CAS :Folitixorin calcium, a calcium salt form of (6R)-Folitixorin, aids enzyme production of 5-methyltetrahydrofolate.Formule :C20H21CaN7O6Couleur et forme :SolidMasse moléculaire :495.50FXR agonist 5
CAS :FXR agonist 5 is an FXR agonist used in the study of liver diseases or diseases mediated by metabolic inflammation.Formule :C40H53N5O5Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :683.88LQ-38
LQ-38 is an orally active, soluble epoxide hydrolase (sEH) inhibitor with an IC50 value of 5.2 nM. It has shown anti-inflammatory activity in rat foot edema models and in mouse models of acute pancreatitis, and exhibits analgesic effects in acetic acid-induced mouse writhing models.Formule :C42H68N2O9Couleur et forme :SolidMasse moléculaire :745.00Glycerophospho-N-Palmitoyl Ethanolamine
CAS :N-Acylated ethanolamines (NAEs) are bioactive lipids; AEA activates CB1/CB2 receptors; PEA, an anti-inflammatory, doesn't bind well to them.Formule :C21H44NO7PCouleur et forme :SolidMasse moléculaire :453.557Methyl Diethyldithiocarbamate
CAS :Methyl diethyldithiocarbamate, a disulfiram metabolite, inhibits rat ALDH (ID50=15.5mg/kg) and affects MAP and heart rate during ethanol challenge.Formule :C6H13NS2Couleur et forme :SolidMasse moléculaire :163.3Casein kinase 1δ-IN-7
CAS :Casein kinase 1δ-IN-7 is a Casein kinase 1δ inhibitor for neurodegenerative diseases such as Alzheimer's disease.Formule :C17H14N4O2SDegré de pureté :98.02%Couleur et forme :SolidMasse moléculaire :338.38
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