Métabolisme

Ro 14-6113 is a metabolite of temarotene, Ro 15-0778.

Butafosfan, often with cyanocobalamin, boosts lipid metabolism in livestock to prevent/treat deficiencies and ketosis.

4-Hydroxyphenylpropionylglycine, a metabolite derived from the conditionally essential amino acid tyrosine, is synthesized through a process involving aromatic

MK-6186 is a novel non-nucleoside reverse transcriptase inhibitor with antiviral activity for the study of viral infections.

2-O-(α-D-Glucopyranosyl)glycerol (2-alphaGG) is present in a few organisms and prolongs the lifespan of erythrosporidium by increasing osmotic pressure.

NY-ESO-1 (157-165) peptide (TFA) is a peptide derived from the NY-ESO-1 protein. This peptide can activate the immune system and is specifically recognized by CD8+ T cells in HLA-A2 positive individuals, thereby initiating an immune response. It is expressed in various tumors and can serve as a target for tumor immunotherapy.

The synthetic compound me4 Peptide, designed from the microexon me4 sequence of the neuronal CPEB4 protein, can inhibit the aggregation of CPEB4 and is applicable in research on autism spectrum disorder-related conditions.

3-Sulfo-taurocholic acid disodium salt (3-Sulfocholyl Taurine disodium salt) is a derivative of bile acid taurine.

Compound PDK0196, with CAS No. 3516-95-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0196 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

E-76 is a peptide with anticoagulant activity that inhibits blood coagulation by specifically binding to the exogenous coagulation factor VIIa (FVIIa). It is utilized in the study of blood coagulation-related diseases.

Synthetic tripeptide NH2-AKK-COOH inhibits ACE; IC50: 0.090/0.178/420.89 μM for FAPGG/HHL/angiotensin-I.

Naphthacene (Benz[b]anthracene) is a useful life science reagent for biochemical experiments and organic synthesis.

Cartilostatin 1, an anti-angiogenic peptide, has potential applications in research focused on angiogenesis inhibition [1].

Razaxaban (also known as BMS-561389 or DPC 906) is an oral inhibitor of Factor Xa, initially developed for the treatment of thrombosis.

(Iso)-Samixogrel shows activity against Carbonic anhydrase and Cyclooxygenase 2.

G43 inhibits glucosyltransferase GtfB (Kd 3.7μM) and GtfC (Kd 46.9nM), and fights Streptococcus mutans in caries research.

hCAXII-IN-9 (Compound 3I) is a selective hCAXII inhibitor with Ki values of 28 nM for hCAXII, 7192.6 nM for hCAI, 188.6 nM for hCAII, and greater than 100000 nM for hCAIX. This compound may be utilized in anti-tumor research.

Acivicin (AT-125) is a chlorinated amino acid antibiotic produced by Streptomyces porcineus, a GGT inhibitor with anticancer and antiparasitic activity.

D-Leu-Pro-Arg-Rh110-D-Pro serves as a substrate for Factor XaI (FXIa) and exhibits binding affinity. This compound is composed of Rhodamine 110 linked to a peptide chain via a cleavable bond. Upon cleavage, the intensity of the fluorophore is enhanced. D-Leu-Pro-Arg-Rh110-D-Pro can be utilized to detect FXIa activity.

Lipoxygenase (LOX) is a dioxygenase that catalyzes the peroxidation of linoleic acid (LA) or arachidonic acid (AA) in the presence of molecular oxygen.

Antitumor agent-127 (compound 1) is a parent macrocyclic peptide that demonstrates nanomolar binding affinity to ROR1 and shows relatively good internalization in 786-O and MDA-MB-231 tumor cell lines.

Compound 1466-67-7, with CAS No. 1466-67-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound 1466-67-7 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Longestin, a specific phosphodiesterase (phosphodiesterase) inhibitor with antitrypanosomal activity, is derived from Streptomyces argenteolus. It is under investigation for its potential use in anti-amnesic medications.

Thymoctonan, as a synthetic octapeptide thymic hormone, can repair immunodeficiency of mice cured of plasmacytoma by melphalan.

Erucic acid sodium, a monounsaturated fatty acid (MUFA) extracted from the seeds of rapeseed, readily crosses the blood-brain barrier (BBB). It normalizes the accumulation of long-chain fatty acids in the brain, enhances cognitive function, and effectively prevents dementia.

Lipase Substrate is a substrate of lipase to detect activity.

S-Phenylmercapturic acid is a metabolite of benzene that can be used as a biomarker to assess benzene exposure.

6-Hydroxywarfarin is a metabolite of (+)-warfarin and a weak vitamin K antagonist.

Vitamin B12a monohydrochloride (Hydroxocobalamin) is an essential water-soluble vitamin.a cyanide detoxifier and nutritional supplement, injection, inhalation.

4''-C18 EGCG is an effective inhibitor of α-amylase and α-glucosidase, with IC50 values of 3.74 and 0.81 μM, respectively. This compound suppresses carbohydrate-hydrolyzing enzymes, reduces oxidative stress and inflammation, and exhibits anti-diabetic activity. Moreover, 4''-C18 EGCG downregulates pro-inflammatory cytokines and demonstrates cytotoxicity at 50 μM against primary human peripheral blood mononuclear cells (PBMC), as well as non-cancerous cell lines 3T3-L1 and HEK 293.

N-Lactylleucine is an endogenous metabolite detectable in patients with intermediate maple syrup urine disease.

CAⅡ-IN-1 (compound 2i) is an inhibitor of the CA Ⅱ isozyme, exhibiting an IC50 of 0.44 µM. This compound is utilized in metabolic research.

α-Glycosidase-IN-2 (compound 8b) is an inhibitor of α-glycosidase, displaying Ki values of 74.16 nM and 6.09 nM for aldose reductase and α-glycosidase, respectively. This compound is utilized in research related to diabetes.

sPLA2 inhibitor 3 (Compound 6c) functions as a potent α-glucosidase inhibitor (IC50= 0.0953 µM) and has potential applications in diabetes research.

ROS-IN-3 (compound x38) is an inhibitor of ROS and is utilized in neuro-related research.

Guanosine triphosphate tritris (GTP tritris) serves as a crucial enhancer in myocyte differentiation, playing an essential role in regulating miRNA-muscle regulatory factors. It promotes the release of exosomes rich in guanine and guanine-derived molecules, and is considered an activation precursor for RNA synthesis. In mitochondrial functionality, GTP is involved in the entry of proteins into the matrix, which is vital for various regulatory pathways. It initiates peptide synthesis by facilitating the binding of formylmethionine-tRNA to the ribosome, and aids in polypeptide chain elongation. Additionally, GTP acts as a carrier for phosphates and pyrophosphates, channeling chemical energy into specific biosynthetic pathways. It activates signal transduction G proteins, regulates cellular processes such as proliferation and differentiation, and its hydrolysis by small GTPases (including Ras and Rho) is indispensable for both proliferation and apoptosis. Furthermore, the small GTPase Rab assists in vesicle docking, fusion, and formation. Beyond signal transduction, GTP is also an energy-rich precursor in the biosynthesis of DNA and RNA enzymes.

α-Glucosidase-IN-75 (compound 13) is an inhibitor of α-glucosidase, exhibiting an IC50 value of 3.81 μM. It is employed in the study of cardiovascular diseases induced by high glucose levels.

21-Deoxy Cortisone (21-Desoxycortisone; NSC 38722) is a corticosteroid metabolite of 11-ketoprogesterone. It is generated from 11-ketoprogesterone by the cytochrome P450 (CYP) isoform CYP17A1, and can also be produced by oxidation via 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) from 21-deoxycorticosterone. In patients with congenital adrenal hyperplasia, a metabolic disorder characterized by a deficiency of 21-hydroxylase, levels of 21-Deoxy Cortisone are elevated.

Triletide is a thromboxane A2 antagonist agent.

Folitixorin calcium, a calcium salt form of (6R)-Folitixorin, aids enzyme production of 5-methyltetrahydrofolate.

N-Lactylvaline is an endogenous metabolite detectable in patients with intermediate maple syrup urine disease.

BuChE-IN-15, a chemical compound, exhibits potent inhibitory activity with IC50 values of 81 nM and 400 nM, respectively. It also demonstrates good blood-brain barrier permeability and neuroprotective properties, making it suitable for research in Alzheimer's disease.

AV22-149 (compound 22) is an inhibitor of Carbonic Anhydrase .

IR-117-17 is an ionizable cationic amino lipid that targets the airways. It is degradable via esterase cleavage, making it less likely to accumulate with repeated dosing.

(Rac)-PDE4-IN-4 is a diastereomeric mixture of PDE4-IN-4. PDE4-IN-4 acts as an M3 antagonist (pIC50 = 10.2) and a PDE4 inhibitor (pIC50 = 8.8), and it is utilized in inhalation studies related to pulmonary diseases.

LQ-38 is an orally active, soluble epoxide hydrolase (sEH) inhibitor with an IC50 value of 5.2 nM. It has shown anti-inflammatory activity in rat foot edema models and in mouse models of acute pancreatitis, and exhibits analgesic effects in acetic acid-induced mouse writhing models.

Compound 6T, designated as Carbonic anhydrase inhibitor26, acts as an inhibitor of Carbonic Anhydrase II (Carbonic AnhydraseII), exhibiting an IC50 value of 9.10 ± 0.26 μM.

CyPep-1 is a novel cationic lytic peptide with antitumor activity. It exerts potent cytotoxicity by interacting with the negatively charged membranes of cancer cells. CyPep-1 demonstrates strong cell lytic activity against cancer cells both in vitro and in vivo, making it useful for researching solid tumors.

2-Deoxy-2-fluoro-L-fucose is a fucosylation inhibitor that inhibits the proliferation of human cancer, and inhibits root growth and cell elongation.

hCA-I/hCA-II-IN-1 (Compound P4) is a potent dual inhibitor of human carbonic anhydrase I (hCA-I) and human carbonic anhydrase II (hCA-II), with Ki values of 0.22 μM and 0.33 μM respectively. hCA-I/hCA-II-IN-1 is useful for research into diseases related to CA enzymes, including glaucoma, hypertension, and ulcers.