Tyrosine Kinase/Adaptateurs
Les inhibiteurs des tyrosines kinases et des adaptateurs sont des composés qui ciblent les tyrosines kinases et leurs protéines adaptatrices associées, jouant des rôles essentiels dans la signalisation cellulaire, la croissance et la différenciation. Ces inhibiteurs sont des outils essentiels dans la recherche sur le cancer, car de nombreuses tyrosines kinases sont impliquées dans les voies de signalisation qui favorisent la croissance tumorale et les métastases. En inhibant les tyrosines kinases, ces composés peuvent bloquer des cascades de signalisation cruciales, offrant ainsi des stratégies thérapeutiques potentielles pour divers cancers et autres maladies impliquant une signalisation cellulaire anormale. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs de tyrosines kinases et d'adaptateurs de haute qualité pour soutenir vos recherches en oncologie, biologie moléculaire et développement de thérapies ciblées.
Sous-catégories appartenant à la catégorie "Tyrosine Kinase/Adaptateurs"
- ALK(112 produits)
- CSF-1R(42 produits)
- EGFR(572 produits)
- Récepteur Ephrin(23 produits)
- FLT(92 produits)
- Récepteur du facteur de croissance des fibroblastes (FGFR)(170 produits)
- SON(5 produits)
- Hck(3 produits)
- IGF-1R(86 produits)
- PDGFR(126 produits)
- PYK2(7 produits)
- Src(78 produits)
- Récepteur TAM(32 produits)
- Tie-2(20 produits)
- Récepteur Trk(59 produits)
- Tyrosine Kinases(27 produits)
- VEGFR(268 produits)
- c-Fms(108 produits)
- c-Kit(101 produits)
- c-Met/HGFR(128 produits)
- c-RET(51 produits)
Affichez 13 plus de sous-catégories
1375 produits trouvés pour "Tyrosine Kinase/Adaptateurs"
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Gilteritinib hemifumarate
CAS :<p>Gilteritinib hemifumarate (ASP2215 hemifumarate) is a potent ATP-competitive dual FLT3 (IC50: 0.29 nM) and AXL (IC50: 0.73 nM) inhibitor for the treatment of</p>Formule :C29H44N8O3C4H4O4Degré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :610.75Glesatinib
CAS :<p>Glesatinib is an orally active and potent dual inhibitor of MET/SMO.</p>Formule :C31H27F2N5O3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :619.7EML4-ALK kinase inhibitor 1
CAS :<p>Potent oral EML4-ALK inhibitor with a 1 nM IC50.</p>Formule :C31H48N8O3Degré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :580.76Gefitinib N-oxide
CAS :<p>Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells. Gefitinib N-oxide is the N-oxide derivative of Gefitinib.</p>Formule :C22H24ClFN4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :462.9Epertinib
CAS :<p>Epertinib is a reversible and selective tyrosine kinase inhibitor of EGFR, HER2, and HER4 (IC50s: 1.48 nM, 7.15 nM, and 2.49 nM).</p>Formule :C30H27ClFN5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :560.02DBPR112
CAS :<p>DBPR112: oral furanopyrimidine EGFR inhibitor; IC50: 15 nM (EGFRWT), 48 nM (L858R/T790M); blocks ATP site, strong antitumor effects.</p>Formule :C32H31N5O3Degré de pureté :99.25%Couleur et forme :SolidMasse moléculaire :533.62AC710 Mesylate
CAS :<p>AC710 Mesylate is a potent PDGFR inhibitor (Kds: 0.6, 1.57, 1, 1.3, 1.0 nM for FLT3, CSF1R, KIT, PDGFRα and PDGFRβ).</p>Formule :C32H46N6O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :658.81EGFR-IN-28
CAS :<p>EGFR-IN-28 is a potent EGFR inhibitor. EGFR-IN-28 has antitumor activity .</p>Formule :C31H39BrN10O3SCouleur et forme :SolidMasse moléculaire :711.68Bezuclastinib
CAS :<p>Bezuclastinib (CGT9486) is a novel, potent and highly selective tyrosine kinase and c-kit D816V inhibitor for the study of advanced mastocytosis.</p>Formule :C19H17N5ODegré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :331.37AC710
CAS :<p>AC710 is a potent PDGFR inhibitor (Kds: 0.6, 1, 1.57, 1.3, 1 nM for FLT3, KIT, CSF1R, PDGFRα and PDGFRβ).</p>Formule :C31H42N6O4Degré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :562.7ALK-IN-5
CAS :<p>ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK, IC50: 2.9 nM).</p>Formule :C24H25FN6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :464.49Limertinib
CAS :<p>Limertinib (ASK120067) is a EGFR tyrosine kinase inhibitor targeting EGFR T790M, applicable for the study of non-small cell lung cancer.</p>Formule :C29H32ClN7O2Degré de pureté :97.44%Couleur et forme :SolidMasse moléculaire :546.06(E/Z)-CP-724714
CAS :<p>(E/Z)-CP-724714, comprising racemic mixtures of (E)-CP-724714 and (Z)-CP-724714 isomers, is a potent, selective, and orally active inhibitor of ErbB2 (HER2)[1].</p>Formule :C27H27N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :469.54BAY 2476568
CAS :<p>BAY 2476568 is a selective and potent EGFR inhibitor that acts on both wild-type EGFR (IC50 <0.2 nM) and mutant EGFR (IC50 <0.2 nM).</p>Formule :C24H27FN4O4Couleur et forme :SolidMasse moléculaire :454.49SSR128129E free acid
CAS :<p>SSR128129E free acid is an orally available and allosteric inhibitor of FGFR(IC50 of 1.9 μM for FGFR1).</p>Formule :C18H16N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :324.33ALK2-IN-2
CAS :<p>ALK2-IN-2 is a potent and selective inhibitor of activin receptor-like kinase 2 (ALK2) (IC50: 9 nM), inhibiting ALK2 700-fold more than ALK3.</p>Formule :C28H27N5O2SDegré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :497.61Mutated EGFR-IN-2
CAS :<p>Mutated EGFR-IN-2 is an inhibitor of mutant-selective EGFR.</p>Formule :C29H35FN8O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :562.64Antiproliferative agent-34
CAS :<p>Antiproliferative Agent-34 (Compound A14), a multitarget kinase inhibitor, demonstrates IC50 values of 177 nM for EGFR L858R/T790M and 1567 nM for EGFR WT.</p>Formule :C27H27N7O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :529.55GW 583340 dihydrochloride
CAS :<p>GW 583340 dihydrochloride is a potent and orally available dual EGFR/ErbB2 inhibitor and inhibits 80% of tumor growth in a mouse xenograft mode.</p>Formule :C28H27Cl3FN5O3S2Degré de pureté :98.80%Couleur et forme :SolidMasse moléculaire :671.03NSC81111
CAS :<p>NSC81111 shows anticaner effects which is a potent and orally active inhibitor of EGFR-TK (IC50 = 0.15 nM) [1].</p>Formule :C19H16O4Couleur et forme :SolidMasse moléculaire :308.33c-Fms-IN-8
CAS :<p>c-Fms-IN-8 is a colony-stimulating factor-1 receptor (CSF-1R, c-FMS) Type II inhibitor (IC50: 9.1 nM). It is compound 4a in the reference.</p>Formule :C27H30N2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :462.54EGFR-IN-67
CAS :<p>EGFR-IN-67 (Compound 7d) is a potent inhibitor of EGFR with anticancer activity (IC 50 = 0.34 μM) [1].</p>Formule :C18H17N3SCouleur et forme :SolidMasse moléculaire :307.41MS 154N
CAS :<p>MS 154N is a negative control for MS 154, binds WT/L858R EGFR tightly (Kd 3-4.3nM), doesn't trigger mutant EGFR degradation.</p>Formule :C47H56ClFN8O8Couleur et forme :SolidMasse moléculaire :915.45Tyrphostin 51
CAS :<p>Tyrphostin 51 is an effective inhibitor of EGFR kinase.</p>Formule :C13H8N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :268.23EGFR/HER2-IN-9
CAS :<p>EGFR/HER2-IN-9, a compound inhibiting both EGFR and HER2, demonstrates potency with IC50 values of 3.2 nM for EGFR, 14 nM for HER2, and 8.3 nM against the EGFR</p>Formule :C25H25ClFN5O4Couleur et forme :SolidMasse moléculaire :513.95JNJ28871063 hydrochloride
CAS :<p>ErbB receptor family inhibitor</p>Formule :C24H28Cl2N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :519.42PDGFRα kinase inhibitor 1
CAS :<p>PDGFRα kinase inhibitor 1 is a type II PDGFRα kinase inhibitor that inhibits both PDGFRα and PDGFRβ.</p>Formule :C34H34N8O2Degré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :586.69TrkA-IN-1
CAS :<p>TrkA-IN-1 is a potent and selective inhibitor of Tropomyosin-related kinase A (TrkA) (IC50: 99 nM in a cell-based assay) with analgesic activity.</p>Formule :C25H20N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :392.45c-Fms-IN-2
CAS :<p>c-Fms-IN-2 is an inhibitor of c-FMS kinase (IC50 = 24 nM).</p>Formule :C19H21N3O3Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :339.39EGFR/C797S-IN-1
CAS :<p>EGFR/C797S-IN-1: Potent EGFR-C797S inhibitor, IC50 of 0.128 µM, dose-dependent p-EGFR suppression, anti-tumor properties.</p>Formule :C28H30N4O3Couleur et forme :SolidMasse moléculaire :470.56BKI-1369
CAS :<p>BKI-1369 is a bumped kinase inhibitor. BKI-1369 increases hERG-inhibitory activity (IC50:1.52 μM).</p>Formule :C23H27N7OCouleur et forme :SolidMasse moléculaire :417.51EGFR-IN-63
CAS :<p>EGFR- IN-63 is an EGFR inhibitor with an IC50 value of 0.096 μM. EGFR- IN-63 exhibited anticancer effects on MCF-7 cells (IC50: 2.49 μM).</p>Formule :C20H12BrN5SCouleur et forme :SolidMasse moléculaire :434.31Tavilermide
CAS :<p>Tavilermide (MIM-D3) is a selective TrkA agonist, a cyclic mimetic, which can be used to study dry keratoconjunctivitis and dry eye syndrome.</p>Formule :C24H32N6O11Degré de pureté :98.98%Couleur et forme :SolidMasse moléculaire :580.54DUN73423
CAS :<p>DUN73423 (RET-IN-21) is a potent tyrosine kinase (RET) inhibitor with antitumour activity for the study of cancer.</p>Formule :C19H16N6ODegré de pureté :98.09%Couleur et forme :SolidMasse moléculaire :344.37EGFR-IN-64
CAS :<p>EGFR-IN-64 inhibits EGFR with 0.33 μM IC50, showing promising anticancer properties.</p>Formule :C20H21N3O3Couleur et forme :SolidMasse moléculaire :351.4LDC0496
CAS :<p>LDC0496: Potent EGFR/Her2 exon 20 inhibitor; selective for wild-type EGFR, kinase-specific.</p>Formule :C32H35N5O3Couleur et forme :SolidMasse moléculaire :537.65BIBX 1382 Dihydrochloride
CAS :<p>BIBX 1382 Dihydrochloride blocks Lassa/Ebola entry, aids in studying virus-host interactions, and hints at kinase targets for therapy.</p>Formule :C18H21Cl3FN7Couleur et forme :SolidMasse moléculaire :460.76PDZ1i
CAS :<p>PDZ1i: potent MDA-9/Syntenin inhibitor; crosses blood-brain barrier; targets GBM, FAK, EGFRvIII; lowers MMP secretion.</p>Formule :C28H26N8O4Couleur et forme :SolidMasse moléculaire :538.56PF-4618433
CAS :<p>PF-4618433 is a selective PYK2 inhibitor with osteogenic activity.</p>Formule :C24H27N7O2Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :445.52MMPP
CAS :<p>MMPP is a VEGFR2 inhibitor with anti-inflammatory activity, inhibits STAT3 , inhibits angiogenesis, and can be used to alleviate myocardial injury.</p>Formule :C17H18O3Degré de pureté :99.31% - 99.83%Couleur et forme :SolidMasse moléculaire :270.32Rp-cAMPS triethylammonium salt
CAS :<p>Rp-cAMPS triethylammonium salt is a competitive inhibitor of cAMP-dependent protein kinase I and II.</p>Formule :C16H27N6O5PSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :446.46Syk-IN-3
CAS :<p>Syk-IN-3 is a Syk inhibitor with potential anti-inflammatory and anticancer activity and can be used to study immune dysregulation.</p>Formule :C24H28N4O3SDegré de pureté :97.29% - >99.99%Couleur et forme :SolidMasse moléculaire :452.57GSK-2250665A
CAS :<p>GSK-2250665A is an (Itk) inhibitor (pKi 9.2) with selectivity over Aurora B and Btk, inhibiting IFNγ in PBMCs for T-cell signaling studies.</p>Formule :C26H29N5OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :459.61EGFR-IN-21
CAS :<p>EGFR-IN-21, a potent EGFR inhibitor, exhibits an IC50 of 0.38 nM, demonstrating significant antitumor activity.</p>Formule :C36H44BrN10O2PCouleur et forme :SolidMasse moléculaire :759.68c-Kit-IN-3
CAS :<p>c-Kit-IN-3 is a selective inhibitor of c-KIT kinase with IC50s of 4 nM and 8 nM for c-Kit (wt) and c-Kit (T670I).</p>Formule :C26H20ClF3N2O4Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :516.9c-Fms-IN-1
CAS :<p>c-Fms-IN-1 is an inhibitor of c-FMS kinase (IC50 = 0.8 nM).</p>Formule :C22H27N5O2Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :393.48Sotuletinib dihydrochloride
CAS :<p>Sotuletinib (BLZ945) dihydrochloride is an orally administered, blood-brain barrier-permeable inhibitor specifically targeting CSF1-R with an IC50 of 1 nM.</p>Formule :C20H24Cl2N4O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :471.4Mutated EGFR-IN-3
CAS :<p>Mutated EGFR-IN-3: ATP-competitive, selective dibenzodiazepinone inhibitor for EGFR mutations, IC50 12-13 nM.</p>Formule :C31H29FN4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :508.59Glesatinib hydrochloride
CAS :<p>Glesatinib hydrochloride is an orally active and potent dual inhibitor of MET/SMO.</p>Formule :C31H28ClF2N5O3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :656.16UNC-CA359
CAS :<p>UNC-CA359: potent EGFR inhibitor, IC50=18 nM, strong anti-tumor effect, promising for chordoma.</p>Formule :C18H14ClN3O2Couleur et forme :SolidMasse moléculaire :339.78Tyrphostin AG 112
CAS :<p>Tyrphostin AG 112 is an inhibitor of EGFR phosphorylation.</p>Formule :C13H8N4ODegré de pureté :97.01%Couleur et forme :SolidMasse moléculaire :236.23EGFR mutant-IN-2
CAS :<p>EGFR mutant-IN-2 (Compound D51) is an inhibitor of EGFR mutants, specifically targeting EGFR L858R/T790M/C797S and EGFR del19/T790M/C797S mutants with IC50 values of 14 nM and 62 nM, respectively. This compound exhibits favorable pharmacokinetic (PK) parameters, safety properties, in vivo stability, and demonstrates antitumor activity [1].</p>Formule :C27H27F3N6O2SCouleur et forme :SolidMasse moléculaire :556.6Infigratinib phosphate
CAS :<p>Infigratinib phosphate (BGJ-398 phosphate) is an effective inhibitor of the FGFR family (IC50: 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and</p>Formule :C26H34Cl2N7O7PDegré de pureté :99.24% - 99.6%Couleur et forme :SolidMasse moléculaire :658.47IACS-9439
CAS :<p>IACS-9439 is a potent, selective, and orally active inhibitor of CSF1R, exhibiting a K(i) of 1 nM.</p>Formule :C23H26ClN7O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :516.02DMH4
CAS :<p>DMH4 is a potent and selective inhibitor of VEGFR2 with an IC50 of 0.16 µM.</p>Formule :C24H24N4O2Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :400.47Spebrutinib besylate
CAS :<p>Spebrutinib besylate (AVL-292 benzenesulfonate; CC-292 besylate) is a Btk kinase activity inhibitor (IC50<0.5 nM, Kinact/Ki=7.69×104 M-1s-1s).</p>Formule :C28H28FN5O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :581.62Sovleplenib
CAS :<p>Sovleplenib (HMPL-523), oral SYK inhibitor, IC50 25 nM, targets tumors & ITP studies.</p>Formule :C24H30N6O3SDegré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :482.6JNJ-64264681
CAS :<p>JNJ-64264681 is a potent, orally active, selective, and irreversible covalent inhibitor of Bruton's tyrosine kinase (BTK).</p>Formule :C27H30N6O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :518.63FN-1501
CAS :<p>FN-1501 is a potent FLT3 and CDK inhibitor (IC50s: 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively).</p>Formule :C22H25N9ODegré de pureté :97.4%Couleur et forme :SolidMasse moléculaire :431.49EGFR-IN-16
CAS :<p>EGFR-IN-16 (AG473) is an inhibitor of EGFR in human A431 cells.</p>Formule :C16H11NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :265.26c-Fms-IN-9
CAS :<p>c-Fms-IN-9 inhibits c-FMS/uFMS and uKIT with IC50 <0.01μM and 0.1-1μM, from patent WO2014145023A1.</p>Formule :C21H23N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :405.45EMI48
CAS :<p>EMI48, a derivative of EMI1, exhibits increased efficacy against mutant EGFR compared to EMI1. It specifically inhibits EGFR triple mutants [1].</p>Formule :C21H20N2O3Couleur et forme :SolidMasse moléculaire :348.4Tarlox-TKI
CAS :<p>Tarlox-TKI (Kinase inhibitor-1) is a pan-ErbB inhibitor, the active ingredient of Tarloxotinib, which has antitumor activity.</p>Formule :C19H18BrClN6ODegré de pureté :97.03%Couleur et forme :SolidMasse moléculaire :461.74EGFR-IN-39
CAS :<p>EGFR-IN-39, an acrylamide, is a potent EGFR inhibitor and antitumor agent targeting NSCLC with low toxicity. See WO2021185348A1 for details.</p>Formule :C24H25ClN6O3Couleur et forme :SolidMasse moléculaire :480.95EMI56
CAS :<p>EMI56, a derivative of EMI1, exhibits enhanced potency against mutant EGFR compared to EMI1. Additionally, EMI56 effectively inhibits EGFR triple mutants[1].</p>Formule :C21H20N2O3Couleur et forme :SolidMasse moléculaire :348.4ER-27319
CAS :<p>ER-27319, an acridone derivative, serves as a potent and selective inhibitor of spleen tyrosine kinase (SYK), effectively impeding both the tyrosine</p>Formule :C20H22N2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :370.4EGFR-IN-89
CAS :<p>EGFR-IN-89 (compound 13k) is a fourth-generation inhibitor selectively targeting EGFR mutations, exhibiting potent activity with an IC50 of 10.1 nM against</p>Formule :C26H31FN8O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :538.64TG-46
CAS :<p>TG-46 (TG46) inhibits JAK2, FLT3, RET, JAK3 and can be used to study glaucoma.</p>Formule :C26H34N6O3SDegré de pureté :98.82% - 99.81%Couleur et forme :SolidMasse moléculaire :510.65JBJ-04-125-02
CAS :<p>JBJ-04-125-02: Oral EGFR inhibitor, targets EGFRL858R/T790M with 0.26 nM IC50, halts cancer growth, anti-tumor.</p>Formule :C29H26FN5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :543.61PD 173955-Analog1
CAS :<p>PD 173955-Analog1 is a potent c-Src inhibitor known to have activity against a variety of cancers including colon, lung, head and neck carcinoma.</p>Formule :C21H14Cl2N4O3Couleur et forme :SolidMasse moléculaire :441.27(E/Z)-AG490
CAS :<p>(E/Z)-AG490 is a racemic mix of (E)- and (Z)-isomers; it inhibits tyrosine kinase, EGFR, Stat-3, and JAK2/3.</p>Formule :C17H14N2O3Couleur et forme :SolidMasse moléculaire :294.3EGA
CAS :<p>EGA blocks the entry of a variety of other acid-dependent bacterial toxins and viruses into mammalian cells and can be used to treat infectious diseases.</p>Formule :C16H16BrN3ODegré de pureté :98% - 99.6%Couleur et forme :SolidMasse moléculaire :346.22EGFR-IN-75
<p>EGFR-IN-75 inhibits EGFR WT/T790M; IC50s: 0.28/5.02 μM. It has anticancer and antioxidant effects.</p>Formule :C10H6N6S2Couleur et forme :SolidMasse moléculaire :274.32DS21360717
CAS :<p>DS21360717 is an effective oral tyrosine kinase inhibitor with anticancer activity and IC50 of 0.49 nM.</p>Formule :C21H23N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :389.45EGFR-IN-53
CAS :<p>EGFR-IN-53 (Compound 7) is a potent inhibitor of EGFR (IC50 = 8.264 μM) that exhibits cytotoxic activity against cancer cell lines [1].</p>Formule :C14H13N3O2SCouleur et forme :SolidMasse moléculaire :287.34EGFR-IN-68
CAS :<p>EGFR-IN-68, an EGFR inhibitor, has an IC50 of 0.33 μM and shows significant anticancer effects.</p>Formule :C24H22N2OCouleur et forme :SolidMasse moléculaire :354.44c-Kit-IN-2
CAS :<p>c-Kit-IN-2 is a c-KIT inhibitor (IC50: 82 nM), shows superior antiproliferative activities against all the three GIST cell lines, GIST430, GIST882, and GIST48 (</p>Formule :C25H29N9O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :519.62Lavendustin C6
CAS :<p>Lavendustin C6 is a effective tyrosine kinase inhibitor.</p>Formule :C20H25NO5Couleur et forme :SolidMasse moléculaire :359.42MS 39
CAS :<p>MS 39, a selective EGFR depressant, degrades mutant receptors in lung cancer lines without affecting wild-type. Effective in vitro and in mice.</p>Formule :C55H71ClFN9O7SCouleur et forme :SolidMasse moléculaire :1056.72Nazartinib mesylate
CAS :<p>Nazartinib mesylate is a novel, covalent mutant-selective inhibitor of EGFR (Ki and Kinact: 31 nM and 0.222/min on EGFR(L858R/790M) mutant).</p>Formule :C27H35ClN6O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :591.12Lanraplenib monosuccinate
CAS :<p>Lanraplenib monosuccinate inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans.</p>Formule :C27H31N9O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :561.59EAI001
CAS :<p>EAI001 is a potent and selective mutant epidermal growth factor receptor (EGFR) variant inhibitor that inhibits EGFRL858R/T790M with an IC50 value of 24 nM.</p>Formule :C19H15N3O2SDegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :349.41EGFR-IN-55
CAS :<p>"EGFR-IN-55 targets EGFRWT (70 nM IC50) & EGFRL858R/T790M (3.9 nM IC50), halts NCI-H1975 cell cycle in G0/G1, showing anticancer properties."</p>Formule :C25H25Cl2N7O2Couleur et forme :SolidMasse moléculaire :526.42RTC-5
CAS :<p>RTC-5 (TRC-382) is a phenothiazine compound that has been specifically enhanced for its potent anti-cancer properties.</p>Formule :C24H22ClF3N2O3SDegré de pureté :98.14%Couleur et forme :SolidMasse moléculaire :510.96JAK-IN-21
CAS :<p>JAK-IN-21 is a selective and potent JAK inhibitor that inhibits JAK1, JAK2, J2V617F and TYK2 with IC50 values of 1.73, 2.04, 109 and 62.9 nM, respectively.</p>Formule :C19H16N8ODegré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :372.38EGFR-IN-49
CAS :<p>EGFR-IN-49 selectively inhibits EGFR mutations T790M (IC50: 65 nM) & T790M/L858R (IC50: 13.6 nM), triggering apoptosis dose-dependently.</p>Formule :C22H15N5O2SCouleur et forme :SolidMasse moléculaire :413.45CE-245677 mesylate
CAS :<p>CE-245677 mesylate is a selective Tie2 kinase inhibitor with oral activity and potential anti-tumor effects, useful in pain research.</p>Formule :C25H26Cl2N6O6SDegré de pureté :99.42%Couleur et forme :SolidMasse moléculaire :609.48Selatinib
CAS :<p>Selatinib is an orally active and potent dual inhibitor of EGFR and ErbB2 with anticancer activity that inhibits the growth of NCI-N87 tumor cells.</p>Formule :C29H26ClFN4O3SDegré de pureté :98.00%Couleur et forme :SolidMasse moléculaire :565.06AXL-IN-13
CAS :<p>AXL-IN-13: potent, oral AXL inhibitor, IC50=1.6nM, Kd=0.26nM, anti-cancer, inhibits EMT, cell migration & invasion.</p>Formule :C34H41FN6O5Degré de pureté :99.20%Couleur et forme :SolidMasse moléculaire :632.72Ansornitinib
CAS :<p>Ansornitinib (ANG-3070) is a KDR and PDGF receptor inhibitor with antifibrotic activity for the study of diseases caused by abnormal or excessive fibrosis.</p>Formule :C30H32N6O4Couleur et forme :SolidMasse moléculaire :540.61FLT3-IN-4
CAS :<p>FLT3-IN-4 (FLT3 inhibitor 9u) is a potent and orally effective Fms-like tyrosine receptor kinase 3 (FLT3; IC50=7 nM) inhibitor ,for treating acute myelogenous</p>Formule :C23H25N7O2Degré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :431.49CGP52411
CAS :<p>CGP52411 is an orally active, and ATP-competitive inhibitor of EGFR (IC50: 0.3 μM).</p>Formule :C20H15N3O2Degré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :329.35EGFR-IN-31
CAS :<p>EGFR-IN-31: Potent EGFR inhibitor, targets mutations & overexpression in NSCLC; potential cancer research compound. (WO2021185298A1, 2)</p>Formule :C32H36FN7O2Couleur et forme :SolidMasse moléculaire :569.67SDZ281-977
CAS :<p>SDZ 281-977 is a derivative of Lavendustin A which is the EGF receptor tyrosine kinase inhibitor.</p>Formule :C18H20O5Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :316.35CGP60474
CAS :<p>CGP60474 is an inhibitor of VEGFR-2 (IC50 = 84 nM) and an inhibitor of ATP-competitive PKC.</p>Formule :C18H18ClN5ODegré de pureté :98.81%Couleur et forme :SolidMasse moléculaire :355.82RU-302
CAS :<p>RU-302 is a pan inhibitor of TAM Receptor blocking the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain.</p>Formule :C24H24F3N3O2SDegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :475.53AMG-Tie2-1
CAS :<p>AMG-Tie2-1 is a Tie2 and VEGFR2 inhibitor with anticancer and antitumor activity for the study of cardiovascular disease and cancer.</p>Formule :C25H20F3N5O2Degré de pureté :98.9%Couleur et forme :SolidMasse moléculaire :479.45OXSI-2
CAS :<p>OXSI-2 (Syk Inhibitor) is an inhibitor of Syk with an EC50 of 313 nM and an IC50 of 14 nM.</p>Formule :C18H15N3O3SDegré de pureté :98%Couleur et forme :Dark Orange SolidMasse moléculaire :353.39EGFR-IN-2
CAS :<p>EGFR-IN-2 is a oral and mutation-selective EGFR inhibito,NSCLC, with high selectivity for resistant single and double mutant T790M.</p>Formule :C26H33N9O3SDegré de pureté :98.52% - 99.79%Couleur et forme :SolidMasse moléculaire :551.66EGFR-IN-69
CAS :<p>EGFR-IN-69: Potent EGFR inhibitor for NSCLC research; IC50: 4.3-25.6 nM against various EGFR mutations.</p>Formule :C31H37Cl2N7O3SCouleur et forme :SolidMasse moléculaire :658.64RO9021
CAS :<p>RO9021 is an orally bioavailable, novel ATP-competitive SYK inhibitor (average IC50: 5.6 nM).</p>Formule :C18H25N7ODegré de pureté :97.19%Couleur et forme :SolidMasse moléculaire :355.44EGFR/HER2-IN-3
CAS :<p>EGFR/HER2-IN-3 (Compound ZINC21942954) is a dual EGFR and HER2 inhibitor.</p>Formule :C26H23N5O3Couleur et forme :SolidMasse moléculaire :453.49Protein kinase inhibitor 5
CAS :<p>Protein kinase inhibitor 5 is a potent inhibitor of TRK-A, demonstrating an IC50 of 1.8 nM, and effectively suppresses cell viability [1].</p>Formule :C29H31F2N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :531.6NSC114126
CAS :<p>NSC114126 is a potent, oral EGFR-TK inhibitor with strong antiproliferative effects, promising for cancer research.</p>Formule :C22H20O4Couleur et forme :SolidMasse moléculaire :348.39EGFR-IN-54
CAS :<p>EGFR-IN-54 (Compound 3c) is a potent inhibitor of EGFR (IC50: 1.623 μM) and is toxic to cancer cells.</p>Formule :C17H14N4O4S3Couleur et forme :SolidMasse moléculaire :434.51EGFR-IN-50
CAS :<p>EGFR-IN-50, a potent EGFR blocker, hinders L858R mutation; GI50: 8 nM for TEL-EGFR-L858R, 6.03 μM for T790M-L858R; curbs cancer cell growth.</p>Formule :C24H26BrN3O4S2Couleur et forme :SolidMasse moléculaire :564.51EGFR-IN-25
CAS :<p>EGFR-IN-25, an efficacious EGFR inhibitor, demonstrates IC50 values of 9 nM for BaF3 cells (EGFR DEL19/T790M/C797S) and 60 nM for A431 cells (WT), respectively.</p>Formule :C34H43N9O2Couleur et forme :SolidMasse moléculaire :609.76CHMFL-BTK-01
CAS :<p>CHMFL-BTK-01 is an irreversible inhibitor of BTK (IC50: 7 nM) and also potently inhibits BTK Y223 auto-phosphorylation.</p>Formule :C38H41N5O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :647.76FGFR2-IN-1
CAS :<p>FGFR2-IN-1 is an FGFR inhibitor that inhibits FGFR1, FGFR2, and FGFR3, and can be used to study FGFR2-associated cancers.</p>Formule :C22H19N3O2Degré de pureté :98.71%Couleur et forme :SolidMasse moléculaire :357.41JBJ-09-063 hydrochloride
<p>JBJ-09-063 hydrochloride: targeted EGFR inhibitor, effective for various mutations and TKI-resistant lung cancer models.</p>Formule :C31H30ClFN4O3SCouleur et forme :SolidMasse moléculaire :593.11AG-183
CAS :<p>(Z)-Tyrphostin A51, a Z-isomer of Lanoconazole A51, is a strong PTK inhibitor blocking [3 H]taurine release and tyrosyl phosphorylation.</p>Formule :C13H8N4O3Couleur et forme :Brown SolidMasse moléculaire :268.23TC-S 7003
CAS :<p>TC-S 7003 (Lck Inhibitor) is a Lck inhibitor with anti-inflammatory activity that inhibits T-cell proliferation and can be used to study arthritis.</p>Formule :C31H30N8ODegré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :530.62EGFR/HER2-IN-2
CAS :<p>EGFR/HER2-IN-2 (Compound ZINC35560729) is a dual EGFR and HER2 inhibitor that acts on both EGFR (IC50: 5.02 μM) and HER2 (IC50: 0.83 μM).</p>Formule :C26H23N5O3Couleur et forme :SolidMasse moléculaire :453.49Nimotuzumab
CAS :<p>Nimotuzumab is a humanized therapeutic monoclonal antibody against epidermal growth factor receptor EGFR).</p>Degré de pureté :95.00% - 98.5% (SDS-PAGE); 96.4% (SEC-HPLC)Couleur et forme :Liquidc-Fms-IN-6
CAS :<p>c-Fms-IN-6 is a potent inhibitor of c-FMS (IC50 ≤10 nM for unphosphorylated c-FMS) and also weakly inhibits unphosphorylated c-KIT and PDGFR (IC50: > 1 μM).</p>Formule :C22H25N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :419.48CSF1R-IN-7
CAS :<p>CSF1R-IN-7 is a highly selective CSF-1R inhibitor with good brain penetration for treatment of diseases associated with microglia-mediated neuroinflammation.</p>Formule :C22H22N6O3Degré de pureté :99.41% - 99.93%Couleur et forme :SolidMasse moléculaire :418.45EGFR-IN-73
CAS :<p>EGFR-IN-73 (Compound 3f) effectively inhibits the prevalent EGFR mutation, EGFR Del19, exhibiting an IC50 value of 119 nM [1].</p>Formule :C19H17ClFN3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :405.81(R)-Zanubrutinib
CAS :<p>(R)-Zanubrutinib ((R)-BGB-3111) is a selective inhibitor of Bruton tyrosine kinase (BTK).</p>Formule :C27H29N5O3Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :471.55AMPK-IN-3
CAS :<p>AMPK-IN-3: potent, selective AMPK (α2/α1) & KDR inhibitor; IC50: 60.7/107/3820 nM; anticancer in K562 cells.</p>Formule :C25H33N5O3Degré de pureté :99.13%Couleur et forme :SolidMasse moléculaire :451.56SKLB 1028
CAS :<p>SKLB 1028, an oral EGFR/FLT3/Abl inhibitor, excels in AML and CML with Abl mutations.</p>Formule :C24H29N9Degré de pureté :99.90% - >99.99%Couleur et forme :SolidMasse moléculaire :443.55I-OMe-Tyrphostin AG 538
CAS :<p>I-OMe-Tyrphostin AG 538: IGF-1R & PI5P4Kα inhibitor, ATP-competitive, IC50 of 1 µM, targets IGF-1R pathway, cytotoxic in nutrient-poor PANC1 cells.</p>Formule :C17H12INO5Degré de pureté :98.23%Couleur et forme :SolidMasse moléculaire :437.19Chiauranib
CAS :<p>Chiauranib, a potent anticancer agent, inhibits angiogenesis kinases (VEGFR1-3, PDGFRα, c-Kit), Aurora B, and CSF1R with IC50 values of 1-9 nM.</p>Formule :C27H21N3O3Degré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :435.47EGFR-IN-99
CAS :<p>EGFR-IN-99 (JBJ-03-142-02) is an EGFR and HER2 Exon 20 insertion mutation inhibitor for the study of non-small cell lung cancer (NSCLC).</p>Formule :C25H22FN7O3Degré de pureté :97.75%Couleur et forme :SolidMasse moléculaire :487.49CGP77675
CAS :<p>CGP77675 (ZINC1488120) is a potent and selective inhibitor of Src family kinase with IC50s of 5-20 and 40 nM for the phosphorylation of peptide substrates and</p>Formule :C26H29N5O2Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :443.54INDY
CAS :<p>INDY is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC50s of 0.24 μM and 0.23 μM and a Ki of 0.18 μM for Dyrk1A ATP pocket, respectively.</p>Formule :C12H13NO2SDegré de pureté :99.26%Couleur et forme :SolidMasse moléculaire :235.3(Z)-FeCP-oxindole
CAS :<p>(Z)-FeCP-oxindole is a selective inhibitor of VEGFR2 with an IC50 of 200 nM for human. (Z)-FeCP-oxindole shows anticancer activity.</p>Formule :C19H15FeNODegré de pureté :99.63% - 99.84%Couleur et forme :SolidMasse moléculaire :329.17CLK-IN-T3
CAS :<p>CLK-IN-T3 is an inhibitor of CLK1, CLK2, and CLK3 with IC50s of 0.67, 15, and 110 nM. CLK-IN-T3 exhibits anti-cancer activity.</p>Formule :C28H30N6O2Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :482.58Pz-1
CAS :<p>Pz-1 is an inhibitor of VEGFR2 and RET (rearranged during transfection) tyrosine kinase that blocks the blood supply required for RET-stimulated growth.</p>Formule :C26H26N6O2Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :454.52SU16f
CAS :<p>SU16f, a 3-substituted indolin-2-one, is a selective PDGFRβ inhibitor; IC50: 10 nM (PDGFRβ), 140 nM (PDGFR1), 2.29 μM (PDGFR2), halts GC cell growth.</p>Formule :C24H22N2O3Degré de pureté :97.69%Couleur et forme :SolidMasse moléculaire :386.44DDR Inhibitor
CAS :<p>DDR inhibitor is a potent discidin domain receptor (DDR) inhibitor. The IC50 of DDR2 is 3.3 nM, and DDR1 has 53% inhibition at 1.5 nM.</p>Formule :C23H20FN5O2Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :417.44Larotinib
CAS :<p>Larotinib is an orally active, potent, and broad-spectrum tyrosine kinase inhibitor (TKI) with an IC50 of 0.6 nM for EGFR.</p>Formule :C24H26ClFN4O4Degré de pureté :98.45%Couleur et forme :SolidMasse moléculaire :488.94GTP-14564
CAS :<p>GTP-14564 is a novel tyrosine kinase inhibitor that also inhibits wt-FLT3 and ITD-FLT3.</p>Formule :C15H10N2ODegré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :234.25(E)-FeCP-oxindole
CAS :<p>(E)-FeCP-oxindole 是一种 VEGFR2 抑制剂，IC50 为 214 nM。</p>Formule :C19H15FeNODegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :329.17Pimicotinib
CAS :<p>Pimicotinib (ABSK021) is a potent CSF1R inhibitor with antitumor activity and can be used to study advanced solid tumors.</p>Formule :C22H24N6O3Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :420.46VEGFR-3-IN-1
CAS :<p>VEGFR-3-IN-1, a potent VEGFR3 inhibitor (IC50=110.4 nM), hinders tumor growth and VEGFR3 signaling, affecting HDLEC and MDA-MB cell proliferation/migration.</p>Formule :C29H29ClF3N7OSDegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :616.1PD 174265
CAS :<p>PD 174265 is an effective, selective and reversible inhibitor of epidermal growth factor receptor (EGFR) with an IC50 of 0.45 nM.</p>Formule :C17H15BrN4ODegré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :371.23Epitinib succinate
CAS :<p>Epitinib succinate (HMPL-813 succinate) is an orally active and brain penetration EGFR tyrosine kinase inhibitor and can be used in studies about cancer.</p>Formule :C28H32N6O6Degré de pureté :98.02% - 99.79%Couleur et forme :SolidMasse moléculaire :548.59Cloperastine fendizoate
CAS :<p>Cloperastine fendizoate (Hustazol) inhibits the hERG K+ currents in a concentration-dependent manner (IC50: 27 nM).</p>Formule :C40H38ClNO5Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :648.19YK-2-69
CAS :<p>YK-2-69 selectively blocks DYRK2 at Lys-231 and Lys-234, outperforming enzalutamide in prostate cancer treatment.</p>Formule :C25H27FN8OSDegré de pureté :98.61% - 99.64%Couleur et forme :SolidMasse moléculaire :506.6ProINDY
CAS :<p>ProINDY (Pro-indy) is a potent DYRK inhibitor that activates NFAT for the study of Down syndrome.</p>Formule :C14H15NO3SDegré de pureté :97.19%Couleur et forme :SolidMasse moléculaire :277.34(±)-Zanubrutinib
CAS :<p>(±)-Zanubrutinib ((±)-BGB-3111) is a potent and orally available Bruton's tyrosine kinase (Btk) inhibitor that demonstrates superior oral bioavailability,</p>Formule :C27H29N5O3Degré de pureté :99.09%Couleur et forme :SolidMasse moléculaire :471.55A 419259 trihydrochloride
CAS :<p>A 419259 trihydrochloride (RK 20449 trihydrochloride) is an Src family kinases inhibitor (IC50s: 9 nM, 3 nM and 3 nM for Src, Lck and Lyn).</p>Formule :C29H37Cl3N6ODegré de pureté :99.75% - 99.96%Couleur et forme :SolidMasse moléculaire :592Tilfrinib
CAS :<p>Tilfrinib is an effective and selective inhibitor of breast tumor kinase(Brk, IC50 = 3.15 nM) which displays anti-proliferative and anti-tumor activities.</p>Formule :C17H13N3ODegré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :275.3ML 315
CAS :<p>ML 315 is a selective Clk and DYRK inhibitor with potential anticancer activity for the study of neurological disorders.</p>Formule :C18H13Cl2N3O2Degré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :374.22Rezivertinib
CAS :<p>Rezivertinib (BPI-7711) is an EGFR inhibitor with antitumor activity and can be used to study central nervous system diseases.</p>Formule :C27H30N6O3Degré de pureté :99.26% - 99.89%Couleur et forme :SolidMasse moléculaire :486.57Falnidamol
CAS :<p>Falnidamol (BIBX 1382), an oral selective EGFR inhibitor, IC50 3 nM, weak on ErbB2 and others, anti-cancer pyrimido-pyrimidine.</p>Formule :C18H19ClFN7Degré de pureté :98.816%Couleur et forme :SolidMasse moléculaire :387.84PP58
CAS :<p>PP58 is an inhibitor of PDGFR, FGFR and Src family.</p>Formule :C22H19Cl2N5O2Degré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :456.32LY 456236 hydrochloride
CAS :<p>LY 456236 hydrochloride (MPMQ hydrochloride) is an mGlu1 receptor antagonist with an ic50 value of 143 nM.</p>Formule :C16H16ClN3O2Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :317.77TG-89
CAS :<p>TG-89 is an inhibitor of JAK2, JAK3, RET and FLT3, and has an IC50 value of 11.2 μM against JAK2, showing anticancer activity in the treatment of ovarian and</p>Formule :C26H34N6O3SDegré de pureté :98.68%Couleur et forme :SolidMasse moléculaire :510.65Sunvozertinib
CAS :<p>Sunvozertinib (DZD9008) is a potent ErbBs and BTK inhibitor, with inhibitory effects on EGFR, Her2.Cost-effective and quality-assured.</p>Formule :C29H35ClFN7O3Degré de pureté :98.11% - 99.63%Couleur et forme :SolidMasse moléculaire :584.08Tyrphostin A25
CAS :<p>Tyrphostin A25 (Tyrphostin AG 82) is a specific EGFR tyrosine kinase inhibitor and GPR35 agonist with an IC50 value of 0.94 μM for GPR35 and an EC50 value of 5.</p>Formule :C10H6N2O3Degré de pureté :98.76%Couleur et forme :Yellow Green Powder /Off-White SolidMasse moléculaire :202.17PKI-166
CAS :<p>PKI-166: oral EGF-R tyrosine kinase inhibitor (IC50: 0.7 nM), halts growth & spread of many human cancers, including pancreatic.</p>Formule :C20H18N4ODegré de pureté :99.2%Couleur et forme :SolidMasse moléculaire :330.38RET-IN-3
CAS :<p>RET-IN-3 is a RETV804M kinase inhibitor with potential anticancer activity for the study of non-small cell lung cancer.</p>Formule :C18H21N5O2Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :339.39c-Fms-IN-13
CAS :<p>c-Fms-IN-13 (compound 14) is a potent FMS kinase inhibitor (IC50= 17 nM). c-Fms-IN-13 is an anti-inflammatory agent.</p>Formule :C22H26N4O2Degré de pureté :99.93% - 99.97%Couleur et forme :SolidMasse moléculaire :378.47EMI1
CAS :<p>EMI1 targets mutated EGFR in drug-resistant NSCLC research.</p>Formule :C20H18N2O3Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :334.37EGFR-IN-9
CAS :<p>EGFR-IN-9 is a potent EGFR kinase inhibitor with IC50s of 7 nM, 28 nM for the wild type EGFR kinase and double mutant EGFR kinase (L858R/T790M).</p>Formule :C29H24N4O3Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :476.53CSF1R-IN-3
CAS :<p>CSF1R-IN-3 is an orally effective CSF-1R inhibitor with an IC50 value of 2.1 nM.</p>Formule :C30H38N8O4Degré de pureté :97.31%Couleur et forme :SolidMasse moléculaire :574.67A-935142
CAS :<p>A-935142 enhances hERG (Kv 11.1) channels, slows inactivation, promotes activation, and shortens repolarization.</p>Formule :C18H19F3N2O2Degré de pureté :98.97% - 99.91%Couleur et forme :SolidMasse moléculaire :352.35LDN-211904 oxalate
CAS :<p>LDN-211904 oxalate (LDN211904 oxalate) is a selective and efficient EphB3 inhibitor with antitumor activity, useful in neurodegenerative disease research.</p>Formule :C21H21ClN4O5Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :444.87AXL-IN-15
CAS :<p>AXL-IN-15 (cpd391) is a potent inhibitor of Axl, exhibiting both a dissociation constant (K i) and a half-maximal inhibitory concentration (IC50) of less than 1</p>Formule :C26H32F3N9O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :575.59AXL-IN-14
CAS :<p>AXL-IN-14: orally active, potent AXL inhibitor (IC50=0.8 nM); hinders Gas6/AXL migration, invasion; lowers p-AXL, p-AKT; anti-tumor.</p>Formule :C32H24F2N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :566.55VEGFR-2-IN-37
CAS :<p>VEGFR-2-IN-37 (compound 12), a VEGFR-2 inhibitor, exhibits an inhibition rate of approximately 56.9 μM at a concentration of 200 μM.</p>Formule :C18H16N2O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :324.4BT424
CAS :<p>BT424, a specific HCK inhibitor, modulates macrophage activation and autophagy in vitro, and mitigates inflammation and renal fibrosis in the UUO model [1].</p>Formule :C22H15BCl2N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :421.08Brepocitinib
CAS :<p>Brepocitinib (PF-06700841) is a potent dual JAK1/TYK2 inhibitor (IC50s: 17 nM/23 nM). Brepocitinib also inhibits JAK2/3 (IC50s: 77 nM/6.49 μM).</p>Formule :C18H21F2N7ODegré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :389.4Axl/Mer/CSF1R-IN-2
CAS :<p>Axl/Mer/CSF1R-IN-2 (Comp 4) serves as an inhibitor for Axl, Mer, and CSF1R [1].</p>Formule :C24H22F3N5O5Couleur et forme :SolidMasse moléculaire :517.46Terevalefim
CAS :<p>Terevalefim (ANG-3777) is an hepatocyte growth factor (HGF) mimetic. Terevalefim selectively activates the c-Met receptor.</p>Formule :C9H8N2SDegré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :176.24Cinsebrutinib
CAS :<p>Cinsebrutinib, a Bruton's tyrosine kinase inhibitor, holds potential for research in cancer treatment.</p>Formule :C22H26FN3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :383.46BMS-599626 Hydrochloride
CAS :<p>BMS-599626 HCl (AC480 HCl) is an oral inhibitor of HER1, HER2, HER4 kinases, potentially blocking tumor growth. IC50: 22/32/190 nM.</p>Formule :C27H28ClFN8O3Degré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :567.01FGFR3-IN-7
CAS :<p>FGFR3-IN-7 is a potent, selective inhibitor of FGFR 3, demonstrating an IC50 value of less than 350 nM , and is utilized in cancer research [1].</p>Formule :C25H24FN9ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :485.52ARRY-382
CAS :<p>ARRY-382 is a highly selective oral inhibitor of CSF-1R with an IC50 of 9 nM.</p>Formule :C32H36N8O2Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :564.68Tyrphostin AG1433
CAS :<p>Tyrphostin AG1433 (AG1433) is an inhibitor of tyrosine kinases and also a dual inhibitor of PDGFRβ(IC50s = 5.0 μM) and VEGFR-2 (Flk-1/KDR)(IC50s = 9.3 μM).</p>Formule :C16H14N2O2Degré de pureté :98.47%Couleur et forme :SolidMasse moléculaire :266.29Resigratinib
CAS :<p>Resigratinib (KIN-3248) is an oral, irreversible pan-FGFR family protein inhibitor, covalently binds to and inhibits all four FGFR isoforms(FGFR1/2/3/4).</p>Formule :C26H27F2N7O3Degré de pureté :98.58%Couleur et forme :SolidMasse moléculaire :523.53BGB-102
CAS :<p>BGB-102 (JNJ-26483327) is a kinase inhibitor targeting FLT3 and YES1 and an antagonist targeting EGFR and VEGFR3.</p>Formule :C22H25BrN4O2Degré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :457.36AKB-6899
CAS :<p>AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated</p>Formule :C14H11FN2O4Degré de pureté :97.87%Couleur et forme :SolidMasse moléculaire :290.25Lifirafenib
CAS :<p>Lifirafenib (Beigene-283) is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinant</p>Formule :C25H17F3N4O3Degré de pureté :98% - 98.25%Couleur et forme :SolidMasse moléculaire :478.42VEGFR-2-IN-9
CAS :<p>VEGFR-2-IN-9 (KDR-in-4) is a potent KDR/VEGFR2 inhibitor (IC50: 7 nM). It can be used to study breast cancer.</p>Formule :C23H25N3O3Degré de pureté :97.19%Couleur et forme :SolidMasse moléculaire :391.46EGFR mutant-IN-1
<p>EGFR mutant-in-1, a 5-methylpyrimidopyridone, selectively inhibits EGFRL858R/T790M/C797S mutants with an IC50 of 27.5 nM, lessening EGFRWT impact.</p>Formule :C34H39ClFN7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :632.17JND3229
CAS :<p>JND3229 inhibits EGFRC797S; IC50: 5.8-30.5 nM; halts cell growth; effective in non-small cell lung cancer study.</p>Formule :C33H41ClN8O2Degré de pureté :98.75%Couleur et forme :SolidMasse moléculaire :617.18EGFR-IN-1
CAS :<p>EGFR-IN-1: an oral, irreversible EGFR inhibitor targeting L858R/T790M mutations with high selectivity, showing potent antitumor effects.</p>Formule :C28H30N6O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :514.58PF-06733804
CAS :<p>PF-06733804 is a potent inhibitor of pan-Trk in cell-based assays (IC50s: 8.4 nM, 6.2 nM, and 2.2 nM for TrkA, TrkB, and TrkC) with anti-hyperalgesic effect.</p>Formule :C20H19F5N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :474.38EGFR-IN-36
CAS :<p>EGFR-IN-36 inhibits EGFR, HER2, & mutants with IC50s: 19.09 nM (EGFR WT), 120.01 nM (HER2 WT), 2.35 nM (HER2 mutant).</p>Formule :C26H25ClN6O2Couleur et forme :SolidMasse moléculaire :488.97EGFR-IN-71
CAS :<p>EGFR-IN-71 is a potent inhibitor of epidermal growth factor receptor (EGFR) (IC50= 3.7 μM). EGFR-IN-71 has research value in chordoma.</p>Formule :C16H9ClIN3Couleur et forme :SolidMasse moléculaire :405.62Pirtobrutinib
CAS :<p>Pirtobrutinib: a selective, non-covalent BTK inhibitor effective against BTK C481 mutations, causing tumor regression in lymphoma models.</p>Formule :C22H21F4N5O3Degré de pureté :99.76% - 99.94%Couleur et forme :SolidMasse moléculaire :479.43VEGFR2-IN-3
CAS :<p>VEGFR2-IN-3 (compound 385) is a potent inhibitor of VEGFR2 [1].</p>Formule :C26H28ClN5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :509.98EGFR-IN-74
<p>EGFR-IN-74 is a potent inhibitor targeting EGFR, specifically effective against the L858R/T790M mutations, exhibiting an IC50 value of 138 nM.</p>Formule :C32H28BrF3N6O4SCouleur et forme :SolidMasse moléculaire :729.57TIE-2/VEGFR-2 kinase-IN-5
CAS :<p>TIE-2/VEGFR-2 kinase-IN-5 is a TIE-2 and VEGFR-2 tyrosine kinase receptor inhibitor commonly used in biomedical research related to angiogenesis.</p>Formule :C21H13F6N5O2Degré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :481.35Simotinib
CAS :<p>Simotinib (AL-6802) is an EGFR tyrosine kinase inhibitor (IC50 : 19.9 nM) with antitumour activity for the study of non-small cell lung cancer.</p>Formule :C25H26ClFN4O4Degré de pureté :99.7%Couleur et forme :SolidMasse moléculaire :500.95EGFR-IN-29
CAS :<p>EGFR-IN-29 is a potent EGFR inhibitor.</p>Formule :C36H46BrN8O2PCouleur et forme :SolidMasse moléculaire :733.68CG 428
CAS :<p>CG 428 is a potent tropomyosin receptor Kinase (TRK) Degrader (uSMITETM) with a DC50 of 0.36 nM.</p>Formule :C43H43FN10O6Degré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :814.86PAT-505
CAS :<p>PAT-505 is an autologous epidermal growth factor inhibitor.</p>Formule :C23H18ClF2N3O2SDegré de pureté :98.84%Couleur et forme :SolidMasse moléculaire :473.92Edralbrutinib
CAS :<p>Edralbrutinib (TG-1701) is a potent BTK inhibitor with anticancer activity and is used in the treatment of tumors, immune system disorders, and blood and</p>Formule :C26H21F2N5O3Degré de pureté :99.41%Couleur et forme :SolidMasse moléculaire :489.47DYRKs-IN-2
CAS :<p>DYRKs-IN-2 has antitumor activity. DYRKs-IN-2 is a potent DYRKs inhibitor with IC50s of 30.6 nM and 12.8 nM for DYRK1B and DYRK1A, respectively.</p>Formule :C32H38ClN9O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :632.16c-met-IN-1
CAS :<p>c-met-IN-1 is a potent and selective c-Met inhibitor (IC50: 1.1 nM) with antitumor activity.</p>Formule :C35H37FN6O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :640.7HKI-357
CAS :<p>HKI-357 irreversibly inhibits EGFR/ERBB2 (IC50: 34/33 nM), blocks EGFR Y1068 autophosphorylation, and AKT/MAPK phosphorylation.</p>Formule :C31H29ClFN5O3Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :574.05BMX-IN-1
CAS :<p>BMX-IN-1 (BMX kinase inhibitor) is a selective inhibitor of bone marrow tyrosine kinase on chromosome X (BMX, IC50 = 8 nM) and the related Bruton’s tyrosine</p>Formule :C29H24N4O4SDegré de pureté :98.38%Couleur et forme :SolidMasse moléculaire :524.59PF-06250112
CAS :<p>PF-06250112 is an effective and highly selective BTK inhibitor (IC50: 0.5 nM.</p>Formule :C22H20F2N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :438.43PF-06459988
CAS :<p>PF-06459988 is a novel, effective, orally active, irreversible, and selective epidermal growth factor receptor (EGFR) mutant inhibitor.</p>Formule :C19H22ClN7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :431.88EGFR-IN-30
CAS :<p>EGFR-IN-30 is an EGFR inhibitor (IC50: 1-10 nM, <1 nM WT/mutants) with potential in cancer research.</p>Formule :C28H33BrN7O2PCouleur et forme :SolidMasse moléculaire :610.49HER2-IN-5
CAS :<p>HER2-IN-5 is an effective inhibitor of orally active HER-2.</p>Formule :C27H33N7O3Couleur et forme :SolidMasse moléculaire :503.6Nazartinib S-enantiomer
CAS :<p>Nazartinib is an EGFR inhibitor. Nazartinib S-enantiomer is the less active S-enantiomer of Nazartinib.</p>Formule :C26H31ClN6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :495.02
