Composés et métabolites pharmaceutiques et vétérinaires

<p>Substance P from alligator: a neuropeptide with structure Arg-Pro-Arg-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2.</p>

<p>(-)-Jasmonoyl-L-isoleucine ((-)-JA-L-Ile), an enantiomer of (+)-JA-L-Ile [1], is an inactive endogenous hormone.</p>

<p>(R)-Citronellol is in herbs, spices, bilberry, black cumin seeds, and Rutaceae plant oils.</p>

<p>Prostaglandin F2β (PGF2β) is the 9β-hydroxy stereoisomer of PGF2α.</p>

<p>Ascorbate oxidase, a REDOX enzyme, catalyzes ascorbic acid and oxygen to dehydroascorbic acid, regulating the extracellular matrix.</p>

<p>Adriamycin Aglycone, also known as Doxorubicinone, is an oncolytic agent. It is a metabolite of Doxorubicin which binds to the DNA minor-groove.</p>

<p>Setosusin, a meroterpenoid from C. setosus, reduces Aβ-induced neurotoxicity in PC12 cells (EC50 = 112.6 μM).</p>

<p>m-Tyramine has effects on the adrenergic and dopaminergic receptor.m-Tyramine is an endogenous trace amine neuromodulator.</p>

<p>Digalacturonic acid, a pectin metabolite, aids in enzyme co-crystallization like proteinase K.</p>

<p>(S)-Salsolidine is a MAO inhibitor with Ki 63μM; its R enantiomer is more effective, Ki 26μM.</p>

<p>Equilenin (E 400) is a natural estrogen that is an endocrine disruptor and has been used in breast cancer research.</p>

<p>ATP dipotassium is key for energy storage, metabolism, cellular processes, and as a signaling molecule for immunity and inflammation.</p>

<p>β-N-Acetylhexosaminidase is an exoglycosidase that catalyzes the hydrolysis of terminal non-reducing β-N-acetylgalactosamine and glucosamine residues in</p>

<p>Angiotensinogen (1-14), human,Liver-synthesized globulin. Precursor to angiotensin I.</p>

<p>Dynorphin (1-8) is an opioid octapeptide from the porcine hypothalamus. It comprises the N-terminal eight residues of dynorphin.</p>

<p>Sapropterin aids in amino acid breakdown and neurotransmitter synthesis, including dopamine and serotonin, and supports nitric oxide production.</p>

<p>Acetoacetyl-CoA sodium is a key metabolite, with a Km of 1.10 mM at pH 7.5, used in PTB and PHB synthesis.</p>

<p>Leucomyosuppressin, isolated from head extracts of the cockroach Leucophaea maderae, inhibits evoked transmitter release at the mealworm neuromuscular junction.</p>

<p>L-Mevalonic acid, a cholesterol precursor, is studied in autoimmune, atherosclerosis, and Alzheimer's research.</p>

<p>1'-Hydroxy bufuralol is a metabolite of bufuralol, an orally active β-adrenoceptor blocker used in the study of hypertension and cardiac arrhythmias.</p>

<p>Promothiocin A is an antibiotic.</p>

<p>Endogenous vasoactive compound, found in platelets and brain cells, part of diadenosine polyphosphates (ApnA, n=2–7).</p>

<p>Methyl ester of 11(Z),14(Z)-eicosadienoic acid is a ω-6 PUFA, inhibits LTB4 binding and IMP dehydrogenase, and might affect sleep.</p>

<p>Lithium sn-glycerol 3-phosphate made by converting dihydroxyacetone phosphate via NADH from glycolysis.</p>

<p>Fungal metabolite 19,20-Epoxycytochalasin D from Nemania sp. kills P. falciparum; non-toxic to Vero, toxic to BT-549, LLC-PK11, P388 cells.</p>

<p>11-trans LTC4 is a C-11 isomer of LTC4, forms slowly on storage, is less common but similarly potent in contractions, pKis: 6.42 (LTC4), 6.58 (11-trans).</p>

<p>D-Ribofuranose 1-phosphate is used to synthesize 5-fluorouracil via uridine phosphorylase.</p>

<p>Methylbenzethonium chloride hydrate exhibits broad-spectrum antimicrobial activity against bacteria, viruses, and fungi. Additionally, it is utilized as a preservative in cosmetics and pharmaceutical formulations to inhibit microbial growth.</p>

<p>Salinosporamide C is a decarboxylated pyrrole analogue isolated from the marine Actinomycete Salinispora tropica.</p>

<p>Malonyl CoA: needed for fat creation, stops fat breakdown, reversibly inhibits CPT1 in mitochondria.</p>

<p>Succinic acid tromethamine is an oral anxiolytic, TCA cycle intermediate, and key precursor in various industries.</p>

<p>AtGalAK, a GHMP kinase, converts d-GalA to GalA-1-P using ATP.</p>

<p>Pristanic acid, found in blood, aids in studying Alpha Methylacyl CoA Racemase Deficiency and Zellweger Syndrome.</p>

<p>Atrial natriuretic factor (1-28) (human, porcine) TFA exhibits antihypertensive activity by promoting sodium and urine excretion. It inhibits the release of adrenocorticotropic hormone (ACTH) and β-endorphin by suppressing pro-opiomelanocortin (POMC) expression. Additionally, it elevates cGMP levels in RMIC cells, with an IC50 of 1.2 nM.</p>

<p>Zymosterol—a cholesterol precursor, vital for biosynthesis, mainly in cell membranes.</p>

<p>H-Ser-His-OH, an endogenous metabolite, is a short peptide with hydrolysis cleavage activity.</p>

<p>17α-Hydroxyprogesterone-d8 is a deuterated compound of 17α-Hydroxyprogesterone.</p>

<p>Strombine is an endogenous anaerobic metabolite and dehydrogenase product of imidazole, exhibiting cryoprotective effects.</p>

<p>Myristoyl Ethanolamide is an endogenous cannabinoid analog belonging to the fatty acyl ethanolamine famil，has physiological activity in the nervous system.</p>

<p>L-Valyl-L-phenylalanine has been reported as biocompatible polymer.</p>

<p>1-Palmitoyl-2-oleoyl-sn-glycerol, an endogenous metabolite, serves as a predominant diacylglycerol in the hormogonium-inducing factor (HIF)-1 [1].</p>

<p>β-Nicotinamide adenine dinucleotide reduced dipotassium is an orally active, reduced coenzyme that functions as a donor of ADP-ribose units in ADP-ribosylation</p>

<p>Substance P TFA is a CNS neuropeptide, serving as a neurotransmitter and modulator, targeting NK1R.</p>

<p>DL-Glutamic acid, conjugate acid of Glutamic acid, is a key metabolite with improved stability over L-Glutamic acid's polymorphs.</p>

<p>4-Methyl-1-phenyl-2-pentanone (Benzyl isobutyl ketone) is a volatile flavor that is used as a food additive.</p>

<p>Creatinase breaks down creatine into sarcosine and urea, crucial for measuring creatinine levels.</p>

<p>2-Hydroxypalmitic acid is a useful organic compound for research related to life sciences. The catalog number is T124257 and the CAS number is 764-67-0.</p>

<p>SAO catalyzes sarcosine into glycine, H2O2, 5,10-CH2-tetrahydrofolate for biochemical reactions.</p>

<p>L-Thyroxine sodium xhydrate is a synthetic thyroid hormone used in the treatment of hypothyroidism.</p>

<p>2-Furoylglycine is a natural product for research related to life sciences. The catalog number is T38061 and the CAS number is 5657-19-2.</p>

<p>UDP-xylose, natural from Cryptococcus laurentii, aids in synthesizing glycoproteins and polysaccharides.</p>

<p>Glycerophosphoric acid is one of the main components of teichoic acid in bacterial cell walls and is a common emulsifier.</p>

<p>17β-Estradiol-2,4-d2 is a deuterated compound of 17β-Estradiol. 17β-Estradiol has a CAS number of 50-28-2. Estradiol is an Estrogen. The mechanism of action of estradiol is as an Estrogen Receptor Agonist.</p>

<p>N6-(m-Methoxybenzyl)adenosine is an adenine nucleoside analog and a cytokinin derivative.</p>

<p>ADS032 (BT-032) is an NLRP1 and NLRP3 inhibitor with anti-inflammatory activity for the study of respiratory inflammation or infection.</p>

<p>[Leu5]-Enkephalin (Leu-enkephalin) is an endogenous neuropeptide involved in nociception and an agonist of δ-opioid and μ-opioid receptors (Kis = 4.0 and 3.4 nM</p>

<p>Debrisoquine is an antihypertensive drug similar to guanethidine.</p>

<p>Phenylpropiolic acid is an endogenous metabolite.</p>

<p>Neuraminidase, an exosialidase, breaks α-ketosidic bonds in sialic acid, aiding mucosal pathogen virulence in infections.</p>

<p>(-)-α-Pinene ((1S)-(-)-Alpha-Pinene) enhances the quantity of NREMS without affecting the intensity of NREMS by prolonging GABAergic synaptic transmission,</p>

<p>Hemicellulase is a glycoside hydrolase enzyme key in degrading plant fibers and carbon cycling.</p>

<p>L-Leucine-1-13C (L-Leucine-13C) is a 13C-labeled L-Leucine that significantly enhances the affinity of GLP-4.</p>

<p>VX-548 is a potassium salt of L-aspartic acid that boosts nitrogen oxides, enhances phagocytosis, aids fish survival, and may stimulate antibiotics.</p>

<p>5'-Guanylic acid, involved in AICA-ribosiduria, ADA deficiency, aprt, and 2-hydroxyglutric aciduria pathways.</p>

<p>Metronidazole acetic acid, a mutagenic metabolite of an antibiotic, targets protozoa and anaerobic bacteria.</p>

<p>Pi-Methylimidazoleacetic acid hydrochloride is a potential neurotoxin.</p>

<p>Lysine monohydrate is a bioactive chemical.</p>

<p>3-Oxopentanedioic acid, a simple carboxylic acid, is useful in organic synthesis and a microbial metabolite.</p>

<p>LNnT is a metabolite that reduces IL-8, has anti-inflammatory effects, and aids in wound healing.</p>

<p>21-Hydroxypregnenolone is an essential intermediate in corticosterone synthesis.</p>

<p>Nucleoside Derivatives –3’-Modified nucleoside</p>

<p>11(Z),14(Z),17(Z)-Eicosatrienoic acid is an unsaturated fatty acid capable of being found in Saccharomyces cerevisiae (KD115).</p>

<p>Sodium 3-methyl-2-oxobutanoate is the precursor of pantothenic acid in Escherichia coli.</p>

<p>(R)-Leucic acid is an metabolite of amino acid.</p>

<p>(R)-(-)-1,2-Propanediol, (R)-enantiomer from glucose via E. coli NADH-linked glycerol dehydrogenase.</p>

<p>Cholesterol oxidase catalyzes the oxidation and isomerization of cholesterol. ChOx competitively inhibits TLR2 enhance ROS production by macrophages.</p>

<p>N,N'-Dimethylarginine-d6 (SDMA-d6) is the deuterated form of N,N'-Dimethylarginine.</p>

<p>Crocin IV (Dicrocin), a crocetin glycoside belonging to the carotenoid pigments, exhibits significant antioxidant activity [1].</p>

<p>Dehydroaripiprazole (DM-14857), aripiprazole's active metabolite, is formed by CYP3A4 and CYP2D6, with similar antipsychotic effects.</p>

<p>Maltose phosphorylase (MP) is a dimeric enzyme that catalyzes the conversion of maltose and inorganic phosphate into β-D-glucose-1-phosphate and glucose.</p>

<p>Protoporphyrin IX disodium, as a radiation sensitizer, enhances the production of ROS and induces DNA damage even under hypoxic conditions. It also acts as a photosensitizer, undergoing direct degradation through photobleaching upon light exposure. This compound accumulates in rat tumor cells following administration of 5-aminolevulinic acid (5-ALA). When activated with a peak wavelength of 405 nm, Protoporphyrin IX disodium selectively improves basal cell carcinoma. It shows promise in pharmacological research of sonodynamic and photodynamic therapy for cancers such as bladder cancer and nodular basal cell carcinoma.</p>

<p>3-Phenoxybenzoic acid is a natural product for research related to life sciences. The catalog number is T35359 and the CAS number is 3739-38-6.</p>

<p>Taurocholic Acid-d4 Sodium is a deuterium-labelled, which can be used for isotopic tracing.Taurocholic Acid is an immunomodulatory bile acid.</p>

<p>p-Tolualdehyde is a RIFM flavor that shows inhibition of mushroom tyrosinase.</p>

<p>DL-α-tocopherol acetate (Vitamin E acetate) is a vitamin E derivative used as a vitamin E supplement in poultry feed.</p>

<p>Protirelin (Thyroliberin) is a tripeptide that stimulates the release of thyrotropin and prolactin.</p>

<p>Angiotensin-converting enzyme (Kininase II) is a zinc-dependent peptidase and extracellular enzyme that is a potent vasoconstrictor.</p>

<p>2'-Deoxy-N2-methylguanosine is a purine nucleoside analog that can be used as a chemical probe to study DNA-protein interactions.</p>

<p>Imidazol-1-yl-acetic acid is a natural product used in life sciences research (Catalog No. T67657, CAS No. 22884-10-2).</p>

<p>GDP-α-D-mannose disodium gives a competitive inhibition with respect to GTP (Ki 14.7 μM) and an uncompetitive inhibition with respect to mannose-1-P (Ki 115 μM</p>

<p>4,4-Dimethoxy-2-butanone showed subacute oral toxicity in experiments on rats.</p>

<p>Metoprolol acid is a urinary metoprolol metabolite and doesn't work pharmacologically.</p>

<p>Plumbic acetate releases acetate ions, acts as an oxidizer for sulfur (VI) synthesis, and reacts with thiodithiazyl dichloride.</p>

<p>Isethionic acid, organosulfur, in F. cylindrus, forms biodegradable surfactants; water-soluble, high-foaming.</p>

<p>N-Acetyl-L-histidine monohydrate is a natural product for research related to life sciences. The catalog number is T38094 and the CAS number is 39145-52-3.</p>

<p>Aglepristone: synthetic steroid, antiprogestogen, some antiglucocorticoid effect, used as abortifacient in animals.</p>

<p>Ascr#2 (asc-C6-MK) is a glycoside analog in Cryptobacterium hidradii that promotes dauer formation and can be used to detect population density.</p>