Apoptosi

<p>Methylstat is a methyl ester prodrug of a Jumonji C domain-containing histone demethylase (JMJD) inhibitor that has favorable cell permeability.</p>

Hydroxy-PP-Me is a CBR1 inhibitor that inhibits apoptosis induced by serum withdrawal.Hydroxy-PP-Me is used in the study of leukemia.

<p>Fmoc-D-Cha-OH (FDCO) is an apoptotic DNase γ inhibitor that inhibits the release of HMGB1.</p>

Fluorizoline is a PHB-binding compound with anticancer and antiproliferative activity and induces apoptosis.

Mardepodect hydrochloride (Mardepodect HCl) is a PDE10A inhibitor.Mardepodect hydrochloride upregulates genes encoding specific growth factors.

Forodesine inhibits lymphocyte growth and induces apoptosis in leukemic cells; oral purine nucleoside phosphorylase blocker; IC50: 0.48-1.57 nM.

3,4,5-Trihydroxycinnamic acid decyl ester is an anti-obesity agent that inhibits lipid absorption and pancreatic lipase (EC50 ≈ 0.9μM).

MPPa, a PDT photosensitizer derived from chlorophyll a, absorbs at 667/674 nm with no dark cytotoxicity.

Benzyl selenocyanate is a chemopreventive agent that effectively inhibits chemically induced tumors at both initiation and postinitiation stages in animal models. It acts as a potent inhibitor of DNA (cytosine-5)-methyltransferase (Mtase) with an IC50 of 8.4 μM.

Sonrotoclax is a potent, orally active inhibitor of Bcl2, demonstrating effective cell-killing activity against a range of lymphoma and leukemia cell lines [1].

Amifostine thiol (WR-1065), an active Amifostine metabolite, is a radioprotective cytoprotectant that activates p53 via JNK pathway.

(R)-CR8 trihydrochloride (CR8, (R)-Isomer trihydrochloride) is a CDK1/2/5/7/9 inhibitor with neuroprotective activity that induces apoptosis.

(-)-Apomorphine hydrochloride hydrate is a broad-spectrum dopamine agonist and ferroptosis inhibitor.

Cerivastatin sodium (BAY W 6228 sodium) is an HMG-CoA reductase inhibitor with lipid-lowering activity that reduces LDL cholesterol levels.

Necrostatin 2 is a RIPK1 inhibitor that can be used to study inner ear disorders such as sudden deafness, dizziness and tinnitus.

Deferasirox (Fe3+ chelate) is an iron chelator with anticancer activity and can be used to study iron overload.

<p>6-Formylpterin (Pterin-6-aldehyde) is an inhibitor of Xanthine Oxidase, which induces ROS generation and apoptosis in HL-60 cells.</p>

LNnT is a metabolite that reduces IL-8, has anti-inflammatory effects, and aids in wound healing.

Venetoclax-d8 (ABT-199-d8) is a deuterated form of Venetoclax, a potent, selective, and orally active Bcl-2 inhibitor that induces autophagy and apoptosis.

Momelotinib sulfate is an ATP-competitive JAK1/JAK2 inhibitor (IC50: 11 nM/18 nM). It has 10-fold selectivity versus JAK3.

TH1834 is a specific inhibitor of Tip60/KAT5 histone acetyltransferase. TH1834 induces apoptosis and DNA damage in MCF.

Furazolidone (Standard) is the standard substance of Furazolidone, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Furazolidone (Furoxone), a nitrofuran derivative, inhibits AML1-ETO transformed cells with IC50 value of 12.7 μM. It is antibacterial and antiprotozoal activity,

NU 9056 is an effective and selective inhibitor of KAT5 histone acetyltransferase with an IC50 of 2 µM.

MC1742 inhibits class I/IIb HDACs, blocks sarcoma CSC growth, and reactivates latent HIV. IC50: HDAC1-3/8 (0.02-0.61 μM), HDAC6/10 (7-40 nM).

CLZ-8 (Mcl1-IN-8) is a Mcl-1-PUMA inhibitor with radioprotective activity and inhibits radiation-induced overexpression of PUMA.

C8 Ceramide, a cell-permeable analog, is analog to naturally occur ceramides.

GLP-2, an intestinal growth factor, may treat various human intestinal diseases.

Phenoxyethanol (Standard) is the standard substance of Phenoxyethanol, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Phenoxyethanol (NSC-1864) is germicidal. It often used together with quaternary ammonium compounds.

Saquinavir mesylate (Ro 31-8959/003) is an Inhibitor of HIV Proteaseused in antiretroviral therapy

4-Benzoyl-L-phenylalanine is an L-phenylalanine derivative and optically active amino acid.

<p>5-Methoxyuridine (Mo5U) is an antitumor purine analog that inhibits DNA synthesis and induces apoptosis in lymphatic cancers.</p>

PRDX1-IN-1 is a and PRDX1 inhibitor with potential anti-inflammatory and anti-cancer activity for the study of breast and esophageal cancer.

CCW16 is a covalent E3 ubiquitin ligase RNF4 ligand, cysteine reactivity, inducing ferroptosis in AML cells by activating ROS signalling.

RKI 1447 dihydrochloride: selective ROCK inhibitor, inhibits colorectal cancer growth, promotes apoptosis (ROCK1 IC50=14.5 nM, ROCK2 IC50=6.2 nM).

Melflufen HCl: prodrug of Melphalan, has antitumor and antiangiogenic effects, causes DNA damage in MM cells.

Monensin sodium salt (Standard) is the standard substance of Monensin sodium salt, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Monensin sodium is an antiprotozoal agent produced by Streptomyces cinnamonensis.Monensin sodium salt (Monensin A sodium salt) causes a marked enlargement of the MVBs and regulates exosome secretion

Iodoacetyl-LC-Biotin (Iaa-Biotin) is a sulfhydryl-responsive probe that forms irreversible thioether bonds at alkaline pH, label protein cysteines.

N-deacetylated BMS-202 is an inhibitor of PD-1/PD-L1 interaction with potential anticancer activity for cancer research.

Hematoporphyrin monomethyl ether is a porphyrin photosensitizer that can be used in studies of port wine stains.

Citrinin: a mycotoxin with antifungal, antibacterial, potential anticancer, and neuroprotective properties; contaminates food.

PT-262: ROCK inhibitor, causes cytoskeleton change, halts lung cancer cell migration.

Olanzapine D3 is the deuterium labeled Olanzapine.

Zinc pyrithione (Standard) is an analytical standard and reference sample. Zinc pyrithione (OM-1563) disrupts membrane transport by inhibiting proton pumps.

PARG-IN-4 (compound A) is an orally active and cell-membrane permeable PARG inhibitor (EC50=1.9 nM) that inhibits tumour growth in mice with antitumour .

Primidone (Standard) is the standard substance of Primidone, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Primidone (NCI-C56360) is a potent anticonvulsant agent. It is a neuronal voltage-gated sodium channel blocker and has value in the study of epilepsy, essential tremor, and psychiatric disorders.

Thalidomide-Piperazine 5-fluoride: a cereblon ligand-linked E3 ligase via PROTAC tech.

JRD-SIK1/2i-4 is a SIK1/2 inhibitor that induces nuclear translocation of CRTC3 at low micromolar concentrations. It is expected to saturate SIK1 and SIK2, but not SIK3.

Compound PDK0035, with CAS No. 119-65-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0035 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Thalidomide-based E3 ligase linker for PROTACs with a PEG3 chain and hydrochloride salt.

Devazepide is a competitive, selective, orally available non-peptide CCK1 receptor antagonist that inhibits proliferation, induce apoptosis.

BCL6-IN-5 is a highly effective inhibitor of BCL6. It exhibits a pIC50 value of 5.82.

Acyclovir (Aciclovir) hydrochloride is an effective oral antiviral agent with potent anti-herpetic activity. It exhibits IC50 values of 0.85 μM for HSV-1 and 0.86 μM for HSV-2, indicating strong inhibitory effects against these strains. Additionally, Acyclovir hydrochloride induces cell cycle disturbances and apoptosis. This compound also prevents bacterial infections during induction therapy for acute leukemia.

Apremilast D5 (CC-10004 D5) is a deuterium-labeled Apremilast.

Ezatiostat (TER199(free base)) is a tripeptide analog of glutathione that can selectively inhibit GSTP1-1 catalytic activity.

Thalidomide-O-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate used in the PROTAC dTAG-13, a degrader of FKBP12F36V and BET[1].

Alternariol (Standard) is the standard substance of Alternariol, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Alternariol (AOH), a mycotoxin synthesized by Alternaria species, displays numerous therapeutic and biological effects, including phytotoxic, cytotoxic, anti-HIV, anti-cancer, and anti-microbial properties. It functions by inhibiting the catalytic activity of topoisomerase I and II enzymes.

Rutin trihydrate is a natural flavonoid with antioxidant, anti-inflammatory, anti-diabetic, and anti-cancer benefits, plus heart and brain protection.

PETCM is a caspase-3 activator and acts as an cytochrome c (cyto c)-dependent manner.

Mycophenolic acid-d3 is a derivative that lowers GTP, affects RNA polymerase II transcription, changes polyadenylation, and counters cordyceps.

Capecitabine-d11 is a deuterated compound of Capecitabine. Capecitabine has a CAS number of 154361-50-9. Capecitabine is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU); subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into the RNA strand.

Pyraclostrobin (Standard) is the standard substance of Pyraclostrobin, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Pyraclostrobin is one of the most heavily used fungicides that inhibits mitochondrial complex III of fungal and mammalian cells.

Sodium catechol sulfate is a bioactive chemical.

Curcumin D6 (difluoroformylmethane D6) is deuterium-labeled curcumin (Turmeric yellow). Curcumin (Turmeric yellow) is a natural phenolic compound with various pharmacological effects, including anti-inflammatory, antioxidant, anti-proliferative and anti-a

α-Vitamin E (Standard) is the standard substance of α-Vitamin E, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. α-Vitamin E (Dexrabeprazole Sodium) is a naturally-occurring form of vitamin E, a fat-soluble vitamin with potent antioxidant properties.

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Metformin-d6 hydrochloride (Metformin-d6 hydrochloride) is a deuteride of Metformin, which can be used to study Metformin metabolism in vivo.

Thioridazine: an antipsychotic, anti-anxiety drug, blocks dopamine D2, PI3K-Akt-mTOR; halts angiogenesis, kills cancer cells, targets CSCs.

SEN177 shows the potential in the research of Huntington's disease that is a potent inhibitor of glutaminyl cyclase (QPCT) with an IC 50 of 0.013μM for glutaminyl-peptide cyclotransferase-like (QPCTL). The Ki value of SEN177 for human glutaminyl cyclase (hQC) is 20 nM. SEN177 significantly reduces the early stages of mutant HTT oligomerisation and reduces the percentage of neurons with Q80 aggregates [1].

Diuron is an orally active benzoylurea herbicide. Diuron inhibits the production of ATP and NADH,, ROS and cancer.

Methopterin shows the activation and bone resorption function of murine osteoclasts.

<p>Sodium cyclamate is a carbonic anhydrase inhibitor, artificial sweetener, with anticonvulsant properties, and used in cancer research.</p>

SLC7A11-IN-1 is an SLC7A11 inhibitor with antiproliferative activity, inhibiting cell invasion and metastasis, useful for research on neurological diseases.

COX-2 expression inhibitor

PBOX 6 is a pyrrolo-1,5-benzoxazepine (PBOX) compound with anticancer and antitumor activity that inhibits the growth of breast cancer cells.

Traumatic Acid aids wound healing in plants by stimulating cell division to create a callus.

SC144 hydrochloride: oral gp130 inhibitor, blocks Stat3 and gene expression, triggers apoptosis in ovarian cancer cells.

Tubulin inhibitor 1 blocks tubulin polymerization, with strong anti-tumor effects, induces apoptosis and G2/M mitotic arrest.

Diphenyl disulfide fights breast cancer by inducing cell death and stopping growth.

Acyclovir sodium is an antimetabolite. Acyclovir sodium inhibits HSV-specified DNA polymerases and prevents further viral DNA synthesis.

Sildenafil-d8 is a deuterated compound of Sildenafil. Sildenafil has a CAS number of 139755-83-2. Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor, used to treat erectile dysfunction and reduce symptoms of pulmonary arterial hypertension (PAH).

IST5-002 (N6-Benzyladenosine-5'-phosphate) is a Stat5a/b inhibitor with anticancer activity and is used in cancer research.

Tacrolimus-13C-d2 is the 13C and deuterated compound of Tacrolimus.

Pitavastatin D4 is deuterium labeled Pitavastatin. Pitavastatin is a potent inhibitor of HMG-CoA reductase.

Thalidomide-piperazine HCl may aid leprosy, multiple myeloma research, and developmental biology studies.

<p>6-Azauridine is a purine analog with antitumor effects, inhibiting DNA synthesis and inducing apoptosis in lymphatic cancers.</p>

Edaravone, a potent free radical scavenger, prevents MMP-9-induced brain bleeds in rats and has a deuterium variant, Edaravone D5.