Apoptosi

<p>Ascorbyl palmitate (L-Ascorbic acid 6-hexadecanoate), an ester formed from ascorbic acid and palmitic acid, produces a fat-soluble form of vitamin C.</p>

<p>Lercanidipine (Masnidipine) is a calcium channel blocker of the dihydropyridine class.</p>

MYCMI-6 inhibits MYC:MAX, reduces tumor growth, triggers apoptosis, minimal side effects.

Adarotene (ST1926) induces apoptosis, causes DNA damage, and has strong antiproliferative effects on human tumors.

Propafenone: a drug for ventricular arrhythmias with mild beta-blocker activity, prolongs refractory period, and reduces heart automaticity.

Fenobam shows inverse agonist activity which blocks the mGlu5 receptor basal activity(IC50: 84 nM).

Trifluridine is a fluorinated thymidine analog with antineoplastic and antiviral properties, disrupting DNA and protein synthesis, leading to apoptosis.

JQAD1, a potent EP300 degrader (DC50≤31.6 nM), induces apoptosis, suppresses tumor growth, and selectively downregulates CRC and MYCN without affecting CBP.

<p>MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept,and as a new class of anticancer agent.</p>

Mirodenafil is a PDE-5 inhibitor developed for the treatment of erectile dysfunction.

Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities.

Lirentelimab (AK002) is a humanized anti-Siglec-8 antibody that induces IL-5-activated apoptosis in eosinophils and inhibits IL-5-mediated mast cell activation.

Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human RANKL. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human RANKL. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human RANKL, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human RANKL in the samples is then determined by comparing the OD of the samples to the standard curve.

Hexylresorcinol (4-Hexylresorcinol) is a substituted dihydroxybenzene used topically as an antiseptic for the treatment of minor skin infections.

Tea polyphenol, also called green tea extract, are a mixture of chemical compounds, such as flavanoids and tannins, found naturally in tea.

Chlorhexidine dihydrochloride (NSC-185) is a disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.

Letolizumab (BMS-986004) is a dimeric antibody that targets CD40L.

HLY78, a Wnt/β-catenin activator, enhances Axin-LRP6 binding by targeting Axin's DIX domain.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human PDCD1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human PDCD1. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human PDCD1, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human PDCD1 in the samples is then determined by comparing the OD of the samples to the standard curve.