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Apoptosi

Apoptosi

Gli inibitori dell'apoptosi sono composti che prevengono o ritardano il processo di morte cellulare programmata, noto come apoptosi. Questi inibitori sono fondamentali per lo studio dei meccanismi di sopravvivenza cellulare e vengono utilizzati per indagare sulle malattie in cui l'apoptosi è disregolata, come il cancro, i disturbi neurodegenerativi e le malattie autoimmuni. Modulando l'apoptosi, questi inibitori possono aiutare nello sviluppo di terapie mirate a controllare la morte cellulare. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'apoptosi di alta qualità per supportare le tue ricerche in biologia cellulare, oncologia e campi correlati.

Sottocategorie di "Apoptosi"

Mostrare 6 più sottocategorie

Trovati 6063 prodotti di "Apoptosi"

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  • EGFR-IN-161
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    EGFR-IN-161

    CAS:
    EGFR-IN-161 (Compound DD-8) is a potent and reversible inhibitor of the L858R/T790M/C797S mutant EGFR kinase, with an IC50 value of 0.87 nM. EGFR-IN-161 effectively inhibits tumor cell apoptosis, G1 phase arrest, and migration.
    Formula:C33H36Cl2N8O2
    Colore e forma:Solid
    Peso molecolare:647.597

    Ref: TM-T206760

  • NSD2-IN-1
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    NSD2-IN-1

    CAS:
    NSD2-IN-1: potent, selective NSD2-PWWP1 inhibitor, IC50 0.11 μM, induces gene expression changes, apoptosis, cell cycle arrest.
    Formula:C29H31N5
    Colore e forma:Solid
    Peso molecolare:449.59

    Ref: TM-T62705

  • Logo CymitQuimica
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    PD-1/PD-L1-IN-17

    <p>PD-1/PD-L1-IN-17 (Compound P20) is a potent PD-1/PD-L1 inhibitor (IC50: 26.8 nM).</p>
    Formula:C23H20ClN3O4
    Colore e forma:Solid
    Peso molecolare:437.88

    Ref: TM-T62501

  • Logo CymitQuimica
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    Topoisomerase I/II inhibitor 4

    Topoisomerase I/II inhibitor 4 halts cell growth and spread, induces apoptosis, and is used in liver cancer research.
    Formula:C27H21N5O6
    Colore e forma:Solid
    Peso molecolare:511.49

    Ref: TM-T63526

  • MI-888 TFA
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    MI-888 TFA

    CAS:
    MI-888 (TFA) is an orally active inhibitor of the MDM2-p53 interaction with a Ki of 0.44 nM. It can induce rapid, complete, and durable tumor regression in xenograft mouse models.
    Formula:C30H33Cl2F4N3O5
    Colore e forma:Solid
    Peso molecolare:662.5

    Ref: TM-T205437

  • 2-Deoxy-L-ribose
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    2-Deoxy-L-ribose

    CAS:
    2-Deoxy-L-ribose is the stereoisomer of 2-Deoxy-D-ribose and can inhibit the anti-apoptotic effects of 2-Deoxy-D-ribose. Additionally, 2-Deoxy-L-ribose is capable of suppressing tumor cell metastasis by downregulating thymidine phosphorylase overexpression.
    Formula:C5H10O4
    Colore e forma:Solid
    Peso molecolare:134.13

    Ref: TM-T205283

  • (R)-SL18
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    (R)-SL18

    CAS:
    (R)-SL18 is a degrader of ANXA3 that facilitates its breakdown via ubiquitination. This compound can inhibit the proliferation, migration, invasion, and colony formation of breast cancer cells, while also inducing apoptosis. (R)-SL18 is applicable for research in triple-negative breast cancer.
    Formula:C26H21ClN6O5S2
    Colore e forma:Solid
    Peso molecolare:597.065

    Ref: TM-T205446

  • PD-L1/VISTA-IN-1
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    PD-L1/VISTA-IN-1

    CAS:
    <p>PD-L1/VISTA-IN-1 (Compound P17) is an orally active dual inhibitor targeting PD-L1 and VISTA. It effectively hinders the PD-1/PD-L1 interaction (IC50: 0.1492 μM) and the VISTA pathway (KD: 0.2723 μM), leading to the reactivation of T cells. Additionally, PD-L1/VISTA-IN-1 exhibits antitumor activity.</p>
    Formula:C22H24N4O4
    Colore e forma:Solid
    Peso molecolare:408.45

    Ref: TM-T205067

  • SIRT-IN-7
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    SIRT-IN-7

    CAS:
    SIRT-IN-7 (Compound 7ba) is a SIRT inhibitor. It effectively suppresses the expression of SIRT1, SIRT2, and SIRT3, leading to increased acetylation and activation of p53. Additionally, SIRT-IN-7 inhibits the proliferation of breast cancer cells and induces apoptosis and autophagy, demonstrating antitumor activity.
    Formula:C24H16BrClN2OS
    Colore e forma:Solid
    Peso molecolare:495.819

    Ref: TM-T205485

  • PKM2 modulator 2
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    PKM2 modulator 2

    CAS:
    <p>PKM2 modulator 2 (compound C599) is a potent inhibitor of PKM2, displaying antiproliferative activity and inducing apoptosis. This compound holds potential for research in glioblastoma.</p>
    Formula:C21H13FN4O3
    Colore e forma:Solid
    Peso molecolare:388.351

    Ref: TM-T205205

  • DDO-8958
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    DDO-8958

    CAS:
    DDO-8958 is an orally active and selective BET BD1 inhibitor, exhibiting a KD of 5.6 nM for BRD4 BD1. It shows low nanomolar inhibitory activity across all BET BD1 bromodomains except for BRDT BD1. DDO-8958 inhibits tumor cell proliferation and migration, induces apoptosis and cell cycle arrest, and demonstrates antitumor activity.
    Formula:C22H22FN5O2
    Colore e forma:Solid
    Peso molecolare:407.441

    Ref: TM-T205605

  • SSB-2548
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    SSB-2548

    CAS:
    SSB-2548 is a CXCR-4 inhibitor that suppresses the proliferation and migration of acute myeloid leukemia cells and induces apoptosis (apoptosis). It is well absorbed in the gastrointestinal tract and can be used for leukemia research.
    Formula:C18H17N5O2
    Colore e forma:Solid
    Peso molecolare:335.36

    Ref: TM-T205550

  • MG28
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    MG28

    CAS:
    <p>MG28 exhibits significant cytotoxic effects, likely stemming from its direct and potent DNA-damaging activity. The compound is utilized in cancer research.</p>
    Formula:C27H25NO3S
    Colore e forma:Solid
    Peso molecolare:443.56

    Ref: TM-T200946

  • PD-L1/HDAC6-IN-1
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    PD-L1/HDAC6-IN-1

    CAS:
    PD-L1/HDAC6-IN-1 (Compound HP29) is an inhibitor targeting both PD-L1 and HDAC6, effectively disrupting the PD-L1/PD-1 interaction and inhibiting HDAC6 activity, with IC50 values of 26.8 nM and 69 nM, respectively. This compound enhances the cytotoxicity of Jurkat T cells against HepG2 cells, exhibiting an IC50 of 3.4 μM. In rats, PD-L1/HDAC6-IN-1 demonstrates favorable pharmacokinetics, showing a drug exposure level of 871.62 ng·h/mL, and displays antitumor activity in a B16-F10 xenograft mouse model.
    Formula:C27H33N3O3
    Colore e forma:Solid
    Peso molecolare:447.569

    Ref: TM-T205403

  • Apoptosis inducer 36
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    Apoptosis inducer 36

    CAS:
    <p>Apoptosisinducer 36 (Compound 42) exhibits anti-leukemic activity by reducing leukemia stem cells (LSC) and inducing differentiation. It inhibits proliferation of AML cells by causing cell cycle arrest in the G1 phase, and induces PANoptosis, which includes apoptosis, pyroptosis, and necrosis.</p>
    Formula:C23H40O3Si
    Colore e forma:Solid
    Peso molecolare:392.647

    Ref: TM-T205614

  • EMT inhibitor-3
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    EMT inhibitor-3

    CAS:
    EMT inhibitor-3 (compound 11i) is an epithelial-mesenchymal transition (EMT) inhibitor that effectively suppresses the proliferation, migration, and invasion of SK-N-SH neuroblastoma cells, with an IC50 value of 2.5 μM. It induces mitochondrial-mediated intrinsic apoptosis in tumor cells by enhancing the Bax/Bcl-2 protein expression ratio, promoting the release of cytochrome C from mitochondria, and activating caspase 9 and caspase 3. EMT inhibitor-3 is applicable for cancer research.
    Formula:C29H21F2N3O4Se
    Colore e forma:Solid
    Peso molecolare:592.45

    Ref: TM-T205130

  • TZEP7
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    TZEP7

    CAS:
    <p>TZEP7 functions as an EGFR kinase inhibitor in cancer cells. It exhibits cytotoxicity and induces apoptosis within these cells. TZEP7 downregulates the anti-apoptotic protein Bcl-2, upregulates the pro-apoptotic protein Bax, and increases caspase levels. This compound holds potential for research in anticancer drug development.</p>
    Formula:C27H19ClFNS
    Colore e forma:Solid
    Peso molecolare:443.963

    Ref: TM-T205353

  • TrxR/EGFR-IN-1
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    TrxR/EGFR-IN-1

    CAS:
    TrxR/EGFR-IN-1 (Compound L1Au2) is a TrxR/EGFR inhibitor with activity against both gefitinib-sensitive and -resistant lung cancer, effectively suppressing tumor proliferation and promoting apoptosis. It enhances GPX4 degradation through autophagosome-lysosome and proteasome pathways, leading to ferroptosis. Additionally, it induces endoplasmic reticulum stress and triggers immunogenic cell death, making it applicable for studies on gefitinib-resistant lung cancer.
    Formula:C24H24AuClFN6O2P
    Colore e forma:Solid
    Peso molecolare:710.878

    Ref: TM-T205519

  • Decarbamoylmitomycin C
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    Decarbamoylmitomycin C

    CAS:
    Decarbamoylmitomycin C, an analog of Mitomycin C (MC), functions as a DNA alkylating agent. It is capable of activating chromatin relaxation by the ataxia-telangiectasia and Rad3-related protein (ATR) in a p53-independent manner.
    Formula:C14H17N3O4
    Colore e forma:Solid
    Peso molecolare:291.302

    Ref: TM-T206609

  • c-Myc inhibitor 16 iodide
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    c-Myc inhibitor 16 iodide

    CAS:
    c-Myc inhibitor16 iodide (Compound W11) is a selective inhibitor of the c-MycG-quadruplex (c-MycG4). It suppresses the transcription and translation of the c-Myc gene, disrupts the tumor cell cycle by halting growth at the G0/G1 phase, and activates mitochondrial apoptotic pathways, leading to early apoptosis in cancer cells. This compound shows potential for research in breast cancer.
    Formula:C26H24INO
    Colore e forma:Solid
    Peso molecolare:493.379

    Ref: TM-T206685