Ciclo cellulare/Checkpoint
Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.
Sottocategorie di "Ciclo cellulare/Checkpoint"
- Chinasi aurora(114 prodotti)
- CDK(546 prodotti)
- Arresto del ciclo cellulare(5 prodotti)
- Chk(48 prodotti)
- DYRK(47 prodotti)
- Dynamin(27 prodotti)
- Ferroptosi(226 prodotti)
- HSP(179 prodotti)
- Integrina(249 prodotti)
- Chinesina(87 prodotti)
- LIM chinasi(20 prodotti)
- Microtubulo associato(274 prodotti)
- PKC(124 prodotti)
- PLK(25 prodotti)
- ROCK(62 prodotti)
- Rho(6 prodotti)
- Wee1(14 prodotti)
- c-Myc(76 prodotti)
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Trovati 3864 prodotti di "Ciclo cellulare/Checkpoint"
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CDK4-IN-1
CAS:CDK4 inhibitor is a novel and specific CDK4/Cyclin D1 inhibitor with an IC50 of 10 nM; 1500 and 500 fold than CDK1/Cyclin B (IC50>15 uM) and CDK2/Cyclin A (IC50Formula:C22H29ClN8Purezza:98%Colore e forma:SolidPeso molecolare:440.97Polθ-IN-8
CAS:Polθ-IN-8 (example 77) is a DNA polymerase θ (Polθ) inhibitor with an IC50 for Polθ ATPase activity of less than 100 nM. Polθ-IN-8 is useful for researching diseases related to Polθ activity, such as cancer.Formula:C22H22ClN7O3SColore e forma:SolidPeso molecolare:499.97Terpendole E
CAS:Terpendole E is an atypical L5 site inhibitor.Formula:C28H39NO3Colore e forma:SolidPeso molecolare:437.61iPAF1C
CAS:iPAF1C is a powerful inhibitor of the polymerase-associated factor 1 complex (PAF1C) and exhibits anti-HIV activity [1].
Formula:C27H26BrFN4OColore e forma:SolidPeso molecolare:521.4212(S)-HETE
CAS:Enpatoran hydrochloride (M5049 hydrochloride) is a TLR7/8 inhibitor with antiviral activity that is used in the study of autoimmune diseases.
Formula:C20H32O3Colore e forma:SolidPeso molecolare:320.47CDK9-IN-34
CAS:CDK9-IN-34 (Compound 1b) is an inhibitor of CDK9 with an IC50 of 0.25 μM. It exhibits cytotoxicity against cancer cell lines HCT116, MCF7, and K652, with IC50 values of 1.43 μM, 3.01 μM, and 50.27 μM, respectively. Additionally, CDK9-IN-34 demonstrates antiviral activity against coronavirus 229E with an IC50 of 145.92 μM.Formula:C18H20N4Colore e forma:SolidPeso molecolare:292.38RECTAS-2.0
CAS:RECTAS-2.0 is a small molecule designed to correct RNA mis-splicing caused by the GLA c.639+919G>A mutation, intended for research in Fabry disease.
Formula:C18H17ClN4O4Colore e forma:SolidPeso molecolare:388.805USP7-IN-6
CAS:USP7-IN-6 is a potent inhibitor of ubiquitin-specific protease 7 (USP7, IC50: 6.8 nM).Formula:C41H43N7O4SPurezza:98%Colore e forma:SolidPeso molecolare:729.89NusB-IN-1
NusB-IN-1 (22r) is an oral bacterial rRNA inhibitor, effective against MRSA and VRSA.Formula:C21H16N2O3Colore e forma:SolidPeso molecolare:344.363-IN-PP1
CAS:3-IN-PP1: PKD inhibitor (IC50: 94-108 nM for PKD1/2/3), broad anticancer agent for research.Formula:C17H18N6Colore e forma:SolidPeso molecolare:306.365'-O-Dmt-n2-isobutyryl-2'-o-methyl-d-guanosine
CAS:5'-O-Dmt-n2-isobutyryl-2'-o-methyl-d-guanosine is a nucleoside synthesized through oxime ring-opening at the 5' position and methylation at the 2' position. In chemotaxis assays, 5'-O-Dmt-n2-isobutyryl-2'-o-methyl-d-guanosine demonstrates tissue affinity.Formula:C36H39N5O8Colore e forma:SolidPeso molecolare:669.724Antiviral agent 67
CAS:Antiviralagent 67 (compound PC6) is an inhibitor of DENVNS5 (RNA-dependent RNA polymerase) with a Ki value of 1.12 nM.Formula:C19H19N3OColore e forma:SolidPeso molecolare:305.374CD 10899
CAS:CD 10899, a hydroxylated metabolite of Volasertib, is pharmacologically active against Polo-like kinase 1 (PLK1) with an IC50 of 6 nM. Volasertib is an orally active, highly potent, and ATP-competitive PLK1 inhibitor. CD 10899 can be used for cancer research [1].Formula:C34H50N8O4Colore e forma:SolidPeso molecolare:634.81CDK8-IN-11
CAS:CDK8-IN-11 is a CDK8 inhibitor that demonstrates anti-proliferative activity against colon cancer cell lines and inhibits the activation of WNT/β-catenin.Formula:C19H15F3N4O2Purezza:99.74%Colore e forma:SolidPeso molecolare:388.34Ref: TM-T61742
1mg54,00€5mg114,00€10mg178,00€25mg409,00€50mg708,00€100mg982,00€1mL*10mM (DMSO)126,00€And1 degrader 1
CAS:And1 degrader 1 (Compound A15) is a degrader of acidic nucleoplasmic DNA-binding protein 1 (And1) that notably induces degradation of And1 in NSCLC cells. When combined with Olaparib (1 μM), And1 degrader 1 at a concentration of 5 μM effectively inhibits proliferation in A549 and H460 cells. This compound is applicable in cancer research studies.Formula:C26H27Cl2N3OColore e forma:SolidPeso molecolare:468.42LN-439A
CAS:LN-439A (compound LN-439A) is a novel BAP1 inhibitor that suppresses the growth of basal-like breast cancer by degrading KLF5.Formula:C24H26FN3O4Colore e forma:SolidPeso molecolare:439.48SR121566A
CAS:SR121566A is a novel non-peptide antagonist of Glycoprotein IIb/IIIa (GP IIb-IIIa).Formula:C20H25N5O4SPurezza:98%Colore e forma:SolidPeso molecolare:431.51CDK2-IN-8
CDK2-IN-8 is a potent CDK2 inhibitor (IC50= 1.74 μM). CDK2-IN-8 exhibits antiproliferative activity. CDK2-IN-8 can be used for the research of melanoma.Formula:C22H25N5O3Colore e forma:SolidPeso molecolare:407.47DNA gyrase B-IN-1
DNA gyrase B-IN-1, a potent inhibitor of P. aeruginosa DNA gyrase B, has IC50 of 2.2 μM with high affinity and stability.Formula:C23H18ClF3N6O4SColore e forma:SolidPeso molecolare:566.94Cdc7-IN-18
CAS:Cdc7-IN-18 (1-2) inhibits CDC7 enzyme (IC50: 1.29 nM) and COLO205 cell proliferation (IC50: 53.62 nM).Formula:C19H21N5OSColore e forma:SolidPeso molecolare:367.47CHK1-IN-11
CAS:CHK1-IN-11 (Compound 1) is an orally active inhibitor of checkpoint kinase 1 (CHK1). It is utilized in research focused on cancers with oncogene amplification.Formula:C20H22N8O2Colore e forma:SolidPeso molecolare:406.44p38α inhibitor 9
CAS:p38α inhibitor9 (Compound 2015) is a p38α inhibitor that effectively blocks the enzyme activity of p38α, with an IC50 of less than 20 nM. It inhibits MK2T334 phosphorylation and activates Cdc25b and Cdc25c while inactivating Wee1, leading to mitotic catastrophe, aneuploidy or polyploidy, and DNA damage. Additionally, p38α inhibitor9 can suppress colorectal cancer (CRC) metastasis.Formula:C27H24FN3O3Colore e forma:SolidPeso molecolare:457.496LNA-GTP
CAS:LNA-GTP is a nucleotide analog used in the synthesis of oligonucleotides.Formula:C11H16N5O14P3Colore e forma:SolidPeso molecolare:535.197-Methylguanosine 5′-monophosphate
CAS:7-Methylguanosine 5′-monophosphate (7-Methylguanylic acid) is a component of nucleic acids.Formula:C11H16N5O8PColore e forma:SolidPeso molecolare:377.25Valopicitabine dihydrochloride
CAS:Valopicitabine, a NS5B inhibitor, is used potentially for the treatment of HCV infection.Formula:C15H25ClN4O6Colore e forma:SolidPeso molecolare:392.84Polθ-IN-5
CAS:Polθ-IN-5 (Compound 139) is an inhibitor of DNA polymerase theta (Polθ) that exhibits antitumor activity.Formula:C23H18ClF2N7O3SColore e forma:SolidPeso molecolare:545.95SGC-CLK-1
CAS:SGC-CLK-1 is a potent and selective inhibitor of Cdc2-like kinases CLK1, CLK2, and CLK4. It effectively inhibits the growth of melanoma and glioblastoma cells.Formula:C19H15F3N6O2Colore e forma:SolidPeso molecolare:416.362′-F-UDP
CAS:2′-F-UDP is a nucleotide analogue used in the synthesis of oligonucleotides.Formula:C9H13FN2O11P2Colore e forma:SolidPeso molecolare:406.15AJI-214
CAS:AJI-214 functions as a dual-target inhibitor that specifically blocks Aurora kinase A and JAK2. By directly inhibiting Aurora kinase A, AJI-214 prevents mitotic progression and cell polarity in T cells while concurrently suppressing JAK2 activation to reduce STAT3 phosphorylation. This inhibition decreases the differentiation of TH1 and TH17 cells. AJI-214 is utilized in research focused on the modulation of immune responses and the prevention of graft-versus-host disease (GVHD).Formula:C17H13ClFN5OColore e forma:SolidPeso molecolare:357.77DYR530
CAS:DYR530 is a ligand for the target protein (protein kinase DYRK1A) of PROTAC.Formula:C23H24FN7Colore e forma:SolidPeso molecolare:417.48CDK8-IN-9
CDK8-IN-9, potent CDK8 inhibitor (IC50: 48.6 nM), curbs tumor growth, useful for colorectal cancer research.Colore e forma:SolidAJI-100
CAS:AJI-100 serves as a dual-target inhibitor, effectively blocking Aurora kinase A and JAK2, with respective IC50 values of 12.7 nM and 18.5 nM. It inhibits T cell mitosis and cell polarity by directly targeting Aurora kinase A and reduces STAT3 phosphorylation by inhibiting JAK2 activation, consequently diminishing the differentiation of TH1 and TH17 cells. This compound is utilized in researching immune response regulation and the prevention of graft-versus-host disease (GVHD).Formula:C17H14FN5OColore e forma:SolidPeso molecolare:323.32Lisavanbulin
CAS:Lisavanbulin (BAL-101553) is a prodrug of Avanbulin (BAL 27862), a microtubule-targeting agent. It exhibits antitumor activity, particularly effective against tumors with high expression of end-binding protein 1.Formula:C26H29N9O3Colore e forma:SolidPeso molecolare:515.57BWC0977
CAS:BWC0977 is an effective topoisomerase inhibitor that disrupts bacterial DNA replication by targeting both DNA gyrase and topoisomerase IV. The minimum inhibitory concentration (MIC90) of BWC0977 against MDR (multi-drug resistant) Gram-negative bacteria ranges from 0.03 to 2 µg/mL.Formula:C22H21FN6O5Colore e forma:SolidPeso molecolare:468.44Cdc7-IN-19
CAS:Cdc7-IN-19 (compound 1-1) is a potent CDC7 inhibitor with an IC 50 of 1.49 nM [1].Formula:C19H21N5O2Colore e forma:SolidPeso molecolare:351.40LNA-AMP
CAS:LNA-AMP is a nucleotide analog used in the synthesis of oligonucleotides.Formula:C11H14N5O7PColore e forma:SolidPeso molecolare:359.23GFB-12811
CAS:GFB-12811 is an orally active, selective, and potent CDK5 inhibitor, used in the study of autosomal dominant polycystic kidney disease.Formula:C22H23F4N5OPurezza:98.88%Colore e forma:SolidPeso molecolare:449.44HRO761
CAS:HRO761 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomach cancer.Formula:C31H31ClF3N9O5Purezza:98.74% - 99.62%Colore e forma:SolidPeso molecolare:702.08Ref: TM-T72107
1mg57,00€5mg118,00€10mg167,00€25mg280,00€50mg475,00€100mg708,00€1mL*10mM (DMSO)778,00€USP15-IN-1
CAS:USP15-IN-1 is a potent USP15 inhibitor (IC50 is 3.76 μM).Formula:C22H23N3O3Purezza:99.509% - 99.81%Colore e forma:SolidPeso molecolare:377.44Elacytarabine
CAS:Elacytarabine (M7594 0037), a lipid-conjugated derivative of the nucleoside analog cytarabine, is an antineoplastic drug. It has cytotoxicity in solid tumors.Formula:C27H45N3O6Purezza:97.69%Colore e forma:SolidPeso molecolare:507.66CTPS1-IN-1
CAS:CTPS1-IN-1 is a cytidine-5′ triphosphate synthase 1 (CTPS1) inhibitor with potential antitumor activity and can be used to study autoimmune diseases.Formula:C21H22N6O4S2Purezza:99.46%Colore e forma:SolidPeso molecolare:486.57VCPIP1-IN-1
CAS:VCPIP1-IN-1 is a VCPIP1 inhibitor used in cancer research.Formula:C13H15ClN2O2Purezza:99.3%Colore e forma:SolidPeso molecolare:266.72Ref: TM-T88664
1mg47,00€5mg92,00€10mg145,00€25mg281,00€50mg447,00€100mg715,00€200mg964,00€1mL*10mM (DMSO)101,00€SR 11302
CAS:SR 11302 is an inhibitor of activator protein-1 (AP-1).Formula:C26H32O2Purezza:98.65%Colore e forma:SolidPeso molecolare:376.53Ref: TM-T23384
1mg93,00€5mg137,00€10mg205,00€25mg356,00€50mg587,00€100mg888,00€1mL*10mM (DMSO)150,00€LY3143921 hydrate
CAS:LY3143921 ((S)-Example 2) hydrate is an orally active CDC7 kinase inhibitor with broad in vitro anticancer activity [1].Formula:C16H14FN5O2Purezza:98.43%Colore e forma:SolidPeso molecolare:327.31INCB086550
CAS:INCB086550 (PD-1/PD-L1-IN-8) (example 24) is a PD-1/PD-L1 inhibitor, with an IC50 <= 10 nM.Formula:C41H39N7O4Purezza:98.49%Colore e forma:SolidPeso molecolare:693.79Troxacitabine
CAS:Troxacitabine, a DNA polymerase inhibitor, is potentially used for the treatment of acute myeloid leukemia (AML). In comparison with gemcitabine, troxacitabine was equally active against MiaPaCa and was more efficacious against Panc-01.Formula:C8H11N3O4Purezza:98%Colore e forma:SolidPeso molecolare:213.19Bicyclomycin benzoate
CAS:Bicyclomycin benzoate (BCM benzoate, FR2054) is a broad-spectrum antibiotic and selective Rho protein inhibitor active against Gram-negative bacteria.Formula:C19H22N2O8Colore e forma:SolidPeso molecolare:406.39NSC639828
CAS:NSC639828 is an efficient inhibitor of DNA polymerase α, exhibiting a remarkable IC50 value of 70 μM. Additionally, NSC639828 demonstrates substantial antitumor activity, making it a promising candidate for cancer research.Formula:C18H13BrClN5O3Colore e forma:SolidPeso molecolare:462.692'-Deoxy-2'-fluoro-5-iodouridine
CAS:2'-Deoxy-2'-fluoro-5-iodouridine is a nucleoside, specifically a fluoro-modified and halo-nucleoside.Formula:C9H10FIN2O5Colore e forma:SolidPeso molecolare:372.09Tanuxiciclib
CAS:Tanuxiciclib is a cyclin dependent kinase (CDK) inhibitor, specifically designed to interfere with cell cycle progression by inhibiting the activity of CDKs, which are crucial regulators of cell division.Formula:C15H13FN6OColore e forma:SolidPeso molecolare:312.308GSK-3/CDK5/CDK2-IN-1
CAS:GSK-3/CDK5/CDK2-IN-1 is an imidazole derivative compound that inhibits cdk5, cdk2, and GSK-3.it has demonstrated applications in cancer research and the study of neurodegenerative diseases [1].Formula:C21H22N4O2Colore e forma:SolidPeso molecolare:362.4333BrB-PP1
CAS:3BrB-PP1 is an ATP-competitive analog that exhibits specific inhibitory activity towards protein kinase, particularly effective against protein kinases with mutations in the ATP-binding pocket, such as the Thr97 mutation within Sty1's ATP-binding pocket.Formula:C16H18BrN5Colore e forma:SolidPeso molecolare:360.2595'-O-DMT-N6-ibu-dA
CAS:5'-O-DMT-N6-ibu-dA can be utilized in the synthesis of oligodeoxyribonucleotides.Formula:C35H37N5O6Colore e forma:SolidPeso molecolare:623.71Formycin A
CAS:Formycin A shows antitumor and antiviral activities. Formycin A , a purine nucleoside antibiotic, is a potent human immunodeficiency virus type 1 (HIV-1) inhibitor with an EC50 of 10 μM.Formula:C10H13N5O4Purezza:98%Colore e forma:SolidPeso molecolare:267.24N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine
CAS:N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine, catalog number T66118 and CAS number 64325-78-6, is a valuable organic compound for life sciences research.Formula:C38H35N5O6Colore e forma:SolidPeso molecolare:657.727Ethynylcytidine
CAS:Ethynylcytidine is a nucleoside antimetabolite.Formula:C11H13N3O5Purezza:98%Colore e forma:SolidPeso molecolare:267.24PLK1-IN-6
PLK1-IN-6: potent, selective PLK1 inhibitor, IC50 = 0.45 nM, hinders cancer cell growth.
Formula:C28H37N9O3Colore e forma:SolidPeso molecolare:547.655'-DMT-3'-TBDMS-ibu-rG
CAS:5'-DMT-3'-TBDMS-ibu-rG is a modified nucleoside employed in deoxyribonucleic acid (DNA) synthesis.Formula:C41H51N5O8SiColore e forma:SolidPeso molecolare:769.96MitoE10
CAS:MitoE10 is an effective mitochondrial targeting antioxidant.Formula:C42H55O5PSColore e forma:SolidPeso molecolare:702.92Ref: TM-T33406
Prodotto fuori produzione6-Amino-5-nitropyridin-2-one
CAS:6-Amino-5-nitropyridin-2-one, a pyridine derivative, serves as a nucleobase within hachimoji DNA, where it is specifically paired with 5-aza-7-deazaguanine.Formula:C5H5N3O3Purezza:98%Colore e forma:SolidPeso molecolare:155.11Ribocil-C
CAS:Ribocil-C is a selective inhibitor of the bacterial riboflavin riboswitch, a synthetic analogue of flavin mononucleotide (FMN), inhibits bacterial cell growth.Formula:C21H21N7OSPurezza:98%Colore e forma:SolidPeso molecolare:419.5Tibremciclib
CAS:Tibremciclib is a cyclin-dependent kinase 4 (CDK4) inhibitor that exhibits antineoplastic properties [1].
Formula:C28H32F2N8Purezza:98%Colore e forma:SolidPeso molecolare:518.6PHI-101
CAS:PHI-101 is a checkpoint kinase 2 (Chk2) inhibitor that can be used for the study of refractory acute myeloid leukemia (AML) and ovarian cancer.
Formula:C19H19FN4O2SPurezza:99.4%Colore e forma:SolidPeso molecolare:386.44YK-2168
CAS:YK-2168 is a differentiated selective inhibitor of CDK9.
Formula:C16H18ClN5Colore e forma:SolidPeso molecolare:315.80Ref: TM-T200769
Prodotto fuori produzione
