Ciclo cellulare/Checkpoint
Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.
Sottocategorie di "Ciclo cellulare/Checkpoint"
- Chinasi aurora(111 prodotti)
- CDK(522 prodotti)
- Arresto del ciclo cellulare(4 prodotti)
- Chk(46 prodotti)
- DYRK(49 prodotti)
- Dynamin(26 prodotti)
- Ferroptosi(225 prodotti)
- HSP(180 prodotti)
- Integrina(256 prodotti)
- Chinesina(85 prodotti)
- LIM chinasi(19 prodotti)
- Microtubulo associato(285 prodotti)
- PKC(111 prodotti)
- PLK(25 prodotti)
- ROCK(67 prodotti)
- Rho(2 prodotti)
- Wee1(14 prodotti)
- c-Myc(75 prodotti)
Mostrare 10 più sottocategorie
Trovati 3739 prodotti di "Ciclo cellulare/Checkpoint"
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R-1479
CAS:R-1479 (4'-Azidocytidine) is an RdRp inhibitor with an IC50 value of 1.28 μM for HCV RNA replication in the HCV subgenomic replicon system.Formula:C9H12N6O5Purezza:98.11% - 99.95%Colore e forma:SolidPeso molecolare:284.23Catumaxomab
CAS:Catumaxomab is a rat-mouse hybrid lgG2 monoclonal and bispecific antibody that binds to the antigens CD3 and EpCAM for malignant ascites in cancer patients.Purezza:95%Colore e forma:Liquid2'-Fluoro-2'-deoxy-arabinoadenosine 5'-triphosphate triethylamine
2’-Fluoro-2’-deoxy-arabinoadenosine 5’-triphosphate (triethylamine) is a purine nucleoside analog with significant antitumor properties, particularly effectiveFormula:C34H75FN9O12P3Colore e forma:SolidPeso molecolare:913.93JAMM protein inhibitor 2
CAS:JAMM inhibitor 2 targets thrombin, Rpn11, MMP2 with IC50s 10, 46, 89 μM, aids cancer research.Formula:C21H26N2O2Purezza:98.57%Colore e forma:SolidPeso molecolare:338.442'-(2-Nitrobenzyl)-ATP trisodium
2'-(2-Nitrobenzyl)-ATP trisodium is an rATP analogue that acts as a transcription terminator. It inhibits T7 RNA polymerase from continuing RNA chain extension.Formula:C17H18N6Na3O15P3Colore e forma:SolidPeso molecolare:707.973615'-O-DMT-Bz-rC
CAS:<p>5’-O-DMT-Bz-Rc is a modified nucleoside and can be used to synthesize DNA or RNA.</p>Formula:C37H35N3O8Colore e forma:SolidPeso molecolare:649.69Obtustatin
<p>Potent α1β1 integrin inhibitor, 0.8 nM IC50 for IV collagen binding. Selective over other integrins. Inhibits FGF2 angiogenesis; antitumor in mouse models.</p>Formula:C184H284N52O57S8Purezza:98%Colore e forma:SolidPeso molecolare:4393.07α2β1 Integrin Ligand Peptide
CAS:The Asp-Gly-Glu-Ala (DGEA) amino acid domain of type I collagen interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellularFormula:C14H22N4O9Purezza:98%Colore e forma:SolidPeso molecolare:390.35SMS 121
CAS:SMS 121 is a novel CD36 inhibitor that impairs fatty acid uptake and cell viability in acute myeloid leukaemia (AML) cells.Formula:C20H21NO5Purezza:98.29%Colore e forma:SoildPeso molecolare:355.38Chrysomycin A
CAS:Chrysomycin A is an antibiotic that can be derived from Streptomyces.Formula:C28H28O9Colore e forma:SolidPeso molecolare:508.52Farletuzumab
CAS:Farletuzumab (MORAb-003), a humanized antibody, inhibits FRα-expressing cell growth for cancer research.Purezza:> 95%Colore e forma:LiquidPeso molecolare:145.36 kDaCTP Synthetase-IN-1 Ammonium salt
<p>CTP Synthetase-IN-1 Ammonium salt is a CTPS inhibitor with potential antibacterial, anti-inflammatory, and antitumor activity for the study of SARS-CoV-2 viral infections</p>Formula:C20H22F3N7O3S2Purezza:99.97%Colore e forma:SolidPeso molecolare:529.56TAS-119
CAS:TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95Formula:C23H22Cl2FN5O3Purezza:99.65%Colore e forma:SolidPeso molecolare:506.36RNA splicing modulator 1
CAS:<p>RNA Splicing Modulator 1 (Compound 233) is a modulator of RNA splicing, exhibiting an AC50 value of less than 100 nM [1].</p>Formula:C19H20N6OSColore e forma:SolidPeso molecolare:380.47(E/Z)-THZ1 2HCl
CAS:<p>THZ1 2HCl: selective CDK7 allosteric inhibitor, IC50 3.2 nM, hinders cancer cell growth.</p>Formula:C31H30Cl3N7O2Purezza:99.51%Colore e forma:SolidPeso molecolare:638.98Echistatin
CAS:Potent αVβ3 integrin blocker, stops osteoclast binding & bone loss, hinders platelet aggregation. Ki=0.27 nM, IC50s: 0.1 nM (bone), 30 nM (platelets).Formula:C217H341N71O74S9Purezza:98%Colore e forma:SolidPeso molecolare:5417.1Clofarabine-5'-diphosphate
CAS:Clofarabine-5'-diphosphate (Clofarabine-DP) is a metabolite resulting from the phosphorylation of Clofarabine by deoxycytidine kinase (dCK). It can undergo further phosphorylation to become Clofarabine-5'-triphosphate, exhibiting cytotoxicity in cancer cells by inhibiting DNA synthesis and repair.Formula:C10H13ClFN5O9P2Colore e forma:SolidPeso molecolare:463.64GSK270822A
CAS:<p>GSK270822A is a selective ROCK1 inhibitor. GSK270822A exhibits IC50 of 9nM, 1100nM, 1550nM for ROCK1, RSK1, p70S6K, respectively.</p>Formula:C24H20N4O2Purezza:98.64% - 99.78%Colore e forma:SolidPeso molecolare:396.44WAY-647802
CAS:<p>WAY-647802 is a CDK inhibitor.</p>Formula:C11H14N4O3Purezza:99.53%Colore e forma:SolidPeso molecolare:250.25PD-1/PD-L1-IN-51
<p>PD-1/PD-L1-IN-51 (Compound III-4) is an inhibitor of PD-1/PD-L1 (IC50: hPD-L1 at 2.9 nM). It binds directly to PD-L1, blocking the interaction between PD-1 and PD-L1, and enhancing the release of IFN-γ. Additionally, PD-1/PD-L1-IN-51 exhibits antitumor activity.</p>Colore e forma:Odour SolidN7-Methyl-2'-O-(2-methoxyethyl) guanosine
N7-Methyl-2’-O-(2-methoxyethyl) guanosine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.Formula:C14H21N5O6Colore e forma:SolidPeso molecolare:355.35CDK5-IN-1
CAS:<p>CDK5-IN-1: Potent CDK5 inhibitor (<10 nM) used in kidney disease research.</p>Formula:C24H25FN6O3SColore e forma:SolidPeso molecolare:496.56FF-10502
CAS:FF-10502, a pyrimidine analog of Gemcitabine, inhibits DNA polymerases α/β, targeting dormant cancer cells.Formula:C9H12FN3O3SColore e forma:SolidPeso molecolare:261.27FRα-targeting peptide C7 TFA
<p>FRα-targeting peptide C7 TFA is a selective peptide ligand for the folate receptor alpha (FRα) that specifically binds to FRα-expressing cells and has tumor-targeting capabilities in vivo. It is applicable in research related to tumor diagnosis and therapy.</p>Colore e forma:Odour SolidDNA Gyrase-IN-12
<p>DNA Gyrase-IN-12 (Compound 6d) is an inhibitor of DNA gyrase. It exhibits antibacterial activity with MIC values ranging from 0.031 to 0.0625 μg/mL against Vancomycin-Intermediate Staphylococcus aureus (VISA) and Enterococcus faecium.</p>Colore e forma:Odour SolidJB300
CAS:JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.Formula:C43H45ClFN7O10SColore e forma:SolidPeso molecolare:906.375CBR-2092
CAS:CBR-2092 is a DNA-directed RNA polymerase and DNA topoisomerase inhibitor.Formula:C65H81FN6O15Colore e forma:SolidPeso molecolare:1205.388PLK1-IN-2
CAS:PLK1-IN-2 is a PLK1 kinase inhibitor with an IC 50 value of 0.384 μM.Formula:C24H27FN8OSColore e forma:SolidPeso molecolare:494.59TTK/PLK1-IN-1
CAS:TTK/PLK1-IN-1 (Formula I) is a dual inhibitor of TTK (threonine tyrosine kinase) and PLK1 (polo-like kinase 1), with IC₅₀ values of 7 nM and 72 nM respectively.Formula:C30H33N7O2Purezza:97.39%Colore e forma:SolidPeso molecolare:523.63SP27
<p>SP27, a selective PROTAC, degrades PLK4 with a DC50 of 19.5 nM and may be utilized in breast cancer research [1].</p>Formula:C40H40F2N12O5Purezza:98%Colore e forma:SolidPeso molecolare:806.82Torvutatug
CAS:Torvutatug is a human IgG1κ monoclonal antibody that acts against FOLR1.Colore e forma:LiquidClofarabine-5'-diphosphate trisodium
<p>Clofarabine-5'-diphosphatetrisodium (Clofarabine-DP trisodium) is the sodium salt form of Clofarabine-5'-diphosphate. As a metabolic product of Clofarabine, it results from phosphorylation by deoxycytidine kinase (dCK). Clofarabine-5'-diphosphate trisodium can undergo further phosphorylation to form Clofarabine-5'-triphosphate, demonstrating cytotoxicity in cancer cells by inhibiting DNA synthesis and repair.</p>Formula:C10H10ClFN5Na3O9P2Colore e forma:SolidPeso molecolare:529.58DSPE-PEG3000-iRGD
DSPE-PEG3000-iRGD is a PEG compound comprising DSPE and the αv-integrin targeting peptide (iRGD). The iRGD peptide binds to αv-integrin and undergoes proteolytic cleavage within tumors to produce CRGDK/R, interacting with neuropilin-1. This results in tumor targeting and penetration capabilities. DSPE-PEG3000-iRGD is applicable in drug delivery.Colore e forma:Odour SolidViquidacin
CAS:NXL-101, an oral/IV antibiotic for Gram-positive bacteria like MRSA, was discontinued by Novexel in 2008.Formula:C25H29FN2O4S2Colore e forma:SolidPeso molecolare:504.64α-Methyl-DL-aspartic acid
CAS:α-Methyl-DL-aspartic acid specifically inhibits argininosuccinate synthase (ASS), the rate-limiting enzyme in 1-citrulline-to-1-arginine recycling.Formula:C5H9NO4Purezza:99.91%Colore e forma:SolidPeso molecolare:147.13c-Myc inhibitor 7
CAS:c-Myc inhibitor 7 degrades c-MYC, CK1α, GSPT1, IKZF1/2/3 proteins in tumors, for research on related diseases.Formula:C35H30N6O5Colore e forma:SoildPeso molecolare:614.655'-O-TBDMS-dG
CAS:5’-O-TBDMS-dG is a modified nucleoside. 5’-O-DMT-2’-O-TBDMS-rI can be used in the synthesis of deoxyribonucleic acid or nucleic acid.Formula:C16H27N5O4SiColore e forma:SolidPeso molecolare:381.50TC113
TC113, a c(RGDyK)-linked Gemcitabine, targets αvβ3 integrin, entering A549 cells, and inhibits WM266.4 and A549 cell growth.Formula:C37H50F2N12O13Colore e forma:SolidPeso molecolare:908.86IV-361
CAS:IV-361, an orally active and selective CDK7 inhibitor with a Ki value of less than or equal to 50 nM, demonstrates potent anti-cancer activity (US20190256531A1Formula:C23H32FN5O2SiColore e forma:SolidPeso molecolare:457.625(+)-Glaucarubinone
(+)-Glaucarubinone is a natural product that can be used as a reference standard.Formula:C25H34O10Colore e forma:SolidPeso molecolare:494.537N1-(2-Methyl)propyl pseudouridine
N1-(2-Methyl)propyl pseudouridine, a purine analog, targets lymphoid cancer by inhibiting DNA synthesis and inducing apoptosis.Formula:C13H20N2O6Colore e forma:SolidPeso molecolare:300.315'-O-TBDMS-N2-ibu-dG
CAS:<p>5'-O-TBDMS-N2-ibu-dG: a nucleoside derivative with strong anti-BVDV activity, useful in lead compound synthesis.</p>Formula:C20H33N5O5SiColore e forma:SolidPeso molecolare:451.59WRN inhibitor 17
CAS:<p>WRN inhibitor 17 (Compound 250) is an orally active inhibitor of Werner syndrome ATP-dependent helicase (WRN), specifically targeting the helicase domain activity of WRN. It holds potential for use in cancer research.</p>Formula:C33H34F4N4O6SColore e forma:SolidPeso molecolare:690.71CDK7-IN-5
CAS:CDK7-IN-5, a CDK7 inhibitor with an IC 50 value of less than 100 nM, exhibits potent anticancer properties (WO2015154022A1, Compound 104).Formula:C34H45N9O2Colore e forma:SolidPeso molecolare:611.795PROTAC CDK9 degrader-2
CAS:PROTAC CDK9 degrader-2, potent, selective, IC50 17 μM in MCF-7, wogonin-derived, targets CRBN.Formula:C39H36N6O10Purezza:98%Colore e forma:SolidPeso molecolare:748.745'-O-DMT-rU
CAS:5’-O-DMT-rU is a modified nucleoside and can be used to synthesize RNA.Formula:C30H30N2O8Colore e forma:SolidPeso molecolare:546.57PROTAC MTP3 degrade-1
PROTACMTP3 degrade-1 is a PROTAC degrader for MYC.Formula:C44H38N6O8Colore e forma:SolidPeso molecolare:778.275112'-Deoxy-2'-fluoro-N3-(n-dodecyl)uridine
<p>2’-Deoxy-2’-fluoro-N3-(n-dodecyl)uridine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.</p>Formula:C21H35FN2O5Colore e forma:SolidPeso molecolare:414.51N4-Benzoyl-3'-O-DMT-2'-O-(2-methoxyethyl)-5-methylcytidine
<p>N4-Benzoyl-3'-O-DMT cytidine analog inhibits DNA methyltransferases like Zebularine.</p>Formula:C41H43N3O9Colore e forma:SolidPeso molecolare:721.79Erythromycin thiocyanate
CAS:Erythromycin thiocyanate, a macrolide from Streptomyces erythreus, binds 50S ribosomes, halting protein synthesis in bacteria.Formula:C38H68N2O13SPurezza:98%Colore e forma:SolidPeso molecolare:793.02(1S,3R,5R)-PIM447 dihydrochloride
<p>(1S,3R,5R)-PIM447 (dihydrochloride) an inhibitor of PIM(IC50 of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3).</p>Formula:C24H25Cl2F3N4OPurezza:98%Colore e forma:SolidPeso molecolare:513.38Heliquinomycin
CAS:Heliquinomycin, a Streptomyces metabolite, inhibits DNA helicase (Ki=6.8 μM) and fights Gram-positive bacteria and various cancer cells.Formula:C33H30O17Colore e forma:SolidPeso molecolare:698.586LY2812223
CAS:LY2812223: selective mGlu2 agonist; binds mGlu2/mGlu3 (Ki=144/156 nM).Formula:C10H12N4O4SPurezza:98%Colore e forma:SolidPeso molecolare:284.29CPS2
CAS:CPS2: potent, selective PROTAC CDK2 degrader. IC50=24nM, targets acute myeloid leukemia research.Formula:C38H42N12O10S2Colore e forma:SolidPeso molecolare:890.9412R-LOX-IN-2
CAS:<p>12R-LOX-IN-2 is a 12R-LOX inhibitor that inhibits the hyperproliferation of psoriatic cells and can be used in the study of psoriasis and other skin diseases.</p>Formula:C19H13NOPurezza:99.84%Colore e forma:SolidPeso molecolare:271.31CDK2/PIM1-IN-1
<p>CDK2/PIM1-IN-1 is an inhibitor of the kinases CDK2 (IC50: 0.27 μM) and PIM1 (IC50: 0.67 μM). It can induce apoptosis (cell death) and reduce the expression of TNF-α, which promotes tumors. CDK2/PIM1-IN-1 exhibits antitumor activity.</p>Colore e forma:Odour Solid16,16-dimethyl Prostaglandin A1
CAS:16,16-dimethyl Prostaglandin A1 is a useful organic compound for research related to life sciences.Formula:C22H36O4Colore e forma:SolidPeso molecolare:364.526JH-XVI-178
CAS:JH-XVI-178: potent CDK8/19 inhibitor with good pharmacokinetics, low clearance, moderate oral bioavailability.Formula:C22H22ClN7OColore e forma:SolidPeso molecolare:435.925'-DMTr-3'dA(Bz)-methylphosphonami dite
5’-DMTr-3’dA(Bz)-methylphosphonamidite, a purine nucleoside analog, exhibits wide-ranging antitumor activity, specifically targeting indolent lymphoidFormula:C45H51N6O6PColore e forma:SolidPeso molecolare:802.9Emicoron
CAS:Importazole is an inhibitor of the transport receptor importin-β. It specifically inhibits importin-β likely by altering its interaction with RanGTP.Formula:C52H58N6O4Purezza:98%Colore e forma:SolidPeso molecolare:831.05N1-Methylxylo-guanosine
N1-Methylxylo-guanosine, a purine analog, targets lymphoid cancer via DNA synthesis inhibition and apoptosis.Formula:C11H15N5O5Colore e forma:SolidPeso molecolare:297.27LEB-03-146
CAS:<p>LEB-03-146: WEE1 DUBTAC linking AZD1775 to OTUB1 via PEG2; stabilizes WEE1 in HEP3B cells.</p>Formula:C46H57N11O8Colore e forma:SolidPeso molecolare:892.01EC0488
CAS:<p>EC0488 was used to synthesize EC0531, which has folic acid receptor specificity and anti-tumor activity.</p>Formula:C65H98N16O34SPurezza:98%Colore e forma:SolidPeso molecolare:1679.63αVβ8-IN-1
CAS:<p>αVβ8-IN-1 is an αVβ8 integrin inhibitor that suppresses the growth of multiple tumour cell lines (EMT6, CT26, KPC, TKCC-10).</p>Formula:C25H32ClN5O4Colore e forma:SolidPeso molecolare:502.01Garenoxacin
CAS:<p>Garenoxacin (BMS284756) is a novel oral des-fluoro(6) quinolone for the treatment of Gram-positive and Gram-negative bacterial infections.</p>Formula:C23H20F2N2O4Purezza:98%Colore e forma:SolidPeso molecolare:426.41AURKA against 1
<p>Compound Ac13, also termed AURKA against 1, acts as an inhibitor of the Aurora kinase (AURKA) with an IC50 of less than 0.5 nM, targeting the acetylation of endogenous lysine (K162) and exhibiting anti-tumor cell proliferation activity. The kinase activity of AURKA, acetylated at K162 and induced by AURKA against 1, is reversibly restored in HCT116 cells transfected with SIRT3.</p>Formula:C28H32FN9O2Colore e forma:SolidPeso molecolare:545.61Ribonuclease T1
CAS:<p>Rnase T1, an endonuclease, degrades single-stranded RNA to yield 3'-GMP oligonucleotides.</p>Colore e forma:Solid5'-ODMT cEt G Phosphoramidite (Amidite)
CAS:5'-ODMT cEt G Amidite is a safe, effective nucleic acid analog with strong antisense activity.Formula:C46H56N7O9PColore e forma:SolidPeso molecolare:881.952-Methylbutyrylcarnitine chloride
<p>2-Methylbutyrylcarnitine (chloride) acts as a gut microbial metabolite that targets integrin α2β1 on platelets, facilitating the activation of cytosolic phospholipase A2 (cPLA2) and enhancing platelet hyperresponsiveness. This compound further augments platelet hyperreactivity and promotes thrombus formation in mice. It is also characterized as a branched-chain acylcarnitine.</p>Formula:C12H24ClNO4Colore e forma:SolidPeso molecolare:281.78PKMYT1-IN-3
PKMYT1-IN-3 (compound 8ma) is a potent, selective inhibitor of PKMYT1, demonstrating an IC50 of 16.5 nM and exhibiting antitumor activity.Formula:C24H26FN5O2Colore e forma:SolidPeso molecolare:435.49Rifalazil
CAS:Rifalazil (KRM-1648) is a benzophenazine antibiotic with antibacterial activity, useful for research on chlamydia infections.Formula:C51H64N4O13Purezza:98%Colore e forma:SolidPeso molecolare:941.07Pseudouridimycin
CAS:Pseudouridimycin: a C-nucleoside antibiotic, inhibits bacterial RNAP, targets Gram-negative and Gram-positive bacteria.Formula:C17H26N8O9Purezza:98%Colore e forma:SolidPeso molecolare:486.44Sarecycline hydrochloride
CAS:Sarecycline hydrochloride is a narrow-spectrum tetracycline antibiotic with antimicrobial and anti-inflammatory activity.Formula:C24H30ClN3O8Purezza:99.23%Colore e forma:SolidPeso molecolare:523.96Anticancer agent 263
Anticanceragent 263 (compound 7) is an effective anticancer agent. It binds with the G-quadruplex DNA (G4) sequence 22-mer Pu22 (a c-Myc DNA analog). As a structural modulator, Anticanceragent 263 significantly enhances the formation of protein α-helices and has the capacity to form a supramolecular network. Furthermore, Anticanceragent 263 exhibits no cytotoxicity.Formula:C13H20N2O6Colore e forma:SolidPeso molecolare:300.308YKL-5-124 TFA
CAS:YKL-5-124 TFA is a potent CDK7 inhibitor (IC50: 53.5 nM), more than 100x selective over CDK9/2, not active on CDK12/13, and disrupts the cell cycle.Formula:C30H34F3N7O5Colore e forma:SolidPeso molecolare:629.63IBU-DC Phosphoramidite
CAS:IBU-DC Phosphoramidite is used for synthesis of oligonucleotides.Formula:C43H54N5O8PColore e forma:SolidPeso molecolare:799.906Stigmatellin
CAS:<p>Stigmatellin is an antibiotic derived from the cell mass of the myxobacterium, effective against yeasts (yeasts), filamentous fungi (filamentous fungi), and several Gram-positive bacteria (Gram-positive bacteria). Additionally, it serves as a potent inhibitor of photosynthetic electron (photosynthetic electron) transfer. Stigmatellin utilizes various sugars, polysaccharides, and acids from the citric acid cycle as substrates, inhibiting RNA and protein synthesis. It has two different inhibitory sites: one located on the reducing side of photosystem II and the other at the cytochrome b6/f complex. Stigmatellin holds potential for use in antimicrobial and photosynthesis research.</p>Formula:C30H42O7Colore e forma:SolidPeso molecolare:514.65MRK-952
MRK-952 is a NUDIX hydrolase inhibitor. NUDIX enzymes play a role in cellular metabolism, homeostasis, and mRNA processing.Formula:C20H20ClF3N6Colore e forma:SolidPeso molecolare:436.861Endo-1,4-β-xylanase
CAS:Endo-1,4-β-xylanase (CtXyn11A) is a type of xylan hydrolase that hydrolyzes the β-1,4-glycosidic bond of the xylan molecule.Colore e forma:SolidCeftriaxone
CAS:Ceftriaxone: cephalosporin antibiotic, effective against Gram-positive/negative bacteria, with anti-inflammatory/antioxidant properties.Formula:C18H18N8O7S3Purezza:96.08%Colore e forma:SolidPeso molecolare:554.58Chrexanthomycin C
<p>Chrexanthomycin C, orally active, binds DNA (G4C2)4 G4, Kd 2.8 mM, potential in ALS research.</p>Formula:C31H24O15Colore e forma:SolidPeso molecolare:636.51Cytarabine triphosphate
CAS:Ara-CTP, active Cytarabine metabolite, inhibits DNA synthesis, predicts leukemic chemosensitivity.Formula:C9H16N3O14P3Colore e forma:SolidPeso molecolare:483.16Methylcarbamyl PAF C-8
Methylcarbamyl PAF C-8 is resistant to degradation by PAF-AH and has a half-life of over 100 minutes in platelet-poor plasma, exhibiting platelet aggregation activity. In NRK-49 cells overexpressing PAF receptor, it induces the expression of c-myc, c-fos, and activates mitogen-activated protein kinase (MAPK). Furthermore, Methylcarbamyl PAF C-8 can induce G1 phase cell cycle arrest. This compound shows potential for research in cardiovascular and anti-cancer applications.Colore e forma:Odour SolidCarbazole
CAS:<p>Carbazole belongs to the class of carbazole-based organic compounds. Carbazole can form novel DNA small groove complexes, inhibiting the synthesis of new DNA or RNA.</p>Formula:C12H9NPurezza:99.82%Colore e forma:SolidPeso molecolare:167.211GS-443902 trisodium
CAS:<p>GS-443902 trisodium, a strong RdRp blocker, inhibits RSV/HCV with IC50 of 1.1/5 μM and is Remdesivir's active form.</p>Formula:C12H16N5O13P3·xNaColore e forma:Solid5-Aza-xylo-cytidine
<p>5-Aza-xylo-cytidine, a purine analog with antitumor effects, inhibits DNA synthesis and induces apoptosis in lymphoid cancers.</p>Formula:C8H12N4O5Colore e forma:SolidPeso molecolare:244.2Mps1-IN-6
Mps1-IN-6 is a potent Mps1 inhibitor that demonstrates antiproliferative and antitumor activities, exhibiting an IC50 of 2.596 nM [1].Formula:C35H39N9O3Colore e forma:SolidPeso molecolare:633.745'-O-TBDMS-dA
CAS:<p>5’-O-TBDMS-dA is a modified nucleoside and can be used to synthesize DNA or RNA.</p>Formula:C16H27N5O3SiColore e forma:SolidPeso molecolare:365.50911H-Benzo[a]carbazole
CAS:11H-Benzo[a]carbazole is a kinesin-like protein KIF11 inhibitor that can inhibit the viability of HeLa cells.Formula:C16H11NPurezza:99.14%Colore e forma:SolidPeso molecolare:217.27N6-Methyl-2'-O-(2-methoxyethyl) adenosine
N6-Methyl-2’-O-(2-methoxyethyl) adenosine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.Formula:C14H21N5O5Colore e forma:SolidPeso molecolare:339.35Anti-EMMPRIN/CD147 Antibody
Anti-EMMPRIN/CD147 Antibody is a human-derived antibody expressed in CHO cells, targeting Basigin. For an isotype control, refer to HumanIgG1kappa, Isotype Control.Colore e forma:Odour LiquidPhen-DC3 Trifluoromethanesulfonate
CAS:Phen-DC3 Trifluoromethanesulfonate targets G-quadruplexes and inhibits FANCJ/DinG helicases; IC50s: 65±6/50±10 nM.Formula:C36H26F6N6O8S2Purezza:98%Colore e forma:SolidPeso molecolare:848.75RNA polymerase II-IN-2
RNA Pol II-IN-2 (20iii) strongly inhibits Pol II (Ki=9.5 nM), is more toxic to CHO/HEK293 than α-amanitin.Formula:C41H58N10O12SColore e forma:SolidPeso molecolare:915.02KIF2C-IN-1
<p>KIF2C-IN-1 (Compound 7S9) is a selective and potent small molecule inhibitor of KIF2C. It stabilizes the interaction between KIF2C and microtubule proteins, preventing the depolymerization of polyglutamylated microtubules. KIF2C-IN-1 enhances the cytotoxicity of Paclitaxel in Paclitaxel-resistant triple-negative breast cancer (TNBC) cells and, when combined with Paclitaxel, significantly reduces tumor growth in mouse models.</p>Formula:C36H39ClN4O9SColore e forma:SolidPeso molecolare:738.21263Lorutengitide
CAS:<p>Lorutengitide is a transcription-regulating peptide with antiproliferative activity.</p>Formula:C30H50N8O12Colore e forma:SolidPeso molecolare:714.764DHFR-IN-8
DHFR-IN-8 (compound 6r), a dihydrofolate reductase (DHFR) inhibitor, disrupts purine and thymidylate biosynthesis critical for cell proliferation and growth.Formula:C18H14N6SColore e forma:SolidPeso molecolare:346.41Xanthosine-5'-Triphosphate
CAS:<p>Xanthosine-5'-Triphosphate (5'-XTP), a nucleotide derived from the deamination of purine bases, plays a crucial role in various biological processes.</p>Formula:C10H15N4O15P3Colore e forma:SolidPeso molecolare:524.1645-Methylcytidine 5′-triphosphate
CAS:5-Methylcytidine 5′-triphosphate (5-Methyl-CTP), a modified nucleoside triphosphate, enhances translational properties and stability while reducing innateFormula:C10H18N3O14P3Colore e forma:SolidPeso molecolare:497.18PAT-LM1
PAT-LM1 is a human monoclonal antibody that targets NRB54/NONO. It is applicable in the study of hematological malignancies.Colore e forma:Odour LiquidTFMU-ADPr triethylamine
<p>TFMU-ADPr triethylamine is a substrate for PARG activity measurement, releasing a fluorophore to indicate PAR hydrolase activity.</p>Formula:C25H26F3N5O16P2·5C6H15NColore e forma:SolidPeso molecolare:1024.42
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