Ciclo cellulare/Checkpoint
Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.
Sottocategorie di "Ciclo cellulare/Checkpoint"
- Chinasi aurora(111 prodotti)
- CDK(522 prodotti)
- Arresto del ciclo cellulare(4 prodotti)
- Chk(46 prodotti)
- DYRK(49 prodotti)
- Dynamin(26 prodotti)
- Ferroptosi(225 prodotti)
- HSP(180 prodotti)
- Integrina(256 prodotti)
- Chinesina(85 prodotti)
- LIM chinasi(19 prodotti)
- Microtubulo associato(285 prodotti)
- PKC(111 prodotti)
- PLK(25 prodotti)
- ROCK(67 prodotti)
- Rho(2 prodotti)
- Wee1(14 prodotti)
- c-Myc(75 prodotti)
Mostrare 10 più sottocategorie
Trovati 3739 prodotti di "Ciclo cellulare/Checkpoint"
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SHP2/CDK4-IN-1
CAS:SHP2/CDK4-IN-1: dual inhibitor, oral, potent (IC50: SHP2 4.3 nM, CDK4 18.2 nM), hinders TNBC growth, strong antitumor effects in mice.Formula:C33H35ClF2N10OSColore e forma:SolidPeso molecolare:693.21Raluridine
CAS:Raluridine is an HIV treatment inhibiting RNA-directed DNA polymerase with IC50 of 1.8 microM, compared to FLT, AZT, ddI, and ddC.Formula:C9H10ClFN2O4Purezza:98%Colore e forma:SolidPeso molecolare:264.64USP7-IN-12
CAS:<p>USP7-IN-12 (compound 1) is a potent, orally active inhibitor of Usp7, exhibiting an IC50 of 3.67 nM and demonstrating antiproliferative activity [1].</p>Formula:C29H28ClFN4O2SColore e forma:SolidPeso molecolare:551.07CDK4/6-IN-17
CAS:CDK4/6-IN-17 (compound 12) is an orally bioavailable inhibitor of CDK4/6, demonstrating potent activity with IC50 values between 10-100 nM in BE(2) cells.Formula:C27H28F4N8Purezza:98%Colore e forma:SolidPeso molecolare:540.56GW814408X
CAS:GW814408X, a kinase chemical genome group (KCGS) compound, inhibits the AURKC kinase, which is involved in cell cycle progression, checkpoint regulation, and cell division. It exhibits cell line-dependent toxicity, such as cytotoxic effects on HeLa cells, and acts as a protein kinase inhibitor across ATP-dependent and -independent luciferases, potentially impacting Fluc reporter assays [1].Formula:C19H16N6OPeso molecolare:344.37Gly-Arg-Gly-Asp-Ser TFA
CAS:Gly-Arg-Gly-Asp-Ser (TFA), osteopontin domain, binds αvβ3 and αvβ5 integrins; IC50s: ~5 μM, ~6.5 μM.Formula:C19H31F3N8O11Colore e forma:SolidPeso molecolare:604.49Aurora kinase inhibitor-8
CAS:Aurora kinase inhibitor-8 is a highly selective inhibitor of Aurora kinase.Formula:C30H29N7O3Colore e forma:SolidPeso molecolare:535.6Anti-hepatic fibrosis agent 2
CAS:Compound 6k, also known as Anti-hepatic fibrosis agent 2, is an orally active inhibitor of the COL1A1 enzyme and exerts anti-fibrogenic effects by targeting theFormula:C26H41N3OColore e forma:SolidPeso molecolare:411.623-Hydroxyxanthone
CAS:3-Hydroxyxanthone (3-Hydroxy-xanthen-9-one), a xanthone derivative, exhibits inhibitory effects on NADPH-catalyzed lipid peroxidation in human umbilical veinFormula:C13H8O3Purezza:98%Colore e forma:SolidPeso molecolare:212.2H3B-968
CAS:H3B-968 is a potent inhibitor of Werner syndrome protein (WRN) with an IC50 of approximately 10 nM, effectively targeting its helicase, ATPase, and exonucleaseFormula:C22H18F6N4O4SPurezza:98%Colore e forma:SolidPeso molecolare:548.46Mps1-IN-10
CAS:Mps1-IN-6 (Compound 9) is a highly effective Mps1 inhibitor with an IC50 value of 6.4 nM and exhibits significant anti-proliferation and anti-tumor effects onFormula:C24H27N7O2Colore e forma:SolidPeso molecolare:445.52HQ005
CAS:HQ005, a potent CCNK degrader, exhibits an impressive DC50 value of 0.041 µM and functions as a molecular-glue degrader.Formula:C15H15N5O2S2Colore e forma:SolidPeso molecolare:361.44TNH
CAS:TNH, a dimeric compound, possesses the ability to penetrate living cells and facilitate the recruitment of proteins into cellular structures [1].Formula:C39H57ClN6O13Colore e forma:SolidPeso molecolare:853.36PD-321852
CAS:PD-321852, a Chk1 inhibitor, boosts gemcitabine's effect in pancreatic cancer cells, varying from minimal in Panc1 to >30-fold in MiaPaCa2.Formula:C24H19Cl2N3O3Colore e forma:SolidPeso molecolare:468.33BMT-090605 hydrochloride
CAS:BMT-090605 HCl: AAK1 inhibitor (IC50=0.6 nM), also targets BIKE (IC50=45 nM) & GAK (IC50=60 nM), with potential in neuropathic pain research.Formula:C21H25ClN4O2Colore e forma:SolidPeso molecolare:400.91(S)-Cdc7-IN-18
CAS:'(S)-Cdc7-IN-18 from patent WO2020239107A1 inhibits CDC7, curbing MCM2 and tumor growth.'Formula:C19H21N5OSColore e forma:SolidPeso molecolare:367.47DNA Gyrase-IN-8
CAS:DNA Gyrase-IN-8 is a potent inhibitor of DNA gyrase, demonstrating antimicrobial activity with an IC50 of 8.45 µM [1].Formula:C19H14BrN5OPurezza:98%Colore e forma:SolidPeso molecolare:408.25CCT-271850
CAS:CCT-271850 is an inhibitor of the spindle checkpoint function of Monospindle 1.Formula:C24H29N7OPurezza:98%Colore e forma:SolidPeso molecolare:431.53CDK9-IN-2
CAS:CDK9-IN-2, a CDK9 inhibitor from patent WO/2012131594A1, IC50: 5 nM in A2058, 7 nM in H929 at 72hr.Formula:C23H25ClFN5Purezza:99%Colore e forma:SolidPeso molecolare:425.93RAD51-IN-4
CAS:RAD51-IN-4, a potent RAD51 inhibitor, may be useful in researching mitochondrial defect-related conditions.Formula:C31H34FN5O5S2Colore e forma:SolidPeso molecolare:639.76PLK1-IN-7
CAS:PLK1-IN-7 (compound 30e) is a potent inhibitor exhibiting an IC50 value of 0.66 nM and demonstrates significant antiproliferative and antitumor activities [1].Formula:C24H24F4N8O2Colore e forma:SolidPeso molecolare:532.49Lotrafiban hydrochloride
CAS:Lotrafiban hydrochloride is an platelet glycoprotein IIb/IIIa blocker with oral activity.Formula:C23H33ClN4O4Colore e forma:SolidPeso molecolare:464.99Balapiravir hydrochloride
CAS:Balapiravir HCl, an NS5B inhibitor, is used potentially for the treatment of HCV infection.Formula:C21H31ClN6O8Colore e forma:SolidPeso molecolare:530.96Lotrafiban
CAS:Lotrafiban: Oral GP IIb/IIIa inhibitor for treating coronary and cerebrovascular disease.Formula:C23H32N4O4Colore e forma:SolidPeso molecolare:428.52Lerociclib
CAS:<p>Lerociclib (G1T38) is a CDK4/6 inhibitor with anticancer and antitumor activities, inhibiting CDK4/CyclinD1 and CDK6/CyclinD3.</p>Formula:C26H34N8OPurezza:99%Colore e forma:SolidPeso molecolare:474.6DAM-IN-1
CAS:DMA-IN-1 is a DNA adenine methyltransferase (DAM) inhibitor with an IC50 value of 48 μM.Formula:C16H17NO4Purezza:98%Colore e forma:SolidPeso molecolare:287.31CDK9-IN-19
CAS:CDK9-IN-19: Potent CDK9 inhibitor, anti-cancer, moderate pharmacokinetics, low hERG impact, effective in AML research.Formula:C26H22F2N4O5Colore e forma:SolidPeso molecolare:508.47BIO-7662
CAS:BIO-7662 is an effective and highly selective antagonist of α4β1 integrin.Formula:C38H48N6O8SPurezza:98%Colore e forma:SolidPeso molecolare:748.89FT206
CAS:FT206 is a carboxamide inhibitor of ubiquitin-specific protease[1].Formula:C25H29N5OSColore e forma:SolidPeso molecolare:447.6TC-I 15
CAS:α2β1 integrin inhibitorFormula:C23H28N4O6S2Purezza:98%Colore e forma:SolidPeso molecolare:520.62Riviciclib
CAS:Riviciclib, a CDK inhibitor (CDK9/T1, CDK4/D1, CDK1/B), has IC50s: 20, 63, 79 nM respectively, and fights cisplatin-resistant tumors.Formula:C21H20ClNO5Purezza:98%Colore e forma:SolidPeso molecolare:401.84ML 315 hydrochloride
CAS:<p>ML 315, a selective dual inhibitor targeting CDK (Cyclin-Dependent Kinase) and DYRK (Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase) with IC50 values of 68 nM and 282 nM, respectively, is utilized in research pertaining to cancer and neurological diseases [1].</p>Formula:C18H14Cl3N3O2Colore e forma:SolidPeso molecolare:410.682CCT241533
CAS:CCT241533 is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).Formula:C23H27FN4O4Purezza:98%Colore e forma:SolidPeso molecolare:442.48TNP-351
CAS:Tnp 351 is a novel antifolate drug being assessed for chemotherapy of lung cancer.Formula:C21H24N6O5Colore e forma:SolidPeso molecolare:440.45CCT-251921
CAS:CCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor (IC50: 2.3 nM).Formula:C21H23ClN6OPurezza:99.07%Colore e forma:SolidPeso molecolare:410.9NU6300
CAS:NU6300 is a covalent CDK2 inhibitor exhibiting irreversible and ATP-competitive properties and also functions as a GSDMD (Gasdermin D) inhibitor.Formula:C20H23N5O3SPurezza:96.08%Colore e forma:SolidPeso molecolare:413.49Phototrexate
CAS:Phototrexate, a photochromic Methotrexate analog, is a UVA-activated, reversible DHFR inhibitor with antifolate properties (IC50: 6 nM cis vs. 34 μM trans).Formula:C20H19N7O5Colore e forma:SolidPeso molecolare:437.41DDD85646
CAS:DDD85646 is an inhibitor of T. brucei N-myristoyltransferase with a Ki of 1.44 nM, an IC50 of 2 nM and an EC50 of 2 nM. The IC50 of hNMT is 4 nM.Formula:C21H24Cl2N6O2SPurezza:97.8% - 99.76%Colore e forma:SolidPeso molecolare:495.43Sovesudil
CAS:Sovesudil (PHP-201) is a potent ROCK inhibitor with IC50 of 3.7 nM/2.3 nM for ROCK-I/II; lowers IOP without hyperemia.Formula:C23H22FN3O3Colore e forma:SolidPeso molecolare:407.445'-ODMT cEt N-Bzm5 C Phosphoramidite (Amidite)
CAS:<p>5'-ODMT cEt N-Bzm5 C Phosphoramidite is a strong modified nucleic acid analog for antisense oligos.</p>Formula:C49H56N5O9PColore e forma:SolidPeso molecolare:889.97ROCK-IN-9
CAS:<p>ROCK-IN-9 (Compound T345), a ROCK inhibitor, exhibits cytotoxicity in HepG2 cells with an IC50 of 40.8 μM.</p>Formula:C20H20FN5O2Purezza:98%Colore e forma:SolidPeso molecolare:381.4L-739758
CAS:L-739758 is a glycoprotein IIb/IIIa inhibitor.Formula:C22H26N4O5S3Colore e forma:SolidPeso molecolare:522.66GGTI 2147
CAS:GGTI 2147 decreased Rac1 activity, down-regulated p65 expression, and ameliorated OGD/R-induced neuronal apoptosis.Formula:C28H30N4O3Purezza:98.24%Colore e forma:SolidPeso molecolare:470.56WRN inhibitor 4
CAS:<p>WRN Inhibitor 4 (Example 107), a cyclic vinyl sulfone-based compound, serves as an inhibitor of the Werner Syndrome ATP-dependent helicase enzyme (WRN).</p>Formula:C16H14N2O5SColore e forma:SolidPeso molecolare:346.36WRN inhibitor 3
CAS:WRN Inhibitor 3 (example 110), a cyclic vinyl sulfone-based compound, serves as an inhibitor of the Werner Syndrome ATP-dependent helicase enzyme (WRN).Formula:C20H20N2O5SColore e forma:SolidPeso molecolare:400.45CDK-IN-11
CAS:CDK-IN-11, a heterocyclic compound, promotes cardiomyocyte maturation [1].Formula:C25H21BrN4O2Colore e forma:SolidPeso molecolare:489.36XL413 hydrochloride
CAS:XL413 hydrochloride (BMS-863233 Hydrochloride) is a potent, selective and ATP competitive inhibitor of Cdc7. XL413 hydrochloride also inhibits CK2 and PIM1.Formula:C14H13Cl2N3O2Purezza:98.81% - 99.8%Colore e forma:SolidPeso molecolare:326.18USP1-IN-3
CAS:USP1-IN-3 is a selective inhibitor of USPI that inhibits USPI-UAFI (IC50<30 nM). USP1-IN-3 can be used to study cancer.Formula:C27H24F3N7OColore e forma:SolidPeso molecolare:519.52c-Myc inhibitor 8
CAS:c-Myc inhibitor 8 suppresses cell growth in various cancers and is used in research.Formula:C19H12BrClF3NO3S2Colore e forma:SolidPeso molecolare:538.79UNC2170 maleate
CAS:53BP1-binding protein 1 (53BP1) engages with dimethylated lysine 20 on histone 4 (H4K20me2) through its tandem tudor domains within a homodimer configuration, crucial for the DNA damage response. UNC2170, a micromolar 53BP1 ligand, selectively interacts with this site, demonstrating at least 17-fold preference for 53BP1 over similar proteins. This interaction occurs in a pocket formed by the 53BP1's tudor domains. Moreover, UNC2170 acts as an antagonist to 53BP1 in cellular lysates, effectively inhibiting class switch recombination, a process dependent on the functional 53BP1 tudor domain, thus confirming its cellular activity.Formula:C14H21BrN2OC4H4O4Colore e forma:SolidPeso molecolare:429.31PF-6808472
CAS:PF-6808472 is a cell-permeable covalent kinase probe, reacts with conserved lysine residues within the ATP-binding site of kinases.Formula:C25H27FN8O3SPurezza:99.02%Colore e forma:SolidPeso molecolare:538.6Integrin Antagonists 27
CAS:Integrin Antagonists 27 is a small molecule integrin αvβ3 antagonist. It has a binding affinity of 18 nM and as a novel anticancer agent.Formula:C24H20N4O5Colore e forma:SolidPeso molecolare:444.44N-desmethyl Netupitant
CAS:<p>N-desmethyl Netupitant is a metabolite of Netupitant and a potential Substance-P receptor agonist.</p>Formula:C29H30F6N4OPurezza:98%Colore e forma:SolidPeso molecolare:564.57OXA-06 hydrochloride
CAS:OXA-06 hydrochloride, an ATP-competitive ROCK inhibitor, impedes anchorage-dependent growth and invasion in non-small cell lung cancer cell lines. It effectively inhibits cofilin phosphorylation without inducing apoptosis [1].Formula:C21H20Cl2FN3Colore e forma:SolidPeso molecolare:404.31Galidesivir hydrochloride
CAS:Galidesivir hydrochloride is an inhibitor of viral RNA-dependent RNA polymerase (RdRp). It inhibits SARS-CoV-2 by tightly binding to its RdRp.Formula:C11H16ClN5O3Purezza:98%Colore e forma:SolidPeso molecolare:301.73CDK9-IN-9
CAS:<p>CDK9-IN-9 is a potent and selective CDK9 inhibitor (IC50: 1.8 nM) with anti-cancer activity. It inhibits CDK2 (IC50: 155 nM).</p>Formula:C22H23F2N5O2SPurezza:98%Colore e forma:SolidPeso molecolare:459.51GSK2646264
CAS:<p>GSK2646264 (Compound 44) inhibits SYK (pIC50=7.1) and kinases like LCK, LRRK2; penetrates skin.</p>Formula:C24H26N2O2Colore e forma:SolidPeso molecolare:374.48Carotegrast
CAS:Carotegrast, an orally available α4 integrin receptor inhibitor, has anti-inflammatories activities.Formula:C27H24Cl2N4O5Colore e forma:SolidPeso molecolare:555.415-Iodo-indirubin-3'-monoxime
CAS:5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase (IC50sFormula:C16H10IN3O2Colore e forma:SolidPeso molecolare:403.17USP1-IN-6
CAS:USP1-IN-6 (Compound 11) functions as a potent USP1 inhibitor, exhibiting an IC50 value of less than 50 nM.Formula:C29H27F3N8OColore e forma:SolidPeso molecolare:560.57CDK8-IN-3
CAS:CDK8-IN-3 is an inhibitor of CDK8.Formula:C22H23N5O2Purezza:98%Colore e forma:SolidPeso molecolare:389.45CDK7-IN-22
CAS:CDK7-IN-22 (compound 101) is a selective CDK7 inhibitor that exhibits antitumor activity, demonstrating specificity for CDK7 [1].Formula:C22H25F3N6Purezza:98%Colore e forma:SolidPeso molecolare:430.47hDHODH-IN-1
CAS:hDHODH-IN-1 is an inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an anti-inflammatory effect.Formula:C17H14N2O2Purezza:99.97%Colore e forma:SolidPeso molecolare:278.31PD-1/PD-L1-IN-33
CAS:PD-1/PD-L1-IN-33 (Compound N11), a PD-1/PD-L1 inhibitor, effectively impedes the interaction between PD-1 and PD-L1 with an IC50 of 6.3 nM.Formula:C26H27N5OPurezza:98%Colore e forma:SolidPeso molecolare:425.53DNA gyrase B-IN-3
CAS:DNA gyrase B-IN-3 (Compound A), with an IC50 of less than 10 nM, acts as an inhibitor of bacterial DNA gyrase B and exhibits antibacterial activity against GramFormula:C14H9Cl2N3O4SPurezza:98%Colore e forma:SolidPeso molecolare:386.21RNA polymerase II-IN-1
CAS:RNA polymerase II-IN-1 (19iv), an amatoxin, inhibits Pol II at 36.66 nM IC50, is more toxic to cancer cells, less to normal cells than α-Amanitin.Formula:C38H53N11O12SPurezza:98%Colore e forma:SolidPeso molecolare:887.96PD-1/PD-L1-IN-34
CAS:PD-1/PD-L1-IN-34 (Compound (1S,2S)-A25) effectively inhibits the PD-1/PD-L1 interaction (IC 50 = 0.029 μM) and demonstrates selective binding affinity to PD-L1Formula:C35H33ClN2O3Purezza:98%Colore e forma:SolidPeso molecolare:565.1Aurora Kinases-IN-4
CAS:<p>Aurora Kinases-IN-4 (Compound 11c) is a covalent, ATP-competitive inhibitor of aurora kinase A with an IC50 value of 1.7 nM.</p>Formula:C26H28N8OPurezza:98%Colore e forma:SolidPeso molecolare:468.55PD-1/PD-L1-IN-26
CAS:PD-1/PD-L1-IN-26 is a strong inhibitor with IC50 of 0.0380 μM that may boost immune response in cancer by aiding CD4+ T cell entry to tumors.Formula:C43H52N4O8Purezza:98%Colore e forma:SolidPeso molecolare:752.89PD-1/PD-L1-IN-27
CAS:PD-1/PD-L1-IN-27: potent anti-cancer, IC50 134nM, minimal T cell harm, boosts CD8+ T cells, reduces fatigue.Formula:C44H35NO6Purezza:98%Colore e forma:SolidPeso molecolare:673.75CDK9-IN-29
CAS:<p>CDK9-IN-29 (compound Z11) is a potent inhibitor of CDK9, exhibiting high kinase selectivity and an IC50 value of 3.20 nM.</p>Formula:C29H33F2N5O4Purezza:98%Colore e forma:SolidPeso molecolare:553.6CDK7-IN-14
CAS:<p>CDK7-IN-14, a potent CDK7 inhibitor from pyrimidines, may treat transcriptionally dysregulated cancers (CN114249712A).</p>Formula:C22H24F3N6OPColore e forma:SolidPeso molecolare:476.43USP1-IN-5
CAS:USP1-IN-5 (compound 10) is a potent inhibitor of both USP1, with an IC50 of less than 50 nM, and MDA-MB-436 cells, where it also exhibits an IC50 of less thanFormula:C27H23F3N8OColore e forma:SolidPeso molecolare:532.52Cdc7-IN-7
CAS:<p>Cdc7-IN-7 is a potent inhibitor of Cdc7 kinase.</p>Formula:C21H22N4O5Purezza:98.78%Colore e forma:SolidPeso molecolare:410.42αvβ1 integrin-IN-2
CAS:<p>αvβ1 integrin-IN-2 (compound 32) is a potent inhibitor of ανβ1 and α5β1 integrins, exhibiting IC50 values of 0.9 nM and 33 nM, respectively.</p>Formula:C29H38N4O4Purezza:98%Colore e forma:SolidPeso molecolare:506.648-Azahypoxanthine
CAS:8-Azahypoxanthine (NSC-22709) inhibits hypoxanthine-guanine-xanthine phosphoribosyltransferase and has antimalarial properties.Formula:C4H3N5OPurezza:99.66%Colore e forma:Light Yellow To Light Beige Fine CrystallinePeso molecolare:137.1DNA polymerase-IN-3
CAS:DNA polymerase-IN-3 (Compd 5b), a coumarin derivative, demonstrates inhibitory activity against Taq DNA polymerase and has potential applications inFormula:C13H12O4Purezza:98%Colore e forma:SolidPeso molecolare:232.23Tirofiban HCl
CAS:<p>Tirofiban HCl is an antagonist of platelet glycoprotein-IIb/IIIa receptor.</p>Formula:C22H37ClN2O5SPurezza:98%Colore e forma:SolidPeso molecolare:477.068-NH2-ATP tetrasodium
CAS:<p>8-NH2-ATP tetrasodium, an inactive ATP variant, originates from 8-NH2-Ado tetrasodium, which triggers the apoptosis-associated cleavage of poly (ADP-ribose) polymerase [1] [2].</p>Formula:C10H13N6Na4O13P3Colore e forma:SolidPeso molecolare:610.12KY386
CAS:KY386 is a potent and selective DHX33 helicase inhibitor with an IC50 value of 19 nM.Formula:C21H19N5O2SColore e forma:SolidPeso molecolare:405.47Palmitoyl 3-carbacyclic phosphatidic acid
CAS:Palmitoyl 3-carbacyclic phosphatidic acid, a palmitoylated Carba-like cyclophosphatidic acid and LPA (lysophosphatidic acid) analog, possesses distinct biological activities compared to LPA, including the inhibition of RhoA activation and melanoma cell migration. This compound has demonstrated efficacy in inhibiting experimental lung metastasis and reducing tumor nodule counts in a B16-F0 xenograft mouse model [1].Formula:C20H39O5PColore e forma:SolidPeso molecolare:390.49WEE1-IN-4
CAS:Wee1 Inhibitor I is an ATP-binding site-targeting Wee1 inhibitor.Formula:C20H11ClN2O3Colore e forma:SolidPeso molecolare:362.77WRN inhibitor 5
CAS:WRN Inhibitor 5 (Example 157), a cyclic vinyl sulfone-based compound, serves as an inhibitor of Werner Syndrome ATP-dependent helicase enzyme (WRN).Formula:C23H20N2O6SColore e forma:SolidPeso molecolare:452.48LDC3140
CAS:LDC3140 is a potent inhibitor of Cyclin-dependent kinase 7 (CDK7).Formula:C23H33N7OPurezza:98%Colore e forma:SolidPeso molecolare:423.55CT1113
CAS:CT1113, a potent inhibitor of both USP28 and USP25, effectively reduces MYC levels in vivo and demonstrates anti-tumor efficacy in a mouse pancreatic cancer CDXFormula:C25H29N5O2SColore e forma:SolidPeso molecolare:463.6TC-A 2317 hydrochloride
CAS:<p>TC-A 2317 HCl inhibits Aurora A kinase (Ki 1.2 nM) over Aurora B (Ki 101 nM), displaying antitumor effects.</p>Formula:C19H29ClN6OPurezza:98%Colore e forma:SolidPeso molecolare:392.93Zaurategrast
CAS:Zaurategrast is an effective and oral-effective inhibitor of the α4-integrin.Formula:C26H25BrN4O3Purezza:98%Colore e forma:SolidPeso molecolare:521.41ML-099
CAS:ML-099 is a pan Ras-related GTPases activator that activates Rac1, Ras, GTP-binding protein (Rab7), Rab2A and cell division cycle 42.Formula:C14H13NO2SPurezza:99.73%Colore e forma:SolidPeso molecolare:259.32NVS-SM2
CAS:NVS-SM2 boosts SMN2 splicing, enhances exon 7 inclusion, and raises SMN protein levels orally.Formula:C23H30N6OColore e forma:SolidPeso molecolare:406.52PLK1/p38γ-IN-1
CAS:<p>PLK1/p38γ-IN-1 (compound 14) serves as a dual inhibitor targeting both PLK1 and p38γ kinases, effectively suppressing the proliferation of human hepatocellular</p>Formula:C21H26ClN3O2Purezza:98%Colore e forma:SolidPeso molecolare:387.9Trovafloxacin mesylate
CAS:Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).Formula:C21H19F3N4O6SPurezza:99.18%Colore e forma:SolidPeso molecolare:512.46SB-267268
CAS:SB-267268: αvβ3 inhibitor (IC50: 0.68 nM human, 0.29 nM mouse), blocks αvβ3/αvβ5 integrins (Ki: 0.9 nM human, 0.5 nM monkey αvβ3, 0.7 nM human αvβ5).Formula:C22H24F3N3O4Purezza:98%Colore e forma:SolidPeso molecolare:451.445'-ODMT cEt m5U Phosphoramidite (Amidite)
CAS:<p>5'-ODMT cEt m5U Phosphoramidite Amidite, a locked nucleic acid (LNA) analog, demonstrates exceptional safety and antisense activity [1] [2].</p>Formula:C42H51N4O9PColore e forma:SolidPeso molecolare:786.853-Cyanovinylcarbazole phosphoramidite
CAS:3-Cyanovinylcarbazole phosphoramidite: an antiviral, hinders viral DNA synthesis, modifies ribonucleotides.Formula:C50H53N4O6PColore e forma:SolidPeso molecolare:836.95BI-1950
CAS:BI-1950: potent inhibitor of LFA-1, key in immune function and drug target.Formula:C32H26Cl2FN7O3Purezza:98%Colore e forma:SolidPeso molecolare:646.55'-ODMT cEt N-Bz A Phosphoramidite (Amidite)
CAS:<p>5'-ODMT cEt N-Bz A Phosphoramidite Amidite, a locked nucleic acid (LNA) analogue, exhibits hybridization and mismatch discrimination capabilities similar to LNA, and shows resistance to exonuclease digestion [1].</p>Formula:C49H54N7O8PColore e forma:SolidPeso molecolare:899.97JNJ-26076713
CAS:JNJ-26076713, an oral alpha V integrin blocker, may treat macular edema, AMD, and diabetic retinopathy.Formula:C29H38N4O3Purezza:98%Colore e forma:SolidPeso molecolare:490.64VER-00158411
CAS:VER-00158411 is a checkpoint kinase 1 and CHK2 inhibitor (IC50: 4.4 nM and 4.5 nM, respectively).Formula:C31H34N6O3Purezza:98%Colore e forma:SolidPeso molecolare:538.64L-Methioninamide hydrochloride
CAS:L-Methioninamide hydrochloride is a potent inhibitor of methionyl-tRNA synthetase that reduces the toxicity of CDDP.Formula:C5H13ClN2OSPurezza:99.93%Colore e forma:SolidPeso molecolare:184.69Mevociclib
CAS:Mevociclib (SY-1365) is a highly selective covalent inhibitor of CDK7. SY-1365 possesses therapeutic potential in both hematological and solid tumors.Formula:C31H35ClN8O2Purezza:98.02% - 98.02%Colore e forma:SolidPeso molecolare:587.11
