Ciclo cellulare/Checkpoint
Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.
Sottocategorie di "Ciclo cellulare/Checkpoint"
- Chinasi aurora(111 prodotti)
- CDK(522 prodotti)
- Arresto del ciclo cellulare(4 prodotti)
- Chk(46 prodotti)
- DYRK(49 prodotti)
- Dynamin(26 prodotti)
- Ferroptosi(225 prodotti)
- HSP(180 prodotti)
- Integrina(256 prodotti)
- Chinesina(85 prodotti)
- LIM chinasi(19 prodotti)
- Microtubulo associato(285 prodotti)
- PKC(111 prodotti)
- PLK(25 prodotti)
- ROCK(67 prodotti)
- Rho(2 prodotti)
- Wee1(14 prodotti)
- c-Myc(75 prodotti)
Mostrare 10 più sottocategorie
Trovati 3739 prodotti di "Ciclo cellulare/Checkpoint"
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GR 122222X
CAS:GR 122222X is an inhibitor of topoisomerase II.Formula:C26H35N5O11SPurezza:98%Colore e forma:SolidPeso molecolare:625.65LNA-GDP
CAS:LNA-GDP is a nucleotide analog utilized in the synthesis of oligonucleotides.Formula:C11H15N5O11P2Colore e forma:SolidPeso molecolare:455.21NusB-IN-1
NusB-IN-1 (22r) is an oral bacterial rRNA inhibitor, effective against MRSA and VRSA.Formula:C21H16N2O3Colore e forma:SolidPeso molecolare:344.36Metesind Glucuronate
CAS:Metesind Glucuronate is an antineoplastic. It also is a specific thymidylate synthase inhibitor.Formula:C29H34N4O10SColore e forma:SolidPeso molecolare:630.67GHP-88309
CAS:<p>GHP-88309 is an orally active, broad-spectrum anti-paramyxovirus agent that targets viral polymerase, interrupting viral RNA synthesis. It effectively inhibits respiratory syncytial virus (RSV), measles virus (MeV), and canine distemper virus (CDV) with an EC50 of 0.06-1.2 μM. In mouse models, GHP-88309 demonstrates significant anti-infective activity.</p>Formula:C16H11FN2OColore e forma:SolidPeso molecolare:266.275-Methylcytosine hydrochloride
CAS:5-Methylcytosine hydrochloride plays a critical role in regulating gene expression, promoting genomic imprinting, and inhibiting transposon factors. It is also closely associated with translation fidelity and tRNA recognition.Formula:C5H8ClN3OColore e forma:SolidPeso molecolare:161.598-Oxo-dATP
CAS:8-Oxo-dATP can be hydrolyzed to its monophosphate form by the oxidation of purine nucleoside triphosphate MTH1, preventing erroneous incorporation during DNA replication or transcription.Formula:C10H12Li4N5O13P3Colore e forma:SolidPeso molecolare:530.913CBP/p300-IN-2
CAS:CBP/EP300-IN-2 is an inhibitor of CBP/EP300 (IC50s: 1.07 nM and 5.96 nM for CBP/HTRF and Myc).Formula:C27H29F2N7O2Purezza:98%Colore e forma:SolidPeso molecolare:521.56NSC 641396
CAS:NSC 641396 is a ribonucleotide reductase (RNR) inhibitor with an IC50 value of 1.2 μM. Additionally, it acts as an inhibitor of protein arginine N-methyltransferase 9 (PRMT9) and exhibits antitumor properties.Formula:C18H13NO3Colore e forma:SolidPeso molecolare:291.301Valopicitabine
CAS:<p>Valopicitabine is an effective prodrug of the effective anti-HCV drug 2'-C-methylcytidine and can be used as a promising antiviral drug for the study of chronic</p>Formula:C15H24N4O6Purezza:98%Colore e forma:SolidPeso molecolare:356.37NVP-BQS481
CAS:NVP-BQS481 (Compound 1) is a selective inhibitor of spindle motor protein 5 (Eg5), with an IC50 of less than 0.5 nM. It demonstrates significant anti-mitotic and anti-tumor activities, exhibiting an IC50 of 0.09 nM against SK-OV-3ip cells. NVP-BQS481 is suitable for use as a cytotoxic payload in the synthesis of antibody-drug conjugates (ADCs).Formula:C27H33F3N4O2Colore e forma:SolidPeso molecolare:502.57Mazethramycin
CAS:<p>Mazethramycin is an antitumor antibiotic that exerts its effects by disrupting DNA replication and RNA synthesis within cells. It is utilized in cancer research.</p>Formula:C17H19N3O4Peso molecolare:329.35Haspin-IN-1
Haspin-IN-1 blocks haspin (IC50: 119 nM) and inhibits CLK1, DYRK1A, CDK9 with potential as an anticancer drug.Formula:C12H8N4O2SColore e forma:SolidPeso molecolare:272.282′-O-MOE-AMP
CAS:2′-O-MOE-AMP is a nucleotide analogue used in the synthesis of oligonucleotides.Formula:C13H20N5O8PColore e forma:SolidPeso molecolare:405.3014α-Demethylase/DNA Gyrase-IN-1
14α-Demethylase/DNA Gyrase-IN-1 (Compound 7c) is a potent inhibitor of 14α-Demethylase/DNA Gyrase with antibacterial activity.Formula:C26H22N4O4Colore e forma:SolidPeso molecolare:454.48Cimpuciclib tosylate
CAS:Cimpuciclib tosylate, a selective CDK4 inhibitor (IC50: 0.49 nM), exhibits anti-tumor activity.Formula:C37H43FN8O4SColore e forma:SolidPeso molecolare:714.85Xanthosine-5'-Triphosphate trisodium
CAS:<p>Xanthosine-5'-Triphosphate (5'-XTP) trisodium is a nucleotide formed through the deamination of purine bases. It serves as a substrate for inosine triphosphate pyrophosphatase (ITPase).</p>Formula:C10H12N4Na3O15P3Colore e forma:SolidPeso molecolare:590.111CDK9-IN-11
CAS:CDK9-IN-11 is a potent CDK9 inhibitor that is the ligand for the PROTAC CDK9 Degrader-1 [1].Formula:C20H25N3O4Purezza:98%Colore e forma:SolidPeso molecolare:371.43Aurora B inhibitor 1
CAS:Aurora B inhibitor 1 is an Aurora B (Aurora-1) inhibitor (Ki <0.010 uM) with potential anticancer activity for cancer research.Formula:C25H26ClF2N7O2Purezza:98.37%Colore e forma:SolidPeso molecolare:529.97CHK1-IN-4
CAS:<p>CHK1-IN-4 is a potent inhibitor of checkpoint kinase 1 (chk1) and potently inhibits chk1 phosphorylation in the tumor cells with anti-tumor activity.</p>Formula:C18H18BrN7O2Purezza:98%Colore e forma:SolidPeso molecolare:444.29Ladirubicin
CAS:Ladirubicin, as an anthracyclines analog is the leading compound of alkylcyclines.Formula:C29H31NO11SColore e forma:SolidPeso molecolare:601.62PLK1-IN-11
CAS:PLK1-IN-11 (Cluster 4, 16953209) is a PLK1 inhibitor with an IC50 of 1 μM. It is applicable in research on various cancers such as pancreatic, ovarian, breast, and non-small cell lung cancer.Formula:C12H11N5OColore e forma:SolidPeso molecolare:241.2492'-(2-Nitrobenzyl)-ATP
CAS:2'-(2-Nitrobenzyl)-ATP is an analog of rATP. It acts as a transcription terminator by inhibiting the elongation of RNA chains by T7 RNA polymerase.Formula:C17H21N6O15P3Colore e forma:SolidPeso molecolare:642.30USP7-IN-10
CAS:USP7-IN-10 is a potent inhibitor of ubiquitin-specific protease 7 (USP7), exhibiting an inhibition concentration half-maximal (IC50) value of 13.39 nM.Formula:C26H29ClN4O3SColore e forma:SolidPeso molecolare:513.05SF0166
CAS:SF0166: potent αvβ3 antagonist, IC50: 0.6 nM. Blocks cell adhesion, IC50: 7.6 pM-76 nM. Reduces neovascularization in mice.Formula:C23H27F2N5O4Colore e forma:SolidPeso molecolare:475.49LIMK-IN-2
CAS:<p>LIMK-IN-2 (Compound 52), an LIMK inhibitor, has demonstrated potential anti-angiogenic activity by suppressing the cell migration of osteosarcoma and cervical cancer cells [1].</p>Formula:C28H27N5O2Colore e forma:SolidPeso molecolare:465.55Mps1-IN-8
CAS:Mps1-IN-8, a Mps1 inhibitor, can be utilized in the study of various tumors [1].Formula:C35H47N8O6PColore e forma:SolidPeso molecolare:706.77iPAF1C
CAS:<p>iPAF1C is a powerful inhibitor of the polymerase-associated factor 1 complex (PAF1C) and exhibits anti-HIV activity [1].</p>Formula:C27H26BrFN4OColore e forma:SolidPeso molecolare:521.42GSK3335103
CAS:GSK3335103 is a non-peptide, orally active inhibitor of αvβ6 integrin (pIC50=8), employed in the study of pulmonary fibrosis.Formula:C27H36FN3O4Colore e forma:SolidPeso molecolare:485.592'-F-AMP
CAS:2'-F-AMP is a nucleotide analogue used in the synthesis of oligonucleotides.Formula:C10H13FN5O6PPeso molecolare:349.21Werner syndrome RecQ helicase-IN-2
CAS:Werner syndrome RecQ helicase-IN-2 is a potent Werner syndrome RecQ DNA helicase (WRN) inhibitor, useful in research on colorectal and gastric cancers.Formula:C32H34F3N9O5Purezza:99.02%Colore e forma:SolidPeso molecolare:681.67JY-3-094
CAS:JY-3-094 is a selective Myc inhibitor that targets the hydrophobic domain of Myc and inhibits the formation of the Myc-Max heterodimer, with an IC50 of 33 μM, and can be used for cancer research.Formula:C13H8N4O5Purezza:98.72%Colore e forma:SolidPeso molecolare:300.235'-DMT-5-F-2'-dU Phosphoramidite
CAS:5'-DMT-5-F-2'-dU Phosphoramidite is a nucleoside phosphoramidite analog employed in oligonucleotide synthesis. It plays a crucial role in developing therapeutic oligonucleotides, which are used in crafting drugs for cancer treatment.Formula:C39H46FN4O8PColore e forma:SolidPeso molecolare:748.777Rhodblock 1a
CAS:<p>Rhodblock 1a is an inhibitor of the Rho kinase signaling pathway, which disrupts the localization and function of proteins within the Rho pathway. This interference hinders the proper formation of the cleavage furrow during cell division, leading to some cells either failing to form the cleavage furrow or forming a ruptured furrow, resulting in binucleated cells. Rhodblock 1a can be utilized for investigating cell division mechanisms and holds potential for research into cardiovascular diseases and cancer.</p>Formula:C20H16N2O2Colore e forma:SolidPeso molecolare:316.353PD-1/PD-L1-IN-53
CAS:<p>PD-1/PD-L1-IN-53 (compound B3) serves as an inhibitor targeting both the PD-1/PD-L1 and VISTA signaling pathways. It is utilized in cancer research.</p>Formula:C31H37N3O4Colore e forma:SolidPeso molecolare:515.64CDK4-IN-1
CAS:CDK4 inhibitor is a novel and specific CDK4/Cyclin D1 inhibitor with an IC50 of 10 nM; 1500 and 500 fold than CDK1/Cyclin B (IC50>15 uM) and CDK2/Cyclin A (IC50Formula:C22H29ClN8Purezza:98%Colore e forma:SolidPeso molecolare:440.97CDK9 autophagic degrader 1
CAS:CDK9 autophagic degrader 1 (Compound 28) is an ATTEC degrader used to target and degrade CDK9, also impacting the levels of its associated Cyclin T1. At a concentration of 100 nM, it exhibits over 80% inhibition of CDK9.Formula:C34H39N7O4S2Colore e forma:SolidPeso molecolare:673.848CDK2/4-IN-2
CAS:<p>CDK2/4-IN-2 (compound 56) serves as a dual inhibitor for CDK2 and CDK4, exhibiting an IC50 of less than 100 nM. It is applicable in cancer research.</p>Formula:C18H20F3N7O3S2Colore e forma:SolidPeso molecolare:503.52PARG-IN-6
CAS:PARG-IN-6 (Compound 2) is an orally bioavailable PARG inhibitor with an IC50 of 0.3 nM. It exhibits significant anticancer activity against cancer cells, with an IC50 of 0.0368 μM for HCC1395 cells. PARG-IN-6 shows potential for research in colon cancer, appendiceal cancer, and pancreatic cancer.Formula:C24H25F4N7O4S3Colore e forma:SolidPeso molecolare:647.69CD 10899
CAS:CD 10899, a hydroxylated metabolite of Volasertib, is pharmacologically active against Polo-like kinase 1 (PLK1) with an IC50 of 6 nM. Volasertib is an orally active, highly potent, and ATP-competitive PLK1 inhibitor. CD 10899 can be used for cancer research [1].Formula:C34H50N8O4Colore e forma:SolidPeso molecolare:634.81And1 degrader 1
CAS:<p>And1 degrader 1 (Compound A15) is a degrader of acidic nucleoplasmic DNA-binding protein 1 (And1) that notably induces degradation of And1 in NSCLC cells. When combined with Olaparib (1 μM), And1 degrader 1 at a concentration of 5 μM effectively inhibits proliferation in A549 and H460 cells. This compound is applicable in cancer research studies.</p>Formula:C26H27Cl2N3OColore e forma:SolidPeso molecolare:468.42Sovesudil hydrochloride
Sovesudil (PHP-201) HCl: potent local ROCK inhibitor; targets ROCK I/II (IC50: 3.7/2.3 nM); lowers IOP, non-congesting.Formula:C23H23ClFN3O3Colore e forma:SolidPeso molecolare:443.9OSI-7904L free acid
CAS:OSI-7904L is a folate-based thymidylate synthase inhibitor. It also has antimalarial and antitumor properties.Formula:C27H24N4O6Purezza:98%Colore e forma:SolidPeso molecolare:500.5Dyrk1A/B-IN-1
Dyrk1A/B-IN-1 (3n) is a potent DYRK1A/B inhibitor, cell-permeable, with Ki values of 67.8 nM (1A) and 237.9 nM (1B), IC50s of 1.1 and 0.8 μM.Formula:C21H17N3O2S2Colore e forma:SolidPeso molecolare:407.51BRD-7880
CAS:BRD-7880 is a potent and highly specific inhibitor of aurora kinases B and C.Formula:C32H38N4O7Colore e forma:SolidPeso molecolare:590.67MRL-436
CAS:MRL-436 is an RNA polymerase inhibitor with antibacterial activity. Its effectiveness depends on the β' subunit and the 622nd residue of the RNAP ω subunit. MRL-436 can inhibit Rifampicin-resistant RNA polymerase derivatives and shows antibacterial activity against Rifampicin-resistant strains.Formula:C24H22N4OColore e forma:SolidPeso molecolare:382.46MtTMPK-IN-7
MtTMPK-IN-7 inhibits MtbTMPK (IC50: 47 μM), active against M. brevis (MIC: 2.3-4.7 μM), useful for tuberculosis research.Formula:C27H29ClN6O3Colore e forma:SolidPeso molecolare:521.01Zalunfiban dihydrochloride
<p>Zalunfiban (RUC-4) is a potent αIIbβ3 platelet antagonist, IC50 45 nM, used in myocardial infarction research.</p>Formula:C16H20Cl2N8O2SColore e forma:SolidPeso molecolare:459.35α5β1 integrin agonist-1
CAS:α5β1 integrin agonist-1 is an α5β1 integrin agonist that selectively delivers 5-FU to tumour cells and induces tumour cell death.Formula:C24H26FN5O9Colore e forma:SolidPeso molecolare:547.4911-Oxahomoaminopterin
CAS:11-Oxahomoaminopterin exhibits antifolate activity against two folate-requiring microorganisms and inhibited Lactobacillus casei DHFR.Formula:C20H21N7O6Purezza:98%Colore e forma:SolidPeso molecolare:455.42Morpholino U subunit
CAS:Morpholino U subunit is one of the fundamental components of morpholino oligonucleotides, capable of pairing with adenine in target RNA.Formula:C30H32ClN4O5PColore e forma:SolidPeso molecolare:595.03CDK1-IN-7
CAS:<p>CDK1-IN-7 (compound M7) is a potent CDK1 inhibitor. It effectively suppresses the proliferation and migration of HCT116 and Lovo cells, making it a valuable tool for colorectal cancer research.</p>Formula:C23H19ClN4O3Colore e forma:SolidPeso molecolare:434.88LN-439A
CAS:LN-439A (compound LN-439A) is a novel BAP1 inhibitor that suppresses the growth of basal-like breast cancer by degrading KLF5.Formula:C24H26FN3O4Colore e forma:SolidPeso molecolare:439.48VPC-80051
CAS:<p>VPC-80051 is an hnRNP A1 splicing activity inhibitor that directly interacts with the hnRNP A1 RBD and reduces AR-V7 messenger levels in the 22Rv1 CRPC cell line. VPC-80051 is applicable in prostate cancer research.</p>Formula:C16H13F2N3OColore e forma:SolidPeso molecolare:301.291PPA-037
CAS:<p>PPA-037 is an orally active and highly selective inhibitor of cyclin-dependent kinase 12 (CDK12). It induces the degradation of Cyclin K, thereby enhancing antiproliferative effects on tumor cells. PPA-037 holds potential for use in cancer research.</p>Formula:C25H27N7Colore e forma:SolidPeso molecolare:425.53CHK1-IN-11
CAS:CHK1-IN-11 (Compound 1) is an orally active inhibitor of checkpoint kinase 1 (CHK1). It is utilized in research focused on cancers with oncogene amplification.Formula:C20H22N8O2Colore e forma:SolidPeso molecolare:406.446-N-Hydroxylaminopurine
CAS:6-N-Hydroxylaminopurine is a base analog with mutagenic activity.Formula:C5H5N5OPeso molecolare:151.13DHICA
CAS:DHICA (5,6-Dihydroxyindole-2-carboxylic acid) is an intermediate in melanin synthesis and a component of eumelanin, as well as acting as a moderate potency agonist of GPR35. In the U2OS cell line, DHICA demonstrates the ability to induce β-arrestin translocation signaling with an EC50 value of 23.2 μM. Additionally, it plays a significant role in promoting and protecting against DNA damage.Formula:C9H7NO4Colore e forma:SolidPeso molecolare:193.16Dyrk1A-IN-8
CAS:Dyrk1A-IN-8 is an active molecule that can be used in life science related research. The CAS number of Dyrk1A-IN-8 is 101578-13-6.Formula:C17H21N3OColore e forma:SolidPeso molecolare:283.37PLK1-IN-5
CAS:PLK1-IN-5, a potent PLK1 inhibitor, has an IC50 of less than 500 nM and demonstrates anticancer effects (WO2008113711A1; compound I-4) [1].Formula:C28H39N7O3Colore e forma:SolidPeso molecolare:521.652'-Deoxycytidine hydrate
CAS:2'-Deoxycytidine (Deoxycytidine) hydrate is a component of nucleic acids.Formula:C9H15N3O5Colore e forma:SolidPeso molecolare:245.23MtTMPK-IN-3
CAS:<p>MtTMPK-IN-3 inhibits Mycobacterium tuberculosis kinase with IC50 0.12μM, MIC 12.5μM on Mtb, cytotoxic EC50 12.5μM on MRC-5 cells.</p>Formula:C23H23Cl2N3O3Colore e forma:SolidPeso molecolare:460.35WEE1 degrader 1
WEE1degrader 1 (Compound 10) functions as a Wee1 degrader, exhibiting a DC50 value of 1.5 nM against Wee1. This compound also possesses anticancer properties that inhibit cell proliferation.Formula:C30H31N5O3Colore e forma:SolidPeso molecolare:509.6TMX-3013
CAS:TMX-3013 is a CDK inhibitor that targets multiple cyclin-dependent kinases, specifically suppressing the activity of CDK1, CDK2, CDK4, CDK5, and CDK6 with IC50 values of 0.9 nM, <0.5 nM, 24.5 nM, 0.5 nM, and 15.6 nM respectively. Additionally, TMX-3013 is utilized in the synthesis of PROTACs, which use polyethylene glycol (PEG) as a linker and Thalidomide as the CRBN-recruiting arm.Formula:C17H14BrFN6O3SColore e forma:SolidPeso molecolare:481.3TH9619
CAS:TH9619 is an effective inhibitor of both dehydrogenase and cyclohydrolase activities in MTHFD1 and MTHFD2 (IC50=47 nM). Anticancer.Formula:C17H18FN7O7Purezza:98.07%Peso molecolare:451.37IRE1α kinase-IN-4
CAS:IRE1α kinase-IN-4 (compound 6) is a potent inhibitor of IRE1α, exhibiting a Ki value of 140 nM. It acts as an ATP-competitive ligand for IRE1α [1].Formula:C29H31N7O2Colore e forma:SolidPeso molecolare:509.6CDK5-IN-2
CAS:CDK5-IN-2 (compound 15) is a highly selective CDK5 inhibitor that acts on CDK5/p25 (IC50: 0.2 nM) and CDK2/CycA (IC50: 23 nM).Formula:C29H28FN5OColore e forma:SolidPeso molecolare:481.562,5-Di-tert-butyl-1,4-benzoquinone
CAS:<p>2,5-Di-tert-butyl-1,4-benzoquinone is a potent antibacterial agent found primarily in marine Streptomyces sp. VITVSK1, effective against emerging antibiotic resistance. Additionally, it serves as a powerful inhibitor of RNA polymerase.</p>Formula:C14H20O2Colore e forma:SolidPeso molecolare:220.31CDK1-IN-6
CDK1-IN-6 (Ligand 3) is an effective inhibitor of CDK1 and shows potential for use in cancer research.Formula:C21H22N4OColore e forma:SolidPeso molecolare:346.43RNase L ligand 3
CAS:RNase L ligand 3 is an RNase L ligand employed in the synthesis of F3-PEG8-RiboTAC.Formula:C27H27N3OSColore e forma:SolidPeso molecolare:441.592′-OMe-GDP
CAS:2′-OMe-GDP is a nucleotide analog utilized for the synthesis of oligonucleotides.Formula:C11H17N5O11P2Colore e forma:SolidPeso molecolare:457.23CDK1-IN-5
CDK1-IN-5 is a selective inhibitor for CDK1 (IC50: 42.19 nM), CDK2, CDK5, halting cancer cell growth.Formula:C27H26ClN5OSColore e forma:SolidPeso molecolare:504.05β-catenin-IN-8
CAS:<p>β-catenin-IN-8 (Compound 25) is an inhibitor of β-catenin. It effectively lowers the levels of both β-catenin and c-Myc proteins and suppresses Wnt target genes (Fgf20 and Sall4). Additionally, β-catenin-IN-8 exhibits anticancer activity against colorectal cancer and possesses metabolic stability.</p>Formula:C15H12ClN3O2SColore e forma:SolidPeso molecolare:333.79CDK2-IN-30
CAS:<p>CDK2-IN-30 (Formula (I)) is a CDK2 inhibitor with an IC50 of ≤20 nM, utilized primarily in tumor research.</p>Formula:C18H25N7O3SColore e forma:SolidPeso molecolare:419.50Epolactaene
CAS:Epolactaene: neuritogenic, inhibits mammalian DNA polymerases & human DNA topoisomerase II.Formula:C21H27NO6Colore e forma:SolidPeso molecolare:389.44CDK7-IN-31
CAS:CDK7-IN-31 (compound 13) is an effective and orally active inhibitor of cyclin-dependent kinase 7 (CDK7) with a dissociation constant (Kd) of 0.18 nM. This compound exhibits anticancer activity.Formula:C27H32F5N6O2PColore e forma:SolidPeso molecolare:598.55CDK6-IN-1
CAS:CDK6-IN-1 (compound 4i) is an inhibitor of CDK6 that suppresses cell growth and induces cell cycle arrest at the G1 phase.Formula:C30H23N5Colore e forma:SolidPeso molecolare:453.54FT3967385
FT3967385: New USP30 inhibitor boosts mitochondrial ubiquitylation via PINK1-PARKIN.Formula:C21H19N5O2Colore e forma:SolidPeso molecolare:373.41LY 254155
CAS:LY 254155, an antifolate,binds to mFBP and inhibits hGARFT with Kis of 1.7±0.1 and 2.1±0.2 nM, respectively.Formula:C19H23N5O6SPurezza:98%Colore e forma:SolidPeso molecolare:449.48Dmf-dg
CAS:Dmf-dg (2'-Deoxy-N2-dimethylaminomethylene-guanosine) is a nucleoside of deoxyguanosine (dG) with a dimethylaminomethylene (DMF) base protection, employed in the synthesis of oligonucleotides.Formula:C13H18N6O4Colore e forma:SolidPeso molecolare:322.322'-F-CDP
CAS:2'-F-CDP is a nucleotide analog that can be utilized in the synthesis of oligonucleotides.Formula:C9H14FN3O10P2Colore e forma:SolidPeso molecolare:405.17Deoxythymidine-5'-triphosphate-d15
CAS:Deoxythymidine-5'-triphosphate-d15 (dTTP-d15) dilithium is a deuterium-labeled form of deoxythymidine-5'-triphosphate. Deoxythymidine-5'-triphosphate (dTTP) is a triphosphate nucleotide utilized in DNA synthesis.Formula:C10H15Li2N2O14P3Colore e forma:SolidPeso molecolare:509.13AGH-107
CAS:AGH-107 is a highly selective 5-HT7 receptor agonist that can cross the blood-brain barrier, featuring a Ki value of 6 nM and an EC50 value of 19 nM. Demonstrating high selectivity for central nervous system targets, AGH-107 also exhibits high metabolic stability and low toxicity in HEK-293 and HepG2 cell cultures.Formula:C13H12IN3Colore e forma:SolidPeso molecolare:337.163'-NH-Tr-2',3'-ddG(iBu)-5'-CE-Phosphoramidite
CAS:3'-NH-Tr-2',3'-ddG(iBu)-5'-CE-Phosphoramidite is a nucleoside phosphoramidite monomer featuring protective group modifications, suitable for RNA oligonucleotide synthesis.Formula:C42H51N8O5PColore e forma:SolidPeso molecolare:778.88LNA-UTP
CAS:LNA-UTP is a nucleotide analogue used in the synthesis of oligonucleotides.Formula:C10H15N2O15P3Colore e forma:SolidPeso molecolare:496.15YKL-1-116
CAS:YKL-1-116 is an effective, selective, and covalent CDK7 inhibitor.Formula:C34H38N8O3Purezza:98%Colore e forma:SolidPeso molecolare:606.72Mitotic kinesin-IN-1 hydrochloride
CAS:Mitotic kinesin-IN-1 hydrochloride (Example 80) is an inhibitor of mitotic kinesin, which suppresses cell proliferation by hindering mitosis. This compound is applicable in research related to cancer, cardiac hypertrophy, immune and inflammatory diseases, and fungal infections.Formula:C22H26ClF2N3OSColore e forma:SolidPeso molecolare:453.98Anticancer agent 30
<p>Anticancer agent 30 (6f-Z), a 3-arylidene-2-oxindole, selectively inhibits CDK2, showing potent anticancer potential.</p>Formula:C22H15ClFNOColore e forma:SolidPeso molecolare:363.81(R)-Atuveciclib
CAS:Atuveciclib (BAY-1143572) is a potent and highly selective, oral PTEFb / CDK9 inhibitor that inhibits CDK9 / CycT1 with an IC 50 of 13 nM [1].Formula:C18H18FN5O2SPurezza:98%Colore e forma:SolidPeso molecolare:387.43LNA-GTP
CAS:LNA-GTP is a nucleotide analog used in the synthesis of oligonucleotides.Formula:C11H16N5O14P3Colore e forma:SolidPeso molecolare:535.19AB25583
CAS:AB25583 is a small molecule inhibitor of Polθ helicase (Polθ-hel) with an IC50 of 6 nM. It selectively kills cells deficient in BRCA1/2 and synergizes with Olaparib in cancer cells harboring pathogenic BRCA1/2 mutations. AB25583 can be utilized in tumor research.Formula:C22H17ClN4O3SColore e forma:SolidPeso molecolare:452.91Dyrk1A-IN-1
Dyrk1A-IN-1 is a triple inhibitor of Dyrk1A kinase activity, aggregation of tau and α-syn oligomers, with an IC50 value of 119 nM for Dyrk1A kinase.Formula:C23H20N4O3SColore e forma:SolidPeso molecolare:432.49(E)-Antiviral agent 67
CAS:<p>(E)-Antiviral agent 67 (compound PC6) is a pyrazolone-based antiviral compound that exhibits inhibitory activity against RNA-dependent RNA polymerase.</p>Formula:C19H19N3OColore e forma:SolidPeso molecolare:305.3742'-O-MOE-UTP
CAS:2'-O-MOE-UTP is a nucleotide analog employed in the synthesis of oligonucleotides.Formula:C12H21N2O16P3Colore e forma:SolidPeso molecolare:542.22P162-0948
CAS:P162-0948 is a selective CDK8 inhibitor with an IC50 value of 50.4 nM. It reduces cell migration and the expression of EMT-related proteins in the A549 human alveolar epithelial cell line. Furthermore, P162-0948 decreases Smad phosphorylation, indicating disruption of the TGF-β/Smad signaling pathway, making it a promising compound for pulmonary fibrosis research.Formula:C20H15FN4O2Colore e forma:SolidPeso molecolare:362.357CDK4/9-IN-1
CAS:CDK4/9-IN-1 (Compound 29) is a selective dual inhibitor of CDK4 and CDK9, exhibiting IC50 values of 23 nM and 12 nM, respectively. It holds potential for use in cancer research.Formula:C22H34N6O2Colore e forma:SolidPeso molecolare:414.544MKLP2-IN-1
CAS:<p>MKLP2-IN-1 (compound 12a) is an inhibitor of MKLP2 that demonstrates excellent oral bioactivity. In vitro, MKLP2-IN-1 inhibits the ATPase activity stimulated by recombinant MKLP2 microtubules and, in a mouse Calu-6 lung cancer model, it effectively suppresses tumor growth.</p>Formula:C23H19BrFN3O2Colore e forma:SolidPeso molecolare:468.318CDK2-IN-39
CAS:<p>CDK2-IN-39 (compound 4) is a CDK2 inhibitor.</p>Formula:C14H15N3O4SColore e forma:SolidPeso molecolare:321.352CDK2-IN-40
CAS:CDK9-IN-40 is an inhibitor of CDK2 (Cyclin-dependent kinase 2). It effectively inhibits CDK2/Cyclin E1, with an IC50 of ≤ 10 nM.Formula:C16H21N7O2Colore e forma:SolidPeso molecolare:343.384MU147
CAS:MU147 is an MRE11 nuclease inhibitor and chemical probe with anticancer properties, exhibiting lethal effects on Ehrlich ascites tumor cells both in vivo and in vitro. It disrupts the MRE11 nuclease-dependent double-strand break repair mechanism without impairing ATM activation. Additionally, MU147 damages the degradation of nascent strands at stalled replication forks and selectively affects BRCA2-deficient cells.Formula:C19H13N3O3SColore e forma:SolidPeso molecolare:363.39
