Ciclo cellulare/Checkpoint
Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.
Sottocategorie di "Ciclo cellulare/Checkpoint"
- Chinasi aurora(114 prodotti)
- CDK(545 prodotti)
- Arresto del ciclo cellulare(5 prodotti)
- Chk(48 prodotti)
- DYRK(47 prodotti)
- Dynamin(27 prodotti)
- Ferroptosi(226 prodotti)
- HSP(179 prodotti)
- Integrina(249 prodotti)
- Chinesina(87 prodotti)
- LIM chinasi(20 prodotti)
- Microtubulo associato(274 prodotti)
- PKC(124 prodotti)
- PLK(25 prodotti)
- ROCK(62 prodotti)
- Rho(6 prodotti)
- Wee1(14 prodotti)
- c-Myc(76 prodotti)
Mostrare 10 più sottocategorie
Trovati 3859 prodotti di "Ciclo cellulare/Checkpoint"
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CK7
CAS:CK7, a Cdk2/9 inhibitor, is instrumental in the synthesis of Nek1 inhibitors BSc5231 and BSc5367.Formula:C14H12N6O2SPurezza:99.54%Colore e forma:SolidPeso molecolare:328.35Ref: TM-T9615
1mg52,00€5mg120,00€10mg187,00€25mg376,00€50mg588,00€100mg905,00€200mg1.216,00€1mL*10mM (DMSO)133,00€SNS-314
CAS:SNS-314 inhibits Aurora kinases A and B, blocking cell division in AK-overexpressing tumors.Formula:C18H15ClN6OS2Purezza:98%Colore e forma:SolidPeso molecolare:430.93BI-847325
CAS:BI-847325 is a selective dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively.Formula:C29H28N4O2Purezza:97.13% - 97.54%Colore e forma:SolidPeso molecolare:464.56BMH-21
CAS:BMH-21, a small molecule DNA intercalator, binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription and not affects phosphorylation of H2AX.Formula:C21H20N4O2Purezza:99.47% - 99.84%Colore e forma:SolidPeso molecolare:360.41Adavosertib
CAS:Adavosertib (MK-1775) is a small molecule inhibitor of the checkpoint kinase WEE1 (IC50: 5.2 nM). It hinders the G2 DNA damage checkpoint.Formula:C27H32N8O2Purezza:98.65% - 99.86%Colore e forma:SolidPeso molecolare:500.6Ref: TM-T2077
5mg46,00€10mg66,00€25mg81,00€50mg96,00€100mg110,00€200mg161,00€500mg260,00€1mL*10mM (DMSO)49,00€GDC0575 monohydrochloride
CAS:GDC0575 (ARRY575), a potent Chk1 inhibitor, IC50 1.2nM, disrupts cell cycle arrest, allowing DNA repair before mitosis.Formula:C16H21BrClN5OPurezza:97.85%Colore e forma:SolidPeso molecolare:414.73Ref: TM-T27407
1mg43,00€2mg55,00€5mg80,00€10mg103,00€25mg177,00€50mg255,00€100mg356,00€200mg520,00€1mL*10mM (DMSO)93,00€Aurora kinase inhibitor-2
CAS:Aurora kinase inhibitor-2 (IUN-70219) is a cell-permeable anilinoquinazoline that inhibit the activity of Aurora A (IC50 = 0.39 M).Formula:C23H20N4O3Purezza:98.66%Colore e forma:SolidPeso molecolare:400.43Ref: TM-T9040
1mg63,00€5mg138,00€10mg200,00€25mg360,00€50mg532,00€100mg788,00€200mg1.063,00€1mL*10mM (DMSO)150,00€SR18662
SR18662, improved ML264 derivative, inhibits KLF5 at 4.4 nM IC50; curbs colorectal cancer cell growth and triggers apoptosis.Formula:C16H19Cl2N3O4SPurezza:98.97% - 99.2%Colore e forma:SolidPeso molecolare:420.31Ref: TM-T22429
1mg46,00€5mg90,00€10mg152,00€25mg295,00€50mg475,00€100mg680,00€200mg888,00€500mg1.378,00€1mL*10mM (DMSO)100,00€BIO-1211
CAS:BIO-1211 is a more potent inhibitor of α4β1 (VLA-4, IC50 = 4 nM) over α4β7(IC50 = 2 μM).Formula:C36H48N6O9Purezza:99.33%Colore e forma:SolidPeso molecolare:708.8Pyridostatin
CAS:Pyridostatin (RR82) is a synthetic small-molecule stabilizer of G-quadruplexes, a secondary structure of DNA that usually exists in the end of the chromosome orFormula:C31H32N8O5Purezza:98%Colore e forma:SolidPeso molecolare:596.64TMPyP4 tosylate
CAS:TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand and is a telomerase inhibitor with antitumor effects in osteosarcoma cell lines.Formula:C72H66N8O12S4Purezza:98.61% - 99.85%Colore e forma:SolidPeso molecolare:1363.6PKD-IN-1
CAS:CRT0066101 is an inhibitor of PKD.Formula:C18H19ClN4OPurezza:98%Colore e forma:SolidPeso molecolare:342.82GNE-6776
CAS:GNE-6776 is a selective USP7 inhibitor.Formula:C20H20N4O2Purezza:96.59% - 98.2%Colore e forma:SolidPeso molecolare:348.4DUB-IN-1
CAS:DUB-IN-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs).Formula:C20H11N5OPurezza:98.33% - 98.96%Colore e forma:SolidPeso molecolare:337.33Ref: TM-T11110
1mg62,00€5mg110,00€10mg173,00€25mg334,00€50mg469,00€100mg618,00€200mg848,00€1mL*10mM (DMSO)122,00€RI-1
CAS:RI-1 (RAD51 inhibitor 1) is a RAD51 inhibitor (IC50: 5-30 μM).Formula:C14H11Cl3N2O3Purezza:99.3% - 99.62%Colore e forma:SolidPeso molecolare:361.61AT7519 TFA
CAS:AT7519 inhibits CDK1-6 kinases; IC50 ranges 0.018-0.66 μM.Formula:C18H18Cl2F3N5O4Colore e forma:SolidPeso molecolare:496.27α2β1 Integrin Ligand Peptide acetate
α2β1 Integrin Ligand Peptide acetate (α2β1 Integrin Ligand Peptide acetate (134580-64-6)) is a potential antagonist of α2β1 integrin receptor.Formula:C16H26N4O11Purezza:98.46%Colore e forma:SolidPeso molecolare:450.4CW-069
CAS:CW-069 (IC50=75 μM）, an allosteric selective inhibitor of microtubule motor protein HSET, exhibits remarkable specificity over KSP.Formula:C23H21IN2O3Purezza:97.52% - 99.52%Colore e forma:SolidPeso molecolare:500.33Ref: TM-T6209
1mg40,00€5mg86,00€10mg118,00€25mg205,00€50mg290,00€100mg409,00€500mg888,00€1mL*10mM (DMSO)94,00€CCG-203971
CAS:CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50: 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM.Formula:C23H21ClN2O3Purezza:98.82% - 99.50%Colore e forma:SolidPeso molecolare:408.88Hydroxyfasudil Hydrochloride
CAS:Hydroxyfasudil Hydrochloride (HA 1100 hydrochloride) is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM).Formula:C14H18ClN3O3SPurezza:98.05%Colore e forma:SolidPeso molecolare:343.83
