Ciclo cellulare/Checkpoint
Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.
Sottocategorie di "Ciclo cellulare/Checkpoint"
- Chinasi aurora(111 prodotti)
- CDK(526 prodotti)
- Arresto del ciclo cellulare(4 prodotti)
- Chk(46 prodotti)
- DYRK(49 prodotti)
- Dynamin(26 prodotti)
- Ferroptosi(225 prodotti)
- HSP(179 prodotti)
- Integrina(256 prodotti)
- Chinesina(87 prodotti)
- LIM chinasi(19 prodotti)
- Microtubulo associato(283 prodotti)
- PKC(111 prodotti)
- PLK(25 prodotti)
- ROCK(66 prodotti)
- Rho(2 prodotti)
- Wee1(14 prodotti)
- c-Myc(76 prodotti)
Mostrare 10 più sottocategorie
Trovati 3756 prodotti di "Ciclo cellulare/Checkpoint"
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MC-Val-Cit-PAB-Ispinesib
CAS:MC-Val-Cit-PAB-Ispinesib (Compound 509) is a potent Eg5 inhibitor and a click chemistry reagent [1].Formula:C59H71ClN10O10Colore e forma:SolidPeso molecolare:1115.71FAICAR
CAS:FAICAR (5-Formamidoimidazole-4-carboxamide ribotide), a purine nucleotide, plays a crucial role in metabolic processes.Formula:C10H15N4O9PColore e forma:SolidPeso molecolare:366.2212R-LOX-IN-1
CAS:12R-LOX-IN-1 (Compound 4a), with an IC50 of 28.25 µM, is an inhibitor of 12R-LOX.Formula:C15H11NO2Colore e forma:SolidPeso molecolare:237.25TC-I 15
CAS:α2β1 integrin inhibitorFormula:C23H28N4O6S2Purezza:98%Colore e forma:SolidPeso molecolare:520.62CDK4/6-IN-17
CAS:CDK4/6-IN-17 (compound 12) is an orally bioavailable inhibitor of CDK4/6, demonstrating potent activity with IC50 values between 10-100 nM in BE(2) cells.Formula:C27H28F4N8Purezza:98%Colore e forma:SolidPeso molecolare:540.563-Hydroxyxanthone
CAS:3-Hydroxyxanthone (3-Hydroxy-xanthen-9-one), a xanthone derivative, exhibits inhibitory effects on NADPH-catalyzed lipid peroxidation in human umbilical veinFormula:C13H8O3Purezza:98%Colore e forma:SolidPeso molecolare:212.2Riviciclib
CAS:Riviciclib, a CDK inhibitor (CDK9/T1, CDK4/D1, CDK1/B), has IC50s: 20, 63, 79 nM respectively, and fights cisplatin-resistant tumors.Formula:C21H20ClNO5Purezza:98%Colore e forma:SolidPeso molecolare:401.84G-5758
CAS:G-5758 is an orally active IRE1α inhibitor with an IC50 of 38 nM for XBP1s. It is used in studies involving multiple myeloma models [KMS-11], demonstrating good tolerance in rats at oral doses up to 500 mg/kg. G-5758 exhibits pharmacodynamic effects comparable to those induced by IRE1 knockdown.Formula:C27H24F4N6O3SColore e forma:SolidPeso molecolare:588.58ML 315 hydrochloride
CAS:<p>ML 315, a selective dual inhibitor targeting CDK (Cyclin-Dependent Kinase) and DYRK (Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase) with IC50 values of 68 nM and 282 nM, respectively, is utilized in research pertaining to cancer and neurological diseases [1].</p>Formula:C18H14Cl3N3O2Colore e forma:SolidPeso molecolare:410.682CCT241533
CAS:CCT241533 is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).Formula:C23H27FN4O4Purezza:98%Colore e forma:SolidPeso molecolare:442.48H3B-968
CAS:H3B-968 is a potent inhibitor of Werner syndrome protein (WRN) with an IC50 of approximately 10 nM, effectively targeting its helicase, ATPase, and exonucleaseFormula:C22H18F6N4O4SPurezza:98%Colore e forma:SolidPeso molecolare:548.46Sapacitabine
CAS:Sapacitabine (CS682) is a nucleoside analog precursor with anticancer activity used in the study of leukemia.Formula:C26H42N4O5Purezza:98.82%Colore e forma:SolidPeso molecolare:490.64DNA Gyrase-IN-8
CAS:DNA Gyrase-IN-8 is a potent inhibitor of DNA gyrase, demonstrating antimicrobial activity with an IC50 of 8.45 µM [1].Formula:C19H14BrN5OPurezza:98%Colore e forma:SolidPeso molecolare:408.25DAM-IN-1
CAS:DMA-IN-1 is a DNA adenine methyltransferase (DAM) inhibitor with an IC50 value of 48 μM.Formula:C16H17NO4Purezza:98%Colore e forma:SolidPeso molecolare:287.31Emzadirib
CAS:Emzadirib (RAD51-IN-2) is a potent RAD51 inhibitor with potential anticancer activity for the study of DNA damage repair.Formula:C27H40N4O6S2Purezza:99.79% - 99.9%Colore e forma:SolidPeso molecolare:580.76TNP-351
CAS:Tnp 351 is a novel antifolate drug being assessed for chemotherapy of lung cancer.Formula:C21H24N6O5Colore e forma:SolidPeso molecolare:440.45CDK9-IN-8
CAS:<p>CDK9-IN-8 is a highly potent and selective CDK9 inhibitor (IC50: 12 nM).</p>Formula:C31H32FN7O3Purezza:99.54%Colore e forma:SolidPeso molecolare:569.63Phototrexate
CAS:Phototrexate, a photochromic Methotrexate analog, is a UVA-activated, reversible DHFR inhibitor with antifolate properties (IC50: 6 nM cis vs. 34 μM trans).Formula:C20H19N7O5Colore e forma:SolidPeso molecolare:437.41Nε-(1-Carboxyethyl)-L-lysine
CAS:Nε-(1-Carboxyethyl)-L-lysine (CEL) is an advanced glycation end-product (AGE). Exposure to CEL reduces glutamate uptake and S100B secretion in the hippocampus.Formula:C9H18N2O4Colore e forma:SolidPeso molecolare:218.259-Deazaguanine
CAS:9-Deazaguanine is a nucleoside analogue exhibiting inhibitory activity against bovine purine nucleoside phosphorylase (PNP).Formula:C6H6N4OPurezza:98%Colore e forma:SolidPeso molecolare:150.14
