Ciclo cellulare/Checkpoint
Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.
Sottocategorie di "Ciclo cellulare/Checkpoint"
- Chinasi aurora(111 prodotti)
- CDK(526 prodotti)
- Arresto del ciclo cellulare(4 prodotti)
- Chk(46 prodotti)
- DYRK(49 prodotti)
- Dynamin(26 prodotti)
- Ferroptosi(225 prodotti)
- HSP(179 prodotti)
- Integrina(256 prodotti)
- Chinesina(87 prodotti)
- LIM chinasi(19 prodotti)
- Microtubulo associato(283 prodotti)
- PKC(111 prodotti)
- PLK(25 prodotti)
- ROCK(66 prodotti)
- Rho(2 prodotti)
- Wee1(14 prodotti)
- c-Myc(76 prodotti)
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Trovati 3756 prodotti di "Ciclo cellulare/Checkpoint"
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GSK2163632A
CAS:GSK2163632A is an insulin-like growth factor 1 receptor inhibitor that acts by binding to a novel region of the GRK active site cleft.Formula:C27H32N8O3SColore e forma:SolidPeso molecolare:548.665,6,7,8-Tetrahydro-8-deazahomofolic acid
CAS:5,6,7,8-Tetrahydro-8-deazahomofolic acid is a potential thymidylate synthase (TS) inhibitor and other folate related enzymes inhibitor.Formula:C21H26N6O6Colore e forma:SolidPeso molecolare:458.47KM05382
CAS:KM05382 inhibits CDK9 and the transcription of GAPDH.Formula:C20H19ClN2O3S2Colore e forma:SolidPeso molecolare:434.96Methotrexate-γ-aspartate
CAS:Methotrexate-gamma-aspartate has growth inhibitory effects. It is used in antibody-targeted liposomes.Formula:C24H27N9O8Purezza:98%Colore e forma:SolidPeso molecolare:569.53Antifolate C1
CAS:Antifolate C1 blocks purine creation, favors uptake via folate receptors/PCFT over RFC.Formula:C19H21N5O6SColore e forma:SolidPeso molecolare:447.465-DACTHF
CAS:5,11-methenyltetrahydrohomofolate blocks GAR & AIR transformylase; used as an anti-purine drug.Formula:C19H24N6O6Purezza:98%Colore e forma:SolidPeso molecolare:432.43Diazoketone methotrexate
CAS:Diazoketone methotrexate is an analog of methotrexate with potential antitumor activity.Formula:C21H22N10O4Colore e forma:SolidPeso molecolare:478.46IIIM-290
CAS:IIIM-290 is an oral CDK inhibitor (IC50s: 90 and 94 nM for CDK2/A and CDK9/T1).Formula:C23H21Cl2NO5Purezza:98%Colore e forma:SolidPeso molecolare:462.32UNC2170 maleate
CAS:53BP1-binding protein 1 (53BP1) engages with dimethylated lysine 20 on histone 4 (H4K20me2) through its tandem tudor domains within a homodimer configuration, crucial for the DNA damage response. UNC2170, a micromolar 53BP1 ligand, selectively interacts with this site, demonstrating at least 17-fold preference for 53BP1 over similar proteins. This interaction occurs in a pocket formed by the 53BP1's tudor domains. Moreover, UNC2170 acts as an antagonist to 53BP1 in cellular lysates, effectively inhibiting class switch recombination, a process dependent on the functional 53BP1 tudor domain, thus confirming its cellular activity.Formula:C14H21BrN2OC4H4O4Colore e forma:SolidPeso molecolare:429.31TAS-114
CAS:<p>TAS-114 is a dUTPase and DPD inhibitor that modulates catabolic pathways to improve systemic availability of 5-FU.</p>Formula:C21H29N3O6SPurezza:99.76%Colore e forma:SolidPeso molecolare:451.54L-Methioninamide hydrochloride
CAS:L-Methioninamide hydrochloride is a potent inhibitor of methionyl-tRNA synthetase that reduces the toxicity of CDDP.Formula:C5H13ClN2OSPurezza:99.93%Colore e forma:SolidPeso molecolare:184.69Spirofylline
CAS:Spirofylline is an agent of bronchodilator, has the potential for asthma and bronchitis and emphysema treatment.Formula:C24H28N6O5Purezza:98%Colore e forma:SolidPeso molecolare:480.52Mevociclib
CAS:Mevociclib (SY-1365) is a highly selective covalent inhibitor of CDK7. SY-1365 possesses therapeutic potential in both hematological and solid tumors.Formula:C31H35ClN8O2Purezza:98.02% - 98.02%Colore e forma:SolidPeso molecolare:587.11Lamifiban
CAS:Lamifiban is a nonpeptide glycoprotein IIb/IIIa antagonist. It prevents platelet loss during experimental cardiopulmonary bypass.Formula:C24H28N4O6Purezza:98%Colore e forma:SolidPeso molecolare:468.5Integrin Antagonists 27
CAS:Integrin Antagonists 27 is a small molecule integrin αvβ3 antagonist. It has a binding affinity of 18 nM and as a novel anticancer agent.Formula:C24H20N4O5Colore e forma:SolidPeso molecolare:444.44OXA-06 hydrochloride
CAS:OXA-06 hydrochloride, an ATP-competitive ROCK inhibitor, impedes anchorage-dependent growth and invasion in non-small cell lung cancer cell lines. It effectively inhibits cofilin phosphorylation without inducing apoptosis [1].Formula:C21H20Cl2FN3Colore e forma:SolidPeso molecolare:404.31Galidesivir hydrochloride
CAS:Galidesivir hydrochloride is an inhibitor of viral RNA-dependent RNA polymerase (RdRp). It inhibits SARS-CoV-2 by tightly binding to its RdRp.Formula:C11H16ClN5O3Purezza:98%Colore e forma:SolidPeso molecolare:301.73NTRC 0066-0
CAS:NTRC 0066-0 is a TTK inhibitor that can be used in cancer research.Formula:C33H39N7O2Purezza:98.30%Colore e forma:SolidPeso molecolare:565.71SC-52012
CAS:<p>SC-52012 is a novel and potent fibrinogen receptor antagonist, an RGD mimetic, which inhibits platelet aggregation.</p>Formula:C25H30N4O6Purezza:97.20%Colore e forma:SolidPeso molecolare:482.53UNC-2170
CAS:UNC-2170 (UNC2170 Maleate) is the methyl-lysine binding protein, 53BP1 ligand.Formula:C14H21BrN2OPurezza:97.44%Colore e forma:SolidPeso molecolare:313.23
