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Ciclo cellulare/Checkpoint

Ciclo cellulare/Checkpoint

Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.

Sottocategorie di "Ciclo cellulare/Checkpoint"

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Trovati 3756 prodotti di "Ciclo cellulare/Checkpoint"

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  • 5'-ODMT cEt m5U Phosphoramidite (Amidite)
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    5'-ODMT cEt m5U Phosphoramidite (Amidite)

    CAS:
    <p>5'-ODMT cEt m5U Phosphoramidite Amidite, a locked nucleic acid (LNA) analog, demonstrates exceptional safety and antisense activity [1] [2].</p>
    Formula:C42H51N4O9P
    Colore e forma:Solid
    Peso molecolare:786.85

    Ref: TM-T74705

  • 3-Cyanovinylcarbazole phosphoramidite
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    3-Cyanovinylcarbazole phosphoramidite

    CAS:
    3-Cyanovinylcarbazole phosphoramidite: an antiviral, hinders viral DNA synthesis, modifies ribonucleotides.
    Formula:C50H53N4O6P
    Colore e forma:Solid
    Peso molecolare:836.95

    Ref: TM-T74188

  • 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite)
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    5'-ODMT cEt N-Bz A Phosphoramidite (Amidite)

    CAS:
    5'-ODMT cEt N-Bz A Phosphoramidite Amidite, a locked nucleic acid (LNA) analogue, exhibits hybridization and mismatch discrimination capabilities similar to LNA, and shows resistance to exonuclease digestion [1].
    Formula:C49H54N7O8P
    Colore e forma:Solid
    Peso molecolare:899.97

    Ref: TM-T74702

  • JNJ-26076713
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    JNJ-26076713

    CAS:
    JNJ-26076713, an oral alpha V integrin blocker, may treat macular edema, AMD, and diabetic retinopathy.
    Formula:C29H38N4O3
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:490.64

    Ref: TM-T27670

  • Voruciclib hydrochloride
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    Voruciclib hydrochloride

    CAS:
    Voruciclib hydrochloride is an orally active and selective inhibitor of CDK (Ki: 0.626 nM-9.1 nM).
    Formula:C22H20Cl2F3NO5
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:506.3

    Ref: TM-T13309

  • Logo CymitQuimica
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    MOMA-341

    CAS:
    MOMA-341 is a highly selective inhibitor targeting the Werner RecQ-like helicase (WRN). It exerts a dual mechanism of allosteric regulation and ATP competitive inhibition by binding to the cysteine 727 site of the WRN protein. In mouse models with mismatch repair deficiency (dMMR) or high microsatellite instability (MSI-H), MOMA-341 can induce DNA damage, cell apoptosis, and promote tumor shrinkage. This compound exhibits significant anti-tumor activity and has potential application prospects in the study of advanced and metastatic solid tumors.
    Formula:C28H26F4N6O3
    Peso molecolare:570.54

    Ref: TM-T210496

  • Cytarabine 5′-monophosphate
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    Cytarabine 5′-monophosphate

    CAS:
    Cytarabine 5′-monophosphate (ara-CMP), an active metabolite of the nucleoside analog cytarabine formed by deoxycytidine kinase, is incorporated into DNA by DNA polymerase α, significantly slowing DNA synthesis. It inhibits nuclear and mitochondrial DNA replication in S. cerevisiae at 15 mM and improves survival in an L1210 murine leukemia model at 3.5-75.1 mg/kg.
    Formula:C9H14N3O8P
    Colore e forma:Solid
    Peso molecolare:323.198

    Ref: TM-T84932

  • 5′-Guanylyl methylenediphosphonate sodium
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    5′-Guanylyl methylenediphosphonate sodium

    CAS:
    5′-Guanylyl methylenediphosphonate (sodium) serves as a GTP analogue and acts as a specific, competitive inhibitor of the GTP reaction in protein synthesis [1].
    Formula:C11H15N5Na3O13P3
    Colore e forma:Solid
    Peso molecolare:587.15

    Ref: TM-T83299

  • Amotosalen free base
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    Amotosalen free base

    CAS:
    Amotosalen is a Dermatologic Agent.
    Formula:C17H19NO4
    Colore e forma:Solid
    Peso molecolare:301.34

    Ref: TM-T30030

  • GRK2 Inhibitor 2
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    GRK2 Inhibitor 2

    CAS:
    GRK2 Inhibitor 2 (Compound 8h), with an IC50 of 19 nM for GRK2 and 137 nM for Aurora-A, enhances β-AR-mediated cAMP accumulation in GRK2-overexpressing HEK293
    Formula:C19H16N4O2
    Colore e forma:Solid
    Peso molecolare:332.36

    Ref: TM-T79913

  • PDD00031705
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    PDD00031705

    CAS:
    PDD00031705 is a benzimidazolone core cell-inactive Poly (ADP-ribose) glycohydrolase (PARG) inhibitor.
    Formula:C20H22N6O3S3
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:490.62

    Ref: TM-T12388

  • Pelitrexol
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    Pelitrexol

    CAS:
    Pelitrexol (AG2037) is a GARFT inhibitor, which can inhibit the activity of mTORC1, block the cell cycle in the s-phase, with antiproliferative activity,NSCLC .
    Formula:C20H25N5O6S
    Purezza:98.03%
    Colore e forma:Solid
    Peso molecolare:463.51

    Ref: TM-T14147

  • LX7101 hydrochloride
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    LX7101 hydrochloride

    CAS:
    LX7101 is a potent inhibitor of both LIM kinase (LIMK) 1 and 2, and Rho-associated kinase 1 (ROCK1) and ROCK2, with IC50 values of 32, 4.3, 69, and 32 nM, respectively. It is selective, demonstrated by its lack of cross-reactivity in a panel of binding assays involving 78 receptors, transporters, and an additional 430 kinases, at a concentration of 10 μM. The topical administration of LX7101 (3 μl of a 1 mg/ml solution) to the eye has been shown to reduce intraocular pressure in a dexamethasone-induced mouse model of glaucoma.
    Formula:C23H29N7O3HCl
    Colore e forma:Solid
    Peso molecolare:488

    Ref: TM-T85304

  • ROCK2-IN-7
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    ROCK2-IN-7

    CAS:
    <p>ROCK2 inhibitor is a chemical compound associated with the therapeutic management of psoriasis.</p>
    Formula:C26H28FN5O
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:445.53

    Ref: TM-T81261

  • DHODH-IN-14
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    DHODH-IN-14

    CAS:
    DHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726.
    Formula:C15H7F4N3O3
    Purezza:99.81%
    Colore e forma:Solid
    Peso molecolare:353.23

    Ref: TM-T11023

  • GSK2850163
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    GSK2850163

    CAS:
    GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit RNase activity and IRE1α kinase activity (IC50s: 200 and 20 nM).
    Formula:C24H29Cl2N3O
    Purezza:99.04%
    Colore e forma:Solid
    Peso molecolare:446.41

    Ref: TM-T11488

  • CASK-IN-1
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    CASK-IN-1

    CAS:
    CASK-IN-1 is a highly potent and selective CASK inhibitor with a K d value of 0.022 μM.
    Formula:C24H30Br2N6O3
    Colore e forma:Solid
    Peso molecolare:610.34

    Ref: TM-T73221

  • TAK 029
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    TAK 029

    CAS:
    TAK 029 is a local glycoprotein IIb/IIIa receptor inhibitor.
    Formula:C19H23N5O7
    Colore e forma:Solid
    Peso molecolare:433.42

    Ref: TM-T28913

  • DHX9-IN-6
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    DHX9-IN-6

    CAS:
    DHX9-IN-6 is a highly effective ATP-dependent RNA helicase A (DHX9) inhibitor, used in cancer research.
    Formula:C23H18ClFN4O4S2
    Purezza:99.71%
    Colore e forma:Solid
    Peso molecolare:533

    Ref: TM-T86202

  • AR-13503
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    AR-13503

    CAS:
    AR-13503, a Netarsudil metabolite, is a ROCK inhibitor, potentially treating glaucoma and lowering eye pressure.
    Formula:C19H19N3O2
    Colore e forma:Solid
    Peso molecolare:321.37

    Ref: TM-T71120