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Ciclo cellulare/Checkpoint

Ciclo cellulare/Checkpoint

Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.

Sottocategorie di "Ciclo cellulare/Checkpoint"

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Trovati 3764 prodotti di "Ciclo cellulare/Checkpoint"

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  • Thymectacin
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    Thymectacin

    CAS:
    Thymectacin (NB 1011) is a selective thymidine synthase (TS) inhibitor with anticancer activity for the study of colon cancer and solid tumors.
    Formula:C21H25BrN3O9P
    Purezza:97.05% - 99.49%
    Colore e forma:Solid
    Peso molecolare:574.32

    Ref: TM-T24881

  • Plogosertib
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    Plogosertib

    CAS:
    Plogosertib (CYC140) is a PLK1 inhibitor with an IC50 value of 3 nM.Plogosertib is antiproliferative and can be used to study solid and hematologic tumors.
    Formula:C34H48N8O3
    Purezza:99.22% - 99.85%
    Colore e forma:Solid
    Peso molecolare:616.797

    Ref: TM-T71399

  • CCT129202
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    CCT129202

    CAS:
    CCT129202 is an ATP-competitive pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 0.042 μM, 0.198 μM and 0.227 μM, respectively.
    Formula:C23H25ClN8OS
    Purezza:98.14%
    Colore e forma:Solid
    Peso molecolare:497.02

    Ref: TM-T6435

  • CF53
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    CF53

    CAS:
    CF53: potent, selective oral BET inhibitor; Ki <1 nM, Kd 2.2 nM, IC50 2 nM for BRD4 BD1; high affinity for BRD2/3/4/BRDT; effective anti-tumor agent.
    Formula:C24H25N7O2
    Purezza:99.72%
    Colore e forma:Solid
    Peso molecolare:443.5

    Ref: TM-T10773

  • αvβ1 integrin-IN-1
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    αvβ1 integrin-IN-1

    CAS:
    <p>αvβ1 integrin-IN-1 is a potent and selective inhibitor of αvβ1 integrin (IC50 of 0.63 nM) with antifibrotic effects.</p>
    Formula:C26H34N6O6S
    Purezza:99.74% - >99.99%
    Colore e forma:Solid
    Peso molecolare:558.65

    Ref: TM-T13473

  • Sorivudine
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    Sorivudine

    CAS:
    Sorivudine (BV-araU) is an antiviral blocking DNA synthesis in viruses like varicella, HSV-1, and Epstein-Barr.
    Formula:C11H13BrN2O6
    Purezza:99.74%
    Colore e forma:Solid
    Peso molecolare:349.13

    Ref: TM-T16911

  • Lomibuvir
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    Lomibuvir

    CAS:
    Lomibuvir (VCH-222, VX-222) is an allosteric inhibitor of HCV NS5B with Kd 17 nM, blocks RNA elongation, EC50 5.2 nM for 1b/Con1.
    Formula:C25H35NO4S
    Purezza:99.83%
    Colore e forma:Solid
    Peso molecolare:445.61

    Ref: TM-T6729

  • And1 degrader 1
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    And1 degrader 1

    CAS:
    And1 degrader 1 (Compound A15) is a degrader of acidic nucleoplasmic DNA-binding protein 1 (And1) that notably induces degradation of And1 in NSCLC cells. When combined with Olaparib (1 μM), And1 degrader 1 at a concentration of 5 μM effectively inhibits proliferation in A549 and H460 cells. This compound is applicable in cancer research studies.
    Formula:C26H27Cl2N3O
    Colore e forma:Solid
    Peso molecolare:468.42

    Ref: TM-T200443

  • Zorubicin
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    Zorubicin

    CAS:
    <p>Zorubicin, a Daunorubicin derivative, targets topoisomerase II, inhibits DNA polymerase, and researches acute leukemia, sarcomas.</p>
    Formula:C34H35N3O10
    Colore e forma:Solid
    Peso molecolare:645.66

    Ref: TM-T69130

  • Polθ-IN-7
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    Polθ-IN-7

    CAS:
    <p>Polθ-IN-7 (example 12) is an inhibitor of DNA polymerase θ (Polθ) with a Ki of 1.27 nM.</p>
    Formula:C28H35F3N6O2
    Colore e forma:Solid
    Peso molecolare:544.612

    Ref: TM-T204135

  • Logo CymitQuimica
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    Dyrk1A/α-synuclein-IN-2

    Dyrk1A/α-synuclein-IN-2 (Compound b20) is a dual inhibitor of Dyrk1A and α-synuclein aggregation that acts on α-synuclein (IC50: 7.8 μM).
    Formula:C21H16N4O4S
    Colore e forma:Solid
    Peso molecolare:420.44

    Ref: TM-T62226

  • DYRK1-IN-1
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    DYRK1-IN-1

    CAS:
    DYRK1-IN-1: Selective DYRK1A inhibitor with IC50 of 220 nM, good permeability, CNS penetrant for research, no P-glycoprotein issues.
    Formula:C12H12N6
    Colore e forma:Solid
    Peso molecolare:240.26

    Ref: TM-T60334

  • LY 254155
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    LY 254155

    CAS:
    LY 254155, an antifolate,binds to mFBP and inhibits hGARFT with Kis of 1.7±0.1 and 2.1±0.2 nM, respectively.
    Formula:C19H23N5O6S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:449.48

    Ref: TM-T11922

  • NVP-BQS481
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    NVP-BQS481

    CAS:
    NVP-BQS481 (Compound 1) is a selective inhibitor of spindle motor protein 5 (Eg5), with an IC50 of less than 0.5 nM. It demonstrates significant anti-mitotic and anti-tumor activities, exhibiting an IC50 of 0.09 nM against SK-OV-3ip cells. NVP-BQS481 is suitable for use as a cytotoxic payload in the synthesis of antibody-drug conjugates (ADCs).
    Formula:C27H33F3N4O2
    Colore e forma:Solid
    Peso molecolare:502.57

    Ref: TM-T212559

  • Logo CymitQuimica
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    FT3967385

    FT3967385: New USP30 inhibitor boosts mitochondrial ubiquitylation via PINK1-PARKIN.
    Formula:C21H19N5O2
    Colore e forma:Solid
    Peso molecolare:373.41

    Ref: TM-T61512

  • ROCK/HDAC-IN-1
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    ROCK/HDAC-IN-1

    ROCK/HDAC-IN-1 (Compound 10h) serves as an orally effective inhibitor of ROCK/HDAC. This compound suppresses ROCK1/2 (IC50: 254.9 nM, 58.18 nM) and HDAC1/2/3/6/8 (IC50: 9.09, 8.03, 6.26, 0.41, 7.69 nM). It stimulates the activation of DAMPs, notably calreticulin (CRT) exposure and HMGB1 release, suggesting its potential as an inducer of immunogenic cell death (ICD). ROCK/HDAC-IN-1 exhibits antiproliferative effects against breast cancer cells (IC50: 0.37 μM for MDA-MB-231 cells), inhibits tumor growth, activates T cells, and shows no significant toxicity.
    Formula:C19H22N4O3S
    Colore e forma:Solid
    Peso molecolare:386.47

    Ref: TM-T201708

  • IXA62
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    IXA62

    CAS:
    IXA62 is an orally active, selective IRE1/XBP1s agonist (EC50= 0.31 μM) that can reduce Aβ secretion.
    Formula:C24H23N3O3
    Colore e forma:Solid
    Peso molecolare:401.458

    Ref: TM-T206732

  • Epolactaene
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    Epolactaene

    CAS:
    Epolactaene: neuritogenic, inhibits mammalian DNA polymerases & human DNA topoisomerase II.
    Formula:C21H27NO6
    Colore e forma:Solid
    Peso molecolare:389.44

    Ref: TM-T70284

  • 3'-Deoxy-GTP
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    3'-Deoxy-GTP

    CAS:
    3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate) is an analog of GTP and serves as an RNA chain terminator, effectively inhibiting RNA synthesis. It can inhibit dengue virus DENV NS5 RdRp with an IC50 of 0.02 μM.
    Formula:C10H16N5O13P3
    Colore e forma:Solid
    Peso molecolare:507.181

    Ref: TM-T206927

  • LIMK1 inhibitor 2
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    LIMK1 inhibitor 2

    CAS:
    LIMK1 inhibitor 2 (compound 41) is a LIMK1 inhibitor with an IC50 value of 9 μM.
    Formula:C10H11N3OS
    Colore e forma:Solid
    Peso molecolare:221.279

    Ref: TM-T204765