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Ciclo cellulare/Checkpoint

Ciclo cellulare/Checkpoint

Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.

Sottocategorie di "Ciclo cellulare/Checkpoint"

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Trovati 3752 prodotti di "Ciclo cellulare/Checkpoint"

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  • Cdc7-IN-19
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    Cdc7-IN-19

    CAS:
    Cdc7-IN-19 (compound 1-1) is a potent CDC7 inhibitor with an IC 50 of 1.49 nM [1].
    Formula:C19H21N5O2
    Colore e forma:Solid
    Peso molecolare:351.40

    Ref: TM-T61223

  • (R)-Atuveciclib
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    (R)-Atuveciclib

    CAS:
    Atuveciclib (BAY-1143572) is a potent and highly selective, oral PTEFb / CDK9 inhibitor that inhibits CDK9 / CycT1 with an IC 50 of 13 nM [1].
    Formula:C18H18FN5O2S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:387.43

    Ref: TM-T10464

  • Dmf-dg
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    Dmf-dg

    CAS:
    Dmf-dg (2'-Deoxy-N2-dimethylaminomethylene-guanosine) is a nucleoside of deoxyguanosine (dG) with a dimethylaminomethylene (DMF) base protection, employed in the synthesis of oligonucleotides.
    Formula:C13H18N6O4
    Colore e forma:Solid
    Peso molecolare:322.32

    Ref: TM-TSW-00950

  • 2'-F-CDP
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    2'-F-CDP

    CAS:
    2'-F-CDP is a nucleotide analog that can be utilized in the synthesis of oligonucleotides.
    Formula:C9H14FN3O10P2
    Colore e forma:Solid
    Peso molecolare:405.17

    Ref: TM-TSW-00957

  • INX-315
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    INX-315

    CAS:
    INX-315 is an orally active, selective CDK2 inhibitor that induces cell cycle arrest and senescence in solid tumours, suppresses E2F target gene expression.
    Formula:C19H21N7O3S
    Purezza:99.88%
    Colore e forma:Solid
    Peso molecolare:427.48

    Ref: TM-T86723

  • Cdc7-IN-18
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    Cdc7-IN-18

    CAS:
    <p>Cdc7-IN-18 (1-2) inhibits CDC7 enzyme (IC50: 1.29 nM) and COLO205 cell proliferation (IC50: 53.62 nM).</p>
    Formula:C19H21N5OS
    Colore e forma:Solid
    Peso molecolare:367.47

    Ref: TM-T61436

  • CDK2 degrader 6
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    CDK2 degrader 6

    CAS:
    CDK2 degrader6 (compound 6) is an orally active CDK2 degrader with a DC50 of 46.5 nM, and is applicable in breast cancer research.
    Formula:C23H22F5N5O3
    Colore e forma:Solid
    Peso molecolare:511.44

    Ref: TM-T207287

  • WRN inhibitor 7
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    WRN inhibitor 7

    CAS:
    <p>WRN inhibitor 7 (Compound h6), a potent inhibitor of Werner syndrome helicase, demonstrates effective suppression of WRN's helicase and ATPase activities with IC50 values of 9.8 μM and 15.8 μM, respectively. This compound is utilized in the study of microsatellite instable (MSI) cancers [1].</p>
    Formula:C27H23N3O6
    Colore e forma:Solid
    Peso molecolare:485.49

    Ref: TM-T87635

  • DB18
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    DB18

    CAS:
    DB18 serves as a potent, selective inhibitor of CDC2-like kinases (CLKs), exhibiting IC50 values between 10-30 nM for CLK1, CLK2, and CLK4. Additionally, it possesses anti-tumor activity [1].
    Formula:C24H18ClN7O3
    Colore e forma:Solid
    Peso molecolare:487.9

    Ref: TM-T86165

  • PKMYT1-IN-2
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    PKMYT1-IN-2

    CAS:
    PKMYT1-IN-2 (compound 2) serves as a powerful inhibitor of PKMYT1, exhibiting an IC 50 of 5.7 nM. Additionally, it effectively suppresses the proliferation of HCC1569 cells with an IC 50 of 22 nM [1].
    Formula:C22H19N5O2
    Colore e forma:Solid
    Peso molecolare:385.42

    Ref: TM-T87219

  • CDK2-IN-18
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    CDK2-IN-18

    CAS:
    <p>CDK2-IN-18 (compound 8q) serves as a powerful inhibitor of CDK 2/E and CDK 4/D1, showing IC50 values of 8 nM and 46 nM, respectively. It effectively inhibits tumor cell proliferation [1].</p>
    Formula:C21H23N7O2S
    Colore e forma:Solid
    Peso molecolare:437.52

    Ref: TM-T86027

  • Uridine 3',5'-diphosphate
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    Uridine 3',5'-diphosphate

    CAS:
    Uridine 3′,5′-diphosphate (3′,5′-UDP; Compound pUp) serves as a competitive RNase inhibitor [1].
    Formula:C9H14N2O12P2
    Colore e forma:Solid
    Peso molecolare:404.16

    Ref: TM-T87599

  • DHX9-IN-9
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    DHX9-IN-9

    CAS:
    DHX9-IN-9 (509) acts as an inhibitor of the RNA helicase DHX9, demonstrating an EC50 of 0.0177 μM in DHX9 cellular target engagement, primarily utilized in cancer research [1].
    Formula:C21H21ClFN5O3S2
    Colore e forma:Solid
    Peso molecolare:510

    Ref: TM-T86205

  • CDK8-IN-14
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    CDK8-IN-14

    CAS:
    <p>CDK8-IN-14 (compound 12) effectively inhibits CDK8, demonstrating an IC50 of 39.2 nM, and exhibits potent anti-AML cell proliferation effects, with a GC50 value of 0.02±0.01μM in MOLM-13 cells and 0.03±0.01μM in MV4-11 cells [1].</p>
    Formula:C18H13N3O2
    Colore e forma:Solid
    Peso molecolare:303.31

    Ref: TM-T86031

  • ROCK-IN-11
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    ROCK-IN-11

    CAS:
    ROCK-IN-11 (example 94) is an effective inhibitor of ROCK1 and ROCK2, with an IC50 of ≤ 5 μM, and plays a significant role in cancer research.
    Formula:C22H20N4O4S
    Colore e forma:Solid
    Peso molecolare:436.484

    Ref: TM-T204468

  • 2'-O-MOE-GTP
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    2'-O-MOE-GTP

    CAS:
    2'-O-MOE-GTP is a nucleotide analog utilized in the synthesis of oligonucleotides.
    Formula:C13H22N5O15P3
    Colore e forma:Solid
    Peso molecolare:581.26

    Ref: TM-TSW-00970

  • KI-CDK9d-32
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    KI-CDK9d-32

    CAS:
    <p>KI-CDK9d-32 is a CDK9 PROTAC degrader with a DC50 of 0.89 nM. It facilitates the ubiquitination and degradation of CDK9, inhibits the MYC pathway, and disrupts nucleolar homeostasis. KI-CDK9d-32 demonstrates anticancer activity.</p>
    Formula:C39H45N9O4
    Colore e forma:Solid
    Peso molecolare:703.83

    Ref: TM-T207184

  • BBI-355
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    BBI-355

    CAS:
    BBI-355 is an oral, potent, and selective small molecule CHK1 inhibitor with an IC50 of 0.3 nM. It exhibits significant antitumor activity, both as a monotherapy and in combination with targeted therapies, across various ecDNA+ oncogene-amplified tumor models.
    Formula:C19H19N7O2
    Colore e forma:Solid
    Peso molecolare:377.40

    Ref: TM-T207786

  • Logo CymitQuimica
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    2'-F-UMP

    CAS:
    <p>2'-F-UMP is a nucleotide analogue used in the synthesis of oligonucleotides.</p>
    Formula:C9H12FN2O8P
    Peso molecolare:326.17

    Ref: TM-TSW-00948

  • 2′-O-MOE-AMP
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    2′-O-MOE-AMP

    CAS:
    2′-O-MOE-AMP is a nucleotide analogue used in the synthesis of oligonucleotides.
    Formula:C13H20N5O8P
    Colore e forma:Solid
    Peso molecolare:405.30

    Ref: TM-TSW-00946