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Ciclo cellulare/Checkpoint

Ciclo cellulare/Checkpoint

Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.

Sottocategorie di "Ciclo cellulare/Checkpoint"

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Trovati 3749 prodotti di "Ciclo cellulare/Checkpoint"

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  • Logo CymitQuimica
    Targetmol
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    RAD51-IN-8

    RAD51-IN-8 inhibits RAD51-BRCA2 interaction and H4A4 with EC50 of 19 μM; a micromolar PPI inhibitor.
    Formula:C16H14Cl2FN3O2
    Colore e forma:Solid
    Peso molecolare:370.21

    Ref: TM-T61469

  • LNA-GMP
    Targetmol
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    LNA-GMP

    CAS:
    LNA-GMP, a nucleotide analogue, is utilized in the synthesis of oligonucleotides.
    Formula:C11H14N5O8P
    Colore e forma:Solid
    Peso molecolare:375.23

    Ref: TM-TSW-00965

  • LN-439A
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    LN-439A

    CAS:
    LN-439A (compound LN-439A) is a novel BAP1 inhibitor that suppresses the growth of basal-like breast cancer by degrading KLF5.
    Formula:C24H26FN3O4
    Colore e forma:Solid
    Peso molecolare:439.48

    Ref: TM-T200435

  • 6-B345TTQ
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    6-B345TTQ

    CAS:
    6-B345TTQ is an α4 integrin inhibitor that can impede the interaction between α4 and Leupaxin. This compound is applicable for studies focused on inflammation research.
    Formula:C22H20BrNO4
    Colore e forma:Solid
    Peso molecolare:442.303

    Ref: TM-T204244

  • And1 degrader 1
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    And1 degrader 1

    CAS:
    And1 degrader 1 (Compound A15) is a degrader of acidic nucleoplasmic DNA-binding protein 1 (And1) that notably induces degradation of And1 in NSCLC cells. When combined with Olaparib (1 μM), And1 degrader 1 at a concentration of 5 μM effectively inhibits proliferation in A549 and H460 cells. This compound is applicable in cancer research studies.
    Formula:C26H27Cl2N3O
    Colore e forma:Solid
    Peso molecolare:468.42

    Ref: TM-T200443

  • Galidesivir
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    Galidesivir

    CAS:
    Galidesivir (BCX4430) is an antiviral compound that inhibits viral RNA-dependent RNA polymerase (RdRp) activity and reduces lung infections in infected animals.
    Formula:C11H15N5O3
    Purezza:96.73% - 99.13%
    Colore e forma:Solid
    Peso molecolare:265.27

    Ref: TM-T10491

  • DYRK1-IN-1
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    DYRK1-IN-1

    CAS:
    DYRK1-IN-1: Selective DYRK1A inhibitor with IC50 of 220 nM, good permeability, CNS penetrant for research, no P-glycoprotein issues.
    Formula:C12H12N6
    Colore e forma:Solid
    Peso molecolare:240.26

    Ref: TM-T60334

  • GR 83895
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    GR 83895

    CAS:
    GR 83895 is an antagonist of prototype fibrinogen receptor.
    Formula:C29H39N9O8S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:673.74

    Ref: TM-T25460

  • KL-50
    Targetmol
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    KL-50

    CAS:
    KL-50, a selective toxin, effectively targets tumors deficient in the DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT), which corrects O6-alkylguanine lesions. This compound induces both DNA damage response pathways and cell cycle arrest in MGMT-deficient cells, regardless of mismatch repair (MMR) status. KL-50 shows promise in the study of brain tumors lacking MGMT.
    Formula:C7H7FN6O2
    Colore e forma:Solid
    Peso molecolare:226.17

    Ref: TM-T200136

  • Pseudouridine 5'-OTBDPS
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    Pseudouridine 5'-OTBDPS

    CAS:
    <p>Pseudouridine5'-OTBDPS [5-(5-O-TBDPS-β-D-ribofuranosyl)uracil] is an intermediate of Pseudouridine.</p>
    Formula:C25H30N2O6Si
    Colore e forma:Solid
    Peso molecolare:482.60

    Ref: TM-TSW-00962

  • AB25583
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    AB25583

    CAS:
    AB25583 is a small molecule inhibitor of Polθ helicase (Polθ-hel) with an IC50 of 6 nM. It selectively kills cells deficient in BRCA1/2 and synergizes with Olaparib in cancer cells harboring pathogenic BRCA1/2 mutations. AB25583 can be utilized in tumor research.
    Formula:C22H17ClN4O3S
    Colore e forma:Solid
    Peso molecolare:452.91

    Ref: TM-T200101

  • LNA-GDP
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    LNA-GDP

    CAS:
    LNA-GDP is a nucleotide analog utilized in the synthesis of oligonucleotides.
    Formula:C11H15N5O11P2
    Colore e forma:Solid
    Peso molecolare:455.21

    Ref: TM-TSW-00961

  • 5-Methylcytosine hydrochloride
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    5-Methylcytosine hydrochloride

    CAS:
    5-Methylcytosine hydrochloride plays a critical role in regulating gene expression, promoting genomic imprinting, and inhibiting transposon factors. It is also closely associated with translation fidelity and tRNA recognition.
    Formula:C5H8ClN3O
    Colore e forma:Solid
    Peso molecolare:161.59

    Ref: TM-T201054

  • Metesind Glucuronate
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    Metesind Glucuronate

    CAS:
    Metesind Glucuronate is an antineoplastic. It also is a specific thymidylate synthase inhibitor.
    Formula:C29H34N4O10S
    Colore e forma:Solid
    Peso molecolare:630.67

    Ref: TM-T24454

  • GHP-88309
    Targetmol
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    GHP-88309

    CAS:
    <p>GHP-88309 is an orally active, broad-spectrum anti-paramyxovirus agent that targets viral polymerase, interrupting viral RNA synthesis. It effectively inhibits respiratory syncytial virus (RSV), measles virus (MeV), and canine distemper virus (CDV) with an EC50 of 0.06-1.2 μM. In mouse models, GHP-88309 demonstrates significant anti-infective activity.</p>
    Formula:C16H11FN2O
    Colore e forma:Solid
    Peso molecolare:266.27

    Ref: TM-T204819

  • Valopicitabine
    Targetmol
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    Valopicitabine

    CAS:
    <p>Valopicitabine is an effective prodrug of the effective anti-HCV drug 2'-C-methylcytidine and can be used as a promising antiviral drug for the study of chronic</p>
    Formula:C15H24N4O6
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:356.37

    Ref: TM-T13281

  • Logo CymitQuimica
    Targetmol
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    14α-Demethylase/DNA Gyrase-IN-1

    14α-Demethylase/DNA Gyrase-IN-1 (Compound 7c) is a potent inhibitor of 14α-Demethylase/DNA Gyrase with antibacterial activity.
    Formula:C26H22N4O4
    Colore e forma:Solid
    Peso molecolare:454.48

    Ref: TM-T62792

  • (R)-CSN5i-3
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    (R)-CSN5i-3

    CAS:
    (R)-CSN5i-3 is CSN5i-3 of the R configuration.
    Formula:C28H29F2N5O2
    Purezza:99.76% - 99.97%
    Colore e forma:Solid
    Peso molecolare:505.56

    Ref: TM-T12620

  • Cimpuciclib tosylate
    Targetmol
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    Cimpuciclib tosylate

    CAS:
    Cimpuciclib tosylate, a selective CDK4 inhibitor (IC50: 0.49 nM), exhibits anti-tumor activity.
    Formula:C37H43FN8O4S
    Colore e forma:Solid
    Peso molecolare:714.85

    Ref: TM-T72433

  • Xanthosine-5'-Triphosphate trisodium
    Targetmol
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    Xanthosine-5'-Triphosphate trisodium

    CAS:
    <p>Xanthosine-5'-Triphosphate (5'-XTP) trisodium is a nucleotide formed through the deamination of purine bases. It serves as a substrate for inosine triphosphate pyrophosphatase (ITPase).</p>
    Formula:C10H12N4Na3O15P3
    Colore e forma:Solid
    Peso molecolare:590.111

    Ref: TM-TXB-00592