CymitQuimica logo
Ciclo cellulare/Checkpoint

Ciclo cellulare/Checkpoint

Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.

Sottocategorie di "Ciclo cellulare/Checkpoint"

Mostrare 10 più sottocategorie

Trovati 3752 prodotti di "Ciclo cellulare/Checkpoint"

Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
prodotti per pagina.
  • Cimpuciclib tosylate
    Targetmol
    + Info

    Cimpuciclib tosylate

    CAS:
    Cimpuciclib tosylate, a selective CDK4 inhibitor (IC50: 0.49 nM), exhibits anti-tumor activity.
    Formula:C37H43FN8O4S
    Colore e forma:Solid
    Peso molecolare:714.85

    Ref: TM-T72433

  • Xanthosine-5'-Triphosphate trisodium
    Targetmol
    + Info

    Xanthosine-5'-Triphosphate trisodium

    CAS:
    <p>Xanthosine-5'-Triphosphate (5'-XTP) trisodium is a nucleotide formed through the deamination of purine bases. It serves as a substrate for inosine triphosphate pyrophosphatase (ITPase).</p>
    Formula:C10H12N4Na3O15P3
    Colore e forma:Solid
    Peso molecolare:590.111

    Ref: TM-TXB-00592

  • AR-13324 M1 metabolite
    Targetmol
    + Info

    AR-13324 M1 metabolite

    CAS:
    <p>AR-13324 M1 metabolite is a hydrolysis metabolite of AR-13324 mesylate.</p>
    Formula:C19H19N3O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:321.37

    Ref: TM-T10358L

  • 8-Oxo-dATP
    Targetmol
    + Info

    8-Oxo-dATP

    CAS:
    8-Oxo-dATP can be hydrolyzed to its monophosphate form by the oxidation of purine nucleoside triphosphate MTH1, preventing erroneous incorporation during DNA replication or transcription.
    Formula:C10H12Li4N5O13P3
    Colore e forma:Solid
    Peso molecolare:530.913

    Ref: TM-T206632

  • NSC 641396
    Targetmol
    + Info

    NSC 641396

    CAS:
    NSC 641396 is a ribonucleotide reductase (RNR) inhibitor with an IC50 value of 1.2 μM. Additionally, it acts as an inhibitor of protein arginine N-methyltransferase 9 (PRMT9) and exhibits antitumor properties.
    Formula:C18H13NO3
    Colore e forma:Solid
    Peso molecolare:291.301

    Ref: TM-T204449

  • UMPK ligand 1
    Targetmol
    + Info

    UMPK ligand 1

    CAS:
    <p>UMPK ligand 1 (ZINC07785412) serves as a ligand for uridine monophosphate kinase (UMPK).</p>
    Formula:C15H22N4O5S
    Colore e forma:Solid
    Peso molecolare:370.424

    Ref: TM-T204579

  • CDK9-IN-11
    Targetmol
    + Info

    CDK9-IN-11

    CAS:
    CDK9-IN-11 is a potent CDK9 inhibitor that is the ligand for the PROTAC CDK9 Degrader-1 [1].
    Formula:C20H25N3O4
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:371.43

    Ref: TM-T10743

  • PT109
    Targetmol
    + Info

    PT109

    CAS:
    PT109 is a multikinase inhibitor that targets JNK and other kinases, playing a crucial role in anti-inflammatory, antioxidative, neurogenic, and synaptogenic processes. Specifically, PT109 inhibits JNK isoforms with the following IC50 values: JNK1 at 0.143 μM, JNK2 at 0.831 μM, and JNK3 at 0.285 μM. It also inhibits SGK isoforms (SGK1: IC50=1.34 μM; SGK2: IC50=5.6 μM; SGK3: IC50=26.4 μM) and ROCK2 (IC50=34 μM). Additionally, PT109 reprograms polymorphic glioblastoma multiforme (GBM) into oligodendroglia via the PTBP1/PKM1/2 pathway and alters the metabolic pattern of GBM to exhibit antiglioma activity.
    Formula:C23H31N3OS2
    Colore e forma:Solid
    Peso molecolare:429.64

    Ref: TM-T201273

  • Ladirubicin
    Targetmol
    + Info

    Ladirubicin

    CAS:
    Ladirubicin, as an anthracyclines analog is the leading compound of alkylcyclines.
    Formula:C29H31NO11S
    Colore e forma:Solid
    Peso molecolare:601.62

    Ref: TM-T32534

  • 2'-(2-Nitrobenzyl)-ATP
    Targetmol
    + Info

    2'-(2-Nitrobenzyl)-ATP

    CAS:
    2'-(2-Nitrobenzyl)-ATP is an analog of rATP. It acts as a transcription terminator by inhibiting the elongation of RNA chains by T7 RNA polymerase.
    Formula:C17H21N6O15P3
    Colore e forma:Solid
    Peso molecolare:642.30

    Ref: TM-T207643

  • USP7-IN-10
    Targetmol
    + Info

    USP7-IN-10

    CAS:
    USP7-IN-10 is a potent inhibitor of ubiquitin-specific protease 7 (USP7), exhibiting an inhibition concentration half-maximal (IC50) value of 13.39 nM.
    Formula:C26H29ClN4O3S
    Colore e forma:Solid
    Peso molecolare:513.05

    Ref: TM-T73136

  • CIB-L43
    Targetmol
    + Info

    CIB-L43

    CAS:
    <p>CIB-L43 is a oral TRBP inhibitor, inhibit miR-21, increase PTEN and Smad7, and block the AKT and TGF-β，inhibit proliferation and migration.</p>
    Formula:C15H16N2O3S
    Purezza:99.64%
    Colore e forma:Solid
    Peso molecolare:304.36

    Ref: TM-T205607

  • SF0166
    Targetmol
    + Info

    SF0166

    CAS:
    SF0166: potent αvβ3 antagonist, IC50: 0.6 nM. Blocks cell adhesion, IC50: 7.6 pM-76 nM. Reduces neovascularization in mice.
    Formula:C23H27F2N5O4
    Colore e forma:Solid
    Peso molecolare:475.49

    Ref: TM-T70368

  • 5'-DMT-5-F-2'-dU Phosphoramidite
    Targetmol
    + Info

    5'-DMT-5-F-2'-dU Phosphoramidite

    CAS:
    5'-DMT-5-F-2'-dU Phosphoramidite is a nucleoside phosphoramidite analog employed in oligonucleotide synthesis. It plays a crucial role in developing therapeutic oligonucleotides, which are used in crafting drugs for cancer treatment.
    Formula:C39H46FN4O8P
    Colore e forma:Solid
    Peso molecolare:748.777

    Ref: TM-T206476

  • CDK9 autophagic degrader 1
    Targetmol
    + Info

    CDK9 autophagic degrader 1

    CAS:
    CDK9 autophagic degrader 1 (Compound 28) is an ATTEC degrader used to target and degrade CDK9, also impacting the levels of its associated Cyclin T1. At a concentration of 100 nM, it exhibits over 80% inhibition of CDK9.
    Formula:C34H39N7O4S2
    Colore e forma:Solid
    Peso molecolare:673.848

    Ref: TM-T204672

  • PD-1-IN-17
    Targetmol
    + Info

    PD-1-IN-17

    CAS:
    PD-1-IN-17 is an inhibitor of programmed cell death-1 (PD-1). PD-1-IN-17 inhibits 92% splenocyte proliferation at 100 nM.
    Formula:C13H22N6O7
    Purezza:99.6%
    Colore e forma:Solid
    Peso molecolare:374.35

    Ref: TM-T12377

  • GSK3335103
    Targetmol
    + Info

    GSK3335103

    CAS:
    GSK3335103 is a non-peptide, orally active inhibitor of αvβ6 integrin (pIC50=8), employed in the study of pulmonary fibrosis.
    Formula:C27H36FN3O4
    Colore e forma:Solid
    Peso molecolare:485.59

    Ref: TM-T200463

  • Logo CymitQuimica
    Targetmol
    + Info

    Sovesudil hydrochloride

    Sovesudil (PHP-201) HCl: potent local ROCK inhibitor; targets ROCK I/II (IC50: 3.7/2.3 nM); lowers IOP, non-congesting.
    Formula:C23H23ClFN3O3
    Colore e forma:Solid
    Peso molecolare:443.9

    Ref: TM-T62608

  • Logo CymitQuimica
    Targetmol
    + Info

    TH9619

    CAS:
    TH9619 is an effective inhibitor of both dehydrogenase and cyclohydrolase activities in MTHFD1 and MTHFD2 (IC50=47 nM). Anticancer.
    Formula:C17H18FN7O7
    Purezza:98.07%
    Peso molecolare:451.37

    Ref: TM-T87512

  • Logo CymitQuimica
    Targetmol
    + Info

    Dyrk1A/B-IN-1

    Dyrk1A/B-IN-1 (3n) is a potent DYRK1A/B inhibitor, cell-permeable, with Ki values of 67.8 nM (1A) and 237.9 nM (1B), IC50s of 1.1 and 0.8 μM.
    Formula:C21H17N3O2S2
    Colore e forma:Solid
    Peso molecolare:407.51

    Ref: TM-T62043