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Ciclo cellulare/Checkpoint

Ciclo cellulare/Checkpoint

Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.

Sottocategorie di "Ciclo cellulare/Checkpoint"

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Trovati 3749 prodotti di "Ciclo cellulare/Checkpoint"

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  • OPN expression inhibitor 1
    Targetmol
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    OPN expression inhibitor 1

    CAS:
    OPN expression inhibitor 1 is an osteopontin expression inhibitor used in the study of breast cancer metastasis.
    Formula:C25H33N3O5
    Purezza:99.78%
    Colore e forma:Solid
    Peso molecolare:455.55

    Ref: TM-T62820

  • Logo CymitQuimica
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    Zalunfiban dihydrochloride

    Zalunfiban (RUC-4) is a potent αIIbβ3 platelet antagonist, IC50 45 nM, used in myocardial infarction research.
    Formula:C16H20Cl2N8O2S
    Colore e forma:Solid
    Peso molecolare:459.35

    Ref: TM-T62878

  • PNR-3-80
    Targetmol
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    PNR-3-80

    CAS:
    PNR-3-80 is a selective inhibitor of apoptotic endonuclease G (EndoG), with an IC50 of 0.67 μM, showing greater inhibition than against DNase I. It exhibits no inhibitory activity against DNase II, RNase A, proteases, lactate dehydrogenase, and superoxide dismutase 1. PNR-3-80 effectively protects human prostate cancer cells from cell death induced by Cisplatin and Docetaxel and inhibits DNA damage and autophagy (autophagy) prompted by Etoposide. This compound is applicable in studies of cellular damage.
    Formula:C24H14ClN3O3S
    Colore e forma:Solid
    Peso molecolare:459.90

    Ref: TM-T212403

  • Logo CymitQuimica
    Targetmol
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    α5β1 integrin agonist-1

    CAS:
    α5β1 integrin agonist-1 is an α5β1 integrin agonist that selectively delivers 5-FU to tumour cells and induces tumour cell death.
    Formula:C24H26FN5O9
    Colore e forma:Solid
    Peso molecolare:547.49

    Ref: TM-T63868

  • FR-145715
    Targetmol
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    FR-145715

    CAS:
    FR-145715 is a histamine H2 receptor antagonist characterized by its specific anti-Helicobacter pylori activity. This compound is utilized in the study of gastric lesions.
    Formula:C16H21N5O2S
    Colore e forma:Solid
    Peso molecolare:347.44

    Ref: TM-T201582

  • Antimalarial agent 44
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    Antimalarial agent 44

    Antimalarial agent 44 (Compound 3) is an antiparasitic agent effective against malaria. It exhibits good permeability in MDCK-MDR1 cell monolayers and has a high clearance rate in mouse liver microsomes.
    Formula:C37H37N5O7
    Colore e forma:Solid
    Peso molecolare:663.72

    Ref: TM-T201453

  • CDK1-IN-7
    Targetmol
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    CDK1-IN-7

    CAS:
    <p>CDK1-IN-7 (compound M7) is a potent CDK1 inhibitor. It effectively suppresses the proliferation and migration of HCT116 and Lovo cells, making it a valuable tool for colorectal cancer research.</p>
    Formula:C23H19ClN4O3
    Colore e forma:Solid
    Peso molecolare:434.88

    Ref: TM-T207488

  • CDK7-IN-26
    Targetmol
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    CDK7-IN-26

    CAS:
    CDK7-IN-26 (compound 36) is an orally active CDK7 inhibitor with an IC50 of 7.4 nM. The compound effectively suppresses the growth of xenograft tumors derived from triple-negative breast cancer (TNBC) cell lines in vivo and has an IC50 of 0.15 μM for inhibiting MDA-MB-453 cells in vitro.
    Formula:C22H22FN6OPS
    Peso molecolare:468.49

    Ref: TM-T208352

  • VPC-80051
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    VPC-80051

    CAS:
    <p>VPC-80051 is an hnRNP A1 splicing activity inhibitor that directly interacts with the hnRNP A1 RBD and reduces AR-V7 messenger levels in the 22Rv1 CRPC cell line. VPC-80051 is applicable in prostate cancer research.</p>
    Formula:C16H13F2N3O
    Colore e forma:Solid
    Peso molecolare:301.291

    Ref: TM-T204737

  • PPA-037
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    PPA-037

    CAS:
    <p>PPA-037 is an orally active and highly selective inhibitor of cyclin-dependent kinase 12 (CDK12). It induces the degradation of Cyclin K, thereby enhancing antiproliferative effects on tumor cells. PPA-037 holds potential for use in cancer research.</p>
    Formula:C25H27N7
    Colore e forma:Solid
    Peso molecolare:425.53

    Ref: TM-T207610

  • NVP-BQS481
    Targetmol
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    NVP-BQS481

    CAS:
    NVP-BQS481 (Compound 1) is a selective inhibitor of spindle motor protein 5 (Eg5), with an IC50 of less than 0.5 nM. It demonstrates significant anti-mitotic and anti-tumor activities, exhibiting an IC50 of 0.09 nM against SK-OV-3ip cells. NVP-BQS481 is suitable for use as a cytotoxic payload in the synthesis of antibody-drug conjugates (ADCs).
    Formula:C27H33F3N4O2
    Colore e forma:Solid
    Peso molecolare:502.57

    Ref: TM-T212559

  • Rhodblock 1a
    Targetmol
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    Rhodblock 1a

    CAS:
    <p>Rhodblock 1a is an inhibitor of the Rho kinase signaling pathway, which disrupts the localization and function of proteins within the Rho pathway. This interference hinders the proper formation of the cleavage furrow during cell division, leading to some cells either failing to form the cleavage furrow or forming a ruptured furrow, resulting in binucleated cells. Rhodblock 1a can be utilized for investigating cell division mechanisms and holds potential for research into cardiovascular diseases and cancer.</p>
    Formula:C20H16N2O2
    Colore e forma:Solid
    Peso molecolare:316.353

    Ref: TM-T206882

  • 2'-Deoxycytidine hydrate
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    2'-Deoxycytidine hydrate

    CAS:
    2'-Deoxycytidine (Deoxycytidine) hydrate is a component of nucleic acids.
    Formula:C9H15N3O5
    Colore e forma:Solid
    Peso molecolare:245.23

    Ref: TM-TSW-00968

  • MtTMPK-IN-3
    Targetmol
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    MtTMPK-IN-3

    CAS:
    MtTMPK-IN-3 inhibits Mycobacterium tuberculosis kinase with IC50 0.12μM, MIC 12.5μM on Mtb, cytotoxic EC50 12.5μM on MRC-5 cells.
    Formula:C23H23Cl2N3O3
    Colore e forma:Solid
    Peso molecolare:460.35

    Ref: TM-T62897

  • Morpholino U subunit
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    Morpholino U subunit

    CAS:
    Morpholino U subunit is one of the fundamental components of morpholino oligonucleotides, capable of pairing with adenine in target RNA.
    Formula:C30H32ClN4O5P
    Colore e forma:Solid
    Peso molecolare:595.03

    Ref: TM-TSW-01102

  • IRE1α kinase-IN-4
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    IRE1α kinase-IN-4

    CAS:
    IRE1α kinase-IN-4 (compound 6) is a potent inhibitor of IRE1α, exhibiting a Ki value of 140 nM. It acts as an ATP-competitive ligand for IRE1α [1].
    Formula:C29H31N7O2
    Colore e forma:Solid
    Peso molecolare:509.6

    Ref: TM-T63511

  • Deoxythymidine-5'-triphosphate-d15
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    Deoxythymidine-5'-triphosphate-d15

    CAS:
    Deoxythymidine-5'-triphosphate-d15 (dTTP-d15) dilithium is a deuterium-labeled form of deoxythymidine-5'-triphosphate. Deoxythymidine-5'-triphosphate (dTTP) is a triphosphate nucleotide utilized in DNA synthesis.
    Formula:C10H15Li2N2O14P3
    Colore e forma:Solid
    Peso molecolare:509.13

    Ref: TM-T211806

  • 3'-NH-Tr-2',3'-ddG(iBu)-5'-CE-Phosphoramidite
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    3'-NH-Tr-2',3'-ddG(iBu)-5'-CE-Phosphoramidite

    CAS:
    3'-NH-Tr-2',3'-ddG(iBu)-5'-CE-Phosphoramidite is a nucleoside phosphoramidite monomer featuring protective group modifications, suitable for RNA oligonucleotide synthesis.
    Formula:C42H51N8O5P
    Colore e forma:Solid
    Peso molecolare:778.88

    Ref: TM-TSW-01143

  • CDK2/4-IN-2
    Targetmol
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    CDK2/4-IN-2

    CAS:
    CDK2/4-IN-2 (compound 56) serves as a dual inhibitor for CDK2 and CDK4, exhibiting an IC50 of less than 100 nM. It is applicable in cancer research.
    Formula:C18H20F3N7O3S2
    Colore e forma:Solid
    Peso molecolare:503.52

    Ref: TM-T200624

  • CDK5-IN-2
    Targetmol
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    CDK5-IN-2

    CAS:
    CDK5-IN-2 (compound 15) is a highly selective CDK5 inhibitor that acts on CDK5/p25 (IC50: 0.2 nM) and CDK2/CycA (IC50: 23 nM).
    Formula:C29H28FN5O
    Colore e forma:Solid
    Peso molecolare:481.56

    Ref: TM-T63184